CA1194794A - Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom - Google Patents

Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom

Info

Publication number
CA1194794A
CA1194794A CA000381825A CA381825A CA1194794A CA 1194794 A CA1194794 A CA 1194794A CA 000381825 A CA000381825 A CA 000381825A CA 381825 A CA381825 A CA 381825A CA 1194794 A CA1194794 A CA 1194794A
Authority
CA
Canada
Prior art keywords
peptide
host
natural
antigenic
related protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000381825A
Other languages
English (en)
French (fr)
Inventor
Richard A. Lerner
Thomas M. Shinnick
J. Gregor Sutcliffe
Nicola Green
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389709&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1194794(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Application granted granted Critical
Publication of CA1194794A publication Critical patent/CA1194794A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00Reverse transcribing DNA viruses
    • C12N2730/00011Details
    • C12N2730/10011Hepadnaviridae
    • C12N2730/10111Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000381825A 1980-07-17 1981-07-16 Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom Expired CA1194794A (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16975880A 1980-07-17 1980-07-17
US169,758 1980-07-17
US20243180A 1980-10-30 1980-10-30
US202,431 1980-10-30
US24805981A 1981-03-27 1981-03-27
US248,059 1981-03-27

Publications (1)

Publication Number Publication Date
CA1194794A true CA1194794A (en) 1985-10-08

Family

ID=27389709

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000381825A Expired CA1194794A (en) 1980-07-17 1981-07-16 Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom

Country Status (15)

