CA1179335A - 5Z-9-DESOXY-6,9-EPOXY-5-IODO-PGF 1N/.alpha. XX - Google Patents

5Z-9-DESOXY-6,9-EPOXY-5-IODO-PGF 1N/.alpha. XX

Info

Publication number
CA1179335A
CA1179335A CA000349870A CA349870A CA1179335A CA 1179335 A CA1179335 A CA 1179335A CA 000349870 A CA000349870 A CA 000349870A CA 349870 A CA349870 A CA 349870A CA 1179335 A CA1179335 A CA 1179335A
Authority
CA
Canada
Prior art keywords
formula
trinor
methyl
compound
oxa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000349870A
Other languages
English (en)
Inventor
Udo F. Axen
Frank H. Lincoln
Roy A. Johnson
Robert C. Kelly
John E. Pike
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of CA1179335A publication Critical patent/CA1179335A/fr
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
CA000349870A 1976-02-04 1978-10-26 5Z-9-DESOXY-6,9-EPOXY-5-IODO-PGF 1N/.alpha. XX Expired CA1179335A (fr)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US65511076A 1976-02-04 1976-02-04
US655,110 1976-02-04
US71696976A 1976-08-23 1976-08-23
US71696076A 1976-08-23 1976-08-23
US71677176A 1976-08-23 1976-08-23
US71677076A 1976-08-23 1976-08-23
US71697276A 1976-08-23 1976-08-23
US716,960 1976-08-23
US716,770 1976-08-23
US716,771 1976-08-23
US716,972 1976-08-23
US716,969 1976-08-23
US72554876A 1976-09-22 1976-09-22
US725,548 1976-09-22

Publications (1)

Publication Number Publication Date
CA1179335A true CA1179335A (fr) 1984-12-11

Family

ID=27569874

Family Applications (3)

Application Number Title Priority Date Filing Date
CA000270416A Expired CA1160627A (fr) 1976-02-04 1977-01-25 9-desoxy-6,9-epoxyprostaglandines
CA000349868A Expired CA1160628A (fr) 1976-02-04 1978-10-26 6-CETO ET 5-HEMICETAL-PCF IN1.alpha. XX, ESTERS METHYLIQUES
CA000349870A Expired CA1179335A (fr) 1976-02-04 1978-10-26 5Z-9-DESOXY-6,9-EPOXY-5-IODO-PGF 1N/.alpha. XX

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA000270416A Expired CA1160627A (fr) 1976-02-04 1977-01-25 9-desoxy-6,9-epoxyprostaglandines
CA000349868A Expired CA1160628A (fr) 1976-02-04 1978-10-26 6-CETO ET 5-HEMICETAL-PCF IN1.alpha. XX, ESTERS METHYLIQUES

Country Status (13)

Country Link
JP (1) JPS5936911B2 (fr)
BE (1) BE851122A (fr)
CA (3) CA1160627A (fr)
CH (2) CH632245A5 (fr)
DE (1) DE2702553C2 (fr)
FR (3) FR2359125B1 (fr)
GB (1) GB1554044A (fr)
HK (1) HK9385A (fr)
IL (1) IL51189A (fr)
MX (1) MX4811E (fr)
NL (2) NL185515C (fr)
NZ (1) NZ183050A (fr)
SE (1) SE435281B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
JPS537665A (en) * 1976-05-11 1978-01-24 Wellcome Found Novel ether* its preparation and its use
GB1595056A (en) * 1976-10-12 1981-08-05 Wellcome Found Pharmaceutical combination
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues
FI71138C (fi) * 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
AU524786B2 (en) * 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
JPS6022710B2 (ja) * 1977-09-16 1985-06-03 小野薬品工業株式会社 プロスタグランジン類似化合物
DE2743283A1 (de) * 1977-09-27 1979-04-05 Hoechst Ag Neue prostacyclin-analoga
IT1088036B (it) 1977-11-25 1985-06-04 Erba Carlo Spa 15-epi-prostaciclina e prostaciclina analoghi
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE2811950A1 (de) * 1978-03-18 1979-12-13 Hoechst Ag Neue analoga von prostacyclin
IT1099575B (it) * 1978-07-20 1985-09-18 Erba Carlo Spa 20-metil-13,14-deidro-pgi2' suoi sali e suoi 16s- e 16r-metil derivati
DE2834248A1 (de) * 1978-08-04 1980-02-28 Hoechst Ag Neue prostaglandinderivate in der delta 2-pgf tief 2 und delta 2-pge tief 2 -reihe
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
JPS56122372A (en) * 1980-03-03 1981-09-25 Toray Ind Inc Prostaglandin i2 derivative
DE3029984C2 (de) * 1980-08-08 1983-12-15 Grünenthal GmbH, 5190 Stolberg 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
CH648556A5 (de) * 1981-03-11 1985-03-29 Hoffmann La Roche Fluorprostacycline.
JPS595155A (ja) * 1982-06-30 1984-01-12 Ono Pharmaceut Co Ltd プロスタグランジンd類似化合物
CA1324129C (fr) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandines de la serie f
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
AU619543B2 (en) * 1988-05-11 1992-01-30 Sucampo Ag Use of 15-ketoprostaglandin e or f compounds for uterine contraction
US5185374A (en) * 1988-05-11 1993-02-09 K.K. Ueno Seiyaku Oyo Kenkyujo Use of 15-ketoprostaglandin E or F compounds for uterine contraction
MX2012000889A (es) 2009-07-28 2012-02-13 Ono Pharmaceutical Co Compuesto biciclico y uso del mismo para propositos medicos.
US9029574B2 (en) 2011-01-27 2015-05-12 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
CN116143742A (zh) * 2023-02-27 2023-05-23 广州楷石生物科技有限公司 依前列醇一氧化氮供体药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351112A1 (fr) * 1975-10-21 1977-12-09 Wellcome Found Derive de prostaglandine et medicament contenant ce derive
JPS537665A (en) * 1976-05-11 1978-01-24 Wellcome Found Novel ether* its preparation and its use
MX4813E (es) * 1976-06-01 1982-10-19 Upjohn Co Procedimiento para preparar analogos de prostaglandinas
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues

Also Published As

Publication number Publication date
NL185515C (nl) 1990-05-01
NL8300921A (nl) 1983-07-01
CA1160628A (fr) 1984-01-17
NZ183050A (en) 1979-06-08
DE2702553A1 (de) 1977-08-18
NL7700896A (nl) 1977-08-08
FR2362833B1 (fr) 1980-08-08
MX4811E (es) 1982-10-19
GB1554044A (en) 1979-10-17
DE2702553C2 (de) 1986-02-20
JPS5295644A (en) 1977-08-11
FR2359125B1 (fr) 1985-11-15
FR2362834B1 (fr) 1980-08-08
HK9385A (en) 1985-02-08
FR2362833A1 (fr) 1978-03-24
IL51189A (en) 1985-08-30
NL185515B (nl) 1989-12-01
CA1160627A (fr) 1984-01-17
FR2362834A1 (fr) 1978-03-24
FR2359125A1 (fr) 1978-02-17
IL51189A0 (en) 1977-02-28
CH637949A5 (en) 1983-08-31
SE7701045L (sv) 1977-08-05
CH632245A5 (en) 1982-09-30
JPS5936911B2 (ja) 1984-09-06
BE851122A (fr) 1977-08-04
SE435281B (sv) 1984-09-17

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CA1179335A (fr) 5Z-9-DESOXY-6,9-EPOXY-5-IODO-PGF 1N/.alpha. XX
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