CA1200761A - Devices and kits for immunological analysis - Google Patents
Devices and kits for immunological analysisInfo
- Publication number
- CA1200761A CA1200761A CA000401717A CA401717A CA1200761A CA 1200761 A CA1200761 A CA 1200761A CA 000401717 A CA000401717 A CA 000401717A CA 401717 A CA401717 A CA 401717A CA 1200761 A CA1200761 A CA 1200761A
- Authority
- CA
- Canada
- Prior art keywords
- antigens
- antibody
- antigen
- immunoglobulins
- solid support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/821—Chemistry: analytical and immunological testing involving complement factors or complement systems
Landscapes
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- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
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- Biomedical Technology (AREA)
- Molecular Biology (AREA)
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Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8113167 | 1981-04-29 | ||
| GB8113167 | 1981-04-29 | ||
| GB8134353 | 1981-11-13 | ||
| GB8134353 | 1981-11-13 | ||
| GB8201289 | 1982-01-18 | ||
| GB8201289 | 1982-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1200761A true CA1200761A (en) | 1986-02-18 |
Family
ID=27261173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000401717A Expired CA1200761A (en) | 1981-04-29 | 1982-04-27 | Devices and kits for immunological analysis |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5486452A (xx) |
| EP (1) | EP0063810B1 (xx) |
| AR (1) | AR231590A1 (xx) |
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| NZ (1) | NZ200443A (xx) |
| PH (1) | PH26773A (xx) |
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Families Citing this family (227)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622871A (en) | 1987-04-27 | 1997-04-22 | Unilever Patent Holdings B.V. | Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents |
| GB2124231B (en) * | 1982-05-24 | 1985-10-02 | Corning Glass Works | Solid phase reagent for immunoassay |
| GB2125547B (en) * | 1982-07-31 | 1986-04-23 | Mochida Pharm Co Ltd | Simultaneous immunoassay of two or more substances |
| US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
| US4666866A (en) * | 1983-04-19 | 1987-05-19 | Krauth Gary H | Immunoassay for antigens employing supported binder |
| AU2706384A (en) * | 1983-05-06 | 1984-11-08 | Monoclonal Antibodies Inc. | Colorimetric immunoassay on solid surface |
| JPS6035263A (ja) * | 1983-08-05 | 1985-02-23 | Wako Pure Chem Ind Ltd | 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬 |
| JPS6039564A (ja) * | 1983-08-12 | 1985-03-01 | Fuji Photo Film Co Ltd | 免疫反応試薬 |
| US4743560A (en) * | 1984-03-26 | 1988-05-10 | Becton Dickinson And Company | Solid phase assay |
| DE3416933A1 (de) * | 1984-05-04 | 1985-11-07 | Dora 1000 Berlin Köhler | Mit antigenen oder antikoerpern beschichteter traeger |
| US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
| EP0170746A1 (en) * | 1984-08-07 | 1986-02-12 | Covalent Technology Corporation | Biologically active material test |
| FR2569478B1 (fr) * | 1984-08-23 | 1987-01-09 | Guerin Bernard | Bandelette d'analyse immunologique et procede pour sa fabrication |
| ATE106565T1 (de) * | 1984-10-31 | 1994-06-15 | Alcon Lab Inc | Sandwich-immunotestverfahren für antigene bei ophthalmischen störungen. |
| FR2576418B1 (fr) * | 1985-01-24 | 1988-04-01 | Ambroise Thomas Pierre | Nouveau support pour tests biologiques in vitro et applications de ce support |
| FI860249A (fi) * | 1985-02-28 | 1986-08-29 | Becton Dickinson Co | Apparat och foerfarande foer flerfaldigt, samtidigt prov. |
| US5879881A (en) * | 1985-04-04 | 1999-03-09 | Hybritech, Incorporated | Solid phase system for use in ligand-receptor assays |
| JPS61247965A (ja) * | 1985-04-25 | 1986-11-05 | Susumu Kogyo Kk | 酵素免疫測定法 |
| US4900663A (en) * | 1985-09-13 | 1990-02-13 | Environmental Diagnostics, Inc. | Test kit for determining the presence of organic materials and method of utilizing same |
| TW203120B (xx) * | 1985-10-04 | 1993-04-01 | Abbott Lab | |
| DE3686474T2 (de) * | 1985-10-11 | 1993-02-11 | Abbott Lab | Diagnostische probe. |
| US6265176B1 (en) * | 1985-10-29 | 2001-07-24 | Cordis Corporation | Dot immunoassay on plastic sheets |
| US5160701A (en) * | 1986-02-18 | 1992-11-03 | Abbott Laboratories | Solid-phase analytical device and method for using same |
| EP0265519B1 (en) * | 1986-04-30 | 1995-09-13 | IGEN, INC. (a California corporation) | Electrochemiluminescent assays |
