PT87039A - Treatment of human viral infections by dsrna combined with viral inhibitors - Google Patents
Treatment of human viral infections by dsrna combined with viral inhibitorsInfo
- Publication number
- PT87039A PT87039A PT87039A PT8703988A PT87039A PT 87039 A PT87039 A PT 87039A PT 87039 A PT87039 A PT 87039A PT 8703988 A PT8703988 A PT 8703988A PT 87039 A PT87039 A PT 87039A
- Authority
- PT
- Portugal
- Prior art keywords
- viral
- treatment
- inhibitors
- human
- dsrna
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2882387A | 1987-03-23 | 1987-03-23 | |
US07/125,097 US4950652A (en) | 1987-03-23 | 1987-11-25 | dsRNAs for combination therapy in the treatment of viral diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
PT87039A true PT87039A (pt) | 1988-04-01 |
PT87039B PT87039B (pt) | 1992-11-30 |
Family
ID=26704119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87039A PT87039B (pt) | 1987-03-23 | 1988-03-22 | Processo para a preparacao de uma composicao farmaceutica para tratamento de infeccoes virais humanas |
Country Status (21)
Country | Link |
---|---|
US (1) | US4950652A (pt) |
EP (1) | EP0286224B1 (pt) |
JP (1) | JP2656938B2 (pt) |
KR (1) | KR960013435B1 (pt) |
CN (1) | CN1049357C (pt) |
AU (1) | AU1256288A (pt) |
CA (1) | CA1316832C (pt) |
DE (1) | DE3876125T2 (pt) |
DK (1) | DK156688A (pt) |
ES (1) | ES2066782T3 (pt) |
FI (1) | FI881305A (pt) |
GR (1) | GR3006340T3 (pt) |
HU (1) | HUT46542A (pt) |
IE (1) | IE63823B1 (pt) |
IL (1) | IL85646A (pt) |
NO (1) | NO881246L (pt) |
NZ (1) | NZ223868A (pt) |
OA (1) | OA08724A (pt) |
PH (1) | PH23333A (pt) |
PT (1) | PT87039B (pt) |
RU (1) | RU2016572C1 (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6130206A (en) * | 1980-07-07 | 2000-10-10 | Hem Research, Inc. | Treating viral infections associated with chronic fatigue with dsRNA |
US9309574B1 (en) | 1984-08-22 | 2016-04-12 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Molecular cloning of HIV-1 from immortalized cell lines |
US5091374A (en) * | 1987-07-17 | 1992-02-25 | Hem Research Inc. | Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function |
US5906980A (en) * | 1987-07-17 | 1999-05-25 | Hem Research Inc. | Treatment of hepatitis with mismatched dsRNA |
US5712257A (en) * | 1987-08-12 | 1998-01-27 | Hem Research, Inc. | Topically active compositions of mismatched dsRNAs |
US4963532A (en) * | 1987-11-25 | 1990-10-16 | Hem Research, Inc. | dsRNA-based prevention of viral escape |
US4960592A (en) * | 1989-04-17 | 1990-10-02 | Lanocare Laboratories | Lanolin and lanolin oil skin treatment composition |
US5132292A (en) * | 1990-05-25 | 1992-07-21 | Hem Research, Inc. | Treatment of viral hepatitis |
US5614504A (en) * | 1990-08-01 | 1997-03-25 | The University Of South Florida | Method of making inosine monophosphate derivatives and immunopotentiating uses thereof |
US6703418B2 (en) * | 1991-02-26 | 2004-03-09 | Unimed Pharmaceuticals, Inc. | Appetite stimulation and induction of weight gain in patients suffering from symptomatic HIV infection |
AU671800B2 (en) * | 1991-04-16 | 1996-09-12 | Hem Pharmaceuticals Corp. | Abrogation of viral resistance to nucleoside analogues by double-stranded RNAs |
GB9108085D0 (en) * | 1991-04-16 | 1991-06-05 | Scras | Complexes of polyadenylic acid with polyuridylic acid |
WO1993001717A1 (en) * | 1991-07-16 | 1993-02-04 | Hem Pharmaceuticals Corp. | Modulation and diagnosis of cytokine dysfunctions |
US20030207813A1 (en) * | 1996-12-09 | 2003-11-06 | G.D. Searle | Retroviral protease inhibitor combinations |
AU723537B2 (en) * | 1995-06-07 | 2000-08-31 | Trimeris Inc. | The treatment of HIV and other viral infections using combinatorial therapy |
US5834443A (en) * | 1996-05-21 | 1998-11-10 | Masiello; Domenick J. | Composition and method for treating herpes simplex |
GB9622681D0 (en) * | 1996-10-31 | 1997-01-08 | Glaxo Group Ltd | Pharmaceutical compositions |
AU736075B2 (en) * | 1997-01-17 | 2001-07-26 | Icn Pharmaceuticals, Inc. | Cytokine related treatments of disease |
LT4475B (lt) * | 1997-02-28 | 1999-02-25 | Virmantas Stunžėnas | Informacinės ribonukleino rūgšties panaudojimas vaistinėse medžiagose, skirtose padidinti šios ribonukleino rūgšties koduojamo baltymo kiekį paciento ląstelėse |
TW589189B (en) | 1997-08-04 | 2004-06-01 | Scras | Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis |
FR2768344B1 (fr) * | 1997-08-26 | 2001-02-16 | Scras | Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale |
FR2766711B1 (fr) * | 1997-08-04 | 2001-02-02 | Sod Conseils Rech Applic | Produit comprenant au moins un arn double brin en association avec au moins un devire du 6-benzyluracile pour une utilisation therapeutique simultanee, separee ou etalee dans le temps |
FR2768345B1 (fr) * | 1997-09-17 | 2001-05-04 | Scras | Produit comprenant au moins un arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique dans le traitement d'une maladie virale, notamment d'une hepatite virale |
FR2766715B1 (fr) * | 1997-08-04 | 2001-02-16 | Scras | Produit comprenant au moins de l'arn double brin en association avec au moins un agent anti-viral pour une utilisation therapeutique simultanee, separee ou etalee dans le temps, dans le traitement d'une maladie virale |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
ATE526406T1 (de) | 1998-03-20 | 2011-10-15 | Commw Scient Ind Res Org | Kontrolle der genexpression |
FR2776927B1 (fr) * | 1998-04-07 | 2002-07-05 | Univ Paris Curie | Compositions pour la vectorisation de molecules |
EP1147204A1 (en) | 1999-01-28 | 2001-10-24 | Medical College Of Georgia Research Institute, Inc. | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
US6423885B1 (en) | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
US20080242627A1 (en) * | 2000-08-02 | 2008-10-02 | University Of Southern California | Novel rna interference methods using dna-rna duplex constructs |
DE10100588A1 (de) * | 2001-01-09 | 2002-07-18 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Zielgens |
CA2369944A1 (en) | 2001-01-31 | 2002-07-31 | Nucleonics Inc. | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
US7354909B2 (en) | 2001-08-14 | 2008-04-08 | The United States Of America As Represented By Secretary Of The Department Of Health And Human Services | Method for rapid generation of mature dendritic cells |
WO2003051301A2 (en) * | 2001-12-14 | 2003-06-26 | Hemispherx Biopharma | USE OF dsRNAs IN STRATEGIC THERAPEUTIC INTERVENTION OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY |
US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
US7615227B2 (en) | 2001-12-20 | 2009-11-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce angiogenesis |
WO2003064625A2 (en) | 2002-02-01 | 2003-08-07 | Sequitur, Inc. | Oligonucleotide compositions with enhanced efficiency |
US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
CA2480775C (en) | 2002-04-04 | 2016-05-31 | Coley Pharmaceutical Gmbh | Immunostimulatory g,u-containing oligoribonucleotides |
US8263091B2 (en) | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
US20050137154A1 (en) * | 2003-05-16 | 2005-06-23 | Hemispherx Biopharma | Treating server acute respiratory syndrome |
US20060035859A1 (en) * | 2003-05-16 | 2006-02-16 | Hemispherx Biopharma | Treating severe and acute viral infections |
US20050113292A1 (en) * | 2003-07-18 | 2005-05-26 | Vanderbilt University | Compositions of protein mimetics and methods of using same against HIV-1, SARS-coV and the like |
US20070219149A1 (en) * | 2003-08-11 | 2007-09-20 | The Research Foundation For Microbial Diseases Of Osaka University | Novel Vaccine Containing Adjuvant Capable Of Inducing Mucosal Immunity |
RU2272631C2 (ru) * | 2004-04-20 | 2006-03-27 | Государственный научный центр вирусологии и биотехнологии "Вектор" (ГНЦ ВБ "Вектор") | Синергическая композиция для ингибирования вич |
DE202005004135U1 (de) * | 2005-03-11 | 2005-05-19 | Klocke Verpackungs-Service Gmbh | Mehrkomponentenverpackung mit Applikator |
