CA2182303C - Procede de preparation d'un vecteur viral par recombinaison homologue intermoleculaire - Google Patents
Procede de preparation d'un vecteur viral par recombinaison homologue intermoleculaire Download PDFInfo
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- CA2182303C CA2182303C CA002182303A CA2182303A CA2182303C CA 2182303 C CA2182303 C CA 2182303C CA 002182303 A CA002182303 A CA 002182303A CA 2182303 A CA2182303 A CA 2182303A CA 2182303 C CA2182303 C CA 2182303C
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| PCT/FR1995/001590 WO1996017070A1 (fr) | 1994-12-01 | 1995-12-01 | Procede de preparation d'un vecteur viral par recombinaison homologue intermoleculaire |
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| CA2182303A1 CA2182303A1 (fr) | 1996-06-06 |
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| FR2727689A1 (fr) * | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
| FR2730504B1 (fr) * | 1995-02-13 | 1997-03-28 | Rhone Poulenc Rorer Sa | Procede de preparation de genomes d'adenovirus recombinants |
| US6143557A (en) | 1995-06-07 | 2000-11-07 | Life Technologies, Inc. | Recombination cloning using engineered recombination sites |
| US6720140B1 (en) * | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| ATE256196T1 (de) * | 1997-06-09 | 2003-12-15 | Genvec Inc | Chimäre vektoren, die die verpackungsregion eines phagengenoms und einen teil des genoms eines eukaryontischen virus enthalten |
| FR2766091A1 (fr) | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| JP2001517455A (ja) | 1997-09-23 | 2001-10-09 | ジェンベク、インコーポレイティッド | 真核生物ウイルスベクター構築用プラスミド |
| JP4303418B2 (ja) * | 1997-10-24 | 2009-07-29 | ライフ テクノロジーズ コーポレーション | 組換え部位を有する核酸を使用する組換えクローニング |
| CN101125873A (zh) * | 1997-10-24 | 2008-02-20 | 茵维特罗根公司 | 利用具重组位点的核酸进行重组克隆 |
| US5922576A (en) * | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
| US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6413776B1 (en) | 1998-06-12 | 2002-07-02 | Galapagos Geonomics N.V. | High throughput screening of gene function using adenoviral libraries for functional genomics applications |
| US7691370B2 (en) * | 1998-10-15 | 2010-04-06 | Canji, Inc. | Selectivity replicating viral vector |
| EP2119788A1 (en) * | 1999-03-02 | 2009-11-18 | Life Technologies Corporation | Compositions and methods for use in recombinational cloning of nucleic acids |
| WO2001042481A2 (en) * | 1999-12-07 | 2001-06-14 | Genethon Iii | Canine adenovirus vectors for the transfer of genes into target cells |
| CN1757724B (zh) * | 1999-12-10 | 2014-06-11 | 茵维特罗根公司 | 具有独特特异性的多个重组位点在重组克隆中的用途 |
| AU8337701A (en) * | 2000-08-14 | 2002-02-25 | Us Health | Enhanced homologous recombination mediated by lambda recombination proteins |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| EP1337656A1 (en) * | 2000-11-10 | 2003-08-27 | AstraZeneca AB | In vitro generation of recombinant adenovirus vectors |
| GB0027501D0 (en) * | 2000-11-10 | 2000-12-27 | Astrazeneca Ab | Vector |
| WO2003051834A2 (en) * | 2001-12-14 | 2003-06-26 | President And Fellows Of Harvard College | Immunocellular receptors related to neurological disorders |
| US7521242B2 (en) * | 2003-05-09 | 2009-04-21 | The United States Of America As Represented By The Department Of Health And Human Services | Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids |
| BRPI0412279A (pt) * | 2003-07-02 | 2006-09-19 | Diversa Corp | glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos |
| DE602004031681D1 (de) | 2003-07-21 | 2011-04-14 | Transgene Sa | Multifunktionelle Cytokine |
| CN1826410B (zh) | 2003-07-21 | 2011-10-26 | 特兰斯吉恩股份有限公司 | 具有改良的胞嘧啶脱氨酶活性的多肽 |
| US8304189B2 (en) | 2003-12-01 | 2012-11-06 | Life Technologies Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
