CA1063107A - Process for producing 2-substituted 1,4-benzodiazepine derivatives - Google Patents

Process for producing 2-substituted 1,4-benzodiazepine derivatives

Info

Publication number
CA1063107A
CA1063107A CA252,134A CA252134A CA1063107A CA 1063107 A CA1063107 A CA 1063107A CA 252134 A CA252134 A CA 252134A CA 1063107 A CA1063107 A CA 1063107A
Authority
CA
Canada
Prior art keywords
methyl
phenyl
benzodiazepine
bromo
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA252,134A
Other languages
English (en)
French (fr)
Inventor
Werner Stuhmer
Horst Zeugner
Wolfgang Milkowski
Renke Budden
Hans Liepmann
Siegfried Funke
Rolf Huschens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kali Chemie AG
Original Assignee
Kali Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie AG filed Critical Kali Chemie AG
Application granted granted Critical
Publication of CA1063107A publication Critical patent/CA1063107A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D245/06—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA252,134A 1975-05-10 1976-05-10 Process for producing 2-substituted 1,4-benzodiazepine derivatives Expired CA1063107A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2520937A DE2520937C3 (de) 1975-05-10 1975-05-10 7-Brom-1 -methyl^-alkoxymethyl-S-(2-halogenphenyl)-lH-23-dihydro-l,4benzodiazepinderivate, deren Säureadditionssalze und pharmazeutische Präparate

Publications (1)

Publication Number Publication Date
CA1063107A true CA1063107A (en) 1979-09-25

Family

ID=5946275

Family Applications (1)

Application Number Title Priority Date Filing Date
CA252,134A Expired CA1063107A (en) 1975-05-10 1976-05-10 Process for producing 2-substituted 1,4-benzodiazepine derivatives

Country Status (28)

Country Link
JP (2) JPS51149293A (de)
AR (1) AR209361A1 (de)
AT (1) AT353274B (de)
AU (1) AU498994B2 (de)
BE (1) BE841549A (de)
CA (1) CA1063107A (de)
CH (1) CH626076A5 (de)
CS (1) CS193075B2 (de)
DD (1) DD124600A5 (de)
DE (1) DE2520937C3 (de)
DK (1) DK145930C (de)
ES (1) ES447737A1 (de)
FI (2) FI62072C (de)
FR (1) FR2310765A1 (de)
GB (1) GB1477999A (de)
GR (1) GR60311B (de)
HU (1) HU174020B (de)
IL (1) IL49548A (de)
MX (1) MX3903E (de)
NL (1) NL187631C (de)
NO (1) NO146238C (de)
NZ (1) NZ180812A (de)
PH (1) PH14964A (de)
PT (1) PT65083B (de)
SE (1) SE422938B (de)
SU (1) SU1126209A3 (de)
YU (1) YU117076A (de)
ZA (1) ZA762785B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2720968C2 (de) * 1977-05-10 1986-05-07 Kali-Chemie Pharma Gmbh, 3000 Hannover N↓1↓-Acyl-2-hydroxy-1,3-diaminopropane und Arzneimittel
DE2835708A1 (de) 1978-08-16 1980-03-06 Kali Chemie Pharma Gmbh Neue eckige klammer auf 1,2 eckige klammer zu-anellierte 7-phenyl-1,4-benzodiazepinderivate, verfahren zu deren herstellung und arzneimittel
DE3138769A1 (de) * 1981-09-30 1983-04-14 Kali-Chemie Pharma Gmbh, 3000 Hannover 7-brom-5-(2-halogenphenyl)-1h-2,3-dihydro-1,4- benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JP4940065B2 (ja) * 2007-08-29 2012-05-30 トヨタ紡織株式会社 グリースの塗布方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2265371C3 (de) * 1972-05-03 1980-12-11 Kali-Chemie Ag, 3000 Hannover N-(3-Benzoylaminopropyl)-aniline

