CA1144170A - Decahydroquinolinol derivatives, process for preparing them and their uses in therapeutics - Google Patents
Decahydroquinolinol derivatives, process for preparing them and their uses in therapeuticsInfo
- Publication number
- CA1144170A CA1144170A CA000360502A CA360502A CA1144170A CA 1144170 A CA1144170 A CA 1144170A CA 000360502 A CA000360502 A CA 000360502A CA 360502 A CA360502 A CA 360502A CA 1144170 A CA1144170 A CA 1144170A
- Authority
- CA
- Canada
- Prior art keywords
- trans
- phenoxy
- decahydroquinoline
- propyl
- axial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229940102223 injectable solution Drugs 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 230000037023 motor activity Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 229960003343 ouabain Drugs 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR79/23289 | 1979-09-19 | ||
| FR7923289A FR2465724A1 (fr) | 1979-09-19 | 1979-09-19 | Nouveaux derives de decahydroquinoleinol, leur procede de preparation ainsi que leurs applications en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1144170A true CA1144170A (en) | 1983-04-05 |
Family
ID=9229781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000360502A Expired CA1144170A (en) | 1979-09-19 | 1980-09-18 | Decahydroquinolinol derivatives, process for preparing them and their uses in therapeutics |
Country Status (37)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4425349A (en) | 1979-07-02 | 1984-01-10 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Sulfur-containing isoquinoline derivatives in pharmaceutical compositions and methods of use |
| FR2565979B1 (fr) * | 1984-06-13 | 1987-03-20 | Labaz Sanofi Nv | Nouveaux derives de decahydroquinoleinol, leur procede de preparation et les compositions les contenant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791678A (fr) * | 1971-11-23 | 1973-05-21 | Labaz | Nouveaux derives de decahydroquinoleinol, leur procede de preparation ainsi que les compositions therapeutiques les contenant |
| US4173636A (en) * | 1975-12-16 | 1979-11-06 | Labaz | Decahydroquinolines, pharmaceutical compositions and methods of use |
-
1979
- 1979-09-19 FR FR7923289A patent/FR2465724A1/fr active Granted
-
1980
- 1980-08-19 MC MC801467A patent/MC1346A1/xx unknown
- 1980-08-21 ZA ZA00805164A patent/ZA805164B/xx unknown
- 1980-08-22 AU AU61687/80A patent/AU530427B2/en not_active Ceased
- 1980-08-25 IS IS2579A patent/IS1122B6/is unknown
- 1980-08-25 IL IL60913A patent/IL60913A/xx unknown
- 1980-08-27 IN IN985/CAL/80A patent/IN152974B/en unknown
- 1980-09-04 US US06/184,129 patent/US4332805A/en not_active Expired - Lifetime
- 1980-09-05 GR GR62820A patent/GR69823B/el unknown
- 1980-09-09 IE IE1888/80A patent/IE50790B1/en unknown
- 1980-09-10 ZW ZW208/80A patent/ZW20880A1/xx unknown
- 1980-09-11 NZ NZ194924A patent/NZ194924A/en unknown
- 1980-09-11 ZM ZM78/80A patent/ZM7880A1/xx unknown
- 1980-09-12 RO RO102150A patent/RO80663B/ro unknown
- 1980-09-15 FI FI802879A patent/FI70705C/fi not_active IP Right Cessation
- 1980-09-16 PT PT71808A patent/PT71808B/pt unknown
- 1980-09-17 AR AR282558A patent/AR224652A1/es active
- 1980-09-17 SU SU802980755A patent/SU936808A3/ru active
- 1980-09-17 PL PL1980226793A patent/PL123443B1/pl unknown
- 1980-09-17 PH PH24595A patent/PH16992A/en unknown
- 1980-09-18 YU YU02396/80A patent/YU239680A/xx unknown
- 1980-09-18 CA CA000360502A patent/CA1144170A/en not_active Expired
- 1980-09-18 BG BG049093A patent/BG31798A3/xx unknown
- 1980-09-18 AT AT0467780A patent/AT375344B/de not_active IP Right Cessation
- 1980-09-18 CS CS806308A patent/CS215072B2/cs unknown
- 1980-09-18 EP EP80870039A patent/EP0026168B1/fr not_active Expired
- 1980-09-18 ES ES495153A patent/ES495153A0/es active Granted
- 1980-09-18 DE DE8080870039T patent/DE3062357D1/de not_active Expired
- 1980-09-18 HU HU802295A patent/HU182204B/hu unknown
- 1980-09-18 NO NO802775A patent/NO153727C/no unknown
- 1980-09-18 DK DK395680A patent/DK149588C/da active
- 1980-09-18 GB GB8030202A patent/GB2061267B/en not_active Expired
- 1980-09-19 OA OA57214A patent/OA06620A/xx unknown
- 1980-09-19 DD DD80224021A patent/DD153118A5/de unknown
- 1980-09-19 MA MA19155A patent/MA18954A1/fr unknown
- 1980-09-19 JP JP13144280A patent/JPS5673063A/ja active Pending
- 1980-09-20 EG EG578/80A patent/EG14833A/xx active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |