CA2163520C - L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents - Google Patents
L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents Download PDFInfo
- Publication number
- CA2163520C CA2163520C CA002163520A CA2163520A CA2163520C CA 2163520 C CA2163520 C CA 2163520C CA 002163520 A CA002163520 A CA 002163520A CA 2163520 A CA2163520 A CA 2163520A CA 2163520 C CA2163520 C CA 2163520C
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- Prior art keywords
- beta
- dideoxy
- present
- hbv
- hiv
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6729993A | 1993-05-25 | 1993-05-25 | |
| US08/067,299 | 1993-07-28 | ||
| US08/098,650 US5627160A (en) | 1993-05-25 | 1993-07-28 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
| US08/098,650 | 1993-07-28 | ||
| PCT/US1994/005790 WO1994027616A1 (en) | 1993-05-25 | 1994-05-23 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2163520A1 CA2163520A1 (en) | 1994-12-08 |
| CA2163520C true CA2163520C (en) | 2006-01-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002163520A Expired - Fee Related CA2163520C (en) | 1993-05-25 | 1994-05-23 | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis b (hbv) and anti-hiv agents |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5627160A (enExample) |
| EP (1) | EP0707481B1 (enExample) |
| JP (2) | JPH08510747A (enExample) |
| KR (1) | KR100279953B1 (enExample) |
| CN (1) | CN1076021C (enExample) |
| AT (1) | ATE195423T1 (enExample) |
| CA (1) | CA2163520C (enExample) |
| DE (1) | DE69425574T2 (enExample) |
| DK (1) | DK0707481T3 (enExample) |
| ES (1) | ES2150993T3 (enExample) |
| GR (1) | GR3034379T3 (enExample) |
| PT (1) | PT707481E (enExample) |
| WO (1) | WO1994027616A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827727A (en) | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
| US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
| CA2637774C (en) * | 1993-09-10 | 2011-07-19 | Emory University | Nucleosides with anti-hepatitis b virus activity |
| US20020120130A1 (en) * | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
| US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| US5512431A (en) * | 1994-06-29 | 1996-04-30 | Darwin Molecular Corporation | Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing |
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-
1993
- 1993-07-28 US US08/098,650 patent/US5627160A/en not_active Expired - Lifetime
-
1994
- 1994-05-23 CA CA002163520A patent/CA2163520C/en not_active Expired - Fee Related
- 1994-05-23 DK DK94919207T patent/DK0707481T3/da active
- 1994-05-23 EP EP94919207A patent/EP0707481B1/en not_active Expired - Lifetime
- 1994-05-23 DE DE69425574T patent/DE69425574T2/de not_active Expired - Lifetime
- 1994-05-23 ES ES94919207T patent/ES2150993T3/es not_active Expired - Lifetime
- 1994-05-23 PT PT94919207T patent/PT707481E/pt unknown
- 1994-05-23 KR KR1019950705353A patent/KR100279953B1/ko not_active Expired - Lifetime
- 1994-05-23 JP JP7500872A patent/JPH08510747A/ja active Pending
- 1994-05-23 WO PCT/US1994/005790 patent/WO1994027616A1/en not_active Ceased
- 1994-05-23 AT AT94919207T patent/ATE195423T1/de not_active IP Right Cessation
- 1994-05-24 CN CN94106188A patent/CN1076021C/zh not_active Expired - Lifetime
-
2000
- 2000-09-08 GR GR20000402067T patent/GR3034379T3/el unknown
-
2004
- 2004-03-31 JP JP2004106919A patent/JP2004244422A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU693795B2 (en) | 1998-07-09 |
| CN1076021C (zh) | 2001-12-12 |
| WO1994027616A1 (en) | 1994-12-08 |
| DK0707481T3 (da) | 2000-10-30 |
| ES2150993T3 (es) | 2000-12-16 |
| AU7043094A (en) | 1994-12-20 |
| GR3034379T3 (en) | 2000-12-29 |
| DE69425574T2 (de) | 2001-01-04 |
| EP0707481A4 (enExample) | 1996-05-29 |
| EP0707481A1 (en) | 1996-04-24 |
| EP0707481B1 (en) | 2000-08-16 |
| CA2163520A1 (en) | 1994-12-08 |
| CN1100303A (zh) | 1995-03-22 |
| JPH08510747A (ja) | 1996-11-12 |
| DE69425574D1 (en) | 2000-09-21 |
| PT707481E (pt) | 2001-02-28 |
| ATE195423T1 (de) | 2000-09-15 |
| US5627160A (en) | 1997-05-06 |
| HK1013257A1 (en) | 1999-10-22 |
| KR100279953B1 (ko) | 2001-02-01 |
| JP2004244422A (ja) | 2004-09-02 |
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