CA1217317A - Smoking substitutes for nasal administration-i - Google Patents

Smoking substitutes for nasal administration-i

Info

Publication number
CA1217317A
CA1217317A CA000445607A CA445607A CA1217317A CA 1217317 A CA1217317 A CA 1217317A CA 000445607 A CA000445607 A CA 000445607A CA 445607 A CA445607 A CA 445607A CA 1217317 A CA1217317 A CA 1217317A
Authority
CA
Canada
Prior art keywords
composition
nicotine
nasally
acceptable
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000445607A
Other languages
English (en)
French (fr)
Inventor
Ove B. Ferno
Corfitz B.I. Ohlsson
Stig K.A. Helgertz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo AB
Original Assignee
Leo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo AB filed Critical Leo AB
Application granted granted Critical
Publication of CA1217317A publication Critical patent/CA1217317A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Tobacco Products (AREA)
CA000445607A 1983-01-21 1984-01-19 Smoking substitutes for nasal administration-i Expired CA1217317A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8301659 1983-01-21
GB838301659A GB8301659D0 (en) 1983-01-21 1983-01-21 Smoking substitutes

Publications (1)

Publication Number Publication Date
CA1217317A true CA1217317A (en) 1987-02-03

Family

ID=10536690

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000445607A Expired CA1217317A (en) 1983-01-21 1984-01-19 Smoking substitutes for nasal administration-i

Country Status (11)

Country Link
US (1) US4579858A (OSRAM)
JP (1) JPS59135878A (OSRAM)
CA (1) CA1217317A (OSRAM)
CH (1) CH663154A5 (OSRAM)
DE (1) DE3401763A1 (OSRAM)
FI (1) FI73869C (OSRAM)
FR (1) FR2539627B1 (OSRAM)
GB (1) GB8301659D0 (OSRAM)
IL (1) IL70577A (OSRAM)
IT (1) IT1178834B (OSRAM)
SE (2) SE8400045L (OSRAM)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920989A (en) * 1985-04-25 1990-05-01 Regents Of The University Of California Method and apparatus for aiding in the reduction of incidence of tobacco smoking
EP0245480A1 (en) * 1985-11-14 1987-11-19 ROSEN, David I. Transdermal application of nicotine
US4821745A (en) * 1985-11-14 1989-04-18 Rosen David I Apparatus and method for overcoming the habit of tobacco smoking
GB8600680D0 (en) * 1986-01-13 1986-02-19 Imp Group Plc Chemical analysis of tobacco/smoking-related products
US4774971A (en) * 1986-06-03 1988-10-04 Vieten Michael J Cigarette substitute
US5055478A (en) * 1986-06-19 1991-10-08 Cooper Thomas M Method for stopping smoking
DE3645036A1 (de) * 1986-11-18 1989-01-05 Forschungsgesellschaft Rauchen Nikotinhaltiges mittel
US4765348A (en) * 1986-12-12 1988-08-23 Brown & Williamson Tobacco Corporation Non-combustible simulated cigarette device
US5174989A (en) * 1987-11-25 1992-12-29 Shiseido Company Ltd. Oral composition
DK556089D0 (da) 1989-11-07 1989-11-07 Anders Dam Ryge supplement eller rygeerstatningsprodukt
US5512306A (en) * 1992-06-19 1996-04-30 Pharmica Ab Smoking substitute
GB9200047D0 (en) * 1992-01-03 1992-02-26 Univ Alberta Nicotine-containing nasal spray
US6024097A (en) * 1992-02-20 2000-02-15 J Mom Trust Product for assisting a smoker in giving up the habit
US5441060A (en) * 1993-02-08 1995-08-15 Duke University Dry powder delivery system
SE9303574D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Composition for drug delivery and method the manufacturing thereof
DE4440563A1 (de) * 1994-11-12 1996-05-15 Herzog Sen Rolf Verfahren und Mittel zum Genuß von Tabak - Nikotin unter Vermeidung schädlicher Verbrennungs - Derivate
JPH11507810A (ja) * 1995-06-05 1999-07-13 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Ｇタンパク質副甲状腺ホルモンレセプターｈｌｔｄｇ７４
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
JPH1142281A (ja) * 1997-07-28 1999-02-16 Ota Seiyaku Kk 薬剤用使い捨て容器
CA2231968A1 (en) * 1998-03-11 1999-09-11 Smoke-Stop, A Partnership Consisting Of Art Slutsky Method of producing a nicotine medicament
US7273618B2 (en) * 1998-12-09 2007-09-25 Chiron Corporation Method for administering agents to the central nervous system
US6248760B1 (en) * 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
US20080138294A1 (en) * 1999-07-16 2008-06-12 Igor Gonda Systems and methods for effecting cessation of tobacco use
US8256433B2 (en) 1999-07-16 2012-09-04 Aradigm Corporation Systems and methods for effecting cessation of tobacco use
US20080138399A1 (en) * 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
US20080138398A1 (en) * 1999-07-16 2008-06-12 Aradigm Corporation Dual release nicotine formulations, and systems and methods for their use
US6712803B1 (en) * 1999-08-11 2004-03-30 Howard Paritsky Drug dispensing system
SE0102197D0 (sv) * 2001-06-20 2001-06-20 Pharmacia Ab New product and use and manufacture thereof
SE521512C2 (sv) * 2001-06-25 2003-11-11 Niconovum Ab Anordning för administrering av en substans till främre delen av en individs munhåla
US20030111088A1 (en) * 2001-10-29 2003-06-19 Addiction Therapies, Inc. Device and method for treating combination dependencies
CA2465266C (en) * 2001-11-22 2009-10-06 Raul Goldemann Inhalation device for dry powder controlled by inspiration
US20060105023A1 (en) * 2001-12-10 2006-05-18 Knight Joseph R Treatment of neurological disorders with nicotine
EA010097B1 (ru) * 2001-12-10 2008-06-30 Джозеф Роберт Найт Способ получения напитка, обработанного никотином или его производным
SE0104388D0 (sv) * 2001-12-27 2001-12-27 Pharmacia Ab New formulation and use and manufacture thereof
US20030159702A1 (en) * 2002-01-21 2003-08-28 Lindell Katarina E.A. Formulation and use manufacture thereof
SE0201669D0 (sv) * 2002-06-03 2002-06-03 Pharmacia Ab New formulation and use thereof
US7767698B2 (en) * 2002-06-03 2010-08-03 Mcneil Ab Formulation and use thereof
US20040002520A1 (en) * 2002-07-01 2004-01-01 Soderlund Patrick L. Composition and method for cessation of Nicotine cravings
EP1380630A3 (en) * 2002-07-11 2004-01-28 Herbal Apothecary Limited Hydrocarbon wetting and separation agent
WO2004041283A1 (en) 2002-10-31 2004-05-21 Recovery Pharmaceuticals, Inc. Device and method for treating combination dependencies
