CA1126280A - Benzimidazole and benzimidazolidine derivatives with diuretic and antihypertensive activity - Google Patents

Benzimidazole and benzimidazolidine derivatives with diuretic and antihypertensive activity

Info

Publication number
CA1126280A
CA1126280A CA324,146A CA324146A CA1126280A CA 1126280 A CA1126280 A CA 1126280A CA 324146 A CA324146 A CA 324146A CA 1126280 A CA1126280 A CA 1126280A
Authority
CA
Canada
Prior art keywords
substituted
chloro
sulfamyl
lower alkyl
benzimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA324,146A
Other languages
English (en)
French (fr)
Inventor
Bola V. Shetty
Arthur Mcfadden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Frederick Co Canada Ltd
Original Assignee
Purdue Frederick Co Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Frederick Co Canada Ltd filed Critical Purdue Frederick Co Canada Ltd
Application granted granted Critical
Publication of CA1126280A publication Critical patent/CA1126280A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA324,146A 1978-04-10 1979-03-26 Benzimidazole and benzimidazolidine derivatives with diuretic and antihypertensive activity Expired CA1126280A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89504878A 1978-04-10 1978-04-10
US895,048 1978-04-10

Publications (1)

Publication Number Publication Date
CA1126280A true CA1126280A (en) 1982-06-22

Family

ID=25403870

Family Applications (1)

Application Number Title Priority Date Filing Date
CA324,146A Expired CA1126280A (en) 1978-04-10 1979-03-26 Benzimidazole and benzimidazolidine derivatives with diuretic and antihypertensive activity

Country Status (19)

Country Link
JP (1) JPS54138561A (fi)
AT (1) AT372951B (fi)
AU (1) AU531086B2 (fi)
BE (1) BE875425A (fi)
CA (1) CA1126280A (fi)
DE (1) DE2914084A1 (fi)
DK (1) DK139079A (fi)
ES (1) ES479446A1 (fi)
FI (1) FI74461C (fi)
FR (1) FR2422644A1 (fi)
GB (1) GB2018766B (fi)
GR (1) GR68483B (fi)
IL (1) IL57105A (fi)
IT (1) IT1193755B (fi)
NL (1) NL7902802A (fi)
NZ (1) NZ190136A (fi)
PT (1) PT69458A (fi)
SE (1) SE446532B (fi)
ZA (1) ZA791726B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102070466A (zh) * 2010-12-28 2011-05-25 天津市筠凯化工科技有限公司 5-氯-2-硝基苯胺制备方法
CN108558712A (zh) * 2018-06-20 2018-09-21 新乡市锦源化工有限公司 一种以乙酰苯胺为原料合成高纯度对氨基苯磺酰胺的方法及对氨基苯磺酰胺
CN110305018B (zh) * 2019-06-06 2022-07-15 浙江普洛家园药业有限公司 一种3-溴-2-氟硝基苯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH404675A (de) * 1961-06-29 1965-12-31 Siegfried Ag Verfahren zur Herstellung neuer heterocyclischer Sulfonamidoverbindungen
FR1469504A (fr) * 1964-10-22 1967-02-17 Fisons Pest Control Ltd Composés insecticides
FR1477792A (fr) * 1965-03-24 1967-04-21 Fisons Pest Control Ltd Nouveaux benzimidazoles
GB1163711A (en) * 1966-01-13 1969-09-10 Fisons Pest Control Ltd Substituted Benzimidazoles and Biocidally-Active Compositions
GB1356244A (en) * 1970-07-29 1974-06-12 Fisons Ltd Substituted benzimidazole parasiticides

Also Published As

Publication number Publication date
NL7902802A (nl) 1979-10-12
AU531086B2 (en) 1983-08-11
GR68483B (fi) 1982-01-04
ES479446A1 (es) 1979-08-01
FI74461C (fi) 1988-02-08
FI791083A (fi) 1979-10-11
NZ190136A (en) 1982-11-23
IL57105A0 (en) 1979-07-25
FI74461B (fi) 1987-10-30
DK139079A (da) 1979-10-11
DE2914084A1 (de) 1979-10-25
ZA791726B (en) 1980-05-28
AT372951B (de) 1983-12-12
SE7902911L (sv) 1979-10-11
GB2018766A (en) 1979-10-24
AU4567579A (en) 1979-10-18
SE446532B (sv) 1986-09-22
BE875425A (fr) 1979-07-31
JPS54138561A (en) 1979-10-27
ATA263379A (de) 1983-04-15
FR2422644B1 (fi) 1982-12-17
PT69458A (en) 1979-05-01
IT7948686A0 (it) 1979-04-10
JPH0250904B2 (fi) 1990-11-05
GB2018766B (en) 1982-09-22
FR2422644A1 (fr) 1979-11-09
IT1193755B (it) 1988-08-24
IL57105A (en) 1983-10-31

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Legal Events

Date Code Title Description
MKEX Expiry