| EP0246643A3 (en) * | 1986-05-20 | 1988-06-01 | DNA PLANT TECHNOLOGY OPERATING CO. (under the laws of the State of Delaware) | Method of preparing diagnostic test dipsticks |
| AU7385687A (en) * | 1986-06-09 | 1987-12-10 | Ortho Diagnostic Systems Inc. | Immunoglobulin immunoassay with internalized control assays |
| DE3722273A1 (de) * | 1986-07-08 | 1988-01-21 | Bio Rad Laboratories | Festphasen-bindungsreagentien, ihre herstellung und sie enthaltende assay-kits |
| US5260194A (en) * | 1986-09-05 | 1993-11-09 | Syntex (U.S.A.) Inc. | Immunoseparating strip |
| US5260193A (en) * | 1986-09-05 | 1993-11-09 | Syntex (U.S.A.) Inc. | Immunoseparating strip |
| US5126240A (en) * | 1986-09-29 | 1992-06-30 | Curtiss Linda K | Hybridomas and monoclonal paratopic molecules to apolipoprotein a-i |
| US4960691A (en) * | 1986-09-29 | 1990-10-02 | Abbott Laboratories | Chromatographic test strip for determining ligands or receptors |
| DE3636060C3 (de) * | 1986-10-23 | 1994-04-07 | Behringwerke Ag | Bioaffine poröse Festphase, Verfahren zu deren Herstellung und ihre Verwendung |
| DE3786875D1 (de) * | 1986-10-23 | 1993-09-09 | Behringwerke Ag | Bioaffine poroese festphasen, ein verfahren zur herstellung von bioaffinen poroesen festphasen und ihre verwendung. |
| JPH01501655A (ja) * | 1986-12-04 | 1989-06-08 | ケメニー，ディビッド マイケル | 固相免疫測定法 |
| US4829010A (en) * | 1987-03-13 | 1989-05-09 | Tanox Biosystems, Inc. | Immunoassay device enclosing matrixes of antibody spots for cell determinations |
| IT1206777B (it) * | 1987-04-06 | 1989-05-03 | Chemetron Del Dr Del Campo Gio | Procedimento di analisi immunologica o chimica per la determinazione di proteine in fluidi biologici e relativo completo (kit) di mezzi analitici. |
| US5100777A (en) * | 1987-04-27 | 1992-03-31 | Tanox Biosystems, Inc. | Antibody matrix device and method for evaluating immune status |
| DE291194T1 (de) * | 1987-04-27 | 1992-03-19 | Unilever N.V., Rotterdam | Immunoassays und vorrichtungen dafuer. |
| CA1313616C (en) * | 1987-06-01 | 1993-02-16 | Robert B. Sargeant | Lateral flow, non-bibulous membrane protocols |
| US4880750A (en) * | 1987-07-09 | 1989-11-14 | Miragen, Inc. | Individual-specific antibody identification methods |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US6004766A (en) * | 1987-07-28 | 1999-12-21 | Biotechnology Australia Pty Limited | Method for detecting low levels of microorganisms |
| EP0301141A1 (en) * | 1987-07-30 | 1989-02-01 | Microbiological Research Corporation | Solid phase enzyme immunoassay test apparatus and process for detecting antibodies |
| US5447837A (en) * | 1987-08-05 | 1995-09-05 | Calypte, Inc. | Multi-immunoassay diagnostic system for antigens or antibodies or both |
| US5807755A (en) * | 1987-08-06 | 1998-09-15 | Multilyte Limited | Determination of ambient concentrations of several analytes |
| GB8803000D0 (en) * | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| US5039604A (en) * | 1987-08-21 | 1991-08-13 | Cellular Products, Inc. | Test device and method of preparing same, assay kit and method for the simultaneous detection of two HTLV or HIV antibodies |
| US4921809A (en) * | 1987-09-29 | 1990-05-01 | Findley Adhesives, Inc. | Polymer coated solid matrices and use in immunoassays |
| US5571667A (en) * | 1987-10-01 | 1996-11-05 | Chu; Albert E. | Elongated membrane flow-through diagnostic device and method |
| EP0319686A3 (en) * | 1987-10-21 | 1991-04-24 | Mochida Pharmaceutical Co., Ltd. | Method for assaying a target substance in a minute amount of nipple discharge and device for such an assay |
| DE3735684A1 (de) * | 1987-10-22 | 1989-05-03 | Boehringer Mannheim Gmbh | Immunreaktives traegermaterial und verfahren zu seiner herstellung |
| JPH01223352A (ja) * | 1988-01-11 | 1989-09-06 | General Biometrics Inc | 固相酵素免疫検定システムおよび方法 |
| DK70488D0 (da) * | 1988-02-11 | 1988-02-11 | Ancos Aps | Fremgangsmaade til paavisning af antistoffer i blod, samt membran og test-saet til anvendelse ved udoevelse af fremgangsmaaden |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US20050032048A1 (en) * | 1988-05-03 | 2005-02-10 | Oxford Gene Technology Limited | Analyzing polynucleotide sequences |
| US7811751B2 (en) | 1988-05-03 | 2010-10-12 | Oxford Gene Technology Limited | Analysing polynucleotide sequences |
| US5700637A (en) * | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US6054270A (en) * | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
| US5620845A (en) * | 1988-06-06 | 1997-04-15 | Ampcor, Inc. | Immunoassay diagnostic kit |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| CA1335880C (en) * | 1988-07-14 | 1995-06-13 | Thomas P. O'connor | Detection of an antibody and antigen in an immunoassay |
| ES2088879T3 (es) * | 1988-08-02 | 1996-10-01 | Abbott Lab | Analizador de muestras biologicas. |
| US5075077A (en) * | 1988-08-02 | 1991-12-24 | Abbott Laboratories | Test card for performing assays |
| US5320808A (en) * | 1988-08-02 | 1994-06-14 | Abbott Laboratories | Reaction cartridge and carousel for biological sample analyzer |
| US5281540A (en) * | 1988-08-02 | 1994-01-25 | Abbott Laboratories | Test array for performing assays |
| US5059522A (en) * | 1988-08-18 | 1991-10-22 | Wayne Lawrence G | Intrinsic enzyme dot blot immunoassay or indentification of microorganisms |
| KR910700354A (ko) * | 1989-02-03 | 1991-03-14 | 존 디. 후써 | 핵산 테스트 제품 및 이것을 이용해 미리 알고있는 핵산을 검출하는 방법 |
| US5120662A (en) * | 1989-05-09 | 1992-06-09 | Abbott Laboratories | Multilayer solid phase immunoassay support and method of use |
| AU637097B2 (en) * | 1989-05-09 | 1993-05-20 | Abbott Laboratories | Process for preparing an improved western blot immunoassay |
| US6919211B1 (en) * | 1989-06-07 | 2005-07-19 | Affymetrix, Inc. | Polypeptide arrays |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US6955915B2 (en) * | 1989-06-07 | 2005-10-18 | Affymetrix, Inc. | Apparatus comprising polymers |
| US6406844B1 (en) | 1989-06-07 | 2002-06-18 | Affymetrix, Inc. | Very large scale immobilized polymer synthesis |
| US5925525A (en) * | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US6551784B2 (en) | 1989-06-07 | 2003-04-22 | Affymetrix Inc | Method of comparing nucleic acid sequences |
| US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
| US6379895B1 (en) | 1989-06-07 | 2002-04-30 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| CA2025476A1 (en) * | 1989-09-27 | 1991-03-28 | Shan F. Ching | Hydrophilic laminated porous membranes and methods of preparing same |
| CA2025475A1 (en) * | 1989-09-27 | 1991-03-28 | Donald I. Stimpson | Hydrophilic laminated porous membranes and methods of preparing same |
| CA2025474A1 (en) * | 1989-09-27 | 1991-03-28 | Donald I. Stimpson | Hydrophilic laminated porous membranes and methods of preparing same |
| US6596476B1 (en) * | 1989-12-22 | 2003-07-22 | Abbott Laboratories | Hepatitis C assay |
| KR910014706A (ko) * | 1990-01-10 | 1991-08-31 | 원본미기재 | 세척이 필요없는 개량된 이뮤노어세이(immunoassay)장치 |
| KR910014705A (ko) * | 1990-01-10 | 1991-08-31 | 원본미기재 | 세척이 필요없은 딥스틱(Dipstick) 형태의 이뮤노어세이(Immunoasssay)장치 |
| US6506558B1 (en) | 1990-03-07 | 2003-01-14 | Affymetrix Inc. | Very large scale immobilized polymer synthesis |
| US5922615A (en) | 1990-03-12 | 1999-07-13 | Biosite Diagnostics Incorporated | Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network |
| US5100626A (en) * | 1990-05-24 | 1992-03-31 | Levin Andrew E | Binding assay device with removable cassette and manifold |
| IE76732B1 (en) * | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
| DK0834575T3 (da) * | 1990-12-06 | 2002-04-02 | Affymetrix Inc A Delaware Corp | Identifikation af nucleinsyrer i prøver |
| US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US5468648A (en) | 1991-05-29 | 1995-11-21 | Smithkline Diagnostics, Inc. | Interrupted-flow assay device |
| WO1993006247A1 (en) * | 1991-09-16 | 1993-04-01 | Abbott Laboratories | Hepatitis c assay |
| US5399484A (en) * | 1991-10-08 | 1995-03-21 | Eastman Kodak Company | Use of blocking protein with high pH extraction in method to determine a microorganism associated with periodontal disease and kit useful therefor |
| US6943034B1 (en) * | 1991-11-22 | 2005-09-13 | Affymetrix, Inc. | Combinatorial strategies for polymer synthesis |
| US6468740B1 (en) | 1992-11-05 | 2002-10-22 | Affymetrix, Inc. | Cyclic and substituted immobilized molecular synthesis |
| ATE241426T1 (de) | 1991-11-22 | 2003-06-15 | Affymetrix Inc A Delaware Corp | Verfahren zur herstellung von polymerarrays |
| US6100099A (en) | 1994-09-06 | 2000-08-08 | Abbott Laboratories | Test strip having a diagonal array of capture spots |
| WO1994003807A1 (en) * | 1992-08-03 | 1994-02-17 | Gec-Marconi Limited | Separation method |
| FI92882C (fi) * | 1992-12-29 | 1995-01-10 | Medix Biochemica Ab Oy | Kertakäyttöinen testiliuska ja menetelmä sen valmistamiseksi |
| US5558869A (en) | 1992-12-30 | 1996-09-24 | University Of Arkansas | Major peanut allergen ara h II |
| AU7541894A (en) * | 1993-09-08 | 1995-03-27 | Merck Patent Gmbh | Cell reagent and assay |
| US5770389A (en) * | 1993-09-27 | 1998-06-23 | Abbott Laboratories | Apparatus and method for determining the quanity of an analyte in a biological sample by means of transmission photometry |
| IL108377A0 (en) * | 1994-01-19 | 1994-04-12 | Orgenics Ltd | Automated analysis with comb-like analyte support |
| US6015880A (en) * | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| EP0695941B1 (en) * | 1994-06-08 | 2002-07-31 | Affymetrix, Inc. | Method and apparatus for packaging a chip |
| US7378236B1 (en) | 1994-06-17 | 2008-05-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for analyzing gene expression patterns |
| US7615368B1 (en) * | 1994-06-17 | 2009-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Microarrays of polypeptides |
| US7323298B1 (en) | 1994-06-17 | 2008-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Microarray for determining the relative abundances of polynuceotide sequences |
| US8236493B2 (en) * | 1994-10-21 | 2012-08-07 | Affymetrix, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
| AU4770296A (en) * | 1995-03-27 | 1996-10-16 | Warner-Lambert Company | Method and apparatus for simultaneously testing a plurality of compounds to detect their activity |
| US5922534A (en) | 1995-03-28 | 1999-07-13 | Hewlett-Packard Company | Dry biochemical assay plate and method for making the same |
| US20010051350A1 (en) | 1995-05-02 | 2001-12-13 | Albert Nazareth | Diagnostic detection device and method |
| US6720149B1 (en) * | 1995-06-07 | 2004-04-13 | Affymetrix, Inc. | Methods for concurrently processing multiple biological chip assays |
| US20030202980A1 (en) * | 1995-12-29 | 2003-10-30 | Caplan Michael J. | Methods and reagents for decreasing clinical reaction to allergy |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US5874216A (en) * | 1996-02-23 | 1999-02-23 | Ensys Environmental Products, Inc. | Indirect label assay device for detecting small molecules and method of use thereof |
| US5716791A (en) * | 1996-05-09 | 1998-02-10 | Meridian Diagnostics, Inc. | Immunoassay for H. pylori in fecal specimens |
| US5932430A (en) * | 1996-05-09 | 1999-08-03 | Meridian Diagnostics, Inc. | Immunoassay for H. pylori in fecal specimens |
| FR2750505B1 (fr) * | 1996-06-27 | 1998-10-16 | Appligene Oncor | Procede de preparation de supports d'analyse de substances chimiques ou biologiques presentant un ensemble ordonne de zones de reaction |
| US6582921B2 (en) * | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| US5804384A (en) * | 1996-12-06 | 1998-09-08 | Vysis, Inc. | Devices and methods for detecting multiple analytes in samples |
| WO1998029736A1 (en) | 1996-12-31 | 1998-07-09 | Genometrix Incorporated | Multiplexed molecular analysis apparatus and method |
| US5879951A (en) | 1997-01-29 | 1999-03-09 | Smithkline Diagnostics, Inc. | Opposable-element assay device employing unidirectional flow |
| CZ297165B6 (cs) * | 1997-04-21 | 2006-09-13 | Randox Laboratories Ltd. A British Company Of Ardmore | Zpusob výroby zarízení s pevnou fází k provádení multianalytních rozboru |
| US5939252A (en) | 1997-05-09 | 1999-08-17 | Lennon; Donald J. | Detachable-element assay device |
| US5976813A (en) * | 1997-12-12 | 1999-11-02 | Abbott Laboratories | Continuous format high throughput screening |
| US20100105572A1 (en) * | 1997-12-19 | 2010-04-29 | Kris Richard M | High throughput assay system |
| US20030039967A1 (en) * | 1997-12-19 | 2003-02-27 | Kris Richard M. | High throughput assay system using mass spectrometry |
| US20030096232A1 (en) | 1997-12-19 | 2003-05-22 | Kris Richard M. | High throughput assay system |
| CA2319828A1 (en) * | 1998-01-29 | 1999-08-05 | Miller, Samuel | High density arrays for proteome analysis and methods and compositions therefor |
| AU743647B2 (en) * | 1998-01-31 | 2002-01-31 | Mt. Sinai School Of Medicine Of New York University | Methods and reagents for decreasing allergic reactions |
| US7879977B2 (en) | 1998-01-31 | 2011-02-01 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
| ATE393912T1 (de) | 1998-02-04 | 2008-05-15 | Invitrogen Corp | Microarrays und ihre verwendungen |
| US7282240B1 (en) * | 1998-04-21 | 2007-10-16 | President And Fellows Of Harvard College | Elastomeric mask and use in fabrication of devices |
| EP1078262A1 (de) * | 1998-05-12 | 2001-02-28 | Virofem Diagnostika GmbH | Indikationsstreifen zum nachweis von antikörpern im blutserum |
| US6545264B1 (en) | 1998-10-30 | 2003-04-08 | Affymetrix, Inc. | Systems and methods for high performance scanning |
| US7297554B2 (en) * | 1998-11-18 | 2007-11-20 | Microdiagnostics, Inc. | Immunoassay system |