Country Link
EP (1) EP0044710B2 (en:Method)
KR (1) KR870000702B1 (en:Method)
AU (1) AU559234B2 (en:Method)
CA (1) CA1194794A (en:Method)
DE (1) DE3174241D1 (en:Method)
DK (1) DK318481A (en:Method)
ES (1) ES8305419A1 (en:Method)
FI (1) FI83662C (en:Method)
GR (1) GR74319B (en:Method)
IE (1) IE51410B1 (en:Method)
IL (1) IL63224A (en:Method)
NO (1) NO812341L (en:Method)
NZ (1) NZ197734A (en:Method)
PH (5) PH20629A (en:Method)
PT (1) PT73346B (en:Method)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5019383A (en) * 1981-01-09 1991-05-28 New York Blood Center, Inc. Fatty acid carriers for synthetic peptides
DE3109696A1 (de) * 1981-03-13 1982-09-30 Gerhard Dr. med. 7800 Freiburg Hunsmann Verfahren zur herstellung eines als impfstoff geeigneten synthetischen peptids und es enthaltender impfstoff
DE3112338C2 (de) * 1981-03-28 1995-02-23 Klaus Von Der Helm Verwendung von Hybridisierungssonden zum Nachweis von HAV
DE3275998D1 (en) * 1981-12-22 1987-05-14 Baylor College Medicine Immunological composition and method for hepatitis b virus
ZA831547B (en) * 1982-03-15 1984-10-31 New York Blood Center Inc Fatty acid carriers for synthetic vaccines
ZA831854B (en) * 1982-03-26 1984-01-25 Biogen Nv Small peptides with the specificity of foot and mouth disease viral antigens
EP0105346B1 (en) * 1982-04-14 1991-11-13 BITTLE, James L. Synthetic picornavirus antigen
DE3228501A1 (de) * 1982-07-30 1984-02-02 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines herpes-antigens, dazu geeignetes mittel sowie verfahren zu seiner herstellung und die verwendung dieses antigens
ZA836080B (en) * 1982-08-23 1984-04-25 Scripps Clinic Res Broad spectrum influenza antisera
EP0105481A1 (en) * 1982-09-30 1984-04-18 The Wellcome Foundation Limited Novel antigens and vaccines containing them
US4483793A (en) * 1982-10-04 1984-11-20 The Regents Of The University Of California Dimeric oligopeptides as heptenic epitopic sites for hepatitis
EP0120906B1 (en) * 1982-10-11 1988-09-21 National Research Development Corporation Polypeptides useful in vaccination against enteroviruses
NZ207394A (en) * 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US5242798A (en) * 1983-07-21 1993-09-07 Scripps Clinic And Research Foundation Synthetic polypeptides corresponding to portions of proteinoids translated from brain-specific mRNAs, receptors, methods and diagnostics using the same
US5030565A (en) * 1983-08-17 1991-07-09 Scripps Clinic And Research Foundation Polypeptide-induced monoclonal receptors to protein ligands
US4615973A (en) * 1983-09-30 1986-10-07 The Rockefeller University Genetically engineered organisms expressing surface proteins of T. cruzi
JPS61500053A (ja) * 1983-09-30 1986-01-16 マサチユ−セツツ インステイチユ−ト オブ テクノロジ− A肝炎ウィルス配列順を表すcDNAの生成
US4777240A (en) * 1984-03-08 1988-10-11 Scripps Clinic And Research Foundation SV40 expression vector containing HBxAg as an expression marker
WO1985004103A1 (en) * 1984-03-09 1985-09-26 Scripps Clinic And Research Foundation Synthetic hepatitis b virus vaccine including both t cell anc b cell determinants
US4599231A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599230A (en) * 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4636463A (en) * 1984-04-05 1987-01-13 Scripps Clinic And Research Foundation Antibodies to human interleukin-2 induced by synthetic polypeptides
US4794168A (en) * 1984-04-24 1988-12-27 Scripps Clinic And Research Foundation Leukemia-associated virus immunogen, vaccine and assay
US4663436A (en) * 1984-04-24 1987-05-05 Scripps Clinic And Research Foundation Leukemia-associated virus immunogen, vaccine and assay
GB8432401D0 (en) * 1984-12-21 1985-02-06 Bennett C E Liver fluke antigens
GB8508685D0 (en) * 1985-04-03 1985-05-09 Minor P D Peptides
US4735896A (en) * 1986-03-04 1988-04-05 United Biomedical, Inc. Synthetic peptide and process of using same for the detection and diagnosis of AIDS and pre-AIDS conditions
JP2702911B2 (ja) * 1985-09-11 1998-01-26 ユナイテツド・バイオメデイカル・インコ−ポレ−テツド 合成ペプチド、並びにそれを用いたエイズおよびプリ・エイズの検出方法
US4772685A (en) * 1985-10-02 1988-09-20 Merck & Co., Inc. Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies
US5066783A (en) * 1986-05-20 1991-11-19 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
US4777239A (en) * 1986-07-10 1988-10-11 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic peptides of human papilloma virus
DK354487A (da) * 1986-07-11 1988-01-12 Noboru Yanaihara Oncogen-relaterede peptider
IL86832A (en) * 1987-06-22 2002-09-12 Medeva Holdings Bv A recombinant DNA molecule containing a nucleotide sequence of part of the region encoding HBV pre-1s, an immunogenic particle containing multiple peptide monomers containing a pre-s1 epitope and pharmaceutical preparations containing it
AU630591B2 (en) * 1987-07-06 1992-11-05 Peptide Technology Limited Growth hormone related peptide
US5128319A (en) * 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
US5055396A (en) * 1987-11-03 1991-10-08 Scripps Clinic And Research Foundation Diagnostic methods and systems for quantifying apo ai
EP0364560A4 (en) * 1988-03-29 1990-12-05 Scripps Clinic And Research Foundation Diagnostic methods and systems for quantifying apo ai
DE3911794A1 (de) * 1989-04-11 1990-10-18 Thomae Gmbh Dr K Monoklonale antikoerper gegen rekombinaten humanen gewebeplasminogenaktivator mit definierter epitopspezifitaet, deren herstellung und deren verwendung
MY105946A (en) * 1989-07-14 1995-02-28 Schering Corp Antagonists of gm-csf derived from the carboxyl terminus.
EP0491077A1 (en) * 1990-12-19 1992-06-24 Medeva Holdings B.V. A composition used as a therapeutic agent against chronic viral hepatic diseases
US7611713B2 (en) 1993-03-05 2009-11-03 Pharmexa Inc. Inducing cellular immune responses to hepatitis B virus using peptide compositions
US7252829B1 (en) 1998-06-17 2007-08-07 Idm Pharma, Inc. HLA binding peptides and their uses
US9340577B2 (en) 1992-08-07 2016-05-17 Epimmune Inc. HLA binding motifs and peptides and their uses
US5387504A (en) * 1992-09-30 1995-02-07 Merck & Co., Inc. Monospecific antibodies and assay system for detecting stromelysin cleavage products
WO1994008597A1 (en) * 1992-10-14 1994-04-28 The Scripps Research Institute Methods for the detection of antigen-specific immune complexes
ES2065254B1 (es) * 1993-01-23 1995-07-16 Inmunologia & Genetica Aplic Peptidos y vacunas sinteticas contra parvovirus canino y otros virus relacionados.
US6632613B1 (en) * 1993-06-02 2003-10-14 University Of Utah Research Foundation Compositions and kits for fluorescence polarization assay of large molecules
EP0733063B1 (en) * 1993-12-09 2003-12-17 University of Utah Research Foundation Compositions and kits for fluorescence polarization assay of large molecules
EP0948533A1 (en) * 1996-12-30 1999-10-13 Innogenetics N.V. ANNEXIN V-BINDING POLYPEPTIDES DERIVED FROM HBsAg AND THEIR USES
WO2001036452A2 (en) 1999-11-18 2001-05-25 Epimmune Inc. Heteroclitic analogs of class i epitodes
US7026443B1 (en) 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
US7462354B2 (en) 1999-12-28 2008-12-09 Pharmexa Inc. Method and system for optimizing minigenes and peptides encoded thereby
JP4460829B2 (ja) * 2000-10-20 2010-05-12 コモ・バイオテック・アンパルトセルスカブ 妊娠関連血漿蛋白−a2(papp−a2)
US7244580B2 (en) * 2001-11-08 2007-07-17 The Regents Of The University Of California Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies
EP3031910B1 (en) 2002-02-21 2017-08-16 Institute Of Virology Mn/ca ix-specific monoclonal antibodies generated from mn/ca ix-deficient mice and methods of use
JP5382570B2 (ja) * 2006-12-20 2014-01-08 株式会社シノテスト ヒトhmgb1と特異的に結合する鳥類由来の抗体、ヒトhmgb1の免疫学的測定方法及びヒトhmgb1の免疫学的測定試薬
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
US10513553B2 (en) 2015-11-13 2019-12-24 Visterra, Inc. Compositions and methods for treating and preventing influenza
WO2017147248A1 (en) 2016-02-24 2017-08-31 Visterra, Inc. Formulations of antibody molecules to influenza virus
WO2020198329A1 (en) 2019-03-25 2020-10-01 Visterra, Inc. Compositions and methods for treating and preventing influenza