ATE359075T1 (de) * 2002-12-20 2007-05-15 Niconovum Ab Chemisch und physikalisch stabiles teilchenförmiges material enthaltend nikotin und microcrystalline cellulose
PL1663168T3 (pl) * 2003-09-08 2009-07-31 Mcneil Ab Preparaty nikotyny i ich zastosowanie
US20070191815A1 (en) 2004-09-13 2007-08-16 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
ES2334681T3 (es) * 2004-03-19 2010-03-15 Mcneil Ab Medios para la administracion transdermica de nicotina.
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
US8323683B2 (en) 2005-05-18 2012-12-04 Mcneil-Ppc, Inc. Flavoring of drug-containing chewing gums
NL1029798C2 (nl) * 2005-08-24 2007-02-27 Tanios Sleiman Toepassing van snuiftabak voor de behandeling van allergie van de luchtwegen.
SE530184C2 (sv) * 2005-12-23 2008-03-18 Kjell Stenberg Bioadhesiv farmaceutisk filmkomposition innehållande lågviskösa alginater
CA2646942C (en) 2006-03-16 2014-07-29 Niconovum Ab Improved snuff composition
US20070269492A1 (en) * 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
US20070269386A1 (en) * 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
EP2322168A1 (en) * 2007-04-02 2011-05-18 Parkinson's Institute Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments
US8991402B2 (en) 2007-12-18 2015-03-31 Pax Labs, Inc. Aerosol devices and methods for inhaling a substance and uses thereof
AT507187B1 (de) 2008-10-23 2010-03-15 Helmut Dr Buchberger Inhalator
US20100124560A1 (en) * 2008-11-14 2010-05-20 Mcneil Ab Multi portion intra-oral dosage form and use thereof
EP2233134A1 (en) 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
US20110182831A1 (en) * 2010-01-25 2011-07-28 Aradigm Corporation Systems and methods used in conjunction with nicotine vaccines for effecting cessation of tobacco use
US20110268809A1 (en) 2010-04-28 2011-11-03 Paul Andrew Brinkley Nicotine-Containing Pharmaceutical Compositions
US20110274628A1 (en) 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
WO2011150960A1 (en) * 2010-05-31 2011-12-08 Fertin Pharma A/S Formulation comprising nicotine and a cation exchange resin
US8728443B2 (en) 2010-05-31 2014-05-20 Fertin Pharma A/S Formulation comprising nicotine and a cation exchange resin
US20120000941A1 (en) * 2010-06-30 2012-01-05 Inspire Pharmaceuticals, Inc. Medicine dispenser
WO2012106739A1 (de) 2011-02-11 2012-08-16 Helmut Buchberger Inhalatorkomponente
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9907748B2 (en) 2011-10-21 2018-03-06 Niconovum Usa, Inc. Excipients for nicotine-containing therapeutic compositions
RU2659887C2 (ru) 2013-05-06 2018-07-04 Джуул Лэбз, Инк. Составы на основе солей никотина для аэрозольных устройств и способы их применения
IL319794A (en) 2013-12-05 2025-05-01 Juul Labs Inc Liquid nicotine formulations for aerosol devices and methods
GB201414796D0 (en) * 2014-08-20 2014-10-01 Nasaleze Patents Ltd Metered dose dispensing apparatus and method of use thereof
EP3200632B1 (en) 2014-10-03 2023-06-07 Fertin Pharma A/S Electronic nicotine delivery system
GB2535427A (en) 2014-11-07 2016-08-24 Nicoventures Holdings Ltd Solution
GB2532062A (en) 2014-11-07 2016-05-11 Nicoventures Holdings Ltd Container
JP2018511355A (ja) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 薬剤送達方法及びシステム
AU2016228779A1 (en) 2015-03-12 2017-09-07 Chrono Therapeutics Inc. Craving input and support system
GB2542838B (en) 2015-10-01 2022-01-12 Nicoventures Trading Ltd Aerosol provision system
US10532046B2 (en) 2015-12-03 2020-01-14 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US20170165252A1 (en) 2015-12-10 2017-06-15 Niconovum Usa Inc. Protein-enriched therapeutic composition
HK1258883A1 (zh) * 2016-04-12 2019-11-22 A‧索利斯‧赫雷拉 用烟硷乙酰胆硷受体激动剂治疗鼻和鼻旁粘膜病症的组合物和方法
DK179552B1 (en) * 2016-10-28 2019-02-13 Smoke-It Aps System and method for storing a product containing nicotine
JP2020503950A (ja) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 経皮薬剤送達の装置及び方法
SE541358C2 (en) 2017-05-30 2019-08-13 Enorama Pharma Ab Nicotine-containing chewing gum compositions
JP7420797B2 (ja) 2018-05-29 2024-01-23 モーニングサイド ベンチャー インベストメンツ リミテッド 薬剤送達の方法及びシステム
EP3574902A1 (en) * 2018-06-01 2019-12-04 Yatzz Limited Nicotine formulation and mode of delivery
WO2019239356A1 (en) 2018-06-15 2019-12-19 R. J. Reynolds Tobacco Company Purification of nicotine
CA3119992A1 (en) 2018-11-16 2020-05-22 Morningside Venture Investments Limited Thermally regulated transdermal drug delivery system
EP4232006A4 (en) * 2020-12-16 2024-05-08 LIW Innovation AB NEW POWDER COMPOSITION

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US865026A (en) * 1906-12-15 1907-09-03 Ellis Foster Co Masticable tobacco preparation.
US2098836A (en) * 1936-04-24 1937-11-09 Du Pont Insecticide
US2346362A (en) * 1941-06-21 1944-04-11 Hercules Glue Company Ltd Spray composition
US2836329A (en) * 1956-11-26 1958-05-27 Joseph C Chenette Measuring dispenser for medicine dropper
US3069314A (en) * 1960-12-29 1962-12-18 James H Jenkins Snake repellent
US3170462A (en) * 1962-01-05 1965-02-23 Merck & Co Inc Aerosol ophthalmic device
FR2428M (fr) * 1962-08-06 1964-03-31 Medical College Of Virginia Fo Antispasmodique.
US3171446A (en) * 1963-02-11 1965-03-02 Delman Co Fluid dispenser and container
US3252802A (en) * 1964-06-11 1966-05-24 Canadian Patents Dev Method of supplementing the feed of growing swine with nicotine
US3368567A (en) * 1965-03-23 1968-02-13 Morton Pharmaceuticals Inc Method of producing a tablet containing a tobacco concentrate
US3870794A (en) * 1974-02-20 1975-03-11 Foundation For Behavioral Rese Treatment of certain emotional disorders with nicotine compounds
GB1502132A (en) * 1975-05-27 1978-02-22 Ici Ltd Smoking materials
GB1528391A (en) * 1976-01-05 1978-10-11 Gildemeister V Aerosol compositions
DE2750090A1 (de) * 1976-11-19 1978-06-01 Sandoz Ag Neue verabreichungsformen fuer organische verbindungen
US4284649A (en) * 1977-11-22 1981-08-18 Wiczer Sol B Thickened gelatinous edible alcoholic medicated carrier
GB2030862A (en) * 1978-04-10 1980-04-16 Smith A A composition for treating drug addiction such as smoking nicotine-containing products
FR2486392A1 (fr) * 1980-07-10 1982-01-15 Marcy Jean Perfectionnements apportes aux pates destinees a etre appliquees sur les muqueuses et notamment aux pates a usage stomatologique
JPS607965B2 (ja) * 1980-08-07 1985-02-28 帝人株式会社 鼻腔粘膜投与用粉剤の製造法
JPS58134008A (ja) * 1982-02-05 1983-08-10 Yoko Kobayashi 猫嫌忌避剤

Also Published As

Publication number Publication date
US4579858A (en) 1986-04-01
IL70577A (en) 1986-12-31
IT8467061A0 (it) 1984-01-20
SE461698B (sv) 1990-03-19
DE3401763A1 (de) 1984-07-26
SE8400045D0 (sv) 1984-01-05
IT8467061A1 (it) 1985-07-20
JPH0532017B2 (OSRAM) 1993-05-14
FI73869B (fi) 1987-08-31
FI840241L (fi) 1984-07-22
FR2539627B1 (fr) 1987-11-13
IL70577A0 (en) 1984-03-30
GB8301659D0 (en) 1983-02-23
DE3401763C2 (OSRAM) 1992-05-14
FI840241A0 (fi) 1984-01-20
FR2539627A1 (fr) 1984-07-27
IT1178834B (it) 1987-09-16
FI73869C (fi) 1987-12-10
CH663154A5 (de) 1987-11-30
SE8400045L (sv) 1984-07-22
JPS59135878A (ja) 1984-08-04

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Legal Events

Date Code Title Description
MKEX Expiry