CA1198422A - N-(vinblastinoyl-23) derivatives of amino acids, their preparation and therapeutical application - Google Patents

N-(vinblastinoyl-23) derivatives of amino acids, their preparation and therapeutical application

Info

Publication number
CA1198422A
CA1198422A CA000416996A CA416996A CA1198422A CA 1198422 A CA1198422 A CA 1198422A CA 000416996 A CA000416996 A CA 000416996A CA 416996 A CA416996 A CA 416996A CA 1198422 A CA1198422 A CA 1198422A
Authority
CA
Canada
Prior art keywords
group
alkyl
hydrogen atom
hydroxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000416996A
Other languages
English (en)
French (fr)
Inventor
Andre B.L. Trouet
Jean A.A.J. Hannart
Kandukuri S.B. Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Omnichem NV SA
Original Assignee
Omnichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem SA filed Critical Omnichem SA
Application granted granted Critical
Publication of CA1198422A publication Critical patent/CA1198422A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA000416996A 1981-12-08 1982-12-03 N-(vinblastinoyl-23) derivatives of amino acids, their preparation and therapeutical application Expired CA1198422A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU83.822 1981-12-08
LU83822A LU83822A1 (fr) 1981-12-08 1981-12-08 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique

Publications (1)

Publication Number Publication Date
CA1198422A true CA1198422A (en) 1985-12-24

Family

ID=19729780

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000416996A Expired CA1198422A (en) 1981-12-08 1982-12-03 N-(vinblastinoyl-23) derivatives of amino acids, their preparation and therapeutical application

Country Status (24)

Country Link
JP (1) JPS58116491A (sv)
AT (1) AT390958B (sv)
AU (1) AU564951B2 (sv)
BE (1) BE895262A (sv)
CA (1) CA1198422A (sv)
CH (1) CH655727A5 (sv)
DD (1) DD205906A5 (sv)
DE (1) DE3245269A1 (sv)
DK (1) DK161833C (sv)
ES (1) ES8401768A1 (sv)
FR (1) FR2517680B1 (sv)
GB (1) GB2111055B (sv)
GR (1) GR77280B (sv)
HU (1) HU187803B (sv)
IE (1) IE55283B1 (sv)
IL (1) IL67366A (sv)
IT (1) IT1157126B (sv)
LU (1) LU83822A1 (sv)
NL (1) NL8204711A (sv)
NZ (1) NZ202708A (sv)
OA (1) OA07270A (sv)
PT (1) PT75949B (sv)
SE (1) SE452622B (sv)
ZA (1) ZA828823B (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR81790B (sv) * 1983-04-29 1984-12-12 Omnichem Sa
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
CA1335686C (fr) * 1986-01-13 1995-05-23 Rao K. S. P. Bhushana Vinblastine et composition pharmaceutique les contenant
US4906086A (en) * 1987-06-19 1990-03-06 Honda Giken Kogyo Kabushiki Kaisha Rearview mirror device for motorcycles
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
US3848234A (en) * 1973-04-04 1974-11-12 Sperry Rand Corp Multi-processor system with multiple cache memories
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.

Also Published As

Publication number Publication date
FR2517680B1 (fr) 1990-05-25
NL8204711A (nl) 1983-07-01
ATA444982A (de) 1990-01-15
SE452622B (sv) 1987-12-07
SE8206981L (sv) 1983-06-09
IT1157126B (it) 1987-02-11
BE895262A (fr) 1983-06-07
AU564951B2 (en) 1987-09-03
IT8268431A0 (it) 1982-12-07
LU83822A1 (fr) 1983-09-01
JPH0449557B2 (sv) 1992-08-11
CH655727A5 (fr) 1986-05-15
PT75949B (fr) 1985-10-04
IE822906L (en) 1983-06-08
DE3245269A1 (de) 1983-07-21
DK161833B (da) 1991-08-19
IE55283B1 (en) 1990-08-01
JPS58116491A (ja) 1983-07-11
DD205906A5 (de) 1984-01-11
ES517942A0 (es) 1984-01-01
OA07270A (fr) 1984-04-30
NZ202708A (en) 1986-01-24
GB2111055A (en) 1983-06-29
DK541882A (da) 1983-06-09
IL67366A0 (en) 1983-03-31
HU187803B (en) 1986-02-28
GB2111055B (en) 1985-07-10
FR2517680A1 (fr) 1983-06-10
ES8401768A1 (es) 1984-01-01
AU9084782A (en) 1983-06-16
PT75949A (fr) 1983-01-01
DK161833C (da) 1992-01-20
GR77280B (sv) 1984-09-11
SE8206981D0 (sv) 1982-12-07
ZA828823B (en) 1983-09-28
IL67366A (en) 1987-01-30
AT390958B (de) 1990-07-25

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