| WO2000054046A2 (en) * | 1999-03-10 | 2000-09-14 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health | Universal protein array system |
| AU3750000A (en) * | 1999-03-15 | 2000-10-04 | Eos Biotechnology, Inc. | Reusable low fluorescent plastic biochip |
| JP4598960B2 (ja) | 1999-05-19 | 2010-12-15 | エッペンドルフ アレイ テクノロジーズ エスアー （エーアーテー） | 生物学的サンプルから得られた標的化合物のチップ上での同定及び／又は定量方法 |
| US20030096321A1 (en) * | 1999-05-19 | 2003-05-22 | Jose Remacle | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips |
| EP1054259A1 (en) * | 1999-05-19 | 2000-11-22 | Remacle, José | Method for the identification of a target compound |
| AU4289799A (en) * | 1999-06-25 | 2001-01-31 | Kyowa Medex Co., Ltd. | Immunoassay supports and immunoasssay solid phases with the use thereof |
| ATE328277T1 (de) * | 1999-07-26 | 2006-06-15 | Us Gov Health & Human Serv | Schichtvorrichtung mit einfangbereichen zur zellulären analyse |
| US7838222B2 (en) * | 1999-07-26 | 2010-11-23 | United States of America/ NIH | Methods, devices and kits for multiplex blotting of biological samples from multi-well plates |
| US7214477B1 (en) | 1999-07-26 | 2007-05-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Layered device with capture regions for cellular analysis |
| US6969615B2 (en) * | 1999-07-26 | 2005-11-29 | 20/20 Genesystems, Inc. | Methods, devices, arrays and kits for detecting and analyzing biomolecules |
| WO2001020325A1 (en) * | 1999-09-16 | 2001-03-22 | Immunetics, Inc. | Membrane immunoassays for detection of multiple tick-borne diseases |
| US6623936B1 (en) | 1999-09-24 | 2003-09-23 | Imgenex | Compositions and methods for improved detection and classification of neoplasms |
| US20070111259A1 (en) * | 1999-10-02 | 2007-05-17 | Medarex, Inc. | Human antibodies |
| US7135287B1 (en) | 1999-10-02 | 2006-11-14 | Biosite, Inc. | Human antibodies |
| US8153367B2 (en) * | 1999-10-29 | 2012-04-10 | Perkinelmer Las, Inc. | Amplified array analysis system |
| US6727073B1 (en) * | 1999-11-19 | 2004-04-27 | Binax, Inc. | Method for detecting enteric disease |
| US6680209B1 (en) * | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
| DE10006432A1 (de) * | 2000-02-14 | 2001-08-16 | Ganzimmun Inst Fuer Ganzheitli | Verfahren zum Nachweis von Helicobacter pylori in Stuhl- und Speichelproben |
| US6893850B2 (en) * | 2000-03-17 | 2005-05-17 | President And Fellows Of Harvard College | Method for cell patterning |
| US8246945B2 (en) * | 2000-04-06 | 2012-08-21 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
| CA2403292C (en) | 2000-04-06 | 2011-02-08 | Panacea Pharmaceuticals, Llc | Microbial delivery system |
| US20050063994A1 (en) * | 2000-04-06 | 2005-03-24 | Caplan Michael J. | Methods and reagents for decreasing clinical reaction to allergy |
| US6673614B2 (en) | 2000-06-27 | 2004-01-06 | Cell Genesys, Inc. | Rapid methods and kits for detection and semi-quantitation of anti-adenovirus antibody |
| CA2412915C (en) * | 2000-07-01 | 2009-04-21 | Clondiag Chip Technologies Gmbh | Method for qualitative and/or quantitative detection of molecular interactions on probe arrays |
| US20060275851A1 (en) * | 2000-07-26 | 2006-12-07 | Emmert-Buck Michael R | Layered peptide/antigen arrays - for high-throughput antibody screening of clinical samples |
| WO2002012898A1 (en) * | 2000-08-04 | 2002-02-14 | University Of Pune | An improved process for preparation of immunochemical complex useful for pathogen detection and determination of their antibiotic sensitivity |
| US20040185464A1 (en) * | 2000-09-15 | 2004-09-23 | Kris Richard M. | High throughput assay system |
| AU2001292959A1 (en) * | 2000-09-22 | 2002-04-02 | Clontech Laboratories, Inc. | Highly sensitive proteomic analysis methods and kits and systems for practicing the same |
| US6528325B1 (en) * | 2000-10-13 | 2003-03-04 | Dexall Biomedical Labs, Inc. | Method for the visual detection of specific antibodies in human serum by the use of lateral flow assays |
| US6905816B2 (en) * | 2000-11-27 | 2005-06-14 | Intelligent Medical Devices, Inc. | Clinically intelligent diagnostic devices and methods |
| US20030129680A1 (en) * | 2001-10-31 | 2003-07-10 | O'connor Thomas Patrick | Multi-analyte assay device |
| US7087389B2 (en) * | 2001-02-09 | 2006-08-08 | Council Of Scientific & Industrial Research | Highly cost-effective analytical device for performing immunoassays with ultra high sensitivity |
| WO2002084249A2 (en) | 2001-04-10 | 2002-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Therapeutic and diagnostic uses of antibody specificity profiles |
| WO2003005013A1 (en) * | 2001-07-03 | 2003-01-16 | Georgia Tech Research Corporation | Filtration-based microarray chip |
| US20030013208A1 (en) * | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
| US20030044869A1 (en) * | 2001-09-04 | 2003-03-06 | Yeung Jupiter M. | Method and apparatus for detecting protein in a sample |
| DK1436621T3 (da) * | 2001-09-17 | 2011-04-04 | Phadia Ab | Multianalytprøveapparat med multi-punkt-detektionszone |
| SE0103072D0 (sv) * | 2001-09-17 | 2001-09-17 | Pharmacia Diagnostics Ab | Multi-analyte assay device with multi-spot detection zone |
| DE10153963A1 (de) * | 2001-11-06 | 2003-05-22 | Aventis Behring Gmbh Intellect | Testsystem zur Untersuchung einer biologischen Flüssigkeit |
| US7141368B2 (en) * | 2002-01-30 | 2006-11-28 | Agilent Technologies, Inc. | Multi-directional deposition in array fabrication |
| US7033777B2 (en) * | 2002-03-22 | 2006-04-25 | Temple University Of The Commonwealth System Of Higher Education | Method for detecting cockroach allergens and determining total allergen level |
| US7154598B2 (en) * | 2002-07-12 | 2006-12-26 | Decision Biomarkers, Inc. | Excitation and imaging of fluorescent arrays |
| US7384742B2 (en) * | 2002-08-16 | 2008-06-10 | Decision Biomarkers, Inc. | Substrates for isolating reacting and microscopically analyzing materials |
| US20060127946A1 (en) * | 2002-08-16 | 2006-06-15 | Montagu Jean I | Reading of fluorescent arrays |
| EP1560917A1 (en) * | 2002-11-08 | 2005-08-10 | University of Copenhagen | Method of immobilising a protein to a zeolite |
| AU2003297301A1 (en) * | 2002-11-25 | 2004-06-18 | The United States Of America As Represented By The Secretary Of Health And Human Services, Nih | Method and apparatus for performing multiple simultaneous manipulations of biomolecules in a two-dimensional array |
| US20040152083A1 (en) * | 2003-01-31 | 2004-08-05 | Leproust Eric M. | Multiple arrays with surface energy transition to maintain separation of samples on the arrays |
| US7935539B2 (en) * | 2003-02-14 | 2011-05-03 | Siemens Healthcare Diagnostics, Inc. | Generic method for latex agglutination assays |
| US6861251B2 (en) * | 2003-02-24 | 2005-03-01 | Pritest, Inc. | Translucent solid matrix assay device for microarray analysis |
| US20040241659A1 (en) * | 2003-05-30 | 2004-12-02 | Applera Corporation | Apparatus and method for hybridization and SPR detection |
| WO2005054501A1 (en) * | 2003-11-28 | 2005-06-16 | Pamgene Bv | Methods and devices for compound screening |
| FR2874093B1 (fr) * | 2004-08-03 | 2006-12-01 | Inodiag Sa | Methode et trousse de determination du statut vaccinal de personnes |
| GB0409771D0 (en) | 2004-04-30 | 2004-06-09 | Mabtech Ab | Assay |
| GB0409775D0 (en) | 2004-04-30 | 2004-06-09 | Mabtech Ab | Assay |
| GB2414298B (en) * | 2004-05-18 | 2008-09-10 | Michael Strachan Walker | Diagnostic method and apparatus |
| US20050277158A1 (en) * | 2004-06-10 | 2005-12-15 | Ge Chen | Method and kit for donor specific complement-fixing antibodies crossmatch |
| US7704730B2 (en) * | 2004-10-14 | 2010-04-27 | Meso Scale Technologies, Llc | Multiplexed assay methods |
| EP1815021A2 (en) * | 2004-11-03 | 2007-08-08 | Almac Diagnostics Limited | Transcriptome microarray technology and methods of using the same |
| US20060115908A1 (en) * | 2004-11-30 | 2006-06-01 | Tetracore, Inc. | Multiplexed analyses of contaminant-laden gas in a particle impact collector |
| US20060154299A1 (en) * | 2005-01-08 | 2006-07-13 | Harvey Michael A | Protein microarray device having internal calibrators and methods of using therefor |
| WO2006138647A2 (en) * | 2005-06-16 | 2006-12-28 | Gtc Biotherapeutics, Inc. | Method of making recombinant human antibodies for use in biosensor technology |
| US20080008699A1 (en) * | 2005-10-28 | 2008-01-10 | Jianxun Li | Method for proteomic analysis utilizing immune recognition and cumulative subtraction |
| DE102006027259A1 (de) * | 2006-06-09 | 2007-12-13 | Protagen Ag | Protein-Biochip zum differentiellen Screenen von Protein-Protein-Wechselwirkungen |
| WO2008008284A2 (en) | 2006-07-14 | 2008-01-17 | The Regents Of The University Of California | Cancer biomarkers and methods of use threof |
| KR20080015339A (ko) * | 2006-08-14 | 2008-02-19 | 삼성전자주식회사 | 가장자리 측벽이 비활성화된 프로브 셀 액티브를 포함하는올리고머 프로브 어레이 및 그 제조 방법 |
| US8003312B2 (en) * | 2007-02-16 | 2011-08-23 | The Board Of Trustees Of The Leland Stanford Junior University | Multiplex cellular assays using detectable cell barcodes |
