CA1120400A - Method of treating hypertension and medicaments therefor - Google Patents
Method of treating hypertension and medicaments thereforInfo
- Publication number
- CA1120400A CA1120400A CA000316609A CA316609A CA1120400A CA 1120400 A CA1120400 A CA 1120400A CA 000316609 A CA000316609 A CA 000316609A CA 316609 A CA316609 A CA 316609A CA 1120400 A CA1120400 A CA 1120400A
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen
- composition
- compound
- lower alkyl
- mercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 206010020772 Hypertension Diseases 0.000 title description 9
- 239000003814 drug Substances 0.000 title description 6
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- 230000001882 diuretic effect Effects 0.000 claims abstract description 21
- 239000001257 hydrogen Substances 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 22
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 20
- 229960002429 proline Drugs 0.000 claims description 20
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 229960003883 furosemide Drugs 0.000 claims description 16
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 16
- 229960002003 hydrochlorothiazide Drugs 0.000 claims description 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- AGHANLSBXUWXTB-UHFFFAOYSA-N tienilic acid Chemical compound ClC1=C(Cl)C(OCC(=O)O)=CC=C1C(=O)C1=CC=CS1 AGHANLSBXUWXTB-UHFFFAOYSA-N 0.000 claims description 7
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- CESYKOGBSMNBPD-UHFFFAOYSA-N Methyclothiazide Chemical compound ClC1=C(S(N)(=O)=O)C=C2S(=O)(=O)N(C)C(CCl)NC2=C1 CESYKOGBSMNBPD-UHFFFAOYSA-N 0.000 claims description 2
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 2
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- NDTSRXAMMQDVSW-UHFFFAOYSA-N benzthiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1N=C2CSCC1=CC=CC=C1 NDTSRXAMMQDVSW-UHFFFAOYSA-N 0.000 claims 1
- 229960003313 hydroflumethiazide Drugs 0.000 claims 1
- DMDGGSIALPNSEE-UHFFFAOYSA-N hydroflumethiazide Chemical compound C1=C(C(F)(F)F)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O DMDGGSIALPNSEE-UHFFFAOYSA-N 0.000 claims 1
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86442877A | 1977-12-27 | 1977-12-27 | |
| US864,428 | 1977-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1120400A true CA1120400A (en) | 1982-03-23 |
Family
ID=25343256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000316609A Expired CA1120400A (en) | 1977-12-27 | 1978-11-21 | Method of treating hypertension and medicaments therefor |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS54110333A (xx) |
| AR (1) | AR230378A1 (xx) |
| AU (1) | AU526239B2 (xx) |
| BE (1) | BE873092A (xx) |
| CA (1) | CA1120400A (xx) |
| CH (1) | CH642542A5 (xx) |
| DE (1) | DE2854316C3 (xx) |
| DK (1) | DK578778A (xx) |
| EG (1) | EG14178A (xx) |
| FI (1) | FI783991A (xx) |
| FR (1) | FR2413089A1 (xx) |
| GB (1) | GB2010675B (xx) |
| GR (1) | GR72951B (xx) |
| HK (1) | HK45483A (xx) |
| HU (1) | HU178747B (xx) |
| IE (1) | IE48306B1 (xx) |
| IL (1) | IL56281A (xx) |
| IT (1) | IT1202811B (xx) |
| KE (1) | KE3235A (xx) |
| LU (1) | LU80709A1 (xx) |
| MY (2) | MY8300240A (xx) |
| NL (2) | NL192870C (xx) |
| NO (1) | NO784357L (xx) |
| NZ (1) | NZ189159A (xx) |
| PH (1) | PH22111A (xx) |
| PL (1) | PL212188A1 (xx) |
| PT (1) | PT68983A (xx) |
