CA2044550C - Method for the biological preparation of hydroxyvitamin d compounds - Google Patents

Method for the biological preparation of hydroxyvitamin d compounds Download PDF

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Publication number
CA2044550C
CA2044550C CA002044550A CA2044550A CA2044550C CA 2044550 C CA2044550 C CA 2044550C CA 002044550 A CA002044550 A CA 002044550A CA 2044550 A CA2044550 A CA 2044550A CA 2044550 C CA2044550 C CA 2044550C
Authority
CA
Canada
Prior art keywords
compound
vitamin
hydroxyvitamin
cyclodextrin
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002044550A
Other languages
English (en)
French (fr)
Other versions
CA2044550A1 (en
Inventor
Koji Takeda
Kiyoshi Kimura
Kazuhiko Okamura
Rokuro Okamoto
Joji Sasaki
Takashi Adachi
Sadafumi Omura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mercian Corp
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corp filed Critical Mercian Corp
Publication of CA2044550A1 publication Critical patent/CA2044550A1/en
Application granted granted Critical
Publication of CA2044550C publication Critical patent/CA2044550C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002044550A 1990-06-15 1991-06-13 Method for the biological preparation of hydroxyvitamin d compounds Expired - Lifetime CA2044550C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP02-157054 1990-06-15
JP15705490 1990-06-15
JP33428390A JP3201411B2 (ja) 1990-06-15 1990-11-30 ビタミンｄ類の生物学的製造方法
JP02-334283 1990-11-30

Publications (2)

Publication Number Publication Date
CA2044550A1 CA2044550A1 (en) 1991-12-16
CA2044550C true CA2044550C (en) 2000-09-26

Family

ID=26484632

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002044550A Expired - Lifetime CA2044550C (en) 1990-06-15 1991-06-13 Method for the biological preparation of hydroxyvitamin d compounds

Country Status (9)

Country Link
US (1) US5474923A (en, 2012)
EP (1) EP0461921B1 (en, 2012)
JP (1) JP3201411B2 (en, 2012)
KR (1) KR100190412B1 (en, 2012)
AT (1) ATE127523T1 (en, 2012)
CA (1) CA2044550C (en, 2012)
DE (1) DE69112716T2 (en, 2012)
ES (1) ES2079573T3 (en, 2012)
TW (1) TW234147B (en, 2012)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3201411B2 (ja) * 1990-06-15 2001-08-20 メルシャン株式会社 ビタミンｄ類の生物学的製造方法
WO1994000576A1 (en) * 1992-06-25 1994-01-06 Taisho Pharmaceutical Co., Ltd. Vitamin d hydroxylase gene
DK0855445T3 (da) 1995-08-28 2003-06-30 Mercian Corp Fremgangsmåde til fremstilling af hydroxylerede cholesteroler ved biologisk omdannelse og dihydroxycholesteroler
AU3837100A (en) * 1999-04-14 2000-11-14 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives and process for producing the same
HUP0501186A2 (en) * 2001-12-03 2006-05-29 Novacea Pharmaceutical compositions comprising active vitamin d compounds
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
KR20060127946A (ko) * 2004-01-29 2006-12-13 에자이 알앤드디 매니지먼트 가부시키가이샤 매크롤라이드계 화합물의 안정화 방법
US20090177002A1 (en) 2006-03-15 2009-07-09 Asako Toyoda Method For Preparing Indene Derivatives, And Intermediates For Preparation Of Derivatives
EP2377942B1 (en) 2008-12-19 2013-11-20 Ildong Pharmaceutical Co., Ltd. Buffer composition for catalyzing the preparation of calcitriol or calcifediol and method for preparing calcitriol or calcifediol using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307025A (en) * 1981-02-17 1981-12-22 Wisconsin Alumni Research Foundation 1α, 25-dihydroxy-2β-fluorovitamin D3
JPH0717686B2 (ja) * 1986-08-08 1995-03-01 メルシャン株式会社 部分メチル化シクロデキストリン及びその製造方法
US4892821A (en) * 1987-07-08 1990-01-09 Taisho Pharmaceutical Co., Ltd. Method for preparing vitamin D compounds
JP2663294B2 (ja) * 1989-03-04 1997-10-15 メルシャン株式会社 ビタミンｄ類の製造方法
JP3201411B2 (ja) * 1990-06-15 2001-08-20 メルシャン株式会社 ビタミンｄ類の生物学的製造方法

Also Published As

Publication number Publication date
ES2079573T3 (es) 1996-01-16
TW234147B (en, 2012) 1994-11-11
JP3201411B2 (ja) 2001-08-20
KR100190412B1 (ko) 1999-06-01
ATE127523T1 (de) 1995-09-15
EP0461921B1 (en) 1995-09-06
JPH04166090A (ja) 1992-06-11
DE69112716D1 (de) 1995-10-12
DE69112716T2 (de) 1996-02-01
KR920000934A (ko) 1992-01-29
EP0461921A2 (en) 1991-12-18
EP0461921A3 (en) 1992-05-20
US5474923A (en) 1995-12-12
CA2044550A1 (en) 1991-12-16

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Legal Events

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EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202