CA1327576C - Phenoxyacetic acid amide derivatives and their use in the treatment of obesity and related conditions - Google Patents

Phenoxyacetic acid amide derivatives and their use in the treatment of obesity and related conditions

Info

Publication number
CA1327576C
CA1327576C CA000542721A CA542721A CA1327576C CA 1327576 C CA1327576 C CA 1327576C CA 000542721 A CA000542721 A CA 000542721A CA 542721 A CA542721 A CA 542721A CA 1327576 C CA1327576 C CA 1327576C
Authority
CA
Canada
Prior art keywords
formula
compound
amino
nr2r3
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000542721A
Other languages
English (en)
French (fr)
Inventor
Brian Roy Holloway
Ralph Howe
Balbir S. Rao
Donald Stribling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868617986A external-priority patent/GB8617986D0/en
Priority claimed from GB878701832A external-priority patent/GB8701832D0/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Application granted granted Critical
Publication of CA1327576C publication Critical patent/CA1327576C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Hydrogenated Pyridines (AREA)
CA000542721A 1986-07-23 1987-07-22 Phenoxyacetic acid amide derivatives and their use in the treatment of obesity and related conditions Expired - Fee Related CA1327576C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB868617986A GB8617986D0 (en) 1986-07-23 1986-07-23 Amide derivatives
GB8617986 1986-07-23
GB878701832A GB8701832D0 (en) 1987-01-28 1987-01-28 Carboxamides
GB8701832 1987-01-28

Publications (1)

Publication Number Publication Date
CA1327576C true CA1327576C (en) 1994-03-08

Family

ID=26291076

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000542721A Expired - Fee Related CA1327576C (en) 1986-07-23 1987-07-22 Phenoxyacetic acid amide derivatives and their use in the treatment of obesity and related conditions

Country Status (24)

Country Link
US (2) US4927836A (OSRAM)
EP (1) EP0254532B1 (OSRAM)
JP (1) JPS6393755A (OSRAM)
KR (1) KR880001576A (OSRAM)
CN (1) CN1015707B (OSRAM)
AT (1) ATE52498T1 (OSRAM)
AU (1) AU604027B2 (OSRAM)
CA (1) CA1327576C (OSRAM)
CS (1) CS264145B2 (OSRAM)
DE (1) DE3762618D1 (OSRAM)
DK (1) DK385387A (OSRAM)
ES (1) ES2018832B3 (OSRAM)
FI (1) FI88289C (OSRAM)
GB (1) GB8714901D0 (OSRAM)
GR (1) GR3000571T3 (OSRAM)
HU (1) HU197293B (OSRAM)
IE (1) IE60887B1 (OSRAM)
IL (1) IL83026A0 (OSRAM)
MY (1) MY102866A (OSRAM)
NO (1) NO174044C (OSRAM)
NZ (1) NZ221158A (OSRAM)
PH (1) PH23607A (OSRAM)
PT (1) PT85379B (OSRAM)
SU (1) SU1549476A3 (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB8925032D0 (en) * 1989-11-06 1989-12-28 Ici Plc Chemical compounds
GB8926083D0 (en) * 1989-11-17 1990-01-10 Ici Plc Therapeutic agents
GB9003185D0 (en) * 1990-02-13 1990-04-11 Ici Plc Pharmaceutical compositions
GB9016655D0 (en) * 1990-07-30 1990-09-12 Ici Plc Therapeutic agents
GB9111426D0 (en) * 1991-05-28 1991-07-17 Ici Plc Chemical compounds
US5502078A (en) * 1991-05-28 1996-03-26 Zeneca Limited Chemical compounds
GB9224740D0 (en) * 1992-11-26 1993-01-13 Ici Plc Therapeutic agents
KR960703120A (ko) * 1993-06-14 1996-06-19 알렌 제이. 스피겔 당뇨 및 비만 치료제로서의 2차아민(secondary amines as antidiabetic and antiobesity agents)
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5627200A (en) * 1994-09-26 1997-05-06 Pfizer Inc β3 -Adrenoceptor agonists and antagonists for the treatment of intestinal motility disorders, depression, prostate disease and dyslipidemia
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US5808080A (en) * 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
DE69711519T2 (de) 1996-09-05 2002-10-31 Eli Lilly And Co., Indianapolis Carbazolanaloge als selektive beta3-adrenergische Agonisten
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6344481B1 (en) 1999-03-01 2002-02-05 Pfizer Inc. Thyromimetic antiobesity agents
US7504435B2 (en) * 2001-01-31 2009-03-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for stimulating weight loss and/or for lowering triglycerides in patients
EP1423168B1 (en) * 2001-09-03 2006-02-08 Newron Pharmaceuticals S.p.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an alpha-aminoamide and its analgesic use
US7202222B2 (en) * 2003-01-06 2007-04-10 National Bioscience Corporation Methods for treatment of obesity and effective fat loss promotion
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
AU2005282028B2 (en) * 2004-09-10 2011-03-24 Newron Pharmaceuticals S.P.A. (halobenzyloxy) benzylamino-propanamides as sodium and/or calcium channel selective modulators
AU2008219585A1 (en) * 2007-02-27 2008-09-04 The Arizona Board Of Regents On Behalf Of The University Of Arizona Administration of 3,5-diiodothyropropionic acid for stimulating weight loss, and/or lowering triglyceride levels, and/or treatment of metabolic syndrome.
US8476227B2 (en) 2010-01-22 2013-07-02 Ethicon Endo-Surgery, Inc. Methods of activating a melanocortin-4 receptor pathway in obese subjects
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
US9751830B2 (en) 2010-03-15 2017-09-05 The Trustees Of The University Of Pennsylvania Inhibitors of the tumor necrosis factor receptor complex
US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
US10080884B2 (en) 2014-12-29 2018-09-25 Ethicon Llc Methods and devices for activating brown adipose tissue using electrical energy
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903091A (en) * 1970-02-06 1975-09-02 Sumitomo Chemical Co 1,2,3,4-Tetrahydroisoquinoline derivatives
IE35386B1 (en) * 1970-05-27 1976-02-04 Ici Ltd Alkanolamine derivatives
US4088764A (en) * 1973-12-27 1978-05-09 Cassella Farbwerke Mainkur Aktiengesellschaft Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol
US4263323A (en) * 1976-10-07 1981-04-21 Aktiebolaget Hassle β-Receptor blocking compounds and treatment of cardiovascular disorders therewith
FI791727A7 (fi) * 1978-06-05 1981-01-01 Ciba Geigy Ag Menetelmä N-alkyloitujen aminoalkoholien valmistamiseksi.
EP0006735B1 (en) * 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
JPS57185243A (en) * 1981-05-08 1982-11-15 Ciba Geigy Ag Substituted 2-aminoethanol
GB8420837D0 (en) * 1984-08-16 1984-09-19 Beecham Group Plc Compounds
US4697033A (en) * 1985-12-24 1987-09-29 Sandoz Ltd. Carbamic and carbamothioic acid esters as pesticides
JPS6422898A (en) * 1987-07-17 1989-01-25 Asahi Breweries Ltd 2-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivative

Also Published As

Publication number Publication date
NO873071L (no) 1988-01-25
PH23607A (en) 1989-09-11
JPH0579057B2 (OSRAM) 1993-11-01
IE60887B1 (en) 1994-08-24
NO174044C (no) 1994-03-09
DE3762618D1 (de) 1990-06-13
CS556587A2 (en) 1988-08-16
NO873071D0 (no) 1987-07-22
CS264145B2 (en) 1989-06-13
CN87105189A (zh) 1988-04-06
FI88289B (fi) 1993-01-15
SU1549476A3 (ru) 1990-03-07
PT85379A (en) 1987-08-01
FI88289C (fi) 1993-04-26
IE871733L (en) 1988-01-23
NO174044B (no) 1993-11-29
AU7503087A (en) 1988-01-28
AU604027B2 (en) 1990-12-06
FI873154A7 (fi) 1988-01-24
US4977148A (en) 1990-12-11
US4927836A (en) 1990-05-22
PT85379B (pt) 1990-04-30
MY102866A (en) 1993-03-31
KR880001576A (ko) 1988-04-25
JPS6393755A (ja) 1988-04-25
NZ221158A (en) 1990-07-26
GB8714901D0 (en) 1987-07-29
DK385387D0 (da) 1987-07-23
FI873154A0 (fi) 1987-07-16
CN1015707B (zh) 1992-03-04
DK385387A (da) 1988-01-24
HU197293B (en) 1989-03-28
ES2018832B3 (es) 1991-05-16
EP0254532B1 (en) 1990-05-09
EP0254532A1 (en) 1988-01-27
ATE52498T1 (de) 1990-05-15
GR3000571T3 (en) 1991-07-31
HUT44001A (en) 1988-01-28
IL83026A0 (en) 1987-12-20

Similar Documents

Publication Publication Date Title
CA1327576C (en) Phenoxyacetic acid amide derivatives and their use in the treatment of obesity and related conditions
US4999377A (en) Chemical compounds
US4663325A (en) 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are useful for treating cerebrovascular disease
CA1317300C (en) Process for the preparation of 2-¬2-¬4-¬(4-chlorophenyl) phenylmethyl|-1-piperazinyl|ethoxy|-acetic acid and its dihydrochloride
DE69232003T2 (de) Benzanilidderivate als 5-HT1D-Antagonisten
US3941789A (en) N-Aryl-N'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
US4772631A (en) Phenyl ethers
EP0099148B1 (en) Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
EP0124783B1 (en) Benzofuran- and benzopyran-carboxamide derivatives
US4202896A (en) N-Benzhydryloxyethyl-N-phenylpropyl-piperazines
HU207988B (en) Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
PL178546B1 (pl) Nowe, zasadniczo czyste optycznie, enancjomery prawoskrętne lub lewoskrętne 1-[(4-chlorofenylo)fenylometylo] piperazyny i sposób ich wytwarzania
US4191765A (en) 1-Aryloxy-2-hydroxy-3-aminopropanes
US3974158A (en) 2-(Substituted anilino)methylmorpholines
US4146629A (en) 4-arylpiperidine derivatives
US4379160A (en) Carbazole compounds and medicinal use thereof
HU222490B1 (hu) Eljárás hexahidroazepin-származékok és az ilyen vegyületeket tartalmazó gyógyászati készítmények előállítására
JPS60112778A (ja) モルホリン誘導体，それらの製法及びそれらを含有する医薬組成物
US5519025A (en) 4-indolylpiperazinyl derivatives
CA1055044A (en) Phenylalkyl esters of amino-acids having antidepressive activity
GB1577670A (en) 1-aryloxy-2 - hydroxy - 3 - aminopropanes and process for their preparation
HU192994B (en) Process for preparing 4-/3-alkynyl-oxy-2-hydroxy-propyl/-piperazin-1-y1-n-phenyl-acetamide derivatives
US2723269A (en) Piperidino tertiary amino alcohols
IL39620A (en) 1-) 4-Imidazolidinonylphenyl-alkyl (4-Phenylpipraazines Converted and their salts, preparations and pharmaceutical preparations containing them
US4127666A (en) Disubstituted 2,5-benzamides and pharmaceutical compositions containing the same

Legal Events

Date Code Title Description
MKLA Lapsed