CA2043631C - Detecting and imaging in biochemical assays using phosphor screens - Google Patents
Detecting and imaging in biochemical assays using phosphor screensInfo
- Publication number
- CA2043631C CA2043631C CA002043631A CA2043631A CA2043631C CA 2043631 C CA2043631 C CA 2043631C CA 002043631 A CA002043631 A CA 002043631A CA 2043631 A CA2043631 A CA 2043631A CA 2043631 C CA2043631 C CA 2043631C
- Authority
- CA
- Canada
- Prior art keywords
- macromolecules
- chemiluminescent
- liquid
- matrix
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 238000003384 imaging method Methods 0.000 title description 6
- 238000010256 biochemical assay Methods 0.000 title description 3
- 239000000758 substrate Substances 0.000 claims abstract description 56
- 229920002521 macromolecule Polymers 0.000 claims abstract description 36
- 238000006243 chemical reaction Methods 0.000 claims abstract description 29
- 239000007791 liquid phase Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims description 31
- 239000011159 matrix material Substances 0.000 claims description 19
- 230000003993 interaction Effects 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 7
- 230000027455 binding Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims description 4
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000004888 barrier function Effects 0.000 claims description 2
- 230000005670 electromagnetic radiation Effects 0.000 claims description 2
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 claims 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 claims 1
- 238000006911 enzymatic reaction Methods 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 150000007523 nucleic acids Chemical group 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000000463 material Substances 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 230000002285 radioactive effect Effects 0.000 description 9
- 238000001514 detection method Methods 0.000 description 7
- 239000004033 plastic Substances 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 6
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 239000007790 solid phase Substances 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 4
- 230000005281 excited state Effects 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 4
- BVTJGGGYKAMDBN-UHFFFAOYSA-N Dioxetane Chemical compound C1COO1 BVTJGGGYKAMDBN-UHFFFAOYSA-N 0.000 description 3
- WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical compound [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 230000009870 specific binding Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- UMTZYGZMIJRCFG-UHFFFAOYSA-N 3-phenyldioxetane Chemical compound C1OOC1C1=CC=CC=C1 UMTZYGZMIJRCFG-UHFFFAOYSA-N 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-OUBTZVSYSA-N Phosphorus-32 Chemical compound [32P] OAICVXFJPJFONN-OUBTZVSYSA-N 0.000 description 2
- -1 alkaline earth metal sulfides Chemical class 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 229910000420 cerium oxide Inorganic materials 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000005283 ground state Effects 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 2
- 229940097886 phosphorus 32 Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000002731 protein assay Methods 0.000 description 2
- KZUNJOHGWZRPMI-UHFFFAOYSA-N samarium atom Chemical compound [Sm] KZUNJOHGWZRPMI-UHFFFAOYSA-N 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WYNZXNXFHYJUTE-UHFFFAOYSA-N 1,2-dioxetanedione Chemical class O=C1OOC1=O WYNZXNXFHYJUTE-UHFFFAOYSA-N 0.000 description 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 1
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 1
- CDEMHJCJMMOFMB-UHFFFAOYSA-M ClC1=CC=C([Mg]Br)C=C1 Chemical compound ClC1=CC=C([Mg]Br)C=C1 CDEMHJCJMMOFMB-UHFFFAOYSA-M 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 239000003298 DNA probe Substances 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108020004518 RNA Probes Proteins 0.000 description 1
- 239000003391 RNA probe Substances 0.000 description 1
- 229910052772 Samarium Inorganic materials 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009830 antibody antigen interaction Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- MKQRDVRSSVPGEB-UHFFFAOYSA-N dioxetan-3-one Chemical group O=C1COO1 MKQRDVRSSVPGEB-UHFFFAOYSA-N 0.000 description 1
- 239000002019 doping agent Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 1
- 229910001940 europium oxide Inorganic materials 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 229910052761 rare earth metal Inorganic materials 0.000 description 1
- 150000002910 rare earth metals Chemical class 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910001954 samarium oxide Inorganic materials 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003346 selenoethers Chemical class 0.000 description 1
