CA1213581A - Process and intermediates for production of 1,1- dioxopenicillanoyloxymethyl 6-(2-amino-2- phenylacetamido) penicillanates - Google Patents

Process and intermediates for production of 1,1- dioxopenicillanoyloxymethyl 6-(2-amino-2- phenylacetamido) penicillanates

Info

Publication number
CA1213581A
CA1213581A CA000398989A CA398989A CA1213581A CA 1213581 A CA1213581 A CA 1213581A CA 000398989 A CA000398989 A CA 000398989A CA 398989 A CA398989 A CA 398989A CA 1213581 A CA1213581 A CA 1213581A
Authority
CA
Canada
Prior art keywords
formula
compound
zero
acid
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000398989A
Other languages
English (en)
French (fr)
Inventor
Vytautas J. Jasys
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Application granted granted Critical
Publication of CA1213581A publication Critical patent/CA1213581A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
CA000398989A 1981-03-23 1982-03-22 Process and intermediates for production of 1,1- dioxopenicillanoyloxymethyl 6-(2-amino-2- phenylacetamido) penicillanates Expired CA1213581A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24645681A 1981-03-23 1981-03-23
US246,456 1981-03-23

Publications (1)

Publication Number Publication Date
CA1213581A true CA1213581A (en) 1986-11-04

Family

ID=22930766

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000398989A Expired CA1213581A (en) 1981-03-23 1982-03-22 Process and intermediates for production of 1,1- dioxopenicillanoyloxymethyl 6-(2-amino-2- phenylacetamido) penicillanates

Country Status (32)

Country Link
EP (1) EP0061274B1 (enExample)
JP (3) JPS57169493A (enExample)
KR (1) KR860001368B1 (enExample)
AU (1) AU531892B2 (enExample)
BG (2) BG37380A3 (enExample)
CA (1) CA1213581A (enExample)
CS (1) CS227345B2 (enExample)
DD (1) DD202163A5 (enExample)
DE (1) DE3267505D1 (enExample)
DK (3) DK162392C (enExample)
EG (1) EG15803A (enExample)
ES (2) ES510655A0 (enExample)
FI (1) FI74284C (enExample)
GB (1) GB2095250A (enExample)
GR (1) GR75935B (enExample)
GT (1) GT198274393A (enExample)
HK (1) HK52487A (enExample)
HU (2) HU187667B (enExample)
IE (1) IE52835B1 (enExample)
IL (1) IL65308A (enExample)
IN (1) IN159362B (enExample)
MY (1) MY8700499A (enExample)
NO (1) NO159658C (enExample)
NZ (1) NZ200066A (enExample)
PH (1) PH17602A (enExample)
PL (3) PL134250B1 (enExample)
PT (1) PT74621B (enExample)
RO (2) RO84278B (enExample)
SG (1) SG23387G (enExample)
SU (2) SU1277897A3 (enExample)
YU (2) YU42761B (enExample)
ZA (1) ZA821899B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0084730A1 (en) * 1982-01-22 1983-08-03 Beecham Group Plc Esters of penicillin derivatives with beta-lactamase inhibitors, their preparation and their use
PH20068A (en) * 1982-12-06 1986-09-18 Pfizer Process and intermediates for sultamicillin and analogs
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
ES2039299B1 (es) * 1991-10-04 1994-05-16 Asturpharma S A Procedimiento de obtencion de esteres de acido 1,1-dioxopenicilanico y sus sales.
ES2100125B1 (es) * 1995-06-02 1998-04-01 Asturpharma S A Procedimiento de preparacion de esteres de metanodiol de acido dioxopenicilanico.
CN112724162B (zh) * 2020-12-28 2022-06-10 华南农业大学 一种阿莫西林-舒巴坦杂合分子的合成方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
KR830001903B1 (ko) * 1979-02-13 1983-09-19 레오 파마슈티칼 프로덕츠 리미티드 페니실란산유도체의 제조방법
SE449103B (sv) * 1979-03-05 1987-04-06 Pfizer Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
ZA80646B (en) * 1979-03-05 1981-02-25 Pfizer Process and intermediates for penicillanic acid,1,1-dioxide and esters thereof
IE50650B1 (en) * 1979-10-11 1986-06-11 Leo Pharm Prod Ltd Method for producing penicillanic acid derivatives

Also Published As

Publication number Publication date
JPH0331717B2 (enExample) 1991-05-08
PL235578A1 (en) 1983-06-20
PT74621A (en) 1982-04-01
RO84278A (ro) 1984-05-23
DK127182A (da) 1982-09-24
JPS57169493A (en) 1982-10-19
HU187667B (en) 1986-02-28
RO87946B (ro) 1985-12-02
EP0061274A1 (en) 1982-09-29
ES518970A0 (es) 1984-03-01
PH17602A (en) 1984-10-05
PT74621B (en) 1984-11-26
PL240664A1 (en) 1983-09-12
EP0061274B1 (en) 1985-11-21
IL65308A0 (en) 1982-05-31
DK21892D0 (da) 1992-02-20
YU42761B (en) 1988-12-31
DK165746B (da) 1993-01-11
DK165746C (da) 1993-06-07
HUT34985A (en) 1985-05-28
DE3267505D1 (en) 1986-01-02
NO159658C (no) 1989-01-25
GB2095250A (en) 1982-09-29
IN159362B (enExample) 1987-05-09
PL240663A1 (en) 1983-09-12
PL139261B1 (en) 1987-01-31
DK162392B (da) 1991-10-21
IL65308A (en) 1985-03-31
ES8305768A1 (es) 1983-04-16
RO84278B (ro) 1984-07-30
JPS63146886A (ja) 1988-06-18
ZA821899B (en) 1983-01-26
PL138851B1 (en) 1986-11-29
FI74284C (fi) 1988-01-11
AU531892B2 (en) 1983-09-08
HK52487A (en) 1987-07-17
KR830009113A (ko) 1983-12-17
GR75935B (enExample) 1984-08-02
SG23387G (en) 1987-07-10
FI820991L (fi) 1982-09-24
PL134250B1 (en) 1985-08-31
NO159658B (no) 1988-10-17
RO87946A (ro) 1985-12-20
HU189917B (en) 1986-08-28
ES510655A0 (es) 1983-04-16
YU61982A (en) 1985-03-20
IE820659L (en) 1982-09-23
MY8700499A (en) 1987-12-31
DK121491D0 (da) 1991-06-21
SU1277898A3 (ru) 1986-12-15
EG15803A (en) 1990-08-30
DK162392C (da) 1992-03-09
AU8176482A (en) 1982-11-04
CS227345B2 (en) 1984-04-16
ES8403132A1 (es) 1984-03-01
KR860001368B1 (ko) 1986-09-17
DD202163A5 (de) 1983-08-31
YU181084A (en) 1987-06-30
BG37380A3 (en) 1985-05-15
NO820898L (no) 1982-09-24
GT198274393A (es) 1983-09-08
YU43585B (en) 1989-08-31
DK121491A (da) 1991-06-21
DK167119B1 (da) 1993-08-30
NZ200066A (en) 1985-08-16
IE52835B1 (en) 1988-03-16
JPS6345287A (ja) 1988-02-26
BG38939A3 (en) 1986-03-14
DK21892A (da) 1992-02-20
SU1277897A3 (ru) 1986-12-15
FI74284B (fi) 1987-09-30

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Legal Events

Date Code Title Description
MKEX Expiry