CA1235079A - Process for the preparation of nucleoside alkyl-, aralkyl- and aryl-phosphonites and -phosphonates - Google Patents

Process for the preparation of nucleoside alkyl-, aralkyl- and aryl-phosphonites and -phosphonates

Info

Publication number
CA1235079A
CA1235079A CA000462469A CA462469A CA1235079A CA 1235079 A CA1235079 A CA 1235079A CA 000462469 A CA000462469 A CA 000462469A CA 462469 A CA462469 A CA 462469A CA 1235079 A CA1235079 A CA 1235079A
Authority
CA
Canada
Prior art keywords
general formula
group
compounds
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000462469A
Other languages
English (en)
French (fr)
Inventor
Joachim Engels
Alfred Jager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA1235079A publication Critical patent/CA1235079A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4883—Amides or esteramides thereof, e.g. RP(NR'2)2 or RP(XR')(NR''2) (X = O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CA000462469A 1983-09-06 1984-09-05 Process for the preparation of nucleoside alkyl-, aralkyl- and aryl-phosphonites and -phosphonates Expired CA1235079A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833332068 DE3332068A1 (de) 1983-09-06 1983-09-06 Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
DEP3332068.3 1983-09-06

Publications (1)

Publication Number Publication Date
CA1235079A true CA1235079A (en) 1988-04-12

Family

ID=6208339

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000462469A Expired CA1235079A (en) 1983-09-06 1984-09-05 Process for the preparation of nucleoside alkyl-, aralkyl- and aryl-phosphonites and -phosphonates

Country Status (11)

Country Link
EP (1) EP0136543B1 (enrdf_load_html_response)
JP (2) JPS6072899A (enrdf_load_html_response)
AT (1) ATE38839T1 (enrdf_load_html_response)
AU (2) AU570266B2 (enrdf_load_html_response)
CA (1) CA1235079A (enrdf_load_html_response)
DE (2) DE3332068A1 (enrdf_load_html_response)
DK (3) DK162895C (enrdf_load_html_response)
ES (1) ES8505384A1 (enrdf_load_html_response)
GR (1) GR80287B (enrdf_load_html_response)
IE (1) IE57904B1 (enrdf_load_html_response)
PT (1) PT79172B (enrdf_load_html_response)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
ES2099718T3 (es) * 1990-07-02 1997-06-01 Hoechst Ag Analogos de oligonucleotidos con uniones internucleotidicas de 3'-3' o 5'-5' terminales.
US5512668A (en) * 1991-03-06 1996-04-30 Polish Academy Of Sciences Solid phase oligonucleotide synthesis using phospholane intermediates
DE69316369D1 (en) * 1992-07-27 1998-02-19 Hybridon Inc Oligonukleotid alkylphosphonothiate
CA2153505A1 (en) * 1993-01-08 1994-07-21 Jin-Yan Tang Synthesis of dimmer blocks and their use in assembling oligonucleotides
US6087491A (en) 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
AU6165494A (en) * 1993-01-25 1994-08-15 Hybridon, Inc. Oligonucleotide alkylphosphonates and alkylphosphonothioates
WO1996003284A1 (fr) * 1994-07-26 1996-02-08 Sony Corporation Procede de transfert d'image, substrat de transfert et ruban encreur utilise a cet effet
ES2202447T3 (es) * 1995-05-26 2004-04-01 Genta Incorporated Metodos de sintesis de derivados organofosforados.
WO1997042208A1 (en) * 1996-05-03 1997-11-13 Hybridon, Inc. In situ preparation of nucleoside phosphoramidites and their use in synthesis of oligonucleotides
DE102004049339A1 (de) 2004-10-08 2006-04-13 Basf Ag Verfahren zur Reinigung von phosphorhaltigen Chelat-Liganden
DE102007038930B4 (de) * 2007-08-13 2013-12-05 Universität Leipzig Neue chemische Verbindung und deren Verwendung in der Medizin, insbesondere für die Verwendung in der Tumortherapie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62834A0 (en) * 1980-05-14 1981-07-31 Ens Bio Logicals Inc Polynucleotide synthesis
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
EP0090789A1 (en) * 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten

Also Published As

Publication number Publication date
DK162895B (da) 1991-12-23
DK424784A (da) 1985-03-07
DE3332068A1 (de) 1985-03-21
DK424784D0 (da) 1984-09-05
DK166585C (da) 1993-10-25
DK162895C (da) 1992-05-11
DK167359B1 (da) 1993-10-18
DK131691D0 (da) 1991-07-05
JPH05262787A (ja) 1993-10-12
PT79172A (de) 1984-10-01
IE57904B1 (en) 1993-05-05
DK131591A (da) 1991-07-05
EP0136543A2 (de) 1985-04-10
DK131591D0 (da) 1991-07-05
JPS6072899A (ja) 1985-04-24
PT79172B (de) 1986-09-10
JPH0662662B2 (ja) 1994-08-17
AU3275684A (en) 1985-03-14
DK131691A (da) 1991-07-05
EP0136543A3 (en) 1986-07-16
AU601257B2 (en) 1990-09-06
AU570266B2 (en) 1988-03-10
DK166585B (da) 1993-06-14
EP0136543B1 (de) 1988-11-23
DE3475307D1 (en) 1988-12-29
JPH0531560B2 (enrdf_load_html_response) 1993-05-12
ATE38839T1 (de) 1988-12-15
GR80287B (en) 1985-01-07
AU1138488A (en) 1988-07-14
ES535627A0 (es) 1985-05-16
ES8505384A1 (es) 1985-05-16
IE842268L (en) 1985-03-06

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Legal Events

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