- ZEGFMFQPWDMMEP-UHFFFAOYSA-N strontium;sulfide Chemical compound [S-2].[Sr+2] ZEGFMFQPWDMMEP-UHFFFAOYSA-N 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229910052844 willemite Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55196190A | 1990-07-12 | 1990-07-12 | |
| US07/551,961 | 1990-07-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2043631A1 CA2043631A1 (en) | 1992-01-13 |
| CA2043631C true CA2043631C (en) | 1998-04-21 |
Family
ID=24203384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002043631A Expired - Fee Related CA2043631C (en) | 1990-07-12 | 1991-05-31 | Detecting and imaging in biochemical assays using phosphor screens |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPH04232864A (de) |
| CA (1) | CA2043631C (de) |
| DE (1) | DE4122839A1 (de) |
| FR (1) | FR2664703B1 (de) |
| GB (1) | GB2246197B (de) |
| HK (1) | HK40795A (de) |
| IT (1) | ITRM910503A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2130947C (en) * | 1993-11-12 | 2001-02-06 | Robert E. Emmons | Dry elements, test devices, test kits and methods for chemiluminescent detection of analytes using peroxidase-labeled reagents |
| DE4410655C2 (de) * | 1994-03-26 | 2001-06-28 | Heiko Schwertner | Verfahren und Vorrichtung zur schnellen kontinuierlichen Sequenzanalyse von verschiedenen linearen polymeren Substanzen nach einer einheitlichen Vorgehensweise |
| US6415038B1 (en) | 1994-05-20 | 2002-07-02 | Fuji Photo Film Co., Ltd. | Image analyzing apparatus |
| JP3571819B2 (ja) * | 1995-01-09 | 2004-09-29 | 富士写真フイルム株式会社 | 生化学画像解析装置 |
| JP3550203B2 (ja) * | 1995-01-10 | 2004-08-04 | 富士写真フイルム株式会社 | 画像解析装置 |
| US5672514A (en) * | 1995-02-01 | 1997-09-30 | Fuji Photo Film Co., Ltd. | Chemiluminescent detecting method and apparatus |
| JPH1021373A (ja) * | 1996-07-05 | 1998-01-23 | Fuji Photo Film Co Ltd | 画像解析装置 |
| JP3851699B2 (ja) | 1997-02-06 | 2006-11-29 | 富士写真フイルム株式会社 | 画像解析装置 |
| DE19704731B4 (de) * | 1997-02-07 | 2006-07-27 | Stratec Biomedical Systems Ag | Meßgerät zur Durchführung von Lumineszenzmessungen |
| JP3474765B2 (ja) | 1998-03-17 | 2003-12-08 | 富士写真フイルム株式会社 | 画像記録・読み取りシステム |
| US6572095B1 (en) | 1999-09-03 | 2003-06-03 | Fuji Photo Film Co., Ltd. | Method of and system for conveying sheet to be scanned |
| JP3897272B2 (ja) | 1999-09-28 | 2007-03-22 | 富士フイルム株式会社 | 画像解析装置 |
| US6781143B2 (en) * | 2001-04-06 | 2004-08-24 | Fuji Photo Film Co., Ltd. | Biochemical analysis data producing method, biochemical analysis data producing apparatus and stimulable phosphor sheet used therefor |
| JP3940995B2 (ja) | 2002-04-19 | 2007-07-04 | 富士フイルム株式会社 | 画像読取装置 |
| JP3913602B2 (ja) | 2002-04-23 | 2007-05-09 | 富士フイルム株式会社 | 読取画像処理方法および装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4396579A (en) * | 1981-08-06 | 1983-08-02 | Miles Laboratories, Inc. | Luminescence detection device |
| GB2116709B (en) * | 1982-03-09 | 1986-02-19 | Wira & Mather | Microbiological testing detecting surface mildew |
| DE3789766T2 (de) * | 1986-07-22 | 1994-09-29 | Thompson Boyce Plant Res | Verwendung von bakteriellen luciferase strukturellen genen zum klonieren und zur steuerung der genexpression in mikroorganismen, sowie zur etikettierung und identifizierung von genetisch gebildeten organismen. |
| CA1250212A (en) * | 1987-04-23 | 1989-02-21 | Merlin M.L. Leong | Method and apparatus for instant photodetection of chemiluminescent immunoassays |
| US4797553A (en) * | 1987-05-11 | 1989-01-10 | E. I. Dupont De Nemours And Company | Method and apparatus for reading a transparent photostimulable luminescent screen |
| GB2207245A (en) * | 1987-07-15 | 1989-01-25 | Unilever Plc | Specific binding chemiluminescent assay |
| JPH01219563A (ja) * | 1988-02-27 | 1989-09-01 | Doujin Kagaku Kenkyusho:Kk | 化学発光の写真法による検出方法 |
| GB2233450B (en) * | 1989-06-24 | 1993-06-30 | Univ Wales Medicine | Detecting or quantifing multiple analytes with luminescent reagents |
-
1991
- 1991-05-17 JP JP3112891A patent/JPH04232864A/ja active Pending
- 1991-05-31 CA CA002043631A patent/CA2043631C/en not_active Expired - Fee Related
- 1991-07-04 FR FR9108381A patent/FR2664703B1/fr not_active Expired - Fee Related
- 1991-07-10 DE DE4122839A patent/DE4122839A1/de not_active Ceased
- 1991-07-10 IT IT91RM000503A patent/ITRM910503A1/it not_active IP Right Cessation
- 1991-07-12 GB GB9115090A patent/GB2246197B/en not_active Expired - Fee Related
-
1995
- 1995-03-23 HK HK40795A patent/HK40795A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9115090D0 (en) | 1991-08-28 |
| GB2246197A (en) | 1992-01-22 |
| DE4122839A1 (de) | 1992-01-16 |
| JPH04232864A (ja) | 1992-08-21 |
| CA2043631A1 (en) | 1992-01-13 |
| FR2664703A1 (fr) | 1992-01-17 |
| FR2664703B1 (fr) | 1995-05-12 |
| ITRM910503A1 (it) | 1992-01-13 |
| ITRM910503A0 (it) | 1991-07-10 |
| GB2246197B (en) | 1994-03-16 |
| HK40795A (en) | 1995-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |