DK424784A - Fremgangsmaade til fremstilling af nucleosidalkyl-, -aralkyl- og -arylphosphonitter og -phosphonater - Google Patents

Fremgangsmaade til fremstilling af nucleosidalkyl-, -aralkyl- og -arylphosphonitter og -phosphonater Download PDF

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Publication number
DK424784A
DK424784A DK424784A DK424784A DK424784A DK 424784 A DK424784 A DK 424784A DK 424784 A DK424784 A DK 424784A DK 424784 A DK424784 A DK 424784A DK 424784 A DK424784 A DK 424784A
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Prior art keywords
denotes
general formula
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meanings given
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Application number
DK424784A
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English (en)
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DK424784D0 (da
DK162895C (da
DK162895B (da
Inventor
Joachim Engels
Alfred Jaeger
Original Assignee
Hoechst Ag
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Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK424784D0 publication Critical patent/DK424784D0/da
Publication of DK424784A publication Critical patent/DK424784A/da
Publication of DK162895B publication Critical patent/DK162895B/da
Application granted granted Critical
Publication of DK162895C publication Critical patent/DK162895C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4883—Amides or esteramides thereof, e.g. RP(NR'2)2 or RP(XR')(NR''2) (X = O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK424784A 1983-09-06 1984-09-05 Fremgangsmaade til fremstilling af desoxyribonucleosidphosphonater DK162895C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3332068 1983-09-06
DE19833332068 DE3332068A1 (de) 1983-09-06 1983-09-06 Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten

Publications (4)

Publication Number Publication Date
DK424784D0 DK424784D0 (da) 1984-09-05
DK424784A true DK424784A (da) 1985-03-07
DK162895B DK162895B (da) 1991-12-23
DK162895C DK162895C (da) 1992-05-11

Family

ID=6208339

Family Applications (3)

Application Number Title Priority Date Filing Date
DK424784A DK162895C (da) 1983-09-06 1984-09-05 Fremgangsmaade til fremstilling af desoxyribonucleosidphosphonater
DK131691A DK167359B1 (da) 1983-09-06 1991-07-05 Nucleosidphosphoniter
DK131591A DK166585C (da) 1983-09-06 1991-07-05 Desoxyribonucleosidthio- og -selenphosphonater

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK131691A DK167359B1 (da) 1983-09-06 1991-07-05 Nucleosidphosphoniter
DK131591A DK166585C (da) 1983-09-06 1991-07-05 Desoxyribonucleosidthio- og -selenphosphonater

Country Status (11)

Country Link
EP (1) EP0136543B1 (da)
JP (2) JPS6072899A (da)
AT (1) ATE38839T1 (da)
AU (2) AU570266B2 (da)
CA (1) CA1235079A (da)
DE (2) DE3332068A1 (da)
DK (3) DK162895C (da)
ES (1) ES8505384A1 (da)
GR (1) GR80287B (da)
IE (1) IE57904B1 (da)
PT (1) PT79172B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
ATE151076T1 (de) * 1990-07-02 1997-04-15 Hoechst Ag Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-internucleotidverknüpfungen
US5512668A (en) * 1991-03-06 1996-04-30 Polish Academy Of Sciences Solid phase oligonucleotide synthesis using phospholane intermediates
WO1994002499A1 (en) * 1992-07-27 1994-02-03 Hybridon, Inc. Oligonucleotide alkylphosphonothioates
JPH08507752A (ja) * 1993-01-08 1996-08-20 ハイブライドン インコーポレイテッド 二量体ブロックの合成と二量体ブロックを使ったオリゴヌクレオチド結合法
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
AU6165494A (en) * 1993-01-25 1994-08-15 Hybridon, Inc. Oligonucleotide alkylphosphonates and alkylphosphonothioates
KR100378965B1 (ko) * 1994-07-26 2003-08-21 소니 가부시끼 가이샤 화상전사방법및이것에사용하는피전사체,잉크리본
ATE245161T1 (de) * 1995-05-26 2003-08-15 Genta Inc Verfahren zur synthese von phosphororganischen verbindungen
DE69726276T2 (de) * 1996-05-03 2004-11-18 Avecia Biotechnology, Inc., Milford In situ herstellung von nukleosid-phosphoramiditen und ihre verwendung in der oligonukleotidsynthese
DE102004049339A1 (de) 2004-10-08 2006-04-13 Basf Ag Verfahren zur Reinigung von phosphorhaltigen Chelat-Liganden
DE102007038930B4 (de) * 2007-08-13 2013-12-05 Universität Leipzig Neue chemische Verbindung und deren Verwendung in der Medizin, insbesondere für die Verwendung in der Tumortherapie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62834A0 (en) * 1980-05-14 1981-07-31 Ens Bio Logicals Inc Polynucleotide synthesis
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
EP0090789A1 (en) * 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten

Also Published As

Publication number Publication date
ES535627A0 (es) 1985-05-16
DE3332068A1 (de) 1985-03-21
ATE38839T1 (de) 1988-12-15
EP0136543B1 (de) 1988-11-23
AU570266B2 (en) 1988-03-10
IE842268L (en) 1985-03-06
DE3475307D1 (en) 1988-12-29
DK424784D0 (da) 1984-09-05
JPH0531560B2 (da) 1993-05-12
JPH0662662B2 (ja) 1994-08-17
AU3275684A (en) 1985-03-14
AU601257B2 (en) 1990-09-06
PT79172A (de) 1984-10-01
CA1235079A (en) 1988-04-12
DK162895C (da) 1992-05-11
DK167359B1 (da) 1993-10-18
GR80287B (en) 1985-01-07
EP0136543A3 (en) 1986-07-16
JPS6072899A (ja) 1985-04-24
DK131591D0 (da) 1991-07-05
JPH05262787A (ja) 1993-10-12
IE57904B1 (en) 1993-05-05
ES8505384A1 (es) 1985-05-16
AU1138488A (en) 1988-07-14
DK131591A (da) 1991-07-05
DK166585C (da) 1993-10-25
DK131691D0 (da) 1991-07-05
DK162895B (da) 1991-12-23
EP0136543A2 (de) 1985-04-10
PT79172B (de) 1986-09-10
DK166585B (da) 1993-06-14
DK131691A (da) 1991-07-05

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