CA1151166A - 5-phenyl-1,3,4,5-tetrahydro-2h-1,4- benzodiazepin-2-ones, process for the preparation thereof and pharmaceutical compositions containing them - Google Patents

5-phenyl-1,3,4,5-tetrahydro-2h-1,4- benzodiazepin-2-ones, process for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
CA1151166A
CA1151166A CA000358371A CA358371A CA1151166A CA 1151166 A CA1151166 A CA 1151166A CA 000358371 A CA000358371 A CA 000358371A CA 358371 A CA358371 A CA 358371A CA 1151166 A CA1151166 A CA 1151166A
Authority
CA
Canada
Prior art keywords
phenyl
hydrogen
benzodiazepin
tetrahydro
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000358371A
Other languages
English (en)
French (fr)
Inventor
Lajos Kisfaludy
Julianna Rochricht
Marton Kajtar
Eva Palosi
Laszlo Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of CA1151166A publication Critical patent/CA1151166A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000358371A 1979-08-16 1980-08-15 5-phenyl-1,3,4,5-tetrahydro-2h-1,4- benzodiazepin-2-ones, process for the preparation thereof and pharmaceutical compositions containing them Expired CA1151166A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU79RI726A HU187262B (en) 1979-08-16 1979-08-16 Process for preparing new tetrahydro-1,4-benzodiazepin-2-ones
HURI-726 1979-08-16

Publications (1)

Publication Number Publication Date
CA1151166A true CA1151166A (en) 1983-08-02

Family

ID=11001109

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000358371A Expired CA1151166A (en) 1979-08-16 1980-08-15 5-phenyl-1,3,4,5-tetrahydro-2h-1,4- benzodiazepin-2-ones, process for the preparation thereof and pharmaceutical compositions containing them

Country Status (11)

Country Link
JP (1) JPS5668675A (de)
BE (1) BE884788A (de)
CA (1) CA1151166A (de)
CH (1) CH647238A5 (de)
DE (1) DE3030364A1 (de)
FR (1) FR2463131A1 (de)
GB (1) GB2056981B (de)
HU (1) HU187262B (de)
IT (1) IT1147764B (de)
NL (1) NL8004564A (de)
SE (1) SE441924B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3921677A1 (de) * 1989-07-01 1991-01-10 Basf Ag Siegelfaehige kunststoff-folie

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3109843A (en) * 1963-11-05 Process for preparing
DE1199776B (de) * 1959-12-10 1965-09-02 Hoffmann La Roche Verfahren zur Herstellung von 5-Phenyl-2-oxo-1, 2, 4, 5-tetrahydro-3H-1, 4-benzodiazepinderivaten
NL131197C (de) * 1963-06-28
US3522289A (en) * 1964-06-15 1970-07-28 Hoffmann La Roche Process for preparing a 2(1-(2-amino-5-phenyl) - 1 - phenylmethylamino)acetic acid derivative
CH510678A (de) * 1966-12-03 1971-07-31 Richter Gedeon Vegyeszet Verfahren zur Herstellung von 1,3,4,5-Tetrahydro-2H-1,4-benzodiazepin-2-on-Derivaten
AT281035B (de) * 1966-12-28 1970-05-11 Richter Gedeon Vegyeszet Verfahren zur Herstellung von 1,3-Dihydro-2H-1,4-benzodiazepinderivaten und deren Säureadditionssalzen
CH558370A (de) * 1970-07-30 1975-01-31 Richter Gedeon Vegyeszet Verfahren zur herstellung von 1,3,4,5-tetrahydro-2h-1, 4-benzodiazepin-2-on-derivaten.
CH557358A (de) * 1970-07-30 1974-12-31 Richter Gedeon Vegyeszet Verfahren zur herstellung von neuen optisch aktiven formen von 1,4-benzodiazepin-2-on-derivaten.
DE2204484B2 (de) * 1971-02-09 1978-04-13 Sumitomo Chemical Co Verfahren zur Herstellung von 5-Phenyl-23-dihydro- IH-1,4-benzodiazepinen
JPS4825199A (de) * 1971-08-03 1973-04-02
US3864330A (en) * 1971-08-31 1975-02-04 Sumitomo Chemical Co Benzodiazepine derivatives and production thereof
HU171033B (hu) * 1974-05-29 1977-10-28 Richter Gedeon Vegyeszet Sposob poluchenija proizvodnykh benzodiazepina
HU170623B (de) * 1974-06-25 1977-07-28

Also Published As

Publication number Publication date
BE884788A (fr) 1981-02-16
GB2056981B (en) 1983-11-23
IT1147764B (it) 1986-11-26
CH647238A5 (de) 1985-01-15
SE8005779L (sv) 1981-02-17
HU187262B (en) 1985-12-28
JPH0325425B2 (de) 1991-04-05
FR2463131A1 (fr) 1981-02-20
FR2463131B1 (de) 1985-04-26
DE3030364A1 (de) 1981-03-26
JPS5668675A (en) 1981-06-09
GB2056981A (en) 1981-03-25
IT8068248A0 (it) 1980-08-04
NL8004564A (nl) 1981-02-18
SE441924B (sv) 1985-11-18

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Legal Events

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