ES2150595T5 - Procedimiento de preparacion de un vector viral de por lo menos 20 kb por recombinacion homologa intermolecular en una celula procariota. - Google Patents
Procedimiento de preparacion de un vector viral de por lo menos 20 kb por recombinacion homologa intermolecular en una celula procariota.Info
- Publication number
- ES2150595T5 ES2150595T5 ES95941755T ES95941755T ES2150595T5 ES 2150595 T5 ES2150595 T5 ES 2150595T5 ES 95941755 T ES95941755 T ES 95941755T ES 95941755 T ES95941755 T ES 95941755T ES 2150595 T5 ES2150595 T5 ES 2150595T5
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| FR2727689A1 (fr) * | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
| FR2730504B1 (fr) * | 1995-02-13 | 1997-03-28 | Rhone Poulenc Rorer Sa | Procede de preparation de genomes d'adenovirus recombinants |
| US6143557A (en) * | 1995-06-07 | 2000-11-07 | Life Technologies, Inc. | Recombination cloning using engineered recombination sites |
| US7670823B1 (en) | 1999-03-02 | 2010-03-02 | Life Technologies Corp. | Compositions for use in recombinational cloning of nucleic acids |
| US6720140B1 (en) * | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| ATE256196T1 (de) | 1997-06-09 | 2003-12-15 | Genvec Inc | Chimäre vektoren, die die verpackungsregion eines phagengenoms und einen teil des genoms eines eukaryontischen virus enthalten |
| FR2766091A1 (fr) | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| AU749856B2 (en) | 1997-09-23 | 2002-07-04 | Genvec, Inc. | Plasmids for construction of eukaryotic viral vectors |
| CN100342008C (zh) * | 1997-10-24 | 2007-10-10 | 茵维特罗根公司 | 利用具重组位点的核酸进行重组克隆 |
| CN101125873A (zh) * | 1997-10-24 | 2008-02-20 | 茵维特罗根公司 | 利用具重组位点的核酸进行重组克隆 |
| US5922576A (en) * | 1998-02-27 | 1999-07-13 | The John Hopkins University | Simplified system for generating recombinant adenoviruses |
| US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6413776B1 (en) | 1998-06-12 | 2002-07-02 | Galapagos Geonomics N.V. | High throughput screening of gene function using adenoviral libraries for functional genomics applications |
| US7691370B2 (en) * | 1998-10-15 | 2010-04-06 | Canji, Inc. | Selectivity replicating viral vector |
| CA2394099A1 (en) * | 1999-12-07 | 2001-06-14 | Genethon Iii | Adenovirus vectors for the transfer of genes in targeted cells |
| CN1757724B (zh) * | 1999-12-10 | 2014-06-11 | 茵维特罗根公司 | 具有独特特异性的多个重组位点在重组克隆中的用途 |
| WO2002014495A2 (en) * | 2000-08-14 | 2002-02-21 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Enhanced homologous recombination mediated by lambda recombination proteins |
| US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| GB0027501D0 (en) * | 2000-11-10 | 2000-12-27 | Astrazeneca Ab | Vector |
| JP2004513638A (ja) * | 2000-11-10 | 2004-05-13 | アストラゼネカ・アクチエボラーグ | ベクター |
| AU2002361728A1 (en) * | 2001-12-14 | 2003-06-30 | President And Fellows Of Harvard College | Immunocellular receptors related to neurological disorders |
| US7521242B2 (en) * | 2003-05-09 | 2009-04-21 | The United States Of America As Represented By The Department Of Health And Human Services | Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids |
| EP2404931A1 (en) * | 2003-07-02 | 2012-01-11 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
| AU2004257935B2 (en) | 2003-07-21 | 2009-11-19 | Transgene S.A. | Polypeptide having an improved cytosine deaminase activity |
| ATE497974T1 (de) | 2003-07-21 | 2011-02-15 | Transgene Sa | Multifunktionelle cytokine |
| ATE469984T1 (de) | 2003-12-01 | 2010-06-15 | Life Technologies Corp | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
| US7674621B2 (en) | 2004-05-21 | 2010-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Plasmids and phages for homologous recombination and methods of use |
| US20060234347A1 (en) * | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
| EP2484375B1 (en) | 2006-09-26 | 2018-05-23 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US20090181078A1 (en) * | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| DK2118292T3 (da) | 2007-01-30 | 2011-10-24 | Transgene Sa | Papillomavirus E2-polypeptid der anvendes til vaccination |
| US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
| AU2010205717A1 (en) | 2009-01-13 | 2010-07-22 | Transgene Sa | Use of a Saccharomyces cerevisiae mitochondrial nucleic acids fraction for immune stimulation |
| JP5379243B2 (ja) | 2009-01-20 | 2013-12-25 | トランジェーヌ、ソシエテ、アノニム | 患者を選択するためのバイオマーカーおよびそれに関連する方法 |
| SG2014014021A (en) | 2009-03-24 | 2014-07-30 | Transgene Sa | Biomarker for monitoring patients |
| PL2419728T3 (pl) | 2009-04-17 | 2014-05-30 | Transgene Sa | Biomarker do monitorowania pacjentów |
| CN102481312B (zh) | 2009-06-05 | 2015-07-15 | 传染性疾病研究院 | 合成的吡喃葡萄糖脂佐剂 |
| US20110015256A1 (en) * | 2009-07-16 | 2011-01-20 | Ihab Mamdouh Ishak Sadek | Delivery of restriction endonucleases to treat hiv, cancer, and other medical conditions |
| US9393299B2 (en) | 2009-08-07 | 2016-07-19 | Transgene S.A. | Composition for treating HBV infection |
| EA027236B1 (ru) | 2011-04-08 | 2017-07-31 | Иммьюн Дизайн Корп. | Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа |
| PL2811981T3 (pl) | 2012-02-07 | 2019-09-30 | Infectious Disease Research Institute | Ulepszone formulacje adiuwantowe zawierające agonistę TLR4 oraz sposoby ich zastosowania |
| PL2850431T3 (pl) | 2012-05-16 | 2018-09-28 | Immune Design Corp. | Szczepionki przeciwko HSV-2 |
| CN109134640A (zh) | 2012-10-23 | 2019-01-04 | 爱默蕾大学 | Gm-csf和il-4轭合物、组合物以及与其相关的方法 |
| HK1214510A1 (zh) | 2013-04-18 | 2016-07-29 | Immune Design Corp. | 用於癌症治疗的gla单一疗法 |
| US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
| CA2975432A1 (en) | 2015-02-13 | 2016-08-18 | Transgene Sa | Immunotherapeutic vaccine and antibody combination therapy |
| US20190134190A1 (en) | 2016-05-04 | 2019-05-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| US11344619B2 (en) | 2016-05-16 | 2022-05-31 | Access To Advanced Health Institute | Formulation containing TLR agonist and methods of use |
| IL315825A (en) | 2016-06-01 | 2024-11-01 | Access To Advanced Health Inst | Nanoalum particles containing a fixing factor |
| HUE064133T2 (hu) | 2016-09-20 | 2024-03-28 | Boehringer Ingelheim Vetmedica Gmbh | Kutya adenovírus vektor |
| EP3516064B1 (en) | 2016-09-20 | 2025-04-16 | Boehringer Ingelheim Vetmedica GmbH | New promoters |
| UY37406A (es) | 2016-09-20 | 2018-03-23 | Boehringer Ingelheim Vetmedica Gmbh | Nuevo sitio de inserción orf70 de ehv |
| WO2018054822A1 (en) | 2016-09-20 | 2018-03-29 | Boehringer Ingelheim Vetmedica Gmbh | New swine influenza vaccine |
| EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
| WO2018093932A2 (en) | 2016-11-16 | 2018-05-24 | Immunomic Therapeutics, Inc. | Nucleic acids for treatment of allergies |
| EP3612556B8 (en) | 2017-04-22 | 2024-11-20 | Immunomic Therapeutics, Inc. | Improved lamp constructs |
| WO2018204534A1 (en) | 2017-05-02 | 2018-11-08 | Immunomic Therapeutics, Inc. | Lamp (lysosomal associated membrane protein) constructs comprising cancer antigens |
| US20200276299A1 (en) | 2017-09-08 | 2020-09-03 | Infectious Disease Research Institute | Liposomal formulations comprising saponin and methods of use |
| WO2019222281A1 (en) | 2018-05-15 | 2019-11-21 | Immunomic Therapeutics, Inc | Improved lamp constructs comprising allergens |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| US20220403438A1 (en) | 2019-10-08 | 2022-12-22 | Trustees Of Boston College | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins |
