CA2030108C - Process for the preparation of genetic vectors for the expression of nerve growth factor in eukaryotic cells - Google Patents
Process for the preparation of genetic vectors for the expression of nerve growth factor in eukaryotic cellsInfo
- Publication number
- CA2030108C CA2030108C CA002030108A CA2030108A CA2030108C CA 2030108 C CA2030108 C CA 2030108C CA 002030108 A CA002030108 A CA 002030108A CA 2030108 A CA2030108 A CA 2030108A CA 2030108 C CA2030108 C CA 2030108C
- Authority
- CA
- Canada
- Prior art keywords
- ngf
- plasmid
- human
- beta
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48564A/89 | 1989-11-16 | ||
| IT04856489A IT1238348B (it) | 1989-11-16 | 1989-11-16 | Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2030108A1 CA2030108A1 (en) | 1991-05-17 |
| CA2030108C true CA2030108C (en) | 1998-04-28 |
Family
ID=11267348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002030108A Expired - Fee Related CA2030108C (en) | 1989-11-16 | 1990-11-15 | Process for the preparation of genetic vectors for the expression of nerve growth factor in eukaryotic cells |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5457034A (enExample) |
| EP (1) | EP0432510B1 (enExample) |
| JP (2) | JP3121611B2 (enExample) |
| KR (1) | KR910009929A (enExample) |
| CN (1) | CN1051934A (enExample) |
| AR (1) | AR246983A1 (enExample) |
| AT (1) | ATE214735T1 (enExample) |
| CA (1) | CA2030108C (enExample) |
| DE (1) | DE69033937T2 (enExample) |
| ES (1) | ES2173856T3 (enExample) |
| FI (1) | FI905691L (enExample) |
| HU (1) | HUT61047A (enExample) |
| IE (1) | IE904120A1 (enExample) |
| IL (1) | IL96347A (enExample) |
| IT (1) | IT1238348B (enExample) |
| NZ (1) | NZ236058A (enExample) |
| PE (1) | PE28191A1 (enExample) |
| PL (1) | PL287811A1 (enExample) |
| PT (1) | PT95911B (enExample) |
| TW (1) | TW205069B (enExample) |
| YU (1) | YU217890A (enExample) |
| ZA (1) | ZA909122B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
| US6964947B1 (en) | 1995-11-07 | 2005-11-15 | Genentech, Inc. | Stabilizing formulation for NGF |
| US6090781A (en) * | 1996-11-06 | 2000-07-18 | Genentech, Inc. | Stabilizing formulation for NGF |
| AU1447600A (en) * | 1998-10-22 | 2000-05-08 | Thomas J. Gardella | Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp) |
| WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| ES2316354T3 (es) | 1999-09-29 | 2009-04-16 | The General Hospital Corporation | Derivados polipeptidos de la hormona paratiroidea (pth). |
| US6696238B2 (en) | 2000-07-28 | 2004-02-24 | Christopher J. Murphy | Transplant media |
| US7572765B2 (en) * | 2001-07-23 | 2009-08-11 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (PTH) analogs |
| AU2003220380A1 (en) | 2003-03-19 | 2004-11-19 | Bristol-Myers Squibb Company | CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS |
| JP4871128B2 (ja) | 2003-07-17 | 2012-02-08 | ザ ジェネラル ホスピタル コーポレイション | 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ |
| US20070207209A1 (en) * | 2004-08-27 | 2007-09-06 | Murphy Christopher J | Trophic factor combinations for nervous system treatment |
| EP2054077A4 (en) * | 2006-08-04 | 2010-10-13 | Gen Hospital Corp | POLYPEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) |
| CN101260398B (zh) | 2007-03-07 | 2013-06-05 | 舒泰神（北京）生物制药股份有限公司 | 神经生长因子基因定位改造动物及其制备方法和应用 |
| BRPI0814962B8 (pt) | 2007-08-01 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica |
| CN101927012B (zh) * | 2009-06-26 | 2013-08-14 | 丽珠医药集团股份有限公司 | 神经生长因子的病毒灭活方法 |
| US9492508B2 (en) | 2010-05-13 | 2016-11-15 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
