CA1101332A - Procedes simplifies pour la preparation de concentres de facteur viii de tres grande purete - Google Patents

Procedes simplifies pour la preparation de concentres de facteur viii de tres grande purete

Info

Publication number
CA1101332A
CA1101332A CA270,497A CA270497A CA1101332A CA 1101332 A CA1101332 A CA 1101332A CA 270497 A CA270497 A CA 270497A CA 1101332 A CA1101332 A CA 1101332A
Authority
CA
Canada
Prior art keywords
factor viii
solution
buffer
polyol
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA270,497A
Other languages
English (en)
French (fr)
Inventor
Edward Shanbrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Merieux SA
Original Assignee
Institut Merieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/653,973 external-priority patent/US4069216A/en
Application filed by Institut Merieux SA filed Critical Institut Merieux SA
Application granted granted Critical
Publication of CA1101332A publication Critical patent/CA1101332A/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Processing Of Solid Wastes (AREA)
CA270,497A 1976-01-30 1977-01-26 Procedes simplifies pour la preparation de concentres de facteur viii de tres grande purete Expired CA1101332A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/653,973 US4069216A (en) 1975-06-16 1976-01-30 Simplified methods for preparation of very high purity Factor VIII concentrate
US653,973 1976-01-30

Publications (1)

Publication Number Publication Date
CA1101332A true CA1101332A (fr) 1981-05-19

Family

ID=24623016

Family Applications (1)

Application Number Title Priority Date Filing Date
CA270,497A Expired CA1101332A (fr) 1976-01-30 1977-01-26 Procedes simplifies pour la preparation de concentres de facteur viii de tres grande purete

Country Status (16)

Country Link
JP (1) JPS52102410A (fi)
AR (1) AR214625A1 (fi)
AT (1) AT354632B (fi)
BE (1) BE850852A (fi)
BR (1) BR7700554A (fi)
CA (1) CA1101332A (fi)
DE (1) DE2703620C2 (fi)
DK (1) DK146855C (fi)
ES (1) ES455473A1 (fi)
FR (1) FR2339621A1 (fi)
GB (1) GB1557609A (fi)
LU (1) LU76652A1 (fi)
MX (1) MX5197E (fi)
NL (1) NL179290C (fi)
NO (1) NO145563C (fi)
SE (1) SE442953B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE448945B (sv) * 1979-12-20 1987-03-30 Blombaeck E G B Forfarande for rening och /eller koncentrering av faktor viii-komplexet
AT369263B (de) * 1980-08-27 1982-12-27 Immuno Ag Verfahren zur herstellung eines faktor viii(ahf) -hochkonzentrates
GB2096174B (en) * 1981-04-08 1984-05-10 Atomic Energy Authority Uk Blood fractionation
US4382028A (en) * 1982-07-19 1983-05-03 Monsanto Company Separation of plasma proteins from cell culture systems
FR2535173A1 (fr) * 1982-11-03 1984-05-04 Protein Sa Produits obtenus a partir de sang d'animaux d'abattoirs et leur procede d'obtention
FR2603805A1 (fr) * 1986-09-16 1988-03-18 Transfusion Sanguine Assoc Rgl Procede d'inactivation par ozonolyse de micro-organismes contaminants presents dans des materiaux biologiques essentiellement proteiques, les produits obtenus et leurs applications biologiques et analytiques
HRP940645A2 (en) * 1993-10-06 1996-12-31 Immuno Ag Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained
EP2864026B8 (en) 2012-06-26 2018-11-07 SWM Luxembourg S.à.R.L. Membrane filtration using low energy feed spacer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286954A (fi) * 1962-01-03
US3652530A (en) * 1967-08-28 1972-03-28 American Nat Red Cross Antihemophilic factor prepared from blood plasma using polyethylene glycol
US3631018A (en) * 1970-05-01 1971-12-28 Baxter Laboratories Inc Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate
US3682881A (en) * 1970-10-02 1972-08-08 Baxter Laboratories Inc Fractionation of plasma using glycine and polyethylene glycol
US3770631A (en) * 1971-06-29 1973-11-06 Baxter Laboratories Inc Clarification of blood serum and plasma
US3839314A (en) * 1971-06-29 1974-10-01 Baxter Laboratories Inc Clarification of blood serum and plasma using block copolymers of ethylene oxide and polyoxypropylene
US4073886A (en) * 1973-01-30 1978-02-14 Baxter Travenol Laboratories, Inc. Blood fractionation process using block copolymers of ethylene oxide and polyoxypropylene
US3893990A (en) * 1973-04-05 1975-07-08 Baxter Laboratories Inc Clarification of blood serum and plasma using a block copolymer of ethylene oxide and polyoxypropylene

Also Published As

Publication number Publication date
ES455473A1 (es) 1978-01-01
NO770293L (no) 1977-08-02
ATA53277A (de) 1979-06-15
JPS6242887B2 (fi) 1987-09-10
JPS52102410A (en) 1977-08-27
AR214625A1 (es) 1979-07-13
FR2339621A1 (fr) 1977-08-26
DK146855C (da) 1984-07-02
NL7700927A (nl) 1977-08-02
BR7700554A (pt) 1977-10-04
DK146855B (da) 1984-01-23
DE2703620C2 (de) 1984-11-22
NO145563B (no) 1982-01-11
BE850852A (fr) 1977-07-28
NL179290B (nl) 1986-03-17
LU76652A1 (fi) 1978-09-13
DE2703620A1 (de) 1977-08-04
AT354632B (de) 1979-01-25
GB1557609A (en) 1979-12-12
NO145563C (no) 1982-04-21
NL179290C (nl) 1986-08-18
SE442953B (sv) 1986-02-10
DK36477A (da) 1977-07-31
FR2339621B1 (fi) 1980-06-06
SE7700864L (sv) 1977-07-31
MX5197E (es) 1983-04-25

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Legal Events

Date Code Title Description
MKEX Expiry