BRPI0913590A2 - novos compostos de uracila ou sal dos mesmos tendo uma atividade inibitória deoxiuridina trifosfatase humana - Google Patents
novos compostos de uracila ou sal dos mesmos tendo uma atividade inibitória deoxiuridina trifosfatase humanaInfo
- Publication number
- BRPI0913590A2 BRPI0913590A2 BRPI0913590A BRPI0913590A BRPI0913590A2 BR PI0913590 A2 BRPI0913590 A2 BR PI0913590A2 BR PI0913590 A BRPI0913590 A BR PI0913590A BR PI0913590 A BRPI0913590 A BR PI0913590A BR PI0913590 A2 BRPI0913590 A2 BR PI0913590A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitory activity
- salt compounds
- deoxyuridine triphosphatase
- novel uracil
- human deoxyuridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008-146334 | 2008-06-03 | ||
| JP2008146334 | 2008-06-03 | ||
| PCT/JP2009/002481 WO2009147843A1 (ja) | 2008-06-03 | 2009-06-02 | ヒトデオキシウリジントリホスファターゼ阻害活性を有する新規ウラシル化合物又はその塩 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0913590A2 true BRPI0913590A2 (pt) | 2015-10-20 |
| BRPI0913590B1 BRPI0913590B1 (pt) | 2021-07-06 |
Family
ID=41397926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0913590-1A BRPI0913590B1 (pt) | 2008-06-03 | 2009-06-02 | Composto de uracila ou sal do mesmo tendo uma atividade inibitória de deoxiuridina trifosfatase humana, composição farmacêutica e inibidor dutpase que compreendem o dito composto de uracila e uso terapêutico do mesmo |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8530490B2 (pt) |
| EP (1) | EP2295414B1 (pt) |
| JP (1) | JP4688975B2 (pt) |
| KR (1) | KR101384940B1 (pt) |
| CN (1) | CN102056905B (pt) |
| AU (1) | AU2009254656B2 (pt) |
| BR (1) | BRPI0913590B1 (pt) |
| CA (1) | CA2726579C (pt) |
| CY (1) | CY1113244T1 (pt) |
| DK (1) | DK2295414T3 (pt) |
| ES (1) | ES2392220T3 (pt) |
| HK (1) | HK1154385A1 (pt) |
| HR (1) | HRP20120820T1 (pt) |
| MX (1) | MX2010013275A (pt) |
| MY (1) | MY149180A (pt) |
| PL (1) | PL2295414T3 (pt) |
| PT (1) | PT2295414E (pt) |
| RU (1) | RU2495873C2 (pt) |
| SI (1) | SI2295414T1 (pt) |
| TW (1) | TWI466871B (pt) |
| WO (1) | WO2009147843A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2906227T3 (es) * | 2009-11-30 | 2022-04-13 | Taiho Pharmaceutical Co Ltd | Potenciador de efecto antitumoral |
| AU2012234259A1 (en) * | 2011-03-31 | 2013-10-03 | Libera-Korner, Jeanette | Perfluorinated compounds for the non-viral transfer of nucleic acids |
| US9809571B2 (en) | 2013-01-07 | 2017-11-07 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2015103489A1 (en) | 2014-01-03 | 2015-07-09 | University Of Southern California | Heteroatom containing deoxyuridine triphosphatase inhibitors |
| US20180110780A1 (en) * | 2015-04-30 | 2018-04-26 | Taiho Pharmaceutical Co., Ltd. | Agent for alleviating side effect of antitumor drug |
| MY185785A (en) * | 2015-05-01 | 2021-06-08 | Taiho Pharmaceutical Co Ltd | Novel crystal of uracil compound |
| WO2017006283A1 (en) | 2015-07-08 | 2017-01-12 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| WO2017006270A1 (en) * | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| JP6836589B2 (ja) | 2015-07-08 | 2021-03-03 | シーブイ６ セラピューティクス （エヌアイ） リミテッド | ヒダントインを含むデオキシウリジントリホスファターゼ阻害剤 |
| MA43590A (fr) | 2016-01-08 | 2018-11-14 | Taiho Pharmaceutical Co Ltd | Agent antitumoral contenant un immunomodulateur et un amplificateur d'effet antitumoral |
| US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| WO2018098208A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| US11174271B2 (en) | 2016-11-23 | 2021-11-16 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| WO2018098209A1 (en) * | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| WO2018128720A1 (en) * | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| US20230263773A1 (en) | 2020-06-26 | 2023-08-24 | Cv6 Therapeutics (Ni) Limited | Combination therapy with deoxyuridine triphosphatase inhibitors |
| CN111763176A (zh) * | 2020-07-10 | 2020-10-13 | 常州制药厂有限公司 | 一种GnRH受体拮抗剂关键中间体及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341161A1 (de) | 1993-12-02 | 1995-06-08 | Michael Prof Dr Zeppezauer | Membrangängiger Wirkstoff zur Störung der DNA-Biosynthese |
| AU681321B2 (en) * | 1995-03-29 | 1997-08-21 | Taiho Pharmaceutical Co., Ltd. | Uracil derivatives, and antitumor effect potentiator and antitumor agent containing the same |
| RU2102390C1 (ru) * | 1996-06-06 | 1998-01-20 | Научно-исследовательская лаборатория иммунохимиотерапии лепры и иммунотропных средств с клиникой и опытно-экспериментальным производством МЗМП России | N-(6-метил-2,4-диоксо-1,2,3,4-тетрагидропиримидинил-5-сульфонил) пиразин-2-карбоксамид, обладающий противолепрозной, противотуберкулезной и иммунотропной активностью, способ его получения |
| JP2002028486A (ja) * | 2000-07-14 | 2002-01-29 | Toyobo Co Ltd | アルデヒド類吸着分解剤及びその製造方法 |
| JP2002284686A (ja) | 2001-03-28 | 2002-10-03 | Sankyo Co Ltd | スルホンアミド化合物を含有する医薬組成物 |
| AU2003218933A1 (en) | 2002-04-17 | 2003-11-03 | Affinium Pharmaceuticals, Inc. | Purified dutpase from helicobacter pylori |
| GB0219896D0 (en) | 2002-08-27 | 2002-10-02 | Bayer Ag | Dihydropyridine derivatives |
| JP4534122B2 (ja) * | 2003-12-26 | 2010-09-01 | トヨタ自動車株式会社 | ハイブリッドシステム |
| GB0400290D0 (en) * | 2004-01-08 | 2004-02-11 | Medivir Ab | dUTPase inhibitors |
| BRPI0714880A2 (pt) * | 2006-07-24 | 2013-05-21 | Gilead Sciences Inc | inibidores da transcriptase reversa do hiv |
| ES2906227T3 (es) * | 2009-11-30 | 2022-04-13 | Taiho Pharmaceutical Co Ltd | Potenciador de efecto antitumoral |
-
2009
- 2009-06-02 AU AU2009254656A patent/AU2009254656B2/en active Active
- 2009-06-02 PL PL09758110T patent/PL2295414T3/pl unknown
- 2009-06-02 KR KR1020107026676A patent/KR101384940B1/ko active IP Right Grant
- 2009-06-02 JP JP2010515773A patent/JP4688975B2/ja active Active
- 2009-06-02 BR BRPI0913590-1A patent/BRPI0913590B1/pt active IP Right Grant
- 2009-06-02 WO PCT/JP2009/002481 patent/WO2009147843A1/ja active Application Filing
- 2009-06-02 US US12/996,079 patent/US8530490B2/en active Active
- 2009-06-02 RU RU2010154425/04A patent/RU2495873C2/ru active
- 2009-06-02 ES ES09758110T patent/ES2392220T3/es active Active
- 2009-06-02 EP EP09758110A patent/EP2295414B1/en active Active
- 2009-06-02 SI SI200930396T patent/SI2295414T1/sl unknown
- 2009-06-02 TW TW98118261A patent/TWI466871B/zh active
- 2009-06-02 CN CN200980120862.5A patent/CN102056905B/zh active Active
- 2009-06-02 DK DK09758110.2T patent/DK2295414T3/da active
- 2009-06-02 CA CA2726579A patent/CA2726579C/en active Active
- 2009-06-02 MX MX2010013275A patent/MX2010013275A/es active IP Right Grant
- 2009-06-02 PT PT09758110T patent/PT2295414E/pt unknown
- 2009-06-02 MY MYPI2010005742A patent/MY149180A/en unknown
-
2011
- 2011-08-15 HK HK11108513.8A patent/HK1154385A1/xx unknown
-
2012
- 2012-10-11 HR HRP20120820AT patent/HRP20120820T1/hr unknown
- 2012-10-19 CY CY20121100981T patent/CY1113244T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20120820T1 (hr) | 2012-11-30 |
| KR20110013427A (ko) | 2011-02-09 |
| EP2295414A1 (en) | 2011-03-16 |
| MX2010013275A (es) | 2011-03-15 |
| CN102056905A (zh) | 2011-05-11 |
| MY149180A (en) | 2013-07-31 |
| EP2295414A4 (en) | 2011-09-14 |
| CY1113244T1 (el) | 2016-04-13 |
| DK2295414T3 (da) | 2012-10-22 |
| BRPI0913590B1 (pt) | 2021-07-06 |
| JP4688975B2 (ja) | 2011-05-25 |
| AU2009254656A2 (en) | 2011-01-13 |
| US20110082163A1 (en) | 2011-04-07 |
| JPWO2009147843A1 (ja) | 2011-10-27 |
| KR101384940B1 (ko) | 2014-04-11 |
| RU2010154425A (ru) | 2012-07-20 |
| PL2295414T3 (pl) | 2013-02-28 |
| HK1154385A1 (en) | 2012-04-20 |
| WO2009147843A1 (ja) | 2009-12-10 |
| EP2295414B1 (en) | 2012-09-26 |
| CA2726579C (en) | 2015-02-17 |
| ES2392220T3 (es) | 2012-12-05 |
| PT2295414E (pt) | 2012-11-30 |
| TW201000452A (en) | 2010-01-01 |
| US8530490B2 (en) | 2013-09-10 |
| AU2009254656A1 (en) | 2009-12-10 |
| CA2726579A1 (en) | 2009-12-10 |
| RU2495873C2 (ru) | 2013-10-20 |
| AU2009254656B2 (en) | 2013-07-18 |
| CN102056905B (zh) | 2014-03-26 |
| SI2295414T1 (sl) | 2012-12-31 |
| TWI466871B (zh) | 2015-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/06/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |