CA1316832C - Treatment of human viral infection by dsrna combined with viral inhibitors - Google Patents

Treatment of human viral infection by dsrna combined with viral inhibitors

Info

Publication number
CA1316832C
CA1316832C CA000562015A CA562015A CA1316832C CA 1316832 C CA1316832 C CA 1316832C CA 000562015 A CA000562015 A CA 000562015A CA 562015 A CA562015 A CA 562015A CA 1316832 C CA1316832 C CA 1316832C
Authority
CA
Canada
Prior art keywords
dsrna
viral
therapeutic composition
composition defined
mismatched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000562015A
Other languages
English (en)
French (fr)
Inventor
William A. Carter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hem Research Inc
Original Assignee
Hem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hem Research Inc filed Critical Hem Research Inc
Application granted granted Critical
Publication of CA1316832C publication Critical patent/CA1316832C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CA000562015A 1987-03-23 1988-03-21 Treatment of human viral infection by dsrna combined with viral inhibitors Expired - Fee Related CA1316832C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2882387A 1987-03-23 1987-03-23
US028,823 1987-03-23
US07/125,097 US4950652A (en) 1987-03-23 1987-11-25 dsRNAs for combination therapy in the treatment of viral diseases
US125,097 1987-11-25

Publications (1)

Publication Number Publication Date
CA1316832C true CA1316832C (en) 1993-04-27

Family

ID=26704119

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000562015A Expired - Fee Related CA1316832C (en) 1987-03-23 1988-03-21 Treatment of human viral infection by dsrna combined with viral inhibitors

Country Status (21)

Country Link
US (1) US4950652A (OSRAM)
EP (1) EP0286224B1 (OSRAM)
JP (1) JP2656938B2 (OSRAM)
KR (1) KR960013435B1 (OSRAM)
CN (1) CN1049357C (OSRAM)
AU (1) AU1256288A (OSRAM)
CA (1) CA1316832C (OSRAM)
DE (1) DE3876125T2 (OSRAM)
DK (1) DK156688A (OSRAM)
ES (1) ES2066782T3 (OSRAM)
FI (1) FI881305A7 (OSRAM)
GR (1) GR3006340T3 (OSRAM)
HU (1) HUT46542A (OSRAM)
IE (1) IE63823B1 (OSRAM)
IL (1) IL85646A (OSRAM)
NO (1) NO881246L (OSRAM)
NZ (1) NZ223868A (OSRAM)
OA (1) OA08724A (OSRAM)
PH (1) PH23333A (OSRAM)
PT (1) PT87039B (OSRAM)
RU (1) RU2016572C1 (OSRAM)