| KR20220083773A (ko) | 2019-10-18 | 2022-06-20 | 이뮤노믹 쎄라퓨틱스, 인크. | 암 항원을 포함하는 개선된 lamp 구축물 |
| AU2020385683A1 (en) | 2019-11-18 | 2022-06-30 | Janssen Biotech, Inc. | Vaccines based on mutant CALR and JAK2 and their uses |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| KR20220150353A (ko) | 2020-03-05 | 2022-11-10 | 네오티엑스 테라퓨틱스 엘티디. | 면역 세포를 사용하여 암을 치료하기 위한 방법 및 조성물 |
| US20210315986A1 (en) | 2020-04-13 | 2021-10-14 | Janssen Biotech, Inc. | Psma and steap1 vaccines and their uses |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| US20230035403A1 (en) | 2020-07-06 | 2023-02-02 | Janssen Biotech, Inc. | Method For Determining Responsiveness To Prostate Cancer Treatment |
| US20230024133A1 (en) | 2020-07-06 | 2023-01-26 | Janssen Biotech, Inc. | Prostate Neoantigens And Their Uses |
| US20250352639A1 (en) | 2022-04-10 | 2025-11-20 | Immunomic Therapeutics, Inc. | Bicistronic LAMP Constructs Comprising Immune Response Enhancing Genes and Methods of Use Thereof |
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|---|---|---|---|---|
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| GB9001766D0 (en) * | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
| FR2705361B1 (fr) | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| WO1995003400A1 (en) * | 1993-07-23 | 1995-02-02 | Johns Hopkins University School Of Medicine | Recombinationally targeted cloning in yeast artificial chromosomes |
| FR2727689A1 (fr) * | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
| US5582362A (en) * | 1995-03-31 | 1996-12-10 | Johnson; John R. | Center feed toilet paper dispenser |
-
1994
- 1994-12-01 FR FR9414470A patent/FR2727689A1/fr active Granted
-
1995
- 1995-12-01 WO PCT/FR1995/001590 patent/WO1996017070A1/fr not_active Ceased
- 1995-12-01 DK DK95941755T patent/DK0742834T4/da active
- 1995-12-01 JP JP51834696A patent/JP3989541B2/ja not_active Expired - Lifetime
- 1995-12-01 PT PT95941755T patent/PT742834E/pt unknown
- 1995-12-01 US US08/682,794 patent/US6110735A/en not_active Expired - Lifetime
- 1995-12-01 EP EP95941755A patent/EP0742834B9/fr not_active Expired - Lifetime
- 1995-12-01 DE DE69518910A patent/DE69518910D1/de not_active Expired - Lifetime
- 1995-12-01 DE DE69518910T patent/DE69518910T3/de not_active Expired - Lifetime
- 1995-12-01 ES ES95941755T patent/ES2150595T5/es not_active Expired - Lifetime
- 1995-12-01 CA CA002182303A patent/CA2182303C/fr not_active Expired - Lifetime
- 1995-12-01 AT AT95941755T patent/ATE196507T1/de active
- 1995-12-01 AU AU43068/96A patent/AU707208B2/en not_active Expired
-
1999
- 1999-12-21 US US09/467,952 patent/US6281000B1/en not_active Expired - Lifetime
-
2000
- 2000-12-12 GR GR20000402737T patent/GR3035050T3/el unknown
-
2001
- 2001-08-27 US US09/938,491 patent/US7067310B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE196507T1 (de) | 2000-10-15 |
| DE69518910T3 (de) | 2006-07-13 |
| US6281000B1 (en) | 2001-08-28 |
| JPH09509330A (ja) | 1997-09-22 |
| US7067310B2 (en) | 2006-06-27 |
| DE69518910T4 (de) | 2006-02-09 |
| ES2150595T3 (es) | 2000-12-01 |
| WO1996017070A1 (fr) | 1996-06-06 |
| AU707208B2 (en) | 1999-07-08 |
| AU4306896A (en) | 1996-06-19 |
| EP0742834A1 (fr) | 1996-11-20 |
| EP0742834B1 (fr) | 2000-09-20 |
| CA2182303A1 (fr) | 1996-06-06 |
| DK0742834T4 (da) | 2005-08-22 |
| GR3035050T3 (en) | 2001-03-30 |
| US20020090715A1 (en) | 2002-07-11 |
| FR2727689A1 (fr) | 1996-06-07 |
| DK0742834T3 (da) | 2001-01-29 |
| JP3989541B2 (ja) | 2007-10-10 |
| EP0742834B9 (fr) | 2005-12-28 |
| CA2182303C (fr) | 2005-06-21 |
| US6110735A (en) | 2000-08-29 |
| PT742834E (pt) | 2001-03-30 |
| FR2727689B1 (enExample) | 1997-02-28 |
| EP0742834B2 (fr) | 2005-08-03 |
| DE69518910D1 (de) | 2000-10-26 |
| DE69518910T2 (de) | 2001-03-29 |
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