| EP2201142A1 (en) * | 2007-08-13 | 2010-06-30 | Almac Diagnostics Limited | A 3' -based sequencing approach for microarray manufacture |
| WO2009039170A2 (en) * | 2007-09-17 | 2009-03-26 | Gentel Biosurfaces, Inc. | Integrated protein chip assay |
| GB0718606D0 (en) * | 2007-09-24 | 2007-10-31 | Bio A R T Sa | Multiparameter assay |
| US20090253586A1 (en) * | 2008-02-21 | 2009-10-08 | Gentel Biosciences, Inc. | Substrates for multiplexed assays and uses thereof |
| DE102009033008A1 (de) | 2009-07-02 | 2011-01-05 | Dst Diagnostische Systeme & Technologien Gmbh | Neues PoC-Testsystem und Verfahren |
| DE102009037791A1 (de) | 2009-08-17 | 2011-02-24 | Dst Diagnostische Systeme & Technologien Gmbh | Testsystem zur visuellen Auswertung |
| CA2684636A1 (en) | 2009-10-30 | 2011-04-30 | Sqi Diagnostics Systems Inc | Multiplex microarrays and methods for the quantification of analytes |
| US20120003639A1 (en) | 2010-04-27 | 2012-01-05 | Prelude, Inc. | Cancer biomarkers and methods of use thereof |
| EP2560004A1 (de) | 2011-08-19 | 2013-02-20 | DST Diagnostische Systeme & Technologien GmbH | Neues PoC-Testsystem und Verfahren |
| RU2495434C2 (ru) * | 2011-12-09 | 2013-10-10 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") | Набор для многопрофильного иммунологического анализа антител в препаратах крови |
| EP2767831A1 (de) | 2013-02-19 | 2014-08-20 | DST Diagnostische Systeme & Technologien GmbH | Neues PoC-Testsystem und Verfahren |
| KR20140111192A (ko) * | 2013-03-08 | 2014-09-18 | (주)프로테옴텍 | 다중 진단용 병렬식 라인형 바이오칩 |
| WO2016090323A1 (en) | 2014-12-05 | 2016-06-09 | Prelude, Inc. | Dcis recurrence and invasive breast cancer |
| RU2686490C1 (ru) * | 2018-06-01 | 2019-04-29 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Набор для мультиплексного иммунохимического анализа антител и антигенов в препаратах крови |
| JP2022500504A (ja) | 2018-09-14 | 2022-01-04 | プレリュード コーポレーションPrelude Corporation | 浸潤性乳癌のリスクを有する対象の治療の選択方法 |
| US20210293806A1 (en) * | 2018-10-23 | 2021-09-23 | Sekisui Medical Co., Ltd. | Immunochromatographic test strip |
| CN112198310B (zh) * | 2020-11-30 | 2021-03-02 | 南京申基医药科技有限公司 | 一种c反应蛋白和血清淀粉样蛋白a联合检测试纸条、试剂盒及试纸条的制备方法 |
| CN115840042B (zh) * | 2023-02-24 | 2023-04-28 | 北京凡知医学科技有限公司 | 一种免疫层析试纸盒及其制备方法和应用 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1573936A (xx) * | 1967-02-16 | 1969-07-11 | ||
| NO122497B (xx) * | 1967-02-16 | 1971-07-05 | Saxholm Rolf | |
| US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| GB1329823A (en) * | 1970-06-09 | 1973-09-12 | Oxoid Ltd | Means for carrying out diagnostic tests for infections |
| US3664421A (en) * | 1970-09-18 | 1972-05-23 | Schlumberger Technology Corp | Methods for inhibiting the production of loose formation materials |
| US3666421A (en) * | 1971-04-05 | 1972-05-30 | Organon | Diagnostic test slide |
| DE2440367C2 (de) * | 1973-08-30 | 1984-03-15 | General Electric Co., Schenectady, N.Y. | Verfahren zum Herstellen multimolekularer Schichten aus immunologisch komplexierten Proteinen auf einem Substrat |
| US4176174A (en) * | 1974-07-19 | 1979-11-27 | Burroughs Wellcome Co. | Viral antibody diagnostic test system |
| US3979509A (en) * | 1974-09-03 | 1976-09-07 | General Electric Company | Opaque layer method for detecting biological particles |
| SE388694B (sv) * | 1975-01-27 | 1976-10-11 | Kabi Ab | Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar |
| US4048298A (en) * | 1975-02-25 | 1977-09-13 | Rohm And Haas Company | Solid phase double-antibody radioimmunoassay procedure |
| DK137089B (da) * | 1975-05-09 | 1978-01-16 | Kai Aage Hansen | Steril indikator til brug ved udvælgelse af baktericide stoffer, samt en fremgangsmåde til fremstilling af en sådan indikator. |
| US4275053A (en) * | 1975-08-14 | 1981-06-23 | Mt. Sinai School Of Medicine Of The City University Of New York | Blood cell typing and compatibility test procedure |
| DE2638207C2 (de) * | 1975-08-27 | 1985-10-03 | General Electric Co., Schenectady, N.Y. | Verfahren zum Bilden multimolekularer immunologisch komplexierter Filme |
| DE2603319C3 (de) * | 1976-01-29 | 1979-08-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Fixierung von biologisch aktiven Proteinen an Trägern |
| US4020151A (en) * | 1976-02-17 | 1977-04-26 | International Diagnostic Technology, Inc. | Method for quantitation of antigens or antibodies on a solid surface |
| FR2353856A1 (fr) * | 1976-06-02 | 1977-12-30 | Chateau Guy | Ruban destine a servir de support a une reaction par exemple chimique ou biochimique, et procede d'analyse le mettant en oeuvre |