| US7674621B2 (en) * | 2004-05-21 | 2010-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Plasmids and phages for homologous recombination and methods of use |
| US20060234347A1 (en) * | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| KR101378872B1 (ko) | 2006-09-26 | 2014-04-11 | 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) | 합성 애주번트를 함유하는 백신 조성물 |
| PE20081723A1 (es) | 2007-01-30 | 2008-12-14 | Transgene Sa | Vacuna contra el papilomavirus |
| US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
| MX2011007494A (es) | 2009-01-13 | 2011-08-12 | Transgene Sa | Uso de una fraccion de la mitocondria de acidos nucleicos de saccharomyces cerevisiae para la estimulacion inmune. |
| MX2011007386A (es) | 2009-01-20 | 2011-08-03 | Transgene Sa | Icam-1 soluble como un biomarcador para la prediccion de una respuesta terapeutica. |
| WO2010108908A1 (en) | 2009-03-24 | 2010-09-30 | Transgene Sa | Biomarker for monitoring patients |
| JP5661738B2 (ja) | 2009-04-17 | 2015-01-28 | トランジェーヌ、ソシエテ、アノニムＴｒａｎｓｇｅｎｅ Ｓ．Ａ． | 患者をモニターするためのバイオマーカー |
| SI2437753T1 (sl) | 2009-06-05 | 2016-12-30 | Infectious Disease Research Institute | Sintetični glukopiranozil-lipidni adjuvansi in cepivni sestavki, ki jih vsebujejo |
| US20110015256A1 (en) * | 2009-07-16 | 2011-01-20 | Ihab Mamdouh Ishak Sadek | Delivery of restriction endonucleases to treat hiv, cancer, and other medical conditions |
| BR112012002628B1 (pt) | 2009-08-07 | 2021-09-08 | Transgene Sa | Composição imunogênica, molécula de ácido nucleico, vetor, partícula viral infecciosa, micro-organismo transgênico, composição, usos da composição imunogênica e kit de partes |
| AU2012243039B2 (en) | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| CN110339160A (zh) | 2012-02-07 | 2019-10-18 | 传染性疾病研究院 | 包含tlr4激动剂的改进佐剂制剂及其使用方法 |
| PT2850431T (pt) | 2012-05-16 | 2018-07-23 | Immune Design Corp | Vacinas para hsv-2 |
| EP3587455A1 (en) | 2012-10-23 | 2020-01-01 | Emory University | Gm-csf and il-4 conjugates, compositions, and methods related thereto |
| EP3711768A1 (en) | 2013-04-18 | 2020-09-23 | Immune Design Corp. | Gla monotherapy for use in cancer treatment |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| ES3011733T3 (en) | 2015-02-13 | 2025-04-08 | Transgene | Immunotherapeutic vaccine and antibody combination therapy |
| EP3452081A1 (en) | 2016-05-04 | 2019-03-13 | Transgene SA | Combination therapy with cpg tlr9 ligand |
| EP4112638A1 (en) | 2016-05-16 | 2023-01-04 | Access to Advanced Health Institute | Formulation containing tlr agonist and methods of use |
| KR102748354B1 (ko) | 2016-06-01 | 2024-12-31 | 액세스 투 어드밴스드 헬스 인스티튜트 | 사이징제를 함유하는 나노명반 입자 |
| AR109538A1 (es) | 2016-09-20 | 2018-12-19 | Boehringer Ingelheim Vetmedica Gmbh | Vacuna contra la gripe porcina |
| CN109715204B (zh) | 2016-09-20 | 2023-08-22 | 勃林格殷格翰动物保健有限公司 | 新的ehv插入位点orf70 |
| DK3516064T3 (da) | 2016-09-20 | 2025-07-14 | Boehringer Ingelheim Vetmedica Gmbh | Nye promotorer |
| AU2017332677B2 (en) | 2016-09-20 | 2024-01-11 | Boehringer Ingelheim Vetmedica Gmbh | Canine adenovirus vectors |
| EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
| US11826423B2 (en) | 2016-11-16 | 2023-11-28 | Immunomic Therapeutics, Inc. | Nucleic acids for treatment of allergies |
| US11203629B2 (en) | 2017-04-22 | 2021-12-21 | Immunomic Therapeutics, Inc. | LAMP constructs |
| CA3061950A1 (en) | 2017-05-02 | 2018-11-08 | Immunomic Therapeutics, Inc. | Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens |
| CN111315406A (zh) | 2017-09-08 | 2020-06-19 | 传染病研究所 | 包括皂苷的脂质体调配物及其使用方法 |
| EP3793595A1 (en) | 2018-05-15 | 2021-03-24 | Immunomic Therapeutics, Inc. | Improved lamp constructs comprising allergens |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| JP7640538B2 (ja) | 2019-10-08 | 2025-03-05 | トラスティーズ オブ ボストン カレッジ | 複数の異なる非天然アミノ酸を含有するタンパク質、並びにそのようなタンパク質の製造方法及び使用方法 |