| CN102816766A (zh) * | 2012-05-04 | 2012-12-12 | 沈阳医学院 | 蛇毒神经生长因子活性多肽的筛选方法 |
| US20240018481A1 (en) * | 2021-07-30 | 2024-01-18 | Chengdu Unovel Biopharma Co., Ltd. | Recombinant cho cell, construction method therefor, and detection system and method using same |
| CN115894705A (zh) * | 2021-09-30 | 2023-04-04 | 三生国健药业（上海）股份有限公司 | 一种β-NGF融合蛋白、其制备方法及用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US4796580A (en) * | 1987-09-11 | 1989-01-10 | Allied-Signal Inc. | Idle control valve for use with a throttle assembly of an internal combustion engine |
| JPH01211490A (ja) * | 1988-02-19 | 1989-08-24 | Tosoh Corp | ヒト神経成長因子遺伝子セグメント |
| US5272063A (en) * | 1988-11-22 | 1993-12-21 | Syntex (U.S.A.) Inc. | Process of making human nerve growth factor |
-
1989
- 1989-11-16 IT IT04856489A patent/IT1238348B/it active IP Right Grant
-
1990
- 1990-11-13 NZ NZ236058A patent/NZ236058A/xx unknown
- 1990-11-14 IL IL96347A patent/IL96347A/xx active IP Right Grant
- 1990-11-14 ZA ZA909122A patent/ZA909122B/xx unknown
- 1990-11-15 YU YU217890A patent/YU217890A/sh unknown
- 1990-11-15 PT PT95911A patent/PT95911B/pt active IP Right Grant
- 1990-11-15 CA CA002030108A patent/CA2030108C/en not_active Expired - Fee Related
- 1990-11-15 IE IE412090A patent/IE904120A1/en unknown
- 1990-11-15 PE PE1990177640A patent/PE28191A1/es unknown
- 1990-11-16 PL PL28781190A patent/PL287811A1/xx unknown
- 1990-11-16 AT AT90121961T patent/ATE214735T1/de not_active IP Right Cessation
- 1990-11-16 JP JP02312577A patent/JP3121611B2/ja not_active Expired - Fee Related
- 1990-11-16 CN CN90109292A patent/CN1051934A/zh active Pending
- 1990-11-16 KR KR1019900018690A patent/KR910009929A/ko not_active Ceased
- 1990-11-16 ES ES90121961T patent/ES2173856T3/es not_active Expired - Lifetime
- 1990-11-16 HU HU907174A patent/HUT61047A/hu unknown
- 1990-11-16 DE DE69033937T patent/DE69033937T2/de not_active Expired - Fee Related
- 1990-11-16 FI FI905691A patent/FI905691L/fi not_active IP Right Cessation
- 1990-11-16 EP EP90121961A patent/EP0432510B1/en not_active Expired - Lifetime
- 1990-11-19 AR AR90318408A patent/AR246983A1/es active
- 1990-12-28 TW TW079110979A patent/TW205069B/zh active
-
1993
- 1993-11-24 US US08/156,792 patent/US5457034A/en not_active Expired - Lifetime
-
2000
- 2000-05-02 JP JP2000133485A patent/JP2001000194A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1051934A (zh) | 1991-06-05 |
| US5457034A (en) | 1995-10-10 |
| IE904120A1 (en) | 1991-05-22 |
| JPH03224490A (ja) | 1991-10-03 |
| EP0432510A1 (en) | 1991-06-19 |
| IT1238348B (it) | 1993-07-13 |
| HUT61047A (en) | 1992-11-30 |
| ATE214735T1 (de) | 2002-04-15 |
| NZ236058A (en) | 1993-04-28 |
| IL96347A (en) | 1997-11-20 |
| ZA909122B (en) | 1991-09-25 |
| DE69033937T2 (de) | 2002-11-14 |
| IL96347A0 (en) | 1991-08-16 |
| JP2001000194A (ja) | 2001-01-09 |
| HU907174D0 (en) | 1991-05-28 |
| PL287811A1 (en) | 1991-12-02 |
| PT95911B (pt) | 1998-01-30 |
| AU6655890A (en) | 1991-05-23 |
| JP3121611B2 (ja) | 2001-01-09 |
| AR246983A1 (es) | 1994-10-31 |
| FI905691A7 (fi) | 1991-05-17 |
| EP0432510B1 (en) | 2002-03-20 |
| PE28191A1 (es) | 1991-10-28 |
| DE69033937D1 (de) | 2002-04-25 |
| YU217890A (sh) | 1993-05-28 |
| PT95911A (pt) | 1991-09-13 |
| FI905691L (fi) | 1991-05-17 |
| KR910009929A (ko) | 1991-06-28 |
| IT8948564A0 (it) | 1989-11-16 |
| CA2030108A1 (en) | 1991-05-17 |
| TW205069B (enExample) | 1993-05-01 |
| FI905691A0 (fi) | 1990-11-16 |
| AU645998B2 (en) | 1994-02-03 |
| ES2173856T3 (es) | 2002-11-01 |
| IT8948564A1 (it) | 1991-05-16 |
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