FR2463131A1 - Nouvelles 5-phenyl-1,3,4,5-tetrahydro-2h-1,4-benzodiazepin-2-ones contenant dans les positions 3 et 5 des centres d'asymetrie a configuration absolue semblable, procede pour leur preparation et leur application en therapeutique - Google Patents

Nouvelles 5-phenyl-1,3,4,5-tetrahydro-2h-1,4-benzodiazepin-2-ones contenant dans les positions 3 et 5 des centres d'asymetrie a configuration absolue semblable, procede pour leur preparation et leur application en therapeutique Download PDF

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Publication number
FR2463131A1
FR2463131A1 FR8017856A FR8017856A FR2463131A1 FR 2463131 A1 FR2463131 A1 FR 2463131A1 FR 8017856 A FR8017856 A FR 8017856A FR 8017856 A FR8017856 A FR 8017856A FR 2463131 A1 FR2463131 A1 FR 2463131A1
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FR
France
Prior art keywords
group
hydrogen
general formula
benzodiazepin
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8017856A
Other languages
English (en)
French (fr)
Other versions
FR2463131B1 (de
Inventor
Julianna Rochricht
Lajos Kisfaludy
Marton Kajtar
Eva Palosi
Laszlo Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt, Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Nyrt
Publication of FR2463131A1 publication Critical patent/FR2463131A1/fr
Application granted granted Critical
Publication of FR2463131B1 publication Critical patent/FR2463131B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR8017856A 1979-08-16 1980-08-13 Nouvelles 5-phenyl-1,3,4,5-tetrahydro-2h-1,4-benzodiazepin-2-ones contenant dans les positions 3 et 5 des centres d'asymetrie a configuration absolue semblable, procede pour leur preparation et leur application en therapeutique Granted FR2463131A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79RI726A HU187262B (en) 1979-08-16 1979-08-16 Process for preparing new tetrahydro-1,4-benzodiazepin-2-ones

Publications (2)

Publication Number Publication Date
FR2463131A1 true FR2463131A1 (fr) 1981-02-20
FR2463131B1 FR2463131B1 (de) 1985-04-26

Family

ID=11001109

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8017856A Granted FR2463131A1 (fr) 1979-08-16 1980-08-13 Nouvelles 5-phenyl-1,3,4,5-tetrahydro-2h-1,4-benzodiazepin-2-ones contenant dans les positions 3 et 5 des centres d'asymetrie a configuration absolue semblable, procede pour leur preparation et leur application en therapeutique

Country Status (11)

Country Link
JP (1) JPS5668675A (de)
BE (1) BE884788A (de)
CA (1) CA1151166A (de)
CH (1) CH647238A5 (de)
DE (1) DE3030364A1 (de)
FR (1) FR2463131A1 (de)
GB (1) GB2056981B (de)
HU (1) HU187262B (de)
IT (1) IT1147764B (de)
NL (1) NL8004564A (de)
SE (1) SE441924B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3921677A1 (de) * 1989-07-01 1991-01-10 Basf Ag Siegelfaehige kunststoff-folie

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1409329A (fr) * 1963-06-28 1965-08-27 Hoffmann La Roche Procédé pour la préparation de dérivés de benzodiazépine
DE1199776B (de) * 1959-12-10 1965-09-02 Hoffmann La Roche Verfahren zur Herstellung von 5-Phenyl-2-oxo-1, 2, 4, 5-tetrahydro-3H-1, 4-benzodiazepinderivaten
FR2126750A5 (de) * 1971-02-09 1972-10-06 Sumitomo Chemical Co
JPS4825199A (de) * 1971-08-03 1973-04-02
FR2272674A1 (de) * 1974-05-29 1975-12-26 Richter Gedeon Vegyeszet
FR2276054A1 (fr) * 1974-06-25 1976-01-23 Richter Gedeon Vegyeszet Nouveaux derives de la benzodiazepine et leur procede de preparation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3109843A (en) * 1963-11-05 Process for preparing
US3522289A (en) * 1964-06-15 1970-07-28 Hoffmann La Roche Process for preparing a 2(1-(2-amino-5-phenyl) - 1 - phenylmethylamino)acetic acid derivative
CH510678A (de) * 1966-12-03 1971-07-31 Richter Gedeon Vegyeszet Verfahren zur Herstellung von 1,3,4,5-Tetrahydro-2H-1,4-benzodiazepin-2-on-Derivaten
AT281035B (de) * 1966-12-28 1970-05-11 Richter Gedeon Vegyeszet Verfahren zur Herstellung von 1,3-Dihydro-2H-1,4-benzodiazepinderivaten und deren Säureadditionssalzen
AT309439B (de) * 1970-07-30 1973-08-27 Richter Gedeon Vegyeszet Verfahren zur Herstellung von neuen optisch aktiven 1,3,4,5-Tetrahydro-2H-1,4-Benzodiazepin-2-on-Derivaten und deren Salzen
CH558370A (de) * 1970-07-30 1975-01-31 Richter Gedeon Vegyeszet Verfahren zur herstellung von 1,3,4,5-tetrahydro-2h-1, 4-benzodiazepin-2-on-derivaten.
US3864330A (en) * 1971-08-31 1975-02-04 Sumitomo Chemical Co Benzodiazepine derivatives and production thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1199776B (de) * 1959-12-10 1965-09-02 Hoffmann La Roche Verfahren zur Herstellung von 5-Phenyl-2-oxo-1, 2, 4, 5-tetrahydro-3H-1, 4-benzodiazepinderivaten
FR1409329A (fr) * 1963-06-28 1965-08-27 Hoffmann La Roche Procédé pour la préparation de dérivés de benzodiazépine
FR2126750A5 (de) * 1971-02-09 1972-10-06 Sumitomo Chemical Co
JPS4825199A (de) * 1971-08-03 1973-04-02
FR2272674A1 (de) * 1974-05-29 1975-12-26 Richter Gedeon Vegyeszet
FR2276054A1 (fr) * 1974-06-25 1976-01-23 Richter Gedeon Vegyeszet Nouveaux derives de la benzodiazepine et leur procede de preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 79, no. 25, 24 décembre 1973, page 332, résumé no. 146570p COLUMBUS, OHIO (US) & JP - A - 73 25 199 (SUMITOMO CHEMICAL CO. LTD) (26 juillet 1973) *
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 37, no. 25, 15 décembre 1972, New York (US) *

Also Published As

Publication number Publication date
SE8005779L (sv) 1981-02-17
IT8068248A0 (it) 1980-08-04
HU187262B (en) 1985-12-28
GB2056981A (en) 1981-03-25
FR2463131B1 (de) 1985-04-26
CA1151166A (en) 1983-08-02
JPS5668675A (en) 1981-06-09
CH647238A5 (de) 1985-01-15
GB2056981B (en) 1983-11-23
IT1147764B (it) 1986-11-26
JPH0325425B2 (de) 1991-04-05
NL8004564A (nl) 1981-02-18
BE884788A (fr) 1981-02-16
DE3030364A1 (de) 1981-03-26
SE441924B (sv) 1985-11-18

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