CA2120599C - Transdermal therapeutic systems containing crystallization inhibitors - Google Patents
Transdermal therapeutic systems containing crystallization inhibitors Download PDFInfo
- Publication number
- CA2120599C CA2120599C CA002120599A CA2120599A CA2120599C CA 2120599 C CA2120599 C CA 2120599C CA 002120599 A CA002120599 A CA 002120599A CA 2120599 A CA2120599 A CA 2120599A CA 2120599 C CA2120599 C CA 2120599C
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- Prior art keywords
- active ingredient
- compound
- matrix
- top coating
- adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
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- HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 description 1
- 229960002240 iloprost Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 1
- 229960000201 isosorbide dinitrate Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- USSIQXCVUWKGNF-QGZVFWFLSA-N levomethadone Chemical compound C=1C=CC=CC=1C(C[C@@H](C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-QGZVFWFLSA-N 0.000 description 1
- 229960002710 levomethadone Drugs 0.000 description 1
- 229960003587 lisuride Drugs 0.000 description 1
- SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960003134 mepindolol Drugs 0.000 description 1
- CPHJTSJQUQZOLJ-ISIDMKFXSA-N mespirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@@H]3[C@]1(C)CC[C@@H]1[C@@]4(C)C=CC(=O)C=C4C[C@H]([C@@H]31)SC(=O)C)CC(=O)O2 CPHJTSJQUQZOLJ-ISIDMKFXSA-N 0.000 description 1
- 229950008481 mespirenone Drugs 0.000 description 1
- UXYRZJKIQKRJCF-TZPFWLJSSA-N mesterolone Chemical compound C1C[C@@H]2[C@@]3(C)[C@@H](C)CC(=O)C[C@@H]3CC[C@H]2[C@@H]2CC[C@H](O)[C@]21C UXYRZJKIQKRJCF-TZPFWLJSSA-N 0.000 description 1
- 229960005272 mesterolone Drugs 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 229960000751 nefopam Drugs 0.000 description 1
- 229950003144 nocloprost Drugs 0.000 description 1
- 229960001652 norethindrone acetate Drugs 0.000 description 1
- 229960002085 oxycodone Drugs 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 229950007140 proterguride Drugs 0.000 description 1
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 1
- 229950005741 rolipram Drugs 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 229940126703 systemic medication Drugs 0.000 description 1
- 229960004558 terguride Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4136057.5 | 1991-10-31 | ||
| DE4136057 | 1991-10-31 | ||
| DE4210711A DE4210711A1 (de) | 1991-10-31 | 1992-03-27 | Transdermale therapeutische systeme mit kristallisationsinhibitoren |
| DEP4210711.3 | 1992-03-27 | ||
| PCT/EP1992/002478 WO1993008795A1 (de) | 1991-10-31 | 1992-10-21 | Transdermale therapeutische systeme mit kristallisationsinhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2120599A1 CA2120599A1 (en) | 1993-05-13 |
| CA2120599C true CA2120599C (en) | 2003-04-15 |
Family
ID=25908725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002120599A Expired - Lifetime CA2120599C (en) | 1991-10-31 | 1992-10-21 | Transdermal therapeutic systems containing crystallization inhibitors |
Country Status (14)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| ATE149349T1 (de) * | 1993-06-25 | 1997-03-15 | Alza Corp | Einarbeitung eines poly-n-vinylamids in ein transdermales system |
| DE4333595A1 (de) * | 1993-10-01 | 1995-04-06 | Labtec Gmbh | Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut |
| DE4405899A1 (de) * | 1994-02-18 | 1995-08-24 | Schering Ag | Mittel zur transdermalen Applikation enthaltend Desogestrel |
| DE4429667C2 (de) * | 1994-08-20 | 1996-07-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
| IL116539A (en) * | 1995-01-06 | 2002-02-10 | Noven Pharma | Preparations given through the skin of unstable anti-acid drugs |
| US6024974A (en) * | 1995-01-06 | 2000-02-15 | Noven Pharmaceuticals, Inc. | Composition and methods for transdermal delivery of acid labile drugs |
| DE19500662C2 (de) * | 1995-01-12 | 2001-04-26 | Lohmann Therapie Syst Lts | Estradiolhaltiges Pflaster und seine Verwendung |
| US5698217A (en) * | 1995-05-31 | 1997-12-16 | Minnesota Mining And Manufacturing Company | Transdermal drug delivery device containing a desiccant |
| CZ292151B6 (cs) † | 1995-06-07 | 2003-08-13 | Ortho-Mcneil Pharmaceutical, Inc. | Transdermální náplast pro podávání 17-deacetylnorgestimátu samotného nebo v kombinaci s estrogenem |
| DE19526864A1 (de) * | 1995-07-22 | 1997-01-23 | Labtec Gmbh | Hormonpflaster |
| US5702720A (en) * | 1995-12-22 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Transdermal device for the delivery of flurbiprofen |
| DE19629468A1 (de) * | 1996-07-11 | 1998-01-15 | Schering Ag | Transdermale therapeutische Systeme |
| DE19649535C2 (de) * | 1996-11-29 | 2000-02-10 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung eines pflasterförmigen therapeutischen Systems |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| GB9720470D0 (en) * | 1997-09-25 | 1997-11-26 | Ethical Pharmaceuticals South | Inhibition of crystallization in transdermal devices |
| DE19827732A1 (de) * | 1998-06-22 | 1999-12-23 | Rottapharm Bv | Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie |
| DE19829713C1 (de) * | 1998-07-03 | 2000-01-05 | Lohmann Therapie Syst Lts | Therapeutisches System mit Zusatz von Perglanzpigmenten |
| DE19834006A1 (de) * | 1998-07-29 | 2000-02-24 | Lohmann Therapie Syst Lts | Estradiolhaltiges Pflaster zur transdermalen Applikation von Hormonen |
| DE19843027A1 (de) * | 1998-09-19 | 2000-03-23 | Labtec Gmbh | Neohesperidin DC als Kristallisationsinhibitor |
| DK1233763T3 (da) * | 1999-11-29 | 2003-10-20 | Lohmann Therapie Syst Lts | Transdermale terapeutiske systemer med forbedret stabilitet og en fremgangsmåde til deres fremstilling |
| DE10012908B4 (de) * | 2000-03-16 | 2005-03-17 | Lts Lohmann Therapie-Systeme Ag | Stabilisierte übersättigte transdermale therapeutische Matrixsysteme und Verfahren zu ihrer Herstellung |
| DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
| NZ530227A (en) * | 2001-06-18 | 2006-09-29 | Noven Pharma | Enhanced drug delivery in transdermal systems |
| AU2004283431B2 (en) | 2003-10-10 | 2009-09-10 | Antares Pharma Ipl Ag | Transdermal pharmaceutical formulation for minimizing skin residues |
| US8431152B2 (en) | 2005-02-28 | 2013-04-30 | Hisamitsu Pharmaceutical Co., Inc. | Transdermally absorbable preparation |
| US9155725B2 (en) | 2008-02-27 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product |
| US8580281B2 (en) | 2008-02-27 | 2013-11-12 | Hisamitsu Pharmaceutical Co., Inc. | Medicated patch |
