CA1209920A - Antimycotic agents in gel form for the treatment of fungal infections of the oral cavity - Google Patents
Antimycotic agents in gel form for the treatment of fungal infections of the oral cavityInfo
- Publication number
- CA1209920A CA1209920A CA000441740A CA441740A CA1209920A CA 1209920 A CA1209920 A CA 1209920A CA 000441740 A CA000441740 A CA 000441740A CA 441740 A CA441740 A CA 441740A CA 1209920 A CA1209920 A CA 1209920A
- Authority
- CA
- Canada
- Prior art keywords
- antimycotic
- gel
- azole compound
- forming agent
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000000214 mouth Anatomy 0.000 title claims abstract description 9
- 239000003429 antifungal agent Substances 0.000 title claims abstract description 8
- 206010017533 Fungal infection Diseases 0.000 title claims abstract description 7
- 208000031888 Mycoses Diseases 0.000 title claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 21
- 230000001857 anti-mycotic effect Effects 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 21
- 239000002543 antimycotic Substances 0.000 claims description 19
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 14
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 12
- -1 azole compound Chemical class 0.000 claims description 11
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 11
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 11
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims description 6
- 229920003086 cellulose ether Polymers 0.000 claims description 6
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims description 6
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 244000215068 Acacia senegal Species 0.000 claims description 5
- 229920002907 Guar gum Polymers 0.000 claims description 5
- 229920000084 Gum arabic Polymers 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims description 5
- 235000010489 acacia gum Nutrition 0.000 claims description 5
- 239000000205 acacia gum Substances 0.000 claims description 5
- 239000000665 guar gum Substances 0.000 claims description 5
- 229960002154 guar gum Drugs 0.000 claims description 5
- 239000004584 polyacrylic acid Substances 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 229920000945 Amylopectin Polymers 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 4
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 4
- 229960004022 clotrimazole Drugs 0.000 claims description 4
- 235000010417 guar gum Nutrition 0.000 claims description 4
- DALSNPRWUFOYDT-UHFFFAOYSA-N 1-[(2-chlorophenyl)-(4-phenylphenyl)methyl]imidazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)C1=CC=C(C=2C=CC=CC=2)C=C1 DALSNPRWUFOYDT-UHFFFAOYSA-N 0.000 claims description 3
- 229950000194 lombazole Drugs 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 2
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims 2
- 229960002206 bifonazole Drugs 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 4
- 238000012154 short term therapy Methods 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 description 14
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 9
- 235000002639 sodium chloride Nutrition 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 150000004804 polysaccharides Chemical class 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229960004217 benzyl alcohol Drugs 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000003019 stabilising effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 241000518994 Conta Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 108010077913 Triamcinolone Acetonide Drug Combination Nystatin Neomycin Sulfate Gramicidin Proteins 0.000 description 1
- 241000589636 Xanthomonas campestris Species 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940024986 topical antifungal imidazole and triazole derivative Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3243546.0 | 1982-11-25 | ||
| DE19823243546 DE3243546A1 (de) | 1982-11-25 | 1982-11-25 | Antimykotische mittel in gelform zur behandlung von pilzinfektionen der mundhoehle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1209920A true CA1209920A (en) | 1986-08-19 |
Family
ID=6178958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000441740A Expired CA1209920A (en) | 1982-11-25 | 1983-11-23 | Antimycotic agents in gel form for the treatment of fungal infections of the oral cavity |
Country Status (12)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4542020A (en) * | 1984-08-17 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Long-lasting adhesive antifungal suppositories |
| JPS61151117A (ja) * | 1984-12-25 | 1986-07-09 | Bayer Yakuhin Kk | 抗真菌ゲル製剤 |
| DE3614095A1 (de) * | 1986-04-25 | 1987-10-29 | Goedecke Ag | Oxyalkylcellulose enthaltende gelzubereitung |
| US5093133A (en) * | 1990-01-24 | 1992-03-03 | Mcneil-Ppc, Inc. | Method for percutaneous delivery of ibuprofen using hydroalcoholic gel |
| RU2120305C1 (ru) * | 1997-11-27 | 1998-10-20 | Открытое акционерное общество Химико-фармацевтический комбинат "Акрихин" | Фармацевтический состав, обладающий противогрибковой активностью, и способ его получения |
| JP2005097271A (ja) * | 2003-08-20 | 2005-04-14 | Matsumoto Shika Univ | 抗真菌剤用組成物 |
| EP1508329A1 (en) * | 2003-08-20 | 2005-02-23 | Matsumoto Dental University | Composition for an antifungal agent for suppressing fungal growth in an oral cavity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE626627A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1962-04-26 | |||
| US4056611A (en) * | 1973-04-16 | 1977-11-01 | Stiefel Laboratories, Inc. | Therapeutic composition |
| US4313765A (en) * | 1980-09-24 | 1982-02-02 | Merck & Co., Inc. | Synergistic blends of cellulase-free xanthan gum and cellulosics |
| DE3045915A1 (de) * | 1980-12-05 | 1982-07-08 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von elastischen fluessig-pflastern |
| JPS57120576A (en) * | 1981-01-20 | 1982-07-27 | Sumitomo Chem Co Ltd | Novel imidazole ester |
| DE3106635A1 (de) * | 1981-02-23 | 1982-09-09 | Bayer Ag | Antimykotisches mittel mit hoher wirkstoff-freisetzung in form von stiften |
-
1982
- 1982-11-25 DE DE19823243546 patent/DE3243546A1/de not_active Withdrawn
-
1983
- 1983-11-14 NO NO834160A patent/NO834160L/no unknown
- 1983-11-17 DE DE8383111479T patent/DE3376386D1/de not_active Expired
- 1983-11-17 EP EP83111479A patent/EP0112485B1/de not_active Expired
- 1983-11-17 AT AT83111479T patent/ATE33759T1/de not_active IP Right Cessation
- 1983-11-22 JP JP58218838A patent/JPS59108712A/ja active Pending
- 1983-11-22 IL IL70290A patent/IL70290A/xx unknown
- 1983-11-23 GR GR73047A patent/GR79726B/el unknown
- 1983-11-23 CA CA000441740A patent/CA1209920A/en not_active Expired
- 1983-11-24 ZA ZA838774A patent/ZA838774B/xx unknown
- 1983-11-24 KR KR1019830005566A patent/KR840006766A/ko not_active Ceased
- 1983-11-24 DK DK538683A patent/DK538683A/da not_active Application Discontinuation
- 1983-11-24 ES ES527514A patent/ES527514A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59108712A (ja) | 1984-06-23 |
| ES8502337A1 (es) | 1985-01-01 |
| EP0112485A2 (de) | 1984-07-04 |
| KR840006766A (ko) | 1984-12-03 |
| GR79726B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1984-10-31 |
| IL70290A0 (en) | 1984-02-29 |
| EP0112485B1 (de) | 1988-04-27 |
| NO834160L (no) | 1984-05-28 |
| DE3376386D1 (en) | 1988-06-01 |
| ZA838774B (en) | 1984-07-25 |
| ATE33759T1 (de) | 1988-05-15 |
| DE3243546A1 (de) | 1984-05-30 |
| DK538683D0 (da) | 1983-11-24 |
| IL70290A (en) | 1988-01-31 |
| EP0112485A3 (en) | 1985-10-23 |
| DK538683A (da) | 1984-05-26 |
| ES527514A0 (es) | 1985-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |