CA1146852A - Reagent for latex agglutination - Google Patents
Reagent for latex agglutinationInfo
- Publication number
- CA1146852A CA1146852A CA000344181A CA344181A CA1146852A CA 1146852 A CA1146852 A CA 1146852A CA 000344181 A CA000344181 A CA 000344181A CA 344181 A CA344181 A CA 344181A CA 1146852 A CA1146852 A CA 1146852A
- Authority
- CA
- Canada
- Prior art keywords
- lower alkyl
- latex
- alkyl group
- latex particles
- diluent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920000126 latex Polymers 0.000 title claims abstract description 93
- 239000004816 latex Substances 0.000 title claims abstract description 89
- 230000004520 agglutination Effects 0.000 title claims abstract description 43
- 239000003153 chemical reaction reagent Substances 0.000 title abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims abstract description 41
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 11
- 125000005360 alkyl sulfoxide group Chemical group 0.000 claims abstract description 9
- 125000003277 amino group Chemical group 0.000 claims abstract description 7
- 239000003085 diluting agent Substances 0.000 claims description 58
- 239000002245 particle Substances 0.000 claims description 53
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical group CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 27
- 239000000872 buffer Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 15
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 12
- 239000004202 carbamide Substances 0.000 claims description 12
- 239000000032 diagnostic agent Substances 0.000 claims description 9
- 229940039227 diagnostic agent Drugs 0.000 claims description 9
- 239000000427 antigen Substances 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 239000004793 Polystyrene Substances 0.000 claims description 5
- 229920002223 polystyrene Polymers 0.000 claims description 5
- 239000003792 electrolyte Substances 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 238000012092 latex agglutination test Methods 0.000 abstract description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 50
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 36
- 239000012153 distilled water Substances 0.000 description 35
- 210000002700 urine Anatomy 0.000 description 33
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 22
- 239000004615 ingredient Substances 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 239000004471 Glycine Substances 0.000 description 11
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 10
- 239000007995 HEPES buffer Substances 0.000 description 10
- 210000002966 serum Anatomy 0.000 description 10
- 230000035935 pregnancy Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 239000008363 phosphate buffer Substances 0.000 description 8
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 7
- 229940098773 bovine serum albumin Drugs 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 238000007865 diluting Methods 0.000 description 6
- 239000002244 precipitate Substances 0.000 description 6
- 108010074051 C-Reactive Protein Proteins 0.000 description 5
- 102100032752 C-reactive protein Human genes 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 4
- XGEGHDBEHXKFPX-UHFFFAOYSA-N N-methyl urea Chemical compound CNC(N)=O XGEGHDBEHXKFPX-UHFFFAOYSA-N 0.000 description 4
- ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical compound CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 108010049003 Fibrinogen Proteins 0.000 description 3
- 102000008946 Fibrinogen Human genes 0.000 description 3