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US6130206A (en) * 1980-07-07 2000-10-10 Hem Research, Inc. Treating viral infections associated with chronic fatigue with dsRNA
US9309574B1 (en) 1984-08-22 2016-04-12 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Molecular cloning of HIV-1 from immortalized cell lines
US5906980A (en) * 1987-07-17 1999-05-25 Hem Research Inc. Treatment of hepatitis with mismatched dsRNA
US5091374A (en) * 1987-07-17 1992-02-25 Hem Research Inc. Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function
US5712257A (en) * 1987-08-12 1998-01-27 Hem Research, Inc. Topically active compositions of mismatched dsRNAs
US4963532A (en) * 1987-11-25 1990-10-16 Hem Research, Inc. dsRNA-based prevention of viral escape
US4960592A (en) * 1989-04-17 1990-10-02 Lanocare Laboratories Lanolin and lanolin oil skin treatment composition
US5132292A (en) * 1990-05-25 1992-07-21 Hem Research, Inc. Treatment of viral hepatitis
US5614504A (en) * 1990-08-01 1997-03-25 The University Of South Florida Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
US6703418B2 (en) * 1991-02-26 2004-03-09 Unimed Pharmaceuticals, Inc. Appetite stimulation and induction of weight gain in patients suffering from symptomatic HIV infection
EP0581906A4 (en) * 1991-04-16 1997-07-23 Hem Pharma Corp Abrogation of viral resistance to nucleoside analogues by double-stranded rnas
GB9108085D0 (en) * 1991-04-16 1991-06-05 Scras Complexes of polyadenylic acid with polyuridylic acid
AU2268892A (en) * 1991-07-16 1993-02-23 Hem Pharmaceuticals Corp. Modulation and diagnosis of cytokine dysfunctions
US20030207813A1 (en) * 1996-12-09 2003-11-06 G.D. Searle Retroviral protease inhibitor combinations
US5766582A (en) * 1994-10-11 1998-06-16 Schering Corporation Stable, aqueous alfa interferon solution formulations
US6475491B1 (en) 1995-06-07 2002-11-05 Trimeris, Inc. Treatment of HIV and other viral infections using combinatorial therapy
US5834443A (en) * 1996-05-21 1998-11-10 Masiello; Domenick J. Composition and method for treating herpes simplex
RU2123339C1 (ru) * 1996-06-18 1998-12-20 Государственный научный центр вирусологии и биотехнологии "Вектор" Противовирусное средство
GB9622681D0 (en) * 1996-10-31 1997-01-08 Glaxo Group Ltd Pharmaceutical compositions
YU61598A (sh) * 1997-01-17 2003-02-28 Icn Pharmaceuticals Inc. Tretmani bolesti uz korišćenje citokina
LT4475B (lt) * 1997-02-28 1999-02-25 Virmantas Stunžėnas Informacinės ribonukleino rūgšties panaudojimas vaistinėse medžiagose, skirtose padidinti šios ribonukleino rūgšties koduojamo baltymo kiekį paciento ląstelėse
FR2766715B1 (fr) * 1997-08-04 2001-02-16 Scras Produit comprenant au moins de l'arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique simultanee, separee ou etalee dans le temps, dans le traitement d'une maladie virale
FR2768345B1 (fr) * 1997-09-17 2001-05-04 Scras Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale, notamment d'une hepatite virale
TW589189B (en) * 1997-08-04 2004-06-01 Scras Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
FR2766711B1 (fr) * 1997-08-04 2001-02-02 Sod Conseils Rech Applic Produit comprenant au moins un arn double brin en association avec au moins un devire du 6-benzyluracile pour une utilisation therapeutique simultanee, separee ou etalee dans le temps
FR2768344B1 (fr) * 1997-08-26 2001-02-16 Scras Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP1624060B1 (en) 1998-03-20 2011-09-28 Commonwealth Scientific and Industrial Research Organisation Control of gene expression
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
FR2776927B1 (fr) * 1998-04-07 2002-07-05 Univ Paris Curie Compositions pour la vectorisation de molecules
EP2314700A1 (en) 1999-01-28 2011-04-27 Medical College of Georgia Research Institute, Inc Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
RU2172631C2 (ru) * 1999-10-08 2001-08-27 Государственный научный центр вирусологии и биотехнологии "Вектор" Индуктор интерферона пролонгированного действия
AU2001227889A1 (en) 2000-01-14 2001-07-24 The United States of America, represented by The Secretary, Department of Health & Human Services Oligodeoxynucleotide and its use to induce an immune response
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
US20080242627A1 (en) * 2000-08-02 2008-10-02 University Of Southern California Novel rna interference methods using dna-rna duplex constructs
DE10100588A1 (de) * 2001-01-09 2002-07-18 Ribopharma Ag Verfahren zur Hemmung der Expression eines Zielgens
CA2369944A1 (en) 2001-01-31 2002-07-31 Nucleonics Inc. Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
US7666674B2 (en) 2001-07-27 2010-02-23 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
WO2003020884A2 (en) 2001-08-14 2003-03-13 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method for rapid generation of mature dendritic cells
WO2003051301A2 (en) * 2001-12-14 2003-06-26 Hemispherx Biopharma USE OF dsRNAs IN STRATEGIC THERAPEUTIC INTERVENTION OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY
AU2002366710A1 (en) 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
DE60329277D1 (de) 2002-02-01 2009-10-29 Life Technologies Corp Oligonukleotidzusammensetzungen mit verbesserter effizienz
RU2302865C2 (ru) 2002-04-04 2007-07-20 Коли Фармасьютикал Гмбх Иммуностимулирующие g, u-содержащие олигорибонуклеотиды
US8263091B2 (en) 2002-09-18 2012-09-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
US20050137154A1 (en) * 2003-05-16 2005-06-23 Hemispherx Biopharma Treating server acute respiratory syndrome
US20060035859A1 (en) * 2003-05-16 2006-02-16 Hemispherx Biopharma Treating severe and acute viral infections
WO2005007831A2 (en) * 2003-07-18 2005-01-27 Vanderbilt University Compositions of protein mimetics and methods of using same against hiv-1, sars-cov and the like
CN1867355A (zh) * 2003-08-11 2006-11-22 财团法人阪大微生物病研究会 包含诱导粘膜免疫的佐剂的新型疫苗
RU2272631C2 (ru) * 2004-04-20 2006-03-27 Государственный научный центр вирусологии и биотехнологии "Вектор" (ГНЦ ВБ "Вектор") Синергическая композиция для ингибирования вич
DE202005004135U1 (de) * 2005-03-11 2005-05-19 Klocke Verpackungs-Service Gmbh Mehrkomponentenverpackung mit Applikator
CN102517292B (zh) * 2005-11-25 2014-12-24 佐蒂斯比利时股份有限公司 免疫刺激性寡核糖核苷酸
CA2644670A1 (en) * 2006-03-08 2008-05-08 Hemispherx Biopharma Inc. Broad spectrum immune and antiviral gene modulation by oral interferon
US8075877B2 (en) 2006-03-08 2011-12-13 Hemispherx Biopharma Broad spectrum immune and antiviral gene modulation by oral interferon
MX2010004734A (es) * 2007-10-29 2010-05-20 Cipla Ltd Nueva combinacion anti-retrovirica.
KR20100126390A (ko) * 2008-02-15 2010-12-01 헤미스펙스 바이오파마 인코포레이티드 톨-유사 수용체 3의 선택적인 작용제

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EP0113162B1 (en) * 1982-09-16 1989-07-19 Hem Research, Inc. Anti-proliferative action of dsnras on tumor cells
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
CA1238277A (en) * 1985-03-16 1988-06-21 Sandra N. Lehrman Antiviral nucleosides
US4795744A (en) * 1986-07-17 1989-01-03 Hem Research, Inc. Modulation of AIDS virus-related events by double-stranded RNAS
CA1326450C (en) * 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)

Also Published As

Publication number Publication date
JP2656938B2 (ja) 1997-09-24
KR960013435B1 (ko) 1996-10-05
NO881246D0 (no) 1988-03-21
FI881305L (fi) 1988-09-24
RU2016572C1 (ru) 1994-07-30
FI881305A7 (fi) 1988-09-24
JPS6425A (en) 1989-01-05
AU1256288A (en) 1988-09-22
DK156688D0 (da) 1988-03-22
CN1049357C (zh) 2000-02-16
ES2066782T3 (es) 1995-03-16
FI881305A0 (fi) 1988-03-18
PT87039B (pt) 1992-11-30
NO881246L (no) 1988-09-26
IL85646A (en) 1993-05-13
IL85646A0 (en) 1988-08-31
KR880010777A (ko) 1988-10-24
OA08724A (fr) 1989-03-31
IE63823B1 (en) 1995-06-14
DE3876125D1 (de) 1993-01-07
EP0286224A2 (en) 1988-10-12
PH23333A (en) 1989-07-14
PT87039A (pt) 1988-04-01
HUT46542A (en) 1988-11-28
IE880839L (en) 1988-09-23
CN88101606A (zh) 1988-12-28
US4950652A (en) 1990-08-21
DE3876125T2 (de) 1993-06-09
DK156688A (da) 1988-09-24
EP0286224B1 (en) 1992-11-25
EP0286224A3 (en) 1988-12-07
NZ223868A (en) 1991-02-26
GR3006340T3 (OSRAM) 1993-06-21

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