CA1077948A - 1,-5 disubstituted-2-pyrrolidones and processes for their production - Google Patents

1,-5 disubstituted-2-pyrrolidones and processes for their production

Info

Publication number
CA1077948A
CA1077948A CA283,598A CA283598A CA1077948A CA 1077948 A CA1077948 A CA 1077948A CA 283598 A CA283598 A CA 283598A CA 1077948 A CA1077948 A CA 1077948A
Authority
CA
Canada
Prior art keywords
pyrrolidone
compound
ppm
group
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA283,598A
Other languages
English (en)
French (fr)
Inventor
Albin J. Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Priority to CA343,178A priority Critical patent/CA1084939A/en
Application granted granted Critical
Publication of CA1077948A publication Critical patent/CA1077948A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA283,598A 1976-08-06 1977-07-27 1,-5 disubstituted-2-pyrrolidones and processes for their production Expired CA1077948A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA343,178A CA1084939A (en) 1976-08-06 1980-01-07 Preparation of novel pyrrolidone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71236276A 1976-08-06 1976-08-06

Publications (1)

Publication Number Publication Date
CA1077948A true CA1077948A (en) 1980-05-20

Family

ID=24861795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA283,598A Expired CA1077948A (en) 1976-08-06 1977-07-27 1,-5 disubstituted-2-pyrrolidones and processes for their production

Country Status (31)

Country Link
JP (2) JPS5321159A (enrdf_load_html_response)
AR (1) AR217080A1 (enrdf_load_html_response)
AT (1) AT362887B (enrdf_load_html_response)
AU (1) AU508007B2 (enrdf_load_html_response)
BE (1) BE857506A (enrdf_load_html_response)
BG (1) BG31073A3 (enrdf_load_html_response)
CA (1) CA1077948A (enrdf_load_html_response)
CH (1) CH624934A5 (enrdf_load_html_response)
CS (1) CS221269B2 (enrdf_load_html_response)
DD (2) DD136135A5 (enrdf_load_html_response)
DE (1) DE2735904A1 (enrdf_load_html_response)
DK (1) DK352077A (enrdf_load_html_response)
ES (2) ES461388A1 (enrdf_load_html_response)
FI (1) FI70009C (enrdf_load_html_response)
FR (1) FR2369260A1 (enrdf_load_html_response)
GB (2) GB1556569A (enrdf_load_html_response)
GR (1) GR68688B (enrdf_load_html_response)
HU (1) HU180273B (enrdf_load_html_response)
IE (1) IE45505B1 (enrdf_load_html_response)
IL (1) IL52615A (enrdf_load_html_response)
LU (1) LU77936A1 (enrdf_load_html_response)
NL (1) NL7708637A (enrdf_load_html_response)
NO (1) NO772752L (enrdf_load_html_response)
NZ (1) NZ184806A (enrdf_load_html_response)
PH (1) PH17398A (enrdf_load_html_response)
PL (2) PL200124A1 (enrdf_load_html_response)
PT (1) PT66891B (enrdf_load_html_response)
SE (1) SE423813B (enrdf_load_html_response)
SU (3) SU703016A3 (enrdf_load_html_response)
YU (1) YU192577A (enrdf_load_html_response)
ZA (1) ZA774704B (enrdf_load_html_response)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5695569A (en) * 1979-12-27 1981-08-03 Canon Inc Forming method for bar lens sphere face
US4321201A (en) * 1980-09-22 1982-03-23 E. I. Du Pont De Nemours And Company Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl) heptanoates
PT1132086E (pt) 2000-01-31 2006-09-29 Pfizer Prod Inc Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica
AU2001290250A1 (en) * 2000-09-21 2002-04-02 Ono Pharmaceutical Co. Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
OA12533A (en) * 2000-11-27 2006-06-05 Pfizer Prod Inc Ep4 receptor selective agonists in the treatment of osteoporosis.
KR20070087078A (ko) * 2001-07-23 2007-08-27 오노 야꾸힝 고교 가부시키가이샤 Ｅｐ４ 아고니스트를 유효 성분으로 하는 골량 저하 질환의치료제
JP2005531516A (ja) * 2002-03-18 2005-10-20 ファイザー・プロダクツ・インク 選択的ｅｐ４受容体アゴニストによる治療方法
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
JP4582456B2 (ja) * 2003-01-21 2010-11-17 小野薬品工業株式会社 ８−アザプロスタグランジン誘導体およびその医薬用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1386146A (en) * 1972-05-03 1975-03-05 Ici Ltd Cyclopentane derivatives
JPS511460A (en) * 1974-06-24 1976-01-08 Tanabe Seiyaku Co 22 piroridonjudotaino seiho
JPS514166A (ja) * 1974-06-28 1976-01-14 Tanabe Seiyaku Co 22piroridonjudotaino seiho
US3975399A (en) * 1974-08-06 1976-08-17 E. I. Du Pont De Nemours And Company 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones
DE2528664A1 (de) * 1975-06-27 1977-01-13 Hoechst Ag Pyrrolidone und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
BE857506A (fr) 1978-02-06
BG31073A3 (bg) 1981-10-15
PT66891B (en) 1979-01-26
NO772752L (no) 1978-02-07
DD136135A5 (de) 1979-06-20
SE7708642L (sv) 1978-02-07
PL112931B1 (en) 1980-11-29
SE423813B (sv) 1982-06-07
CH624934A5 (enrdf_load_html_response) 1981-08-31
AR217080A1 (es) 1980-02-29
SU850000A3 (ru) 1981-07-23
FR2369260B1 (enrdf_load_html_response) 1982-02-12
SU703016A3 (ru) 1979-12-05
AU2751577A (en) 1979-02-08
LU77936A1 (enrdf_load_html_response) 1978-04-27
CS221269B2 (en) 1983-04-29
NZ184806A (en) 1980-04-28
FI70009C (fi) 1986-09-12
JPS5555161A (en) 1980-04-22
DK352077A (da) 1978-02-07
PT66891A (en) 1977-09-01
ES461388A1 (es) 1978-12-01
FI772376A7 (enrdf_load_html_response) 1978-02-07
PL200124A1 (pl) 1978-05-22
IL52615A0 (en) 1977-10-31
NL7708637A (nl) 1978-02-08
IE45505L (en) 1978-02-06
JPS585196B2 (ja) 1983-01-29
ES471349A1 (es) 1979-09-16
GR68688B (enrdf_load_html_response) 1982-02-01
DD143768A5 (de) 1980-09-10
GB1556570A (en) 1979-11-28
FI70009B (fi) 1986-01-31
AU508007B2 (en) 1980-03-06
DE2735904A1 (de) 1978-02-09
GB1556569A (en) 1979-11-28
PH17398A (en) 1984-08-08
ZA774704B (en) 1978-06-28
JPS5321159A (en) 1978-02-27
IE45505B1 (en) 1982-09-08
HU180273B (en) 1983-02-28
JPS5531147B2 (enrdf_load_html_response) 1980-08-15
AT362887B (de) 1981-06-25
IL52615A (en) 1981-09-13
ATA579477A (de) 1980-11-15
SU818480A3 (ru) 1981-03-30
YU192577A (en) 1983-04-30
FR2369260A1 (fr) 1978-05-26

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Legal Events

Date Code Title Description
MKEX Expiry