CA1208560A - Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma - Google Patents
Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucomaInfo
- Publication number
- CA1208560A CA1208560A CA000427097A CA427097A CA1208560A CA 1208560 A CA1208560 A CA 1208560A CA 000427097 A CA000427097 A CA 000427097A CA 427097 A CA427097 A CA 427097A CA 1208560 A CA1208560 A CA 1208560A
- Authority
- CA
- Canada
- Prior art keywords
- pgf2
- eye
- iop
- alpha
- eyes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 57
- 208000010412 Glaucoma Diseases 0.000 title claims abstract description 15
- 150000002066 eicosanoids Chemical class 0.000 title abstract description 19
- 206010030043 Ocular hypertension Diseases 0.000 title abstract description 12
- 230000000699 topical effect Effects 0.000 claims abstract description 35
- 241000288906 Primates Species 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 16
- PXGPLTODNUVGFL-YNNPMVKQSA-N prostaglandin F2alpha Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O PXGPLTODNUVGFL-YNNPMVKQSA-N 0.000 claims abstract description 13
- 125000005907 alkyl ester group Chemical group 0.000 claims abstract description 7
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 claims description 93
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- -1 PGF2.alpha. isobutyl ester Chemical class 0.000 claims description 10
- 235000019483 Peanut oil Nutrition 0.000 claims description 7
- 239000000312 peanut oil Substances 0.000 claims description 7
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- 239000002480 mineral oil Substances 0.000 claims description 3
- 235000010446 mineral oil Nutrition 0.000 claims description 3
- PJDMFGSFLLCCAO-NVRZHKMMSA-N PGF2alpha methyl ester Chemical group CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC PJDMFGSFLLCCAO-NVRZHKMMSA-N 0.000 claims description 2
- FPABVZYYTCHNMK-YNRDDPJXSA-N PGF2alpha isopropyl ester Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC(C)C FPABVZYYTCHNMK-YNRDDPJXSA-N 0.000 claims 1
- 125000003473 lipid group Chemical group 0.000 claims 1
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- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 abstract description 51
- 229960002986 dinoprostone Drugs 0.000 abstract description 49
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- BFUUJUGQJUTPAF-UHFFFAOYSA-N 2-(3-amino-4-propoxybenzoyl)oxyethyl-diethylazanium;chloride Chemical compound [Cl-].CCCOC1=CC=C(C(=O)OCC[NH+](CC)CC)C=C1N BFUUJUGQJUTPAF-UHFFFAOYSA-N 0.000 description 8
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- 206010020565 Hyperaemia Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- ZAHXYMFVNNUHCP-UHFFFAOYSA-N Naphazoline nitrate Chemical compound O[N+]([O-])=O.C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 ZAHXYMFVNNUHCP-UHFFFAOYSA-N 0.000 description 1
- JWOLLWQJKQOEOL-UHFFFAOYSA-N OOOOOOOOOOOOO Chemical compound OOOOOOOOOOOOO JWOLLWQJKQOEOL-UHFFFAOYSA-N 0.000 description 1
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- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MUCZHBLJLSDCSD-UHFFFAOYSA-N diisopropyl fluorophosphate Chemical compound CC(C)OP(F)(=O)OC(C)C MUCZHBLJLSDCSD-UHFFFAOYSA-N 0.000 description 1
- 229960001342 dinoprost Drugs 0.000 description 1
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- DZUXGQBLFALXCR-CDIPTNKSSA-N prostaglandin F1alpha Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(O)=O DZUXGQBLFALXCR-CDIPTNKSSA-N 0.000 description 1
- 239000002089 prostaglandin antagonist Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US374,165 | 1982-05-03 | ||
| US06/374,165 US4599353A (en) | 1982-05-03 | 1982-05-03 | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1208560A true CA1208560A (en) | 1986-07-29 |
Family
ID=23475591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000427097A Expired CA1208560A (en) | 1982-05-03 | 1983-04-29 | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4599353A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0093380B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS591418A (cg-RX-API-DMAC7.html) |
| AU (1) | AU560189B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1208560A (cg-RX-API-DMAC7.html) |
| DE (1) | DE3369068D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK195083A (cg-RX-API-DMAC7.html) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263054B2 (en) | 2002-02-04 | 2012-09-11 | Allergan, Inc. | Method of enhancing hair growth |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US8859616B2 (en) | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| EP1225168B2 (en) † | 1988-09-06 | 2015-01-21 | Pfizer Health AB | Prostaglandin-F-2 alpha derivative for the treatment of glaucoma or ocular hypertension |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US9750750B2 (en) | 2009-11-09 | 2017-09-05 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
Families Citing this family (205)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU602509B2 (en) * | 1986-03-13 | 1990-10-18 | Trustees Of Columbia University In The City Of New York, The | Use of A,B and C prostaglandins and derivatives therof to treat ocular hypertension and glaucoma |
| DE3785602T2 (de) * | 1986-03-13 | 1993-09-02 | Univ Columbia | Verwendung von a-, b- und c-prostaglandinen und deren derivaten zur behandlung von augen-hypertension und glaukom. |
| US4883819A (en) * | 1986-07-31 | 1989-11-28 | The Trustees Of Columbia University In The City Of New York | Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK7679A (da) * | 1978-01-17 | 1979-07-18 | Sandoz Ag | Fremgangsmaade til fremstilling af et prostaglandinholdigt praeparat |
| US4254145A (en) * | 1978-08-16 | 1981-03-03 | American Cyanamid Company | Topical application of prostaglandin hypotensive agents |
| US4311707A (en) * | 1979-02-12 | 1982-01-19 | American Cyanamid Company | Process for topically producing cutaneous vasodilation for the treatment of vasospastic or ischemic conditions |
-
1982
- 1982-05-03 US US06/374,165 patent/US4599353A/en not_active Expired - Lifetime
-
1983
- 1983-04-26 AU AU13916/83A patent/AU560189B2/en not_active Expired
- 1983-04-26 DE DE8383104083T patent/DE3369068D1/de not_active Expired
- 1983-04-26 EP EP83104083A patent/EP0093380B1/en not_active Expired
- 1983-04-28 JP JP58076053A patent/JPS591418A/ja active Granted
- 1983-04-29 CA CA000427097A patent/CA1208560A/en not_active Expired
- 1983-05-02 DK DK195083A patent/DK195083A/da not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| DK195083A (da) | 1983-11-04 |
| EP0093380B1 (en) | 1987-01-14 |
| EP0093380A3 (en) | 1984-03-28 |
| DK195083D0 (da) | 1983-05-02 |
| JPS591418A (ja) | 1984-01-06 |
| AU560189B2 (en) | 1987-04-02 |
| DE3369068D1 (en) | 1987-02-19 |
| US4599353A (en) | 1986-07-08 |
| JPH0468288B2 (cg-RX-API-DMAC7.html) | 1992-11-02 |
| EP0093380A2 (en) | 1983-11-09 |
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