CA2169750A1 - Di- et tetrahydrobenzo[f]quinolein-3-ones - Google Patents

Di- et tetrahydrobenzo[f]quinolein-3-ones

Info

Publication number
CA2169750A1
CA2169750A1 CA002169750A CA2169750A CA2169750A1 CA 2169750 A1 CA2169750 A1 CA 2169750A1 CA 002169750 A CA002169750 A CA 002169750A CA 2169750 A CA2169750 A CA 2169750A CA 2169750 A1 CA2169750 A1 CA 2169750A1
Authority
CA
Canada
Prior art keywords
anyone
compound
quinolin
alpha
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002169750A
Other languages
English (en)
Inventor
Dennis Alan Holt
Dennis Shinji Yamashita
Hwa-Kwo Yen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2169750A1 publication Critical patent/CA2169750A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne des composés de di- et tétra-hydrobenzo[f]quinoléin-3-ones, des compositions pharmaceutiques contenant ces composés et des procédés d'utilisation desdits composés, afin d'inhiber la stéroïde 5- alpha -réductase. Elle concerne également des procédés de préparation desdits composés.
CA002169750A 1993-08-20 1994-08-19 Di- et tetrahydrobenzo[f]quinolein-3-ones Abandoned CA2169750A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9317314.4 1993-08-20
GB939317314A GB9317314D0 (en) 1993-08-20 1993-08-20 Compounds

Publications (1)

Publication Number Publication Date
CA2169750A1 true CA2169750A1 (fr) 1995-03-02

Family

ID=10740766

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002169750A Abandoned CA2169750A1 (fr) 1993-08-20 1994-08-19 Di- et tetrahydrobenzo[f]quinolein-3-ones

Country Status (8)

Country Link
EP (1) EP0724440A4 (fr)
JP (1) JPH09501695A (fr)
CN (1) CN1133007A (fr)
AU (1) AU7634194A (fr)
CA (1) CA2169750A1 (fr)
GB (1) GB9317314D0 (fr)
WO (1) WO1995005821A1 (fr)
ZA (1) ZA946308B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037326A (en) * 1996-12-31 2000-03-14 Styczynski; Peter Reduction of hair growth
GB0129567D0 (en) 2001-12-11 2002-01-30 Trikon Technologies Ltd Diffusion barrier

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198300A (en) * 1975-02-20 1976-08-30 Kanputoteshin oyobi sonoruijitaino seizoho
CA1110234A (fr) * 1978-01-18 1981-10-06 Hoffmann-La Roche Limited Acides 4-pyridone-3-carboxyliques et procede de fabrication
YU7087A (en) * 1986-01-23 1988-06-30 Hoffmann La Roche Process for obtaining benzazecine derivatives
US5250539A (en) * 1991-08-21 1993-10-05 Eli Lilly And Company Hexahydrobenzo[f]quinolinones
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones

Also Published As

Publication number Publication date
EP0724440A4 (fr) 1996-11-20
ZA946308B (en) 1995-04-03
GB9317314D0 (en) 1993-10-06
EP0724440A1 (fr) 1996-08-07
WO1995005821A1 (fr) 1995-03-02
AU7634194A (en) 1995-03-21
JPH09501695A (ja) 1997-02-18
CN1133007A (zh) 1996-10-09

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Legal Events

Date Code Title Description
FZDE Dead