- 239000006173 Good's buffer Substances 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000000502 dialysis Methods 0.000 description 3
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 3
- 229940012952 fibrinogen Drugs 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- SBYMUDUGTIKLCR-UHFFFAOYSA-N 2-chloroethenylbenzene Chemical compound ClC=CC1=CC=CC=C1 SBYMUDUGTIKLCR-UHFFFAOYSA-N 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- SUAKHGWARZSWIH-UHFFFAOYSA-N N,N‐diethylformamide Chemical compound CCN(CC)C=O SUAKHGWARZSWIH-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000007994 TES buffer Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 239000012888 bovine serum Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 229940106780 human fibrinogen Drugs 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- AJFDBNQQDYLMJN-UHFFFAOYSA-N n,n-diethylacetamide Chemical compound CCN(CC)C(C)=O AJFDBNQQDYLMJN-UHFFFAOYSA-N 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 238000005185 salting out Methods 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000003462 sulfoxides Chemical class 0.000 description 2
- MCRJLMXYVFDXLS-ZRAJAZRZSA-N (5e,8e,10e,14e,17e)-12-hydroxyicosa-5,8,10,14,17-pentaenoic acid Chemical compound CC\C=C\C\C=C\CC(O)\C=C\C=C\C\C=C\CCCC(O)=O MCRJLMXYVFDXLS-ZRAJAZRZSA-N 0.000 description 1
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
- JLBJTVDPSNHSKJ-UHFFFAOYSA-N 4-Methylstyrene Chemical compound CC1=CC=C(C=C)C=C1 JLBJTVDPSNHSKJ-UHFFFAOYSA-N 0.000 description 1
- 240000005020 Acaciella glauca Species 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 102100035683 Axin-2 Human genes 0.000 description 1
- 101700047552 Axin-2 Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 101710197836 HLA class I histocompatibility antigen, alpha chain G Proteins 0.000 description 1
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 108010062374 Myoglobin Proteins 0.000 description 1
- 102000036675 Myoglobin Human genes 0.000 description 1
- MGJKQDOBUOMPEZ-UHFFFAOYSA-N N,N'-dimethylurea Chemical compound CNC(=O)NC MGJKQDOBUOMPEZ-UHFFFAOYSA-N 0.000 description 1
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 description 1
- JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 description 1
- SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- MPMBRWOOISTHJV-UHFFFAOYSA-N but-1-enylbenzene Chemical compound CCC=CC1=CC=CC=C1 MPMBRWOOISTHJV-UHFFFAOYSA-N 0.000 description 1
- 229940047583 cetamide Drugs 0.000 description 1
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 1
- YACLQRRMGMJLJV-UHFFFAOYSA-N chloroprene Chemical compound ClC(=C)C=C YACLQRRMGMJLJV-UHFFFAOYSA-N 0.000 description 1
- 238000007374 clinical diagnostic method Methods 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- CCAFPWNGIUBUSD-UHFFFAOYSA-N diethyl sulfoxide Chemical compound CCS(=O)CC CCAFPWNGIUBUSD-UHFFFAOYSA-N 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- -1 ethylene, propylene Chemical group 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 1
- 229940094342 human immunoglobulin m Drugs 0.000 description 1
- 125000001145 hydrido group Chemical group *[H] 0.000 description 1
- 229940027941 immunoglobulin g Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
- Y10S436/814—Pregnancy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
- Y10S436/818—Human chorionic gonadotropin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10552/1979 | 1979-01-31 | ||
| JP1055279A JPS55101862A (en) | 1979-01-31 | 1979-01-31 | Reagent for diagnosing pregnancy |
| JP6850479A JPS604941B2 (ja) | 1979-05-31 | 1979-05-31 | ラテツクス凝集反応用試薬 |
