CA2216809A1 - Imidazo[1,2-a]pyridine derivatives - Google Patents

Imidazo[1,2-a]pyridine derivatives Download PDF

Info

Publication number
CA2216809A1
CA2216809A1 CA002216809A CA2216809A CA2216809A1 CA 2216809 A1 CA2216809 A1 CA 2216809A1 CA 002216809 A CA002216809 A CA 002216809A CA 2216809 A CA2216809 A CA 2216809A CA 2216809 A1 CA2216809 A1 CA 2216809A1
Authority
CA
Canada
Prior art keywords
formula
compounds
compound
4alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002216809A
Other languages
English (en)
French (fr)
Inventor
Alan Naylor
Ian Baxter Campbell
Paul John Beswick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9506965.4A external-priority patent/GB9506965D0/en
Priority claimed from GBGB9512099.4A external-priority patent/GB9512099D0/en
Priority claimed from GBGB9516117.0A external-priority patent/GB9516117D0/en
Application filed by Individual filed Critical Individual
Publication of CA2216809A1 publication Critical patent/CA2216809A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002216809A 1995-04-04 1996-04-02 Imidazo[1,2-a]pyridine derivatives Abandoned CA2216809A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9506965.4A GB9506965D0 (en) 1995-04-04 1995-04-04 Chemical compounds
GB9506965.4 1995-04-04
GBGB9512099.4A GB9512099D0 (en) 1995-06-14 1995-06-14 Chemical compounds
GB9512099.4 1995-06-14
GBGB9516117.0A GB9516117D0 (en) 1995-08-05 1995-08-05 Chemical compounds
GB9516117.0 1995-08-05

Publications (1)

Publication Number Publication Date
CA2216809A1 true CA2216809A1 (en) 1996-10-10

Family

ID=27267657

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002216809A Abandoned CA2216809A1 (en) 1995-04-04 1996-04-02 Imidazo[1,2-a]pyridine derivatives

Country Status (17)

Country Link
EP (1) EP0819127A1 (ja)
JP (1) JPH11501049A (ja)
KR (1) KR19980703559A (ja)
CN (1) CN1186492A (ja)
AU (1) AU5276696A (ja)
BG (1) BG101934A (ja)
CA (1) CA2216809A1 (ja)
CZ (1) CZ313397A3 (ja)
EA (1) EA199700209A1 (ja)
HU (1) HUP9801602A3 (ja)
IS (1) IS4570A (ja)
NO (1) NO974595L (ja)
NZ (1) NZ304886A (ja)
PL (1) PL322623A1 (ja)
SK (1) SK133297A3 (ja)
TR (1) TR199701105T1 (ja)
WO (1) WO1996031509A1 (ja)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2764292B1 (fr) * 1997-06-10 2000-12-29 Innothera Lab Sa Utilisation de derives de tetracycles dicetoniques, nouveaux composes obtenus et leur application en therapeutique
US6525053B1 (en) 1997-08-22 2003-02-25 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
US6307047B1 (en) 1997-08-22 2001-10-23 Abbott Laboratories Prostaglandin endoperoxide H synthase biosynthesis inhibitors
DE69816651T2 (de) 1997-09-05 2004-04-01 Glaxo Group Ltd., Greenford 2,3-diaryl-pyrazolo[1,5-b]pyridazin derivate, deren herstellung und deren verwendung als cyclooxygenase 2 (cox-2) inhibitoren
FR2770131A1 (fr) * 1997-10-27 1999-04-30 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
FR2771005B1 (fr) * 1997-11-18 2002-06-07 Union Pharma Scient Appl Nouvelle association pharmaceutique a activite analgesique
GB9810920D0 (en) * 1998-05-21 1998-07-22 Merck Sharp & Dohme Therapeutic use
ES2140354B1 (es) * 1998-08-03 2000-11-01 S A L V A T Lab Sa Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2.
TW587079B (en) * 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
PL348208A1 (en) * 1998-11-03 2002-05-06 Glaxo Group Ltd Pyrazolopyridine derivatives as selective cox-2 inhibitors
AU2661400A (en) 1999-02-27 2000-09-21 Glaxo Group Limited Pyrazolopyridines
GB9930358D0 (en) 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
EP1246621A4 (en) 1999-12-23 2004-11-24 Nitromed Inc NITROSED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS FOR THEIR USE
GB0002312D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
PE20011333A1 (es) 2000-03-16 2002-01-16 Almirall Prodesfarma Ag Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
PT1303265E (pt) 2000-07-20 2007-10-09 Lauras As ''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida''
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
GB0025449D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
WO2002048148A2 (en) 2000-12-15 2002-06-20 Glaxo Group Limited Pyrazolopyridine derivatives
JP2004518651A (ja) 2000-12-15 2004-06-24 グラクソ　グループ　リミテッド 治療用化合物
ES2227451T3 (es) 2001-03-08 2005-04-01 Smithkline Beecham Corporation Derivados de pirazolopiridina.
WO2002078700A1 (en) 2001-03-30 2002-10-10 Smithkline Beecham Corporation Pyralopyridines, process for their preparation and use as therapteutic compounds
US7695736B2 (en) 2001-04-03 2010-04-13 Pfizer Inc. Reconstitutable parenteral composition
JP4219171B2 (ja) 2001-04-10 2009-02-04 スミスクライン ビーチャム コーポレーション 抗ウイルス性ピラゾロピリジン化合物
ES2242028T3 (es) 2001-04-27 2005-11-01 Smithkline Beecham Corporation Derivados de pirazolo(1,5-a)piridina.
US6756498B2 (en) 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
IL158667A0 (en) 2001-06-21 2004-05-12 Smithkline Beecham Corp Imidazo [1,2-a] pyridine derivatives for the prophylaxis and treatment of herpes viral infections
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
DE60211539T2 (de) 2001-10-05 2006-09-21 Smithkline Beecham Corp. Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124936D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124931D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
ATE373000T1 (de) 2001-12-11 2007-09-15 Smithkline Beecham Corp Pyrazolopyridin-derivate als antiherpesmittel
BRPI0307351B8 (pt) 2002-02-12 2021-05-25 Smithkline Beecham Corp composto, composição farmacêutica, uso de um composto, e, processo para preparar um composto
WO2004002420A2 (en) 2002-06-28 2004-01-08 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
GB0217757D0 (en) 2002-07-31 2002-09-11 Glaxo Group Ltd Novel compounds
WO2004033454A1 (en) 2002-10-03 2004-04-22 Smithkline Beecham Corporation Therapeutic compounds based on pyrazolopyridine derivatives
KR20040072004A (ko) 2003-02-07 2004-08-16 삼성에스디아이 주식회사 유기 전계 발광 소자용 발광 화합물 및 그를 이용한 유기전계발광 소자
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308185D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
AU2004237439B2 (en) 2003-05-07 2009-09-10 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
GB0318814D0 (en) 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
US8067464B2 (en) 2004-10-04 2011-11-29 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
WO2007016677A2 (en) 2005-08-02 2007-02-08 Nitromed, Inc. Nitric oxide enhancing antimicrobial compounds, compositions and methods of use
CA2647859C (en) 2006-03-29 2016-01-05 Nitromed, Inc. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
AU2007316417B2 (en) 2006-11-06 2013-08-22 Tolero Pharmaceuticals, Inc. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
ES2671748T3 (es) 2011-07-21 2018-06-08 Tolero Pharmaceuticals, Inc. Inhibidores heterocíclicos de proteína quinasas
WO2016177776A1 (en) 2015-05-04 2016-11-10 Academisch Medisch Centrum Biomarkers for the detection of aspirin insensitivity
KR20210146290A (ko) 2019-02-12 2021-12-03 스미토모 다이니폰 파마 온콜로지, 인크. 헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455924A (en) * 1967-02-08 1969-07-15 Upjohn Co Dianisylimidazoles

Also Published As

Publication number Publication date
IS4570A (is) 1997-09-25
WO1996031509A1 (en) 1996-10-10
HUP9801602A3 (en) 1999-01-28
BG101934A (en) 1999-04-30
NO974595D0 (no) 1997-10-03
JPH11501049A (ja) 1999-01-26
EA199700209A1 (ru) 1998-04-30
NO974595L (no) 1997-12-03
CN1186492A (zh) 1998-07-01
CZ313397A3 (cs) 1998-03-18
SK133297A3 (en) 1998-07-08
NZ304886A (en) 1998-11-25
MX9707379A (es) 1997-11-29
PL322623A1 (en) 1998-02-02
AU5276696A (en) 1996-10-23
EP0819127A1 (en) 1998-01-21
HUP9801602A2 (hu) 1998-11-30
KR19980703559A (ko) 1998-11-05
TR199701105T1 (xx) 1998-02-21

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Legal Events

Date Code Title Description
FZDE Discontinued