DK131591D0 - Desoxyribonucleosidthio- og selenphosphonater - Google Patents
Desoxyribonucleosidthio- og selenphosphonaterInfo
- Publication number
- DK131591D0 DK131591D0 DK911315A DK131591A DK131591D0 DK 131591 D0 DK131591 D0 DK 131591D0 DK 911315 A DK911315 A DK 911315A DK 131591 A DK131591 A DK 131591A DK 131591 D0 DK131591 D0 DK 131591D0
- Authority
- DK
- Denmark
- Prior art keywords
- denotes
- general formula
- see diagramm
- given above
- meanings given
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 239000000460 chlorine Chemical group 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 239000002777 nucleoside Substances 0.000 abstract 4
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 4
- 125000006239 protecting group Chemical group 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 abstract 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 239000005549 deoxyribonucleoside Substances 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229910052711 selenium Inorganic materials 0.000 abstract 2
- 239000011669 selenium Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
- C07F9/4883—Amides or esteramides thereof, e.g. RP(NR'2)2 or RP(XR')(NR''2) (X = O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Silicon Polymers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833332068 DE3332068A1 (de) | 1983-09-06 | 1983-09-06 | Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten |
| DE3332068 | 1983-09-06 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK131591A DK131591A (da) | 1991-07-05 |
| DK131591D0 true DK131591D0 (da) | 1991-07-05 |
| DK166585B DK166585B (da) | 1993-06-14 |
| DK166585C DK166585C (da) | 1993-10-25 |
Family
ID=6208339
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK424784A DK162895C (da) | 1983-09-06 | 1984-09-05 | Fremgangsmaade til fremstilling af desoxyribonucleosidphosphonater |
| DK131591A DK166585C (da) | 1983-09-06 | 1991-07-05 | Desoxyribonucleosidthio- og -selenphosphonater |
| DK131691A DK167359B1 (da) | 1983-09-06 | 1991-07-05 | Nucleosidphosphoniter |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK424784A DK162895C (da) | 1983-09-06 | 1984-09-05 | Fremgangsmaade til fremstilling af desoxyribonucleosidphosphonater |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK131691A DK167359B1 (da) | 1983-09-06 | 1991-07-05 | Nucleosidphosphoniter |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0136543B1 (da) |
| JP (2) | JPS6072899A (da) |
| AT (1) | ATE38839T1 (da) |
| AU (2) | AU570266B2 (da) |
| CA (1) | CA1235079A (da) |
| DE (2) | DE3332068A1 (da) |
| DK (3) | DK162895C (da) |
| ES (1) | ES535627A0 (da) |
| GR (1) | GR80287B (da) |
| IE (1) | IE57904B1 (da) |
| PT (1) | PT79172B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4959463A (en) * | 1985-10-15 | 1990-09-25 | Genentech, Inc. | Intermediates |
| DE3916871A1 (de) * | 1989-05-24 | 1990-11-29 | Boehringer Mannheim Gmbh | Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren |
| DK0464638T3 (da) * | 1990-07-02 | 1997-10-13 | Hoechst Ag | Oligonukleotidanaloge med terminale 3-3- eller 5-5-internukleotidbindinger. |
| US5512668A (en) * | 1991-03-06 | 1996-04-30 | Polish Academy Of Sciences | Solid phase oligonucleotide synthesis using phospholane intermediates |
| AU678769B2 (en) * | 1992-07-27 | 1997-06-12 | Hybridon, Inc. | Oligonucleotide alkylphosphonothioates |
| WO1994015946A1 (en) * | 1993-01-08 | 1994-07-21 | Hybridon, Inc. | Synthesis of dimmer blocks and their use in assembling oligonucleotides |
| US6087491A (en) * | 1993-01-08 | 2000-07-11 | Hybridon, Inc. | Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks |
| ES2086997T3 (es) * | 1993-01-25 | 1996-07-01 | Hybridon Inc | Oligonucleotido-alquilfosfonatos y -alquilfosfonotioatos. |
| KR100378965B1 (ko) * | 1994-07-26 | 2003-08-21 | 소니 가부시끼 가이샤 | 화상전사방법및이것에사용하는피전사체,잉크리본 |
| DE69629112T2 (de) * | 1995-05-26 | 2004-04-22 | Genta Inc., San Diego | Verfahren zur synthese von phosphororganischen verbindungen |
| ATE254627T1 (de) * | 1996-05-03 | 2003-12-15 | Avecia Biotechnology Inc | In situ herstellung von nukleosid- phosphoramiditen und ihre verwendung in der oligonukleotidsynthese |
| DE102004049339A1 (de) * | 2004-10-08 | 2006-04-13 | Basf Ag | Verfahren zur Reinigung von phosphorhaltigen Chelat-Liganden |
| DE102007038930B4 (de) * | 2007-08-13 | 2013-12-05 | Universität Leipzig | Neue chemische Verbindung und deren Verwendung in der Medizin, insbesondere für die Verwendung in der Tumortherapie |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL62834A0 (en) * | 1980-05-14 | 1981-07-31 | Ens Bio Logicals Inc | Polynucleotide synthesis |
| US4415732A (en) * | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| EP0090789A1 (en) * | 1982-03-26 | 1983-10-05 | Monsanto Company | Chemical DNA synthesis |
| DE3239888A1 (de) * | 1982-10-28 | 1984-05-03 | Hubert Prof. Dr. 2000 Hamburg Köster | Verfahren zur herstellung von oligonucleosidphosphonaten |
-
1983
- 1983-09-06 DE DE19833332068 patent/DE3332068A1/de not_active Withdrawn
-
1984
- 1984-08-30 AT AT84110314T patent/ATE38839T1/de not_active IP Right Cessation
- 1984-08-30 DE DE8484110314T patent/DE3475307D1/de not_active Expired
- 1984-08-30 EP EP84110314A patent/EP0136543B1/de not_active Expired
- 1984-09-04 PT PT79172A patent/PT79172B/pt active IP Right Revival
- 1984-09-04 GR GR80287A patent/GR80287B/el unknown
- 1984-09-04 ES ES535627A patent/ES535627A0/es active Granted
- 1984-09-05 JP JP59184717A patent/JPS6072899A/ja active Granted
- 1984-09-05 AU AU32756/84A patent/AU570266B2/en not_active Expired
- 1984-09-05 DK DK424784A patent/DK162895C/da active
- 1984-09-05 CA CA000462469A patent/CA1235079A/en not_active Expired
- 1984-09-05 IE IE2268/84A patent/IE57904B1/en not_active IP Right Cessation
-
1988
- 1988-02-08 AU AU11384/88A patent/AU601257B2/en not_active Expired
-
1991
- 1991-07-05 DK DK131591A patent/DK166585C/da active
- 1991-07-05 DK DK131691A patent/DK167359B1/da active IP Right Grant
-
1992
- 1992-11-18 JP JP4307481A patent/JPH0662662B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU601257B2 (en) | 1990-09-06 |
| PT79172B (de) | 1986-09-10 |
| PT79172A (de) | 1984-10-01 |
| AU570266B2 (en) | 1988-03-10 |
| DK131591A (da) | 1991-07-05 |
| ES8505384A1 (es) | 1985-05-16 |
| JPS6072899A (ja) | 1985-04-24 |
| DE3475307D1 (en) | 1988-12-29 |
| DK162895C (da) | 1992-05-11 |
| DK167359B1 (da) | 1993-10-18 |
| GR80287B (en) | 1985-01-07 |
| DK166585C (da) | 1993-10-25 |
| JPH0531560B2 (da) | 1993-05-12 |
| JPH0662662B2 (ja) | 1994-08-17 |
| ATE38839T1 (de) | 1988-12-15 |
| EP0136543A2 (de) | 1985-04-10 |
| DK131691A (da) | 1991-07-05 |
| DK166585B (da) | 1993-06-14 |
| IE57904B1 (en) | 1993-05-05 |
| AU1138488A (en) | 1988-07-14 |
| DK424784D0 (da) | 1984-09-05 |
| DE3332068A1 (de) | 1985-03-21 |
| EP0136543B1 (de) | 1988-11-23 |
| AU3275684A (en) | 1985-03-14 |
| IE842268L (en) | 1985-03-06 |
| JPH05262787A (ja) | 1993-10-12 |
| ES535627A0 (es) | 1985-05-16 |
| DK131691D0 (da) | 1991-07-05 |
| EP0136543A3 (en) | 1986-07-16 |
| DK162895B (da) | 1991-12-23 |
| DK424784A (da) | 1985-03-07 |
| CA1235079A (en) | 1988-04-12 |
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