BRPI0821616B8 - composição micelar de copolímero de bloco anfifílico contendo taxano e método para preparação da mesma - Google Patents
composição micelar de copolímero de bloco anfifílico contendo taxano e método para preparação da mesmaInfo
- Publication number
- BRPI0821616B8 BRPI0821616B8 BRPI0821616A BRPI0821616A BRPI0821616B8 BR PI0821616 B8 BRPI0821616 B8 BR PI0821616B8 BR PI0821616 A BRPI0821616 A BR PI0821616A BR PI0821616 A BRPI0821616 A BR PI0821616A BR PI0821616 B8 BRPI0821616 B8 BR PI0821616B8
- Authority
- BR
- Brazil
- Prior art keywords
- block copolymer
- preparing
- composition
- amphiphilic block
- same
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
- C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
- C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/15—Heterocyclic compounds having oxygen in the ring
- C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
- C08K5/1525—Four-membered rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Biological Depolymerization Polymers (AREA)
- Colloid Chemistry (AREA)
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2007-0141181 | 2007-12-31 | ||
KR20070141181 | 2007-12-31 | ||
KR1020080098521A KR101024742B1 (ko) | 2007-12-31 | 2008-10-08 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
KR10-2008-0098521 | 2008-10-08 | ||
PCT/KR2008/006021 WO2009084801A1 (en) | 2007-12-31 | 2008-10-13 | Amphiphilic block copolymer micelle composition containing taxane and manufacturing process of the same |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0821616A2 BRPI0821616A2 (pt) | 2015-06-16 |
BRPI0821616B1 BRPI0821616B1 (pt) | 2020-10-06 |
BRPI0821616B8 true BRPI0821616B8 (pt) | 2021-05-25 |
Family
ID=41331066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0821616A BRPI0821616B8 (pt) | 2007-12-31 | 2008-10-13 | composição micelar de copolímero de bloco anfifílico contendo taxano e método para preparação da mesma |
Country Status (8)
Country | Link |
---|---|
US (1) | US20100286075A1 (pt) |
JP (2) | JP2011509322A (pt) |
KR (1) | KR101024742B1 (pt) |
CN (2) | CN104098780A (pt) |
AU (1) | AU2008344184B2 (pt) |
BR (1) | BRPI0821616B8 (pt) |
CA (1) | CA2709993C (pt) |
RU (1) | RU2449785C2 (pt) |
Families Citing this family (24)
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EP2376062B1 (en) * | 2008-12-26 | 2017-04-26 | Samyang Biopharmaceuticals Corporation | Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug |
KR101224004B1 (ko) * | 2009-12-29 | 2013-01-22 | 주식회사 삼양바이오팜 | 단백질, 폴리펩타이드 또는 펩타이드 약물 전달용 고분자 및 그 제조방법, 및 단백질, 폴리펩타이드 또는 펩타이드 약물의 서방형 조성물 및 그 제조 방법 |
EP2712611A1 (en) * | 2012-09-27 | 2014-04-02 | B. Braun Melsungen AG | Stabilized aqueous compositions of neuromuscular blocking agents |
CN103772686B (zh) | 2012-10-26 | 2015-01-07 | 苏州雷纳药物研发有限公司 | 一种两亲性嵌段共聚物及其制备方法、以及该共聚物与抗肿瘤药物形成的胶束载药系统 |
CN103768013A (zh) * | 2014-01-17 | 2014-05-07 | 丽珠医药集团股份有限公司 | 以精制两亲性嵌段共聚物为载体的紫杉醇聚合物胶束 |
CN104758256B (zh) * | 2014-02-14 | 2016-05-04 | 苏州海特比奥生物技术有限