| JP2022551732A (ja) | 2019-10-18 | 2022-12-13 | イミュノミック セラピューティックス， インコーポレイテッド | がん抗原を含む改良ｌａｍｐ構築物 |
| CN114980920A (zh) | 2019-11-18 | 2022-08-30 | 詹森生物科技公司 | 基于突变体calr和jak2的疫苗及其用途 |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| AU2021357520A1 (en) | 2020-03-05 | 2022-09-29 | Neotx Therapeutics Ltd. | Methods and compositions for treating cancer with immune cells |
| EP4135757A1 (en) | 2020-04-13 | 2023-02-22 | Janssen Biotech, Inc. | Psma and steap1 vaccines and their uses |
| WO2022009052A2 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| US20230024133A1 (en) | 2020-07-06 | 2023-01-26 | Janssen Biotech, Inc. | Prostate Neoantigens And Their Uses |
| WO2022009051A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | A method for determining responsiveness to prostate cancer treatment |
| CA3247515A1 (en) | 2022-04-10 | 2023-10-19 | Immunomic Therapeutics, Inc. | Bicistronic lamp constructions comprising genes that enhance the immune response and methods of their use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| GB9001766D0 (en) * | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
| FR2705361B1 (fr) | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| WO1995003400A1 (en) * | 1993-07-23 | 1995-02-02 | Johns Hopkins University School Of Medicine | Recombinationally targeted cloning in yeast artificial chromosomes |
| FR2727689A1 (fr) * | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
| US5582362A (en) * | 1995-03-31 | 1996-12-10 | Johnson; John R. | Center feed toilet paper dispenser |
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1994
- 1994-12-01 FR FR9414470A patent/FR2727689A1/fr active Granted
-
1995
- 1995-12-01 US US08/682,794 patent/US6110735A/en not_active Expired - Lifetime
- 1995-12-01 JP JP51834696A patent/JP3989541B2/ja not_active Expired - Lifetime
- 1995-12-01 CA CA002182303A patent/CA2182303C/fr not_active Expired - Lifetime
- 1995-12-01 DE DE69518910T patent/DE69518910T3/de not_active Expired - Lifetime
- 1995-12-01 WO PCT/FR1995/001590 patent/WO1996017070A1/fr not_active Ceased
- 1995-12-01 AT AT95941755T patent/ATE196507T1/de active
- 1995-12-01 ES ES95941755T patent/ES2150595T5/es not_active Expired - Lifetime
- 1995-12-01 PT PT95941755T patent/PT742834E/pt unknown
- 1995-12-01 AU AU43068/96A patent/AU707208B2/en not_active Expired
- 1995-12-01 DK DK95941755T patent/DK0742834T4/da active
- 1995-12-01 EP EP95941755A patent/EP0742834B9/fr not_active Expired - Lifetime
- 1995-12-01 DE DE69518910A patent/DE69518910D1/de not_active Expired - Lifetime
-
1999
- 1999-12-21 US US09/467,952 patent/US6281000B1/en not_active Expired - Lifetime
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2000
- 2000-12-12 GR GR20000402737T patent/GR3035050T3/el unknown
-
2001
- 2001-08-27 US US09/938,491 patent/US7067310B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2150595T5 (es) | 2005-12-01 |
| US6281000B1 (en) | 2001-08-28 |
| AU707208B2 (en) | 1999-07-08 |
| EP0742834B2 (fr) | 2005-08-03 |
| EP0742834A1 (fr) | 1996-11-20 |
| US6110735A (en) | 2000-08-29 |
| US7067310B2 (en) | 2006-06-27 |
| EP0742834B1 (fr) | 2000-09-20 |
| DE69518910T4 (de) | 2006-02-09 |
| ES2150595T3 (es) | 2000-12-01 |
| ATE196507T1 (de) | 2000-10-15 |
| DK0742834T4 (da) | 2005-08-22 |
| JPH09509330A (ja) | 1997-09-22 |
| DE69518910T2 (de) | 2001-03-29 |
| FR2727689B1 (enExample) | 1997-02-28 |
| FR2727689A1 (fr) | 1996-06-07 |
| JP3989541B2 (ja) | 2007-10-10 |
| DK0742834T3 (da) | 2001-01-29 |
| CA2182303A1 (fr) | 1996-06-06 |
| AU4306896A (en) | 1996-06-19 |
| DE69518910T3 (de) | 2006-07-13 |
| GR3035050T3 (en) | 2001-03-30 |
| EP0742834B9 (fr) | 2005-12-28 |
| US20020090715A1 (en) | 2002-07-11 |
| WO1996017070A1 (fr) | 1996-06-06 |
| DE69518910D1 (de) | 2000-10-26 |
| PT742834E (pt) | 2001-03-30 |
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