CA1214168A - 6-substituted-s-triazole¬3,4-a|phthalazine derivatives - Google Patents

6-substituted-s-triazole¬3,4-a|phthalazine derivatives

Info

Publication number
CA1214168A
CA1214168A CA000419398A CA419398A CA1214168A CA 1214168 A CA1214168 A CA 1214168A CA 000419398 A CA000419398 A CA 000419398A CA 419398 A CA419398 A CA 419398A CA 1214168 A CA1214168 A CA 1214168A
Authority
CA
Canada
Prior art keywords
formula
phenyl
compound
substituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000419398A
Other languages
English (en)
French (fr)
Inventor
Emilio Occelli
Domenico Barone
Adele Giunta
Giorgio Tarzia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA filed Critical Gruppo Lepetit SpA
Application granted granted Critical
Publication of CA1214168A publication Critical patent/CA1214168A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA000419398A 1982-01-18 1983-01-13 6-substituted-s-triazole¬3,4-a|phthalazine derivatives Expired CA1214168A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8201273 1982-01-18
GB8201273 1982-01-18

Publications (1)

Publication Number Publication Date
CA1214168A true CA1214168A (en) 1986-11-18

Family

ID=10527683

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000419398A Expired CA1214168A (en) 1982-01-18 1983-01-13 6-substituted-s-triazole¬3,4-a|phthalazine derivatives

Country Status (20)

Country Link
US (1) US4788186A (OSRAM)
EP (1) EP0085840B1 (OSRAM)
JP (1) JPS58124786A (OSRAM)
KR (1) KR890000184B1 (OSRAM)
AT (1) ATE22562T1 (OSRAM)
AU (1) AU564026B2 (OSRAM)
CA (1) CA1214168A (OSRAM)
DE (1) DE3366494D1 (OSRAM)
DK (1) DK163145C (OSRAM)
ES (1) ES531458A0 (OSRAM)
FI (1) FI81350C (OSRAM)
GR (1) GR78442B (OSRAM)
HU (1) HU193033B (OSRAM)
IE (1) IE55032B1 (OSRAM)
IL (1) IL67697A (OSRAM)
NO (1) NO161674C (OSRAM)
NZ (1) NZ203021A (OSRAM)
PH (1) PH21834A (OSRAM)
PT (1) PT76107A (OSRAM)
ZA (1) ZA83224B (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
CA2260900A1 (en) 1996-07-25 1998-02-05 Merck Sharp & Dohme Limited Substituted triazolo pyridazine derivatives as inverse agonists of the gabaa.alpha.5 receptor subtype
TR199900047T2 (xx) 1996-07-25 1999-03-22 Merck Sharp & Dohme Limited Gaba resept�rleri ligandlar� olarak ikame triazolo-piridazin t�revleri
ES2179490T3 (es) 1997-05-08 2003-01-16 Merck Sharp & Dohme Derivados de 1,2,4-triazolo(3,4-a)ftalazina sustituidos como ligandos de gaba alfa 5.
ES2137113B1 (es) * 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents
GB9723999D0 (en) 1997-11-13 1998-01-14 Merck Sharp & Dohme Therapeutic use
GB9726702D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
WO1999025353A1 (en) * 1997-11-13 1999-05-27 Merck Sharp & Dohme Limited Therapeutic uses of triazolo-pyridazine derivatives
GB9726699D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
GB9726701D0 (en) * 1997-12-18 1998-02-18 Merck Sharp & Dohme Therapeutic use
US6110915A (en) * 1997-12-18 2000-08-29 Merck & Co., Inc. Antiemetic use of triazolo-pyridazine derivatives
EP1047697A1 (en) 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801208D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
CN1110498C (zh) 1998-01-21 2003-06-04 默克·夏普-道姆公司 作为gaba受体的配体的三唑并－哒嗪衍生物
GB9801202D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801234D0 (en) * 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801210D0 (en) 1998-01-21 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801397D0 (en) 1998-01-22 1998-03-18 Merck Sharp & Dohme Therapeutic agents
GB9801538D0 (en) 1998-01-23 1998-03-25 Merck Sharp & Dohme Pharmaceutical product
HUP0100647A3 (en) * 1998-02-25 2003-03-28 Merck Sharp & Dohme Ltd Hoddes Substituted 1,2,4-triazolo[3,4-a]pyridazine and its pharmaceutical use
US6448249B1 (en) 1998-02-25 2002-09-10 Merck Sharp & Dohme Ltd. Substituted 1,2,4-triazolo[3,4-A]phthalazine derivatives as GABAα5 ligands
GB9824897D0 (en) 1998-11-12 1999-01-06 Merck Sharp & Dohme Therapeutic compounds
EP1129094A2 (en) 1998-11-12 2001-09-05 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
GB9929569D0 (en) * 1999-12-14 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0028583D0 (en) 2000-11-23 2001-01-10 Merck Sharp & Dohme Therapeutic compounds
AU2002307163B2 (en) * 2001-04-10 2006-06-29 Merck & Co., Inc. A method of treating cancer
US6958334B2 (en) * 2001-04-10 2005-10-25 Merck & Co., Inc. Inhibitors of Akt activity
EP1496981A2 (en) * 2002-04-08 2005-01-19 Merck & Co., Inc. Method of treating cancer
US20050054647A1 (en) * 2002-12-27 2005-03-10 Detlev Schuppan New pharmaceutical combination
WO2006024640A2 (en) * 2004-09-02 2006-03-09 Altana Pharma Ag Triazolophthalazines
US7671050B2 (en) 2005-01-05 2010-03-02 Nycomed Gmbh Triazolophthalazines
CN101103033B (zh) 2005-01-05 2010-08-04 尼科梅德有限责任公司 作为pde2抑制剂的三唑并酞嗪
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) * 2014-01-09 2016-03-30 郑州大学 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途
CN104016986B (zh) * 2014-03-13 2016-02-03 郑州大学 3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途
EP4279074A1 (en) * 2022-05-19 2023-11-22 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Azolo compounds for treatment of fibrotic diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2484029A (en) * 1945-12-21 1949-10-11 Ciba Pharm Prod Inc Hydrazine derivatives of pyridazine compounds
GB629177A (en) * 1945-12-21 1949-09-14 Ciba Ltd Manufacture of new hydrazine compounds and derivatives thereof
JPS5132598A (en) * 1974-09-13 1976-03-19 Eisai Co Ltd Toriazoro * 3 44 ee * futarajinjudotai no goseiho
JPS603080B2 (ja) * 1976-08-10 1985-01-25 三菱化学株式会社 Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロ フタラジン類
GR70309B (OSRAM) * 1979-10-29 1982-09-08 Dow Chemical Co

Also Published As

Publication number Publication date
US4788186A (en) 1988-11-29
JPS58124786A (ja) 1983-07-25
EP0085840A1 (en) 1983-08-17
DK163145B (da) 1992-01-27
FI830100A0 (fi) 1983-01-12
HU193033B (en) 1987-08-28
AU1055083A (en) 1983-07-28
ES8601995A1 (es) 1985-11-01
KR840003254A (ko) 1984-08-20
NZ203021A (en) 1986-05-09
DK163145C (da) 1992-06-22
ATE22562T1 (de) 1986-10-15
IL67697A0 (en) 1983-05-15
FI830100L (fi) 1983-07-19
NO161674B (no) 1989-06-05
JPH048428B2 (OSRAM) 1992-02-17
KR890000184B1 (ko) 1989-03-09
FI81350C (fi) 1990-10-10
FI81350B (fi) 1990-06-29
AU564026B2 (en) 1987-07-30
ES531458A0 (es) 1985-11-01
ZA83224B (en) 1983-10-26
NO161674C (no) 1989-09-13
IE830082L (en) 1983-07-18
DK17983A (da) 1983-07-19
IE55032B1 (en) 1990-05-09
NO830110L (no) 1983-07-19
DK17983D0 (da) 1983-01-18
DE3366494D1 (de) 1986-11-06
PH21834A (en) 1988-03-17
PT76107A (en) 1983-02-01
EP0085840B1 (en) 1986-10-01
IL67697A (en) 1990-02-09
GR78442B (OSRAM) 1984-09-27

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