| EP2258396B1 (en) | 2008-03-03 | 2017-09-06 | Hisamitsu Pharmaceutical Co., Inc. | Transdermally absorbable preparation |
| JP5766475B2 (ja) * | 2010-03-30 | 2015-08-19 | 日東電工株式会社 | 貼付製剤およびその製造方法 |
| DE102010040299A1 (de) | 2010-09-06 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner) |
| ES2958185T3 (es) | 2013-09-11 | 2024-02-05 | Medrx Co Ltd | Nueva composición para material de base de apósito en una preparación de esparadrapo |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8512358D0 (en) * | 1985-05-16 | 1985-06-19 | Euro Celtique Sa | Transdermal delivery system |
| IL86211A (en) * | 1987-05-04 | 1992-03-29 | Ciba Geigy Ag | Oral forms of administration for carbamazepine in the forms of stable aqueous suspension with delayed release and their preparation |
| DE3933460A1 (de) * | 1989-10-06 | 1991-04-18 | Lohmann Therapie Syst Lts | Oestrogenhaltiges wirkstoffpflaster |
| WO1991005529A1 (en) * | 1989-10-13 | 1991-05-02 | Watson Laboratories, Inc. | Drug delivery systems and matrix therefor |
| JPH07116032B2 (ja) * | 1990-04-06 | 1995-12-13 | 積水化学工業株式会社 | ニトログリセリン貼付剤 |
-
1992
- 1992-03-27 DE DE4210711A patent/DE4210711A1/de not_active Withdrawn
- 1992-10-21 JP JP50815093A patent/JP3526864B2/ja not_active Expired - Lifetime
- 1992-10-21 CA CA002120599A patent/CA2120599C/en not_active Expired - Lifetime
- 1992-10-21 AT AT92922822T patent/ATE158181T1/de active
- 1992-10-21 AU AU28953/92A patent/AU2895392A/en not_active Abandoned
- 1992-10-21 ES ES92922822T patent/ES2106888T3/es not_active Expired - Lifetime
- 1992-10-21 WO PCT/EP1992/002478 patent/WO1993008795A1/de active IP Right Grant
- 1992-10-21 EP EP92922822A patent/EP0610357B1/de not_active Expired - Lifetime
- 1992-10-21 DE DE59208918T patent/DE59208918D1/de not_active Expired - Lifetime
- 1992-10-21 DK DK92922822.9T patent/DK0610357T3/da active
- 1992-10-29 PT PT101019A patent/PT101019B/pt not_active IP Right Cessation
- 1992-11-23 HU HU9401257A patent/HU227531B1/hu unknown
-
1994
- 1994-04-29 FI FI942011A patent/FI110061B/fi not_active IP Right Cessation
- 1994-04-29 NO NO941593A patent/NO307644B1/no not_active IP Right Cessation
-
1997
- 1997-03-25 AU AU16529/97A patent/AU712692B2/en not_active Expired
- 1997-10-31 GR GR970402873T patent/GR3025237T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9401257D0 (en) | 1994-08-29 |
| NO941593D0 (enrdf_load_stackoverflow) | 1994-04-29 |
| FI942011A0 (fi) | 1994-04-29 |
| HU227531B1 (en) | 2011-07-28 |
| AU2895392A (en) | 1993-06-07 |
| FI942011L (fi) | 1994-04-29 |
| EP0610357A1 (de) | 1994-08-17 |
| JPH07506083A (ja) | 1995-07-06 |
| JP3526864B2 (ja) | 2004-05-17 |
| DK0610357T3 (da) | 1998-05-11 |
| AU712692B2 (en) | 1999-11-11 |
| EP0610357B1 (de) | 1997-09-17 |
| PT101019B (pt) | 1999-10-29 |
| NO941593L (no) | 1994-04-29 |
| DE59208918D1 (de) | 1997-10-23 |
| ATE158181T1 (de) | 1997-10-15 |
| AU1652997A (en) | 1997-05-29 |
| NO307644B1 (no) | 2000-05-08 |
| WO1993008795A1 (de) | 1993-05-13 |
| CA2120599A1 (en) | 1993-05-13 |
| DE4210711A1 (de) | 1993-05-06 |
| GR3025237T3 (en) | 1998-02-27 |
| ES2106888T3 (es) | 1997-11-16 |
| PT101019A (pt) | 1994-02-28 |
| HUT72964A (en) | 1996-06-28 |
| FI110061B (fi) | 2002-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20121022 |