Also Published As

Publication number Publication date
ZA762785B (en) 1977-04-27
JPS51149293A (en) 1976-12-22
SE422938B (sv) 1982-04-05
PH14964A (en) 1982-02-05
JPS61178970A (ja) 1986-08-11
DK205676A (da) 1976-11-11
ES447737A1 (es) 1977-06-01
DE2520937C3 (de) 1978-10-12
DE2520937A1 (de) 1976-11-18
DK145930C (da) 1983-09-26
PT65083A (en) 1976-06-01
ATA335776A (de) 1979-04-15
CH626076A5 (en) 1981-10-30
MX3903E (es) 1981-09-11
FI62072B (fi) 1982-07-30
NO146238B (no) 1982-05-18
YU117076A (en) 1982-08-31
AT353274B (de) 1979-11-12
FR2310765B1 (de) 1979-07-13
DD124600A5 (de) 1977-03-02
FI813680L (fi) 1981-11-19
NO146238C (no) 1982-08-25
FI761284A (de) 1976-11-11
JPS6212222B2 (de) 1987-03-17
AU1377976A (en) 1977-11-17
IL49548A0 (en) 1976-07-30
FI62072C (fi) 1982-11-10
CS193075B2 (en) 1979-09-17
NO761581L (de) 1976-11-11
FR2310765A1 (fr) 1976-12-10
HU174020B (hu) 1979-10-28
SE7605200L (sv) 1976-11-11
AU498994B2 (en) 1979-03-29
DE2520937B2 (de) 1978-02-16
SU1126209A3 (ru) 1984-11-23
PT65083B (en) 1977-09-14
DK145930B (da) 1983-04-18
BE841549A (fr) 1976-09-01
NL7604974A (nl) 1976-11-12
GB1477999A (en) 1977-06-29
NL187631C (nl) 1991-12-02
AR209361A1 (es) 1977-04-15
NZ180812A (en) 1978-03-06
GR60311B (en) 1978-05-08
IL49548A (en) 1980-02-29

Similar Documents

Publication Publication Date Title
Sternbach et al. Quinazolines and 1, 4-Benzodiazepines. VI. 1a Halo-, Methyl-, and Methoxy-substituted 1, 3-Dihydro-5-phenyl-2H-1, 4-benzodiazepin-2-ones1b, c
EP0005205B1 (de) Substituierte 5,6-Dimethylpyrrolo(2,3-d)pyrimidine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4614740A (en) 5H-2,3-benzodiazepine derivatives and pharmaceutical compositions containing the same
US4108852A (en) Process for preparing 1,5-benzodiazepine-2-ones
USRE30293E (en) Process for preparing 1,5-benzodiazepine-2-ones
US4096261A (en) Dibenzodiazepines
AU569537B2 (en) Novel 1-piperazinecarboxamide derivatives
CA1063107A (en) Process for producing 2-substituted 1,4-benzodiazepine derivatives
DE2118261A1 (de) Neue N-haltige Bicyclen, deren Säureadditionssalze sowie Verfahren zu deren Herstellung
US4170649A (en) 1,4-Benzodiazepine derivatives, pharmaceutical compositions thereof, and process for their preparation
EP1105392B1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
JPH04282374A (ja) 新規５ｈ−ベンゾジアゼピン誘導体、それを含有してなる製剤組成物、およびそれらの製造方法
NO131546B (de)
US3903103A (en) 4-Amino-s-triazolo-{8 4,3-a{9 {8 1,4{9 benzodiazepine
US4191760A (en) Dibenzodiazepines
US3959278A (en) Method of synthesis of pteridines
US3389176A (en) 2-aminophenyl-cycloalkyl-ketoximes
US4244869A (en) Benzodiazepine derivatives and process of making them
DE2308280A1 (de) Verfahren zur herstellung von neuen diazepinderivaten
EP0623118B1 (de) Carbaminsäure estern derivate und deren verwendung in heilmittel
US4239684A (en) 1,5'-Benzodiazepine-2-ones, pharmaceutical compositions thereof and method of use thereof
CH644380A5 (de) Benzodiazepinderivate.
US3179656A (en) Azepine x-oxidss
US3336296A (en) Preparation of 5-substituted-2h-1, 4-benzodiazepin-2-one-4-oxides
US3338886A (en) 5-cycloalkyl-3h-1, 4-benzodiazepin-2(1h)-ones