| JP68504/1979 | 1979-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1146852A true CA1146852A (en) | 1983-05-24 |
Family
ID=26345837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000344181A Expired CA1146852A (en) | 1979-01-31 | 1980-01-22 | Reagent for latex agglutination |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4292038A (en, 2012) |
| CA (1) | CA1146852A (en, 2012) |
| DE (1) | DE3002973A1 (en, 2012) |
| FR (1) | FR2448150A1 (en, 2012) |
| GB (1) | GB2042170B (en, 2012) |
| HK (1) | HK9686A (en, 2012) |
| IT (1) | IT1193902B (en, 2012) |
| MY (1) | MY8500423A (en, 2012) |
| SE (1) | SE447308B (en, 2012) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56141559A (en) * | 1980-04-04 | 1981-11-05 | Toray Ind Inc | Reagent for immunological inspection |
| AU543007B2 (en) * | 1980-04-15 | 1985-03-28 | Technicon Instruments Corportion | Agglutination immunoassay |
| US4503146A (en) * | 1980-10-01 | 1985-03-05 | Technicon Instruments Corporation | Method for eliminating turbidity in a biological fluid and reagent therefor |
| US4695537A (en) * | 1982-05-21 | 1987-09-22 | The University Of Tennessee Research Corp. | Particles sensitized with detergent-treated antigen for agglutination immunoassay |
| DE3303083A1 (de) * | 1983-01-31 | 1984-08-02 | Behringwerke Ag, 3550 Marburg | Immunologisches latex-agglutinationsverfahren und mittel |
| US4609630A (en) * | 1983-03-23 | 1986-09-02 | Yanovsky Jorge F | Method for improving the specificity of immunoassays |
| DE3322643C2 (de) * | 1983-06-23 | 1986-07-10 | Brigitte Dr. Ebener | Verfahren zur Herstellung eines Latextestreagenz zum Nachweis und zur Differenzierung von Humanhämoglobin, Humanhämoglobinbestandteilen oder Humanhämoglobinvarianten |
| US4536478A (en) * | 1984-04-05 | 1985-08-20 | Seragan Diagnostics, Inc. | Method for reducing non-specific interferences in agglutination immunoassays |
| US5252459A (en) * | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
| US4978632A (en) * | 1988-12-15 | 1990-12-18 | Kallestad Diagnostics, Inc. | Method of pre-treating samples in peroxidase-catalyzed enzyme assays |
| WO1992005440A1 (en) * | 1990-09-26 | 1992-04-02 | Akers Research Corporation | Improved ligand assay |
| US5231035A (en) * | 1991-01-11 | 1993-07-27 | Akers Research Corporation | Latex agglutination assay |
| DE4202924A1 (de) * | 1992-02-01 | 1993-08-05 | Behringwerke Ag | Verfahren zur bestimmung von rheumafaktoren und mittel zur durchfuehrung des verfahrens |
| US5506151A (en) * | 1994-02-09 | 1996-04-09 | Mitsubishi Kasei Corporation | Non-specific reaction suppressor |
| US5486479A (en) * | 1994-05-02 | 1996-01-23 | Mitsubishi Chemical Corporation | Buffer for immunoassay, kit including same and immunoassay method using said buffer |
| US6890765B2 (en) * | 2001-11-02 | 2005-05-10 | Roche Diagnostics Operations, Inc. | Particles for immunoassays and methods for treating the same |
| US6777246B2 (en) | 2001-12-18 | 2004-08-17 | Roche Diagnostics Gmbh | Tertiary amine compounds for use in immunoassays |
| JP5317040B2 (ja) * | 2006-10-17 | 2013-10-16 | 公益財団法人東京都医学総合研究所 | 尿中成分の免疫学的測定方法およびそれに用いるための試薬 |
| EP2241886A1 (en) * | 2009-04-15 | 2010-10-20 | Beckman Coulter Biomedical Limited | Homogeneous agglutination immunoassay method and kit for such method |
| CN104977404B (zh) * | 2015-07-07 | 2016-08-17 | 宁波瑞源生物科技有限公司 | 抑制类风湿因子干扰的胶乳增强免疫比浊试剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6509726A (en, 2012) * | 1965-07-28 | 1967-01-30 | ||
| FR1493772A (fr) * | 1965-07-28 | 1967-09-01 | Organon Nv | Procédé pour le traitement des érythrocytes |