| SE (1) | SE445173B (xx) |
| SG (1) | SG41482G (xx) |
| ZA (1) | ZA786948B (xx) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5829950B2 (ja) * | 1978-10-05 | 1983-06-25 | ウェルファイド株式会社 | 環状イミノカルボン酸誘導体およびその塩類 |
| US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| US4482725A (en) * | 1980-04-03 | 1984-11-13 | E. R. Squibb & Sons, Inc. | S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4532342A (en) * | 1981-02-20 | 1985-07-30 | Warner-Lambert Company | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
| US4898729A (en) * | 1983-12-09 | 1990-02-06 | Euroceltique, S.A. | Treatment of hypertension, compounds and compositions for antihypertension and diuresis |
| DE3532036A1 (de) * | 1985-09-09 | 1987-03-26 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des bluthochdrucks |
| DK9200258U4 (da) * | 1992-03-11 | 1993-07-23 | Merck & Co Inc | Farmaceutisk præparat indeholdende enalapril til brug mod hypertension |
| WO1996024358A1 (en) * | 1995-02-10 | 1996-08-15 | G.D. Searle & Co. | Use of low dose amount of spironolactone for treatment of cardiovascular disease |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1978
- 1978-11-21 CA CA000316609A patent/CA1120400A/en not_active Expired
- 1978-11-29 AU AU42041/78A patent/AU526239B2/en not_active Expired
- 1978-12-06 FR FR7834359A patent/FR2413089A1/fr active Granted
- 1978-12-06 IE IE2413/78A patent/IE48306B1/en unknown
- 1978-12-12 ZA ZA786948A patent/ZA786948B/xx unknown
- 1978-12-13 NZ NZ189159A patent/NZ189159A/en unknown
- 1978-12-14 NL NL7812164A patent/NL192870C/nl not_active IP Right Cessation
- 1978-12-14 GR GR57879A patent/GR72951B/el unknown
- 1978-12-14 CH CH1273778A patent/CH642542A5/de not_active IP Right Cessation
- 1978-12-15 DE DE2854316A patent/DE2854316C3/de not_active Expired - Lifetime
- 1978-12-19 PH PH21971A patent/PH22111A/en unknown
- 1978-12-21 GB GB7849703A patent/GB2010675B/en not_active Expired
- 1978-12-22 IL IL56281A patent/IL56281A/xx unknown
- 1978-12-22 DK DK578778A patent/DK578778A/da not_active Application Discontinuation
- 1978-12-22 HU HU78SU1000A patent/HU178747B/hu unknown
- 1978-12-22 SE SE7813277A patent/SE445173B/sv not_active IP Right Cessation
- 1978-12-22 NO NO784357A patent/NO784357L/no unknown
- 1978-12-22 LU LU80709A patent/LU80709A1/de unknown
- 1978-12-22 IT IT31266/78A patent/IT1202811B/it active Protection Beyond IP Right Term
- 1978-12-25 EG EG740/78A patent/EG14178A/xx active
- 1978-12-25 JP JP16462778A patent/JPS54110333A/ja active Granted
- 1978-12-26 PT PT68983A patent/PT68983A/pt unknown
- 1978-12-27 AR AR274975A patent/AR230378A1/es active
- 1978-12-27 FI FI783991A patent/FI783991A/fi unknown
- 1978-12-27 BE BE192574A patent/BE873092A/xx not_active IP Right Cessation
- 1978-12-27 PL PL21218878A patent/PL212188A1/xx unknown
-
1982
- 1982-09-02 SG SG414/82A patent/SG41482G/en unknown
- 1982-09-14 KE KE3235A patent/KE3235A/xx unknown
-
1983
- 1983-10-20 HK HK454/83A patent/HK45483A/xx not_active IP Right Cessation
- 1983-12-30 MY MY240/83A patent/MY8300240A/xx unknown
-
1987
- 1987-10-31 MY MYPI87003001A patent/MY102991A/en unknown
-
1998
- 1998-04-24 NL NL980017C patent/NL980017I1/nl unknown
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| Date | Code | Title | Description |
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| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 19990323 |