| IL52322A (en) * | 1976-06-18 | 1980-10-26 | Alfa Laval Ab | Method of making reagent test device and device made accorording to this method |
| GB1597345A (en) * | 1976-12-16 | 1981-09-03 | Millipore Corp | Diagnostic immunochemical test materials and procedure |
| US4200690A (en) * | 1976-12-16 | 1980-04-29 | Millipore Corporation | Immunoassay with membrane immobilized antibody |
| US4407943A (en) * | 1976-12-16 | 1983-10-04 | Millipore Corporation | Immobilized antibody or antigen for immunoassay |
| CH620300A5 (en) * | 1977-04-29 | 1980-11-14 | Miles Lab | Reactive strip for analysis |
| US4157895A (en) * | 1977-10-07 | 1979-06-12 | Nuclear International Corporation | RIA reagents and processes |
| US4139346A (en) * | 1977-11-28 | 1979-02-13 | Enzo Bio Chem Incorporated | Nucleic acid and protein binding paper |
| US4189464A (en) * | 1978-05-05 | 1980-02-19 | Institute For Cancer Research | Hepatitis B testing reagent and method |
| US4216245A (en) * | 1978-07-25 | 1980-08-05 | Miles Laboratories, Inc. | Method of making printed reagent test devices |
| US4267270A (en) * | 1979-05-21 | 1981-05-12 | Enzyme Technology, Inc. | Method for the determination of antigens and antibodies using site-deactivating media |
| US4414324A (en) * | 1979-05-21 | 1983-11-08 | Bma Laboratory Services, Inc. | Immunoassay method and apparatus |
| US4302204A (en) * | 1979-07-02 | 1981-11-24 | The Board Of Trustees Of Leland Stanford Junior University | Transfer and detection of nucleic acids |
| US4305720A (en) * | 1979-08-20 | 1981-12-15 | Becton Dickinson & Company | Gentamicin assay and products therefor |
| US4305721A (en) * | 1979-08-20 | 1981-12-15 | Becton Dickinson & Company | Agglutination assay |
| US4378344A (en) * | 1979-09-28 | 1983-03-29 | Ventrex Laboratories, Inc. | Method and apparatus for performing multiple, simultaneous in vitro diagnostic tests using a solid phase system |
| US4452901A (en) * | 1980-03-20 | 1984-06-05 | Ciba-Geigy Corporation | Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays |
| US4332283A (en) * | 1980-08-18 | 1982-06-01 | Ajay Enterprises, Inc. | Device for supporting and protecting golf clubs |
| JPS57501692A (xx) * | 1980-09-24 | 1982-09-16 | ||
| US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| US4436824A (en) * | 1981-06-09 | 1984-03-13 | Ortho Diagnostic Systems, Inc. | Leukocyte migration through antigen containing agaroses for immunocompetence testing |
| US4459360A (en) * | 1981-10-05 | 1984-07-10 | Mast Medical Industries, Ltd. | Multiple-component binding assay system and method of making and using it |
| US4591570A (en) * | 1983-02-02 | 1986-05-27 | Centocor, Inc. | Matrix of antibody-coated spots for determination of antigens |
-
1982
- 1982-04-26 AR AR289207A patent/AR231590A1/es active
- 1982-04-26 DE DE8282103520T patent/DE3269567D1/de not_active Expired
- 1982-04-26 FI FI821441A patent/FI76888C/fi not_active IP Right Cessation
- 1982-04-26 EP EP82103520A patent/EP0063810B1/en not_active Expired
- 1982-04-27 ES ES511735A patent/ES8400199A1/es not_active Expired
- 1982-04-27 IL IL65627A patent/IL65627A/xx not_active IP Right Cessation
- 1982-04-27 GR GR68001A patent/GR75430B/el unknown
- 1982-04-27 CA CA000401717A patent/CA1200761A/en not_active Expired
- 1982-04-28 MX MX192469A patent/MX160043A/es unknown
- 1982-04-28 IE IE998/82A patent/IE53295B1/en not_active IP Right Cessation
- 1982-04-28 AU AU83069/82A patent/AU560790B2/en not_active Expired
- 1982-04-28 GB GB8212275A patent/GB2099578B/en not_active Expired
- 1982-04-28 NO NO821411A patent/NO161347C/no not_active IP Right Cessation
- 1982-04-28 NZ NZ200443A patent/NZ200443A/en unknown
- 1982-04-28 DK DK189182A patent/DK160336C/da not_active IP Right Cessation
- 1982-04-28 PH PH27205A patent/PH26773A/en unknown
- 1982-04-29 BR BR8202492A patent/BR8202492A/pt unknown
- 1982-04-29 PT PT74816A patent/PT74816B/pt unknown
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1983
- 1983-06-30 ES ES523722A patent/ES8405156A1/es not_active Expired
- 1983-06-30 ES ES523723A patent/ES8405157A1/es not_active Expired
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1987
- 1987-04-10 US US07/038,470 patent/US5486452A/en not_active Expired - Lifetime
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1988
- 1988-04-12 SG SG252/88A patent/SG25288G/en unknown
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1989
- 1989-03-10 CY CY1437A patent/CY1437A/xx unknown
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