CA1155109A - Process for producing an insulin - Google Patents

Process for producing an insulin

Info

Publication number
CA1155109A
CA1155109A CA000373706A CA373706A CA1155109A CA 1155109 A CA1155109 A CA 1155109A CA 000373706 A CA000373706 A CA 000373706A CA 373706 A CA373706 A CA 373706A CA 1155109 A CA1155109 A CA 1155109A
Authority
CA
Canada
Prior art keywords
insulin
chain
sulfonate
reducing agent
thiol reducing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000373706A
Other languages
English (en)
French (fr)
Inventor
Ronald E. Chance
James A. Hoffmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1155109A publication Critical patent/CA1155109A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA000373706A 1980-03-27 1981-03-24 Process for producing an insulin Expired CA1155109A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13439080A 1980-03-27 1980-03-27
US134,390 1980-03-27

Publications (1)

Publication Number Publication Date
CA1155109A true CA1155109A (en) 1983-10-11

Family

ID=22463156

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000373706A Expired CA1155109A (en) 1980-03-27 1981-03-24 Process for producing an insulin

Country Status (28)

Country Link
EP (1) EP0037256B1 (en:Method)
JP (1) JPS56154443A (en:Method)
KR (1) KR840000947B1 (en:Method)
AR (1) AR227305A1 (en:Method)
AT (1) ATE4638T1 (en:Method)
AU (1) AU540645B2 (en:Method)
CA (1) CA1155109A (en:Method)
CS (1) CS236463B2 (en:Method)
DD (1) DD157613A5 (en:Method)
DE (1) DE3160862D1 (en:Method)
DK (1) DK149756C (en:Method)
EG (1) EG15248A (en:Method)
ES (1) ES500750A0 (en:Method)
FI (1) FI810918L (en:Method)
GB (1) GB2072680B (en:Method)
GR (1) GR73619B (en:Method)
HU (1) HU185416B (en:Method)
IE (1) IE51608B1 (en:Method)
IL (1) IL62483A (en:Method)
NO (1) NO151897C (en:Method)
NZ (1) NZ196610A (en:Method)
PH (1) PH16153A (en:Method)
PL (1) PL128599B1 (en:Method)
PT (1) PT72733B (en:Method)
RO (1) RO81640B (en:Method)
SU (1) SU1327790A3 (en:Method)
YU (1) YU76981A (en:Method)
ZA (1) ZA811970B (en:Method)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451396A (en) * 1983-08-01 1984-05-29 Eli Lilly And Company Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法

Also Published As

Publication number Publication date
KR830004855A (ko) 1983-07-20
IL62483A0 (en) 1981-05-20
PL230295A1 (en:Method) 1981-11-13
NZ196610A (en) 1984-03-16
ES8207551A1 (es) 1982-09-16
DD157613A5 (de) 1982-11-24
PT72733B (en) 1982-03-22
EG15248A (en) 1985-12-31
PL128599B1 (en) 1984-02-29
GB2072680B (en) 1983-09-21
JPS56154443A (en) 1981-11-30
ATE4638T1 (de) 1983-09-15
NO811038L (no) 1981-09-28
PH16153A (en) 1983-07-12
AU6884481A (en) 1981-10-01
ES500750A0 (es) 1982-09-16
IE810680L (en) 1981-09-27
NO151897C (no) 1985-06-26
KR840000947B1 (ko) 1984-07-01
GB2072680A (en) 1981-10-07
ZA811970B (en) 1982-11-24
CS236463B2 (en) 1985-05-15
AR227305A1 (es) 1982-10-15
HU185416B (en) 1985-02-28
FI810918A7 (fi) 1981-09-28
JPS6318960B2 (en:Method) 1988-04-20
AU540645B2 (en) 1984-11-29
DK136581A (da) 1981-09-28
EP0037256B1 (en) 1983-09-14
PT72733A (en) 1981-04-01
FI810918L (fi) 1981-09-28
RO81640A (ro) 1983-04-29
NO151897B (no) 1985-03-18
DK149756C (da) 1987-06-15
YU76981A (en) 1983-09-30
IL62483A (en) 1984-05-31
RO81640B (ro) 1983-04-30
SU1327790A3 (ru) 1987-07-30
IE51608B1 (en) 1987-01-21
DK149756B (da) 1986-09-22
GR73619B (en:Method) 1984-03-26
EP0037256A1 (en) 1981-10-07
DE3160862D1 (en) 1983-10-20

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Legal Events

Date Code Title Description
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