CA2630738C (en) * | 2005-11-25 | 2013-09-03 | Coley Pharmaceutical Gmbh | Immunostimulatory oligoribonucleotides |
CN101437534A (zh) * | 2006-03-08 | 2009-05-20 | 半球生物制药公司 | 口服干扰素的广谱免疫和抗病毒基因调节作用 |
US8075877B2 (en) | 2006-03-08 | 2011-12-13 | Hemispherx Biopharma | Broad spectrum immune and antiviral gene modulation by oral interferon |
CA2703918C (en) * | 2007-10-29 | 2016-10-18 | Cipla Limited | Solid pharmaceutical dosage forms of atazanavir and ritonavir combinations |
NZ587371A (en) * | 2008-02-15 | 2012-12-21 | Hemispherx Biopharma Inc | The use of poly(I:C11-14U) for treating bacterial and protozoan infection |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3380200D1 (en) * | 1982-09-16 | 1989-08-24 | William Alvin Carter | Anti-proliferative action of dsnras on tumor cells |
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
DE3687069T2 (de) * | 1985-03-16 | 1993-03-25 | Wellcome Found | Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen. |
CA1326450C (en) * | 1985-08-26 | 1994-01-25 | William A. Carter | Modulation of aids virus-related events by double stranded rnas (dsrnas) |
US4795744A (en) * | 1986-07-17 | 1989-01-03 | Hem Research, Inc. | Modulation of AIDS virus-related events by double-stranded RNAS |
-
1987
- 1987-11-25 US US07/125,097 patent/US4950652A/en not_active Expired - Lifetime
-
1988
- 1988-03-02 DE DE8888301824T patent/DE3876125T2/de not_active Expired - Fee Related
- 1988-03-02 ES ES88301824T patent/ES2066782T3/es not_active Expired - Lifetime
- 1988-03-02 AU AU12562/88A patent/AU1256288A/en not_active Abandoned
- 1988-03-02 EP EP88301824A patent/EP0286224B1/en not_active Expired - Lifetime
- 1988-03-03 PH PH36590A patent/PH23333A/en unknown
- 1988-03-07 IL IL85646A patent/IL85646A/xx not_active IP Right Cessation
- 1988-03-11 NZ NZ223868A patent/NZ223868A/xx unknown
- 1988-03-18 FI FI881305A patent/FI881305A/fi not_active Application Discontinuation
- 1988-03-21 NO NO881246A patent/NO881246L/no unknown
- 1988-03-21 CA CA000562015A patent/CA1316832C/en not_active Expired - Fee Related
- 1988-03-22 IE IE83988A patent/IE63823B1/en not_active IP Right Cessation
- 1988-03-22 RU SU884355439A patent/RU2016572C1/ru not_active IP Right Cessation
- 1988-03-22 HU HU881441A patent/HUT46542A/hu unknown
- 1988-03-22 JP JP63065933A patent/JP2656938B2/ja not_active Expired - Fee Related
- 1988-03-22 DK DK156688A patent/DK156688A/da not_active IP Right Cessation
- 1988-03-22 KR KR1019880003033A patent/KR960013435B1/ko not_active IP Right Cessation
- 1988-03-22 PT PT87039A patent/PT87039B/pt not_active IP Right Cessation
- 1988-03-23 OA OA59306A patent/OA08724A/xx unknown
- 1988-03-23 CN CN88101606A patent/CN1049357C/zh not_active Expired - Fee Related
-
1992
- 1992-11-26 GR GR920402678T patent/GR3006340T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IE880839L (en) | 1988-09-23 |
IL85646A (en) | 1993-05-13 |
CN88101606A (zh) | 1988-12-28 |
JP2656938B2 (ja) | 1997-09-24 |
EP0286224B1 (en) | 1992-11-25 |
JPS6425A (en) | 1989-01-05 |
KR880010777A (ko) | 1988-10-24 |
DE3876125T2 (de) | 1993-06-09 |
IL85646A0 (en) | 1988-08-31 |
CN1049357C (zh) | 2000-02-16 |
HUT46542A (en) | 1988-11-28 |
OA08724A (fr) | 1989-03-31 |
US4950652A (en) | 1990-08-21 |
NZ223868A (en) | 1991-02-26 |
FI881305A (fi) | 1988-09-24 |
PH23333A (en) | 1989-07-14 |
RU2016572C1 (ru) | 1994-07-30 |
CA1316832C (en) | 1993-04-27 |
PT87039B (pt) | 1992-11-30 |
KR960013435B1 (ko) | 1996-10-05 |
NO881246L (no) | 1988-09-26 |
AU1256288A (en) | 1988-09-22 |
GR3006340T3 (pt) | 1993-06-21 |
IE63823B1 (en) | 1995-06-14 |
NO881246D0 (no) | 1988-03-21 |
EP0286224A2 (en) | 1988-10-12 |
ES2066782T3 (es) | 1995-03-16 |
DK156688A (da) | 1988-09-24 |
EP0286224A3 (en) | 1988-12-07 |
DK156688D0 (da) | 1988-03-22 |
FI881305A0 (fi) | 1988-03-18 |
DE3876125D1 (de) | 1993-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19920504 |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20061106 |