CA2110575A1 - Utilisation de derives de tetrahydrobenzazepine dans le traitement de l'hypertension et de la migraine spleniques - Google Patents

Utilisation de derives de tetrahydrobenzazepine dans le traitement de l'hypertension et de la migraine spleniques

Info

Publication number
CA2110575A1
CA2110575A1 CA002110575A CA2110575A CA2110575A1 CA 2110575 A1 CA2110575 A1 CA 2110575A1 CA 002110575 A CA002110575 A CA 002110575A CA 2110575 A CA2110575 A CA 2110575A CA 2110575 A1 CA2110575 A1 CA 2110575A1
Authority
CA
Canada
Prior art keywords
tetrahydro
benzazepine
compound
hydroxy
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002110575A
Other languages
English (en)
Inventor
John Gerard Ward
Rodney Christopher Young
Alberto Julio Kaumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919113377A external-priority patent/GB9113377D0/en
Priority claimed from GB919113379A external-priority patent/GB9113379D0/en
Application filed by Individual filed Critical Individual
Publication of CA2110575A1 publication Critical patent/CA2110575A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
CA002110575A 1991-06-21 1992-06-17 Utilisation de derives de tetrahydrobenzazepine dans le traitement de l'hypertension et de la migraine spleniques Abandoned CA2110575A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9113379.3 1991-06-21
GB919113377A GB9113377D0 (en) 1991-06-21 1991-06-21 Medicaments
GB9113377.7 1991-06-21
GB919113379A GB9113379D0 (en) 1991-06-21 1991-06-21 Medicaments

Publications (1)

Publication Number Publication Date
CA2110575A1 true CA2110575A1 (fr) 1993-01-07

Family

ID=26299102

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002110575A Abandoned CA2110575A1 (fr) 1991-06-21 1992-06-17 Utilisation de derives de tetrahydrobenzazepine dans le traitement de l'hypertension et de la migraine spleniques

Country Status (9)

Country Link
EP (1) EP0589973A1 (fr)
JP (1) JPH06508352A (fr)
KR (1) KR940701258A (fr)
AU (1) AU1927992A (fr)
CA (1) CA2110575A1 (fr)
IE (1) IE921990A1 (fr)
MX (1) MX9203012A (fr)
PT (1) PT100602A (fr)
WO (1) WO1993000094A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
CN1106196C (zh) * 1996-03-25 2003-04-23 伊莱利利公司 奥氮平在制备用于治疗偏头痛的药物中的应用
WO2002074746A1 (fr) * 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Derives de benzazepine
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
DE60329123D1 (de) 2002-12-20 2009-10-15 Glaxo Group Ltd Benzoädüazepinderivate für die behandlung von neurologischen krankheiten
US8367657B2 (en) 2003-06-17 2013-02-05 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
US7704993B2 (en) 2003-06-17 2010-04-27 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
TW200510324A (en) * 2003-08-11 2005-03-16 Lilly Co Eli 6-(2,2,2-trifluoroethylamino)-7-chiloro-2, 3, 4, 5-tetrahydro-1h-benzo[d]azepine as a 5-ht2c receptor agonist
SI1838677T1 (sl) 2004-12-21 2010-01-29 Arena Pharm Inc Kristalne oblike (R)-8-kloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepin hidroklorida
BRPI0515862A2 (pt) 2004-12-23 2011-10-11 Arena Pharm Inc uso de fentermina e agonista seletivo do receptor de 5ht-2c na preparação de composições, composições moduladoras do receptor de 5ht-2c e forma de dosagem unitária compreendendo as mesmas
EP2001852A2 (fr) 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Procédés de préparation de 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et produits intermédiaires associés
EP2099743B1 (fr) 2006-12-05 2014-08-27 Arena Pharmaceuticals, Inc. Procédés de préparation de (r)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1h-3-benzazépine et intermédiaires de celle-ci
EP2288585A1 (fr) 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Procédés de préparation d'intermédiaires se rapportant à l'agoniste 5-ht2c (r)-8-chloro-1-méthyl-2,3,4,5-tétrahydro-1h-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
WO2011153206A1 (fr) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Procédés pour la préparation d'agonistes du récepteur 5-ht2c
CN103189053A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 用于体重控制的5-ht2c激动剂的调节释放剂型
CN103189360A (zh) * 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
IN2013DN02552A (fr) * 2010-09-01 2015-08-07 Arena Pharm Inc
JP2013540719A (ja) 2010-09-01 2013-11-07 アリーナ ファーマシューティカルズ， インコーポレイテッド 腎欠陥を有する個体へのロルカセリンの投与
SG188364A1 (en) * 2010-09-01 2013-04-30 Arena Pharm Inc Salts of lorcaserin with optically active acids
JP2015534563A (ja) 2012-10-09 2015-12-03 アリーナ ファーマシューティカルズ， インコーポレイテッド 体重管理の方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659706A (en) * 1985-12-20 1987-04-21 Smithkline Beckman Corporation Sulfinyl and sulfonyl substituted 3-benzazepines

Also Published As

Publication number Publication date
WO1993000094A3 (fr) 1993-03-04
MX9203012A (es) 1993-07-01
JPH06508352A (ja) 1994-09-22
IE921990A1 (en) 1992-12-30
KR940701258A (ko) 1994-05-28
EP0589973A1 (fr) 1994-04-06
PT100602A (pt) 1993-09-30
AU1927992A (en) 1993-01-25
WO1993000094A2 (fr) 1993-01-07

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Legal Events

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FZDE Dead