| US3564089A (en) * | 1966-09-29 | 1971-02-16 | Sandra Jean Kiddy | Diagnostic reagent for syphilis |
| JPS549078B1 (en, 2012) * | 1971-02-23 | 1979-04-20 | ||
| GB1501395A (en) * | 1974-07-19 | 1978-02-15 | Wellcome Found | Viral anti-body detection |
| IL47223A (en) * | 1975-05-02 | 1979-01-31 | Rafa Labor Ltd | Method for the determination of pregnancy and serodiagnostic composition therefor |
| US4046723A (en) * | 1976-04-22 | 1977-09-06 | The Dow Chemical Company | Azide bonding of a protein to a latex |
| JPS5933228B2 (ja) * | 1978-12-25 | 1984-08-14 | 武田薬品工業株式会社 | 妊娠診断反応用被検液の前処理方法ならびに前処理剤 |
-
1980
- 1980-01-22 CA CA000344181A patent/CA1146852A/en not_active Expired
- 1980-01-28 FR FR8001799A patent/FR2448150A1/fr active Granted
- 1980-01-29 US US06/116,465 patent/US4292038A/en not_active Expired - Lifetime
- 1980-01-29 DE DE19803002973 patent/DE3002973A1/de active Granted
- 1980-01-30 GB GB8003197A patent/GB2042170B/en not_active Expired
- 1980-01-30 SE SE8000738A patent/SE447308B/sv not_active IP Right Cessation
- 1980-01-30 IT IT19573/80A patent/IT1193902B/it active
-
1985
- 1985-12-30 MY MY423/85A patent/MY8500423A/xx unknown
-
1986
- 1986-02-05 HK HK96/86A patent/HK9686A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2042170B (en) | 1983-11-02 |
| IT8019573A0 (it) | 1980-01-30 |
| FR2448150B1 (en, 2012) | 1985-03-08 |
| SE8000738L (sv) | 1980-08-01 |
| SE447308B (sv) | 1986-11-03 |
| HK9686A (en) | 1986-02-14 |
| FR2448150A1 (fr) | 1980-08-29 |
| DE3002973C2 (en, 2012) | 1987-12-10 |
| US4292038A (en) | 1981-09-29 |
| MY8500423A (en) | 1985-12-31 |
| GB2042170A (en) | 1980-09-17 |
| DE3002973A1 (de) | 1980-08-07 |
| IT1193902B (it) | 1988-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1146852A (en) | Reagent for latex agglutination | |
| US4060597A (en) | Serological reagent and preparation thereof | |
| EP0559738B1 (en) | Methods for detection and quantitation of cell subsets within subpopulations of a mixed cell population | |
| US4590169A (en) | Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations | |
| WO2002039114A2 (en) | Improved assay and reagents or immunological determination of analyte concentration | |
| US4332788A (en) | Method of determining an antigen, antibody for antigen-antibody complex including fixing the aggregates thereof | |
| EP2023141A2 (en) | Carrier particle latex for assay reagent and assay reagent | |
| CN112763731B (zh) | 一种脂蛋白(a)测定试剂盒及其检测方法 | |
| EP0064275B1 (en) | Immunochemical reagent | |
| Cuilliere et al. | Microparticle-enhanced nephelometric immunoassay (Nephelia) for immunoglobulins G, A, and M | |
| JP2682697B2 (ja) | 免疫測定試薬および免疫測定法 | |
| CA1339932C (en) | Buffer and method for detecting rheumatoid factor | |
| JP3220546B2 (ja) | 免疫複合体存在下の抗原または抗体の測定方法 | |
| EP0108136B1 (en) | Competitive immunofluorescence assay and test kit | |
| JP2001091516A (ja) | ヒトα−フェトプロテインの定量法および測定キット | |
| JP3644704B2 (ja) | 免疫測定法 | |
| JPH10104233A (ja) | ヒトアンチトロンビンｉｉｉの定量方法及び測定キット | |
| JP3438962B2 (ja) | 免疫学的凝集反応試薬 | |
| Stevens et al. | An automated test for rheumatoid factor | |
| JPH1026622A (ja) | ヒトα−フェトプロテインの定量法および測定キット | |
| JP2004151000A (ja) | 抗ミトコンドリアｍ２抗体の検出方法及び該検出方法を用いた抗ミトコンドリアｍ２抗体の免疫学的検出用キット | |
| Borque et al. | Development and validation of an automated particle‐enhanced nephelometric immunoassay method for the measurement of human plasma c1q | |
| JP2668448B2 (ja) | 糖尿病性腎症診断のための尿中の蛋白量判定方法および感作ラテックス | |
| JPS6229746B2 (en, 2012) | ||
| JP3290521B2 (ja) | 抗リン脂質抗体測定法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |