CA1244427A - Tricyclic oxindole antiinflammatory agents - Google Patents

Tricyclic oxindole antiinflammatory agents

Info

Publication number
CA1244427A
CA1244427A CA000489226A CA489226A CA1244427A CA 1244427 A CA1244427 A CA 1244427A CA 000489226 A CA000489226 A CA 000489226A CA 489226 A CA489226 A CA 489226A CA 1244427 A CA1244427 A CA 1244427A
Authority
CA
Canada
Prior art keywords
compound
formula
het
thiazolyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000489226A
Other languages
English (en)
French (fr)
Inventor
Lawrence S. Melvin, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Application granted granted Critical
Publication of CA1244427A publication Critical patent/CA1244427A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
CA000489226A 1984-08-24 1985-08-22 Tricyclic oxindole antiinflammatory agents Expired CA1244427A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1984/001371 WO1986001510A1 (en) 1984-08-24 1984-08-24 Tricyclic oxindole antiinflammatory agents
US84/01371 1984-08-24

Publications (1)

Publication Number Publication Date
CA1244427A true CA1244427A (en) 1988-11-08

Family

ID=22182243

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000489226A Expired CA1244427A (en) 1984-08-24 1985-08-22 Tricyclic oxindole antiinflammatory agents

Country Status (21)

Country Link
US (1) US4695571A (ref)
EP (1) EP0173520B1 (ref)
JP (1) JPS6157554A (ref)
KR (1) KR870001144B1 (ref)
AT (1) ATE49211T1 (ref)
AU (1) AU553859B2 (ref)
CA (1) CA1244427A (ref)
DE (1) DE3575140D1 (ref)
DK (1) DK160098C (ref)
EG (1) EG17287A (ref)
ES (2) ES8704497A1 (ref)
FI (1) FI79319C (ref)
GR (1) GR852026B (ref)
HU (2) HU203238B (ref)
IE (1) IE58739B1 (ref)
IL (1) IL76175A (ref)
PH (1) PH23065A (ref)
PL (2) PL147395B1 (ref)
PT (1) PT81004B (ref)
WO (1) WO1986001510A1 (ref)
ZA (1) ZA856403B (ref)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS63223492A (ja) * 1987-03-11 1988-09-16 Okawara Mfg Co Ltd 熱交換器
WO1990008145A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-3-acyl-2-oxindoles
US5128352A (en) * 1989-01-10 1992-07-07 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
JPH04217684A (ja) * 1990-05-30 1992-08-07 Shionogi & Co Ltd アルド−ス還元酵素阻害物質
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
EP2671507A3 (en) 2005-04-28 2014-02-19 Proteus Digital Health, Inc. Pharma-informatics system
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents

Also Published As

Publication number Publication date
US4695571A (en) 1987-09-22
DE3575140D1 (de) 1990-02-08
HUT47580A (en) 1989-03-28
HU203238B (en) 1991-06-28
EP0173520A3 (en) 1986-05-14
DK382685D0 (da) 1985-08-23
AU4663785A (en) 1986-02-27
ES546377A0 (es) 1987-04-01
PH23065A (en) 1989-03-27
FI79319C (fi) 1989-12-11
ATE49211T1 (de) 1990-01-15
PL255089A1 (en) 1986-12-30
EP0173520B1 (en) 1990-01-03
PT81004B (pt) 1987-12-30
KR870002143A (ko) 1987-03-30
FI861704A0 (fi) 1986-04-23
HU203350B (en) 1991-07-29
EP0173520A2 (en) 1986-03-05
IE852081L (en) 1986-02-24
ZA856403B (en) 1987-04-29
EG17287A (en) 1993-02-28
DK160098B (da) 1991-01-28
GR852026B (ref) 1985-12-19
ES8706116A1 (es) 1987-06-01
IL76175A0 (en) 1985-12-31
IL76175A (en) 1989-08-15
PL147395B1 (en) 1989-05-31
KR870001144B1 (ko) 1987-06-11
AU553859B2 (en) 1986-07-31
PL147393B1 (en) 1989-05-31
JPH0450316B2 (ref) 1992-08-13
IE58739B1 (en) 1993-11-03
ES552044A0 (es) 1987-06-01
WO1986001510A1 (en) 1986-03-13
ES8704497A1 (es) 1987-04-01
FI861704A7 (fi) 1986-04-23
JPS6157554A (ja) 1986-03-24
PT81004A (en) 1985-09-01
DK382685A (da) 1986-02-25
DK160098C (da) 1991-06-24
FI79319B (fi) 1989-08-31
HU902020D0 (en) 1990-07-28

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Legal Events

Date Code Title Description
MKEX Expiry