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237224A (en) * 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
US4075194A (en) * 1976-12-09 1978-02-21 Yeda Research And Development Co., Ltd. Novel synthetic undecapeptide and clinical assay
BE871782A (fr) * 1977-11-08 1979-05-07 Genentech Inc Procede permettant l'expression microbienne de polypeptides et moyens appropries
US4193915A (en) * 1978-04-13 1980-03-18 Mckerns Kenneth W Contraceptive, antibody generating, polypeptides
DK171727B1 (da) * 1978-12-22 1997-04-14 Biogen Inc Rekombinante hepatitis B virus DNA-molekyler, værtsorganismer transformeret hermed, HBV-antigenspecifikke polypeptider, DNA-sekvenser kodende for HBV-antigenspecifikke polypeptider, metoder til påvisning af hepatitis B virus-antistoffer, metoder til fremstilling af nævnte DNA-molekyler, fremgangsmåder til fremstilling af nævnte polypeptider og midler til påvisning af HBV-infektion
US4220565A (en) * 1979-01-18 1980-09-02 Scripps Clinic & Research Foundation Immunochemical conjugates: method and composition
SE447263B (sv) * 1979-04-20 1986-11-03 Bonnierfoeretagen Ab Syntetisk, antigeniskt aktiv polypeptid och antigeniskt medel innehallande nemnda polypeptid
IE52036B1 (en) * 1979-05-24 1987-05-27 Univ California Non-passageable viruses

Also Published As

Publication number Publication date
IL63224A (en) 1985-05-31
FI83662C (fi) 1991-08-12
ES504033A0 (es) 1983-04-01
NO812341L (no) 1982-01-18
PH20629A (en) 1987-03-06
EP0044710A1 (en) 1982-01-27
PH20597A (en) 1987-02-24
AU7283681A (en) 1982-01-21
AU559234B2 (en) 1987-03-05
PT73346A (en) 1981-08-01
NZ197734A (en) 1985-05-31
DE3174241D1 (en) 1986-05-07
PT73346B (en) 1982-09-02
IL63224A0 (en) 1981-10-30
KR870000702B1 (ko) 1987-04-07
ES8305419A1 (es) 1983-04-01
IE811595L (en) 1982-01-17
PH20598A (en) 1987-02-24
PH20133A (en) 1986-10-02
FI83662B (fi) 1991-04-30
EP0044710B1 (en) 1986-04-02
FI812092L (fi) 1982-01-18
GR74319B (en:Method) 1984-06-22
IE51410B1 (en) 1986-12-24
KR830006423A (ko) 1983-09-24
PH20603A (en) 1987-02-24
EP0044710B2 (en) 1991-02-06
DK318481A (da) 1982-01-18

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