CA1285566C - 2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-isoquinoline compounds - Google Patents
2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-isoquinoline compoundsInfo
- Publication number
- CA1285566C CA1285566C CA000512101A CA512101A CA1285566C CA 1285566 C CA1285566 C CA 1285566C CA 000512101 A CA000512101 A CA 000512101A CA 512101 A CA512101 A CA 512101A CA 1285566 C CA1285566 C CA 1285566C
- Authority
- CA
- Canada
- Prior art keywords
- pyridyl
- methyl
- hexahydro
- oxo
- isoquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60-144008 | 1985-07-02 | ||
| JP60144008A JPS625963A (ja) | 1985-07-02 | 1985-07-02 | イソキノリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1285566C true CA1285566C (en) | 1991-07-02 |
Family
ID=15352167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000512101A Expired - Lifetime CA1285566C (en) | 1985-07-02 | 1986-06-20 | 2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-isoquinoline compounds |
Country Status (5)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6136266A (ja) * | 1984-07-26 | 1986-02-20 | Mitsui Toatsu Chem Inc | イソキノリン誘導体およびそれを有効成分として含有する治療用組成物 |
| JPS62187467A (ja) * | 1986-02-12 | 1987-08-15 | Mitsui Toatsu Chem Inc | ４−アセチルイソキノリノン化合物の新規製造法 |
| US4714705A (en) * | 1986-07-07 | 1987-12-22 | Ortho Pharmaceutical Corporation | 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties |
| JPH0637491B2 (ja) * | 1986-08-27 | 1994-05-18 | 三井東圧化学株式会社 | イソキノリン誘導体 |
| JPH0674263B2 (ja) * | 1987-04-22 | 1994-09-21 | 三井東圧化学株式会社 | イソキノリン誘導体 |
| US8067433B2 (en) | 2005-11-09 | 2011-11-29 | Zalicus Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| CN103073401B (zh) * | 2013-01-25 | 2015-07-15 | 湖南化工研究院 | 对甲氧基环己酮的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2759936A (en) * | 1953-02-18 | 1956-08-21 | Bristol Lab Inc | Isoquinolone derivatives |
| US3480634A (en) * | 1966-02-28 | 1969-11-25 | Hoffmann La Roche | 1,4-dihydro-3(2h)-isoquinolones and process for their preparation |
| IT8367883A0 (it) * | 1982-08-23 | 1983-08-22 | Rorer Int Overseas | Composti cardiotonici del 2 piridone 5 biciclico eteroaril sostituito e relative composizioni farmaceutiche |
| JPS6136266A (ja) * | 1984-07-26 | 1986-02-20 | Mitsui Toatsu Chem Inc | イソキノリン誘導体およびそれを有効成分として含有する治療用組成物 |
-
1985
- 1985-07-02 JP JP60144008A patent/JPS625963A/ja active Granted
-
1986
- 1986-06-20 US US06/878,527 patent/US4639521A/en not_active Expired - Fee Related
- 1986-06-20 CA CA000512101A patent/CA1285566C/en not_active Expired - Lifetime
- 1986-07-01 DE DE8686108954T patent/DE3682446D1/de not_active Expired - Lifetime
- 1986-07-01 EP EP86108954A patent/EP0207500B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3682446D1 (de) | 1991-12-19 |
| EP0207500A2 (en) | 1987-01-07 |
| JPS625963A (ja) | 1987-01-12 |
| EP0207500A3 (en) | 1988-01-13 |
| JPS6320816B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-04-30 |
| US4639521A (en) | 1987-01-27 |
| EP0207500B1 (en) | 1991-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2814556A1 (de) | Substituierte phenylessigsaeurederivate und verfahren zu deren herstellung | |
| DE69204252T2 (de) | Chinoline Derivate, nützlich als Angiotensin-II-Antagonisten. | |
| JPH0256468A (ja) | ピリダジノン誘導体及びその製造方法 | |
| CA1285566C (en) | 2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-isoquinoline compounds | |
| JP3037991B2 (ja) | 新規なアコニチン系化合物および鎮痛・抗炎症剤 | |
| JP2005523324A (ja) | カンプトテシン誘導体の調製に有用な化合物 | |
| JPS60248672A (ja) | ロイコトリエンおよびリポキシゲナーゼ抑制剤としての５，６，７，８‐テトラヒドロキノリン類および５，６‐ジヒドロピリンジン類の使用法およびそれらの新規３位置換化合物 | |
| JPH0377867A (ja) | 新規オキサゾロピリジン誘導体 | |
| US3933826A (en) | Protoberberine derivatives | |
| US3072648A (en) | X-phenyl-s | |
| US4845228A (en) | Pyridyl-cyclohexanone compounds | |
| JPS62167796A (ja) | ステロイド誘導体の３位置オキシムの製造用中間体 | |
| FI61694C (fi) | Foerfarande foer framstaellning av substituerade arylalkylaminer med blodtrycket och hjaertslagfrekvensen saenkande verkan | |
| JPS6183163A (ja) | 抗腫瘍剤 | |
| Potts et al. | Synthesis of sempervirine | |
| CA1288437C (en) | 4 - (pyridyl) cyclohexanone derivatives | |
| JPH0546338B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| JPS60172964A (ja) | 桂皮酸誘導体及びその製法 | |
| HU197894B (en) | Process for producing 4-acetyl-1-methyl-7-/4-pyridyl/-5,6,7,8-tetrahydro-3/2h/-isoquinolinone | |
| JPS61291569A (ja) | ４−ピリジルシクロヘキサノン誘導体 | |
| JPS61291568A (ja) | ２―アセチル―４―（４―ピリジル）シクロヘキサノン及びその製法 | |
| JPH0357896B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| EP0252986A1 (en) | Hydrazone derivatives | |
| JPS5817190B2 (ja) | シンキナ ４，５− ジアルキルベンゾモルフアンユウドウタイノセイホウ | |
| JP2744653B2 (ja) | ジフエニルメチルアミン誘導体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |