GR80287B - Method for the preparation of nucleosidalkyl-aralkyl-,-arylphosphonites and -phosphonates - Google Patents

Method for the preparation of nucleosidalkyl-aralkyl-,-arylphosphonites and -phosphonates

Info

Publication number
GR80287B
GR80287B GR80287A GR840180287A GR80287B GR 80287 B GR80287 B GR 80287B GR 80287 A GR80287 A GR 80287A GR 840180287 A GR840180287 A GR 840180287A GR 80287 B GR80287 B GR 80287B
Authority
GR
Greece
Prior art keywords
denotes
general formula
see diagramm
given above
meanings given
Prior art date
Application number
GR80287A
Other languages
English (en)
Inventor
Engels Dr Joachim
Jager Dr Alfred
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of GR80287B publication Critical patent/GR80287B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids R—P(OH)2; Thiophosphonous acids including RHP(=O)(OH); Derivatives thereof
    • C07F9/4883—Amides or esteramides thereof, e.g. RP(NR'2)2 or RP(XR')(NR''2) (X = O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
GR80287A 1983-09-06 1984-09-04 Method for the preparation of nucleosidalkyl-aralkyl-,-arylphosphonites and -phosphonates GR80287B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833332068 DE3332068A1 (de) 1983-09-06 1983-09-06 Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten

Publications (1)

Publication Number Publication Date
GR80287B true GR80287B (en) 1985-01-07

Family

ID=6208339

Family Applications (1)

Application Number Title Priority Date Filing Date
GR80287A GR80287B (en) 1983-09-06 1984-09-04 Method for the preparation of nucleosidalkyl-aralkyl-,-arylphosphonites and -phosphonates

Country Status (11)

Country Link
EP (1) EP0136543B1 (el)
JP (2) JPS6072899A (el)
AT (1) ATE38839T1 (el)
AU (2) AU570266B2 (el)
CA (1) CA1235079A (el)
DE (2) DE3332068A1 (el)
DK (3) DK162895C (el)
ES (1) ES535627A0 (el)
GR (1) GR80287B (el)
IE (1) IE57904B1 (el)
PT (1) PT79172B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
DK0464638T3 (da) * 1990-07-02 1997-10-13 Hoechst Ag Oligonukleotidanaloge med terminale 3-3- eller 5-5-internukleotidbindinger.
US5512668A (en) * 1991-03-06 1996-04-30 Polish Academy Of Sciences Solid phase oligonucleotide synthesis using phospholane intermediates
RU95104940A (ru) * 1992-07-27 1997-01-10 Хайбрайдон Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
DE69402177T2 (de) * 1993-01-08 1997-06-26 Hybridon Inc Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden
DE69400208T2 (de) * 1993-01-25 1996-11-28 Hybridon Inc Olionukleotidalkylphosphonate und -phosphonothioate
WO1996003284A1 (fr) * 1994-07-26 1996-02-08 Sony Corporation Procede de transfert d'image, substrat de transfert et ruban encreur utilise a cet effet
CA2222048A1 (en) * 1995-05-26 1996-11-28 Polska Akademia Nauk Compositions and methods for the synthesis of organophosphorus derivatives
ATE254627T1 (de) * 1996-05-03 2003-12-15 Avecia Biotechnology Inc In situ herstellung von nukleosid- phosphoramiditen und ihre verwendung in der oligonukleotidsynthese
DE102004049339A1 (de) * 2004-10-08 2006-04-13 Basf Ag Verfahren zur Reinigung von phosphorhaltigen Chelat-Liganden
DE102007038930B4 (de) * 2007-08-13 2013-12-05 Universität Leipzig Neue chemische Verbindung und deren Verwendung in der Medizin, insbesondere für die Verwendung in der Tumortherapie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL62834A0 (en) * 1980-05-14 1981-07-31 Ens Bio Logicals Inc Polynucleotide synthesis
US4415732A (en) * 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
EP0090789A1 (en) * 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
DE3239888A1 (de) * 1982-10-28 1984-05-03 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur herstellung von oligonucleosidphosphonaten

Also Published As

Publication number Publication date
DE3332068A1 (de) 1985-03-21
EP0136543A2 (de) 1985-04-10
AU1138488A (en) 1988-07-14
ES8505384A1 (es) 1985-05-16
EP0136543A3 (en) 1986-07-16
PT79172B (de) 1986-09-10
DK166585B (da) 1993-06-14
DE3475307D1 (en) 1988-12-29
JPS6072899A (ja) 1985-04-24
DK424784D0 (da) 1984-09-05
ATE38839T1 (de) 1988-12-15
DK162895C (da) 1992-05-11
DK167359B1 (da) 1993-10-18
DK131591D0 (da) 1991-07-05
ES535627A0 (es) 1985-05-16
AU601257B2 (en) 1990-09-06
IE57904B1 (en) 1993-05-05
DK131691A (da) 1991-07-05
DK131591A (da) 1991-07-05
AU570266B2 (en) 1988-03-10
JPH05262787A (ja) 1993-10-12
CA1235079A (en) 1988-04-12
JPH0531560B2 (el) 1993-05-12
JPH0662662B2 (ja) 1994-08-17
DK131691D0 (da) 1991-07-05
IE842268L (en) 1985-03-06
EP0136543B1 (de) 1988-11-23
PT79172A (de) 1984-10-01
DK162895B (da) 1991-12-23
DK424784A (da) 1985-03-07
DK166585C (da) 1993-10-25
AU3275684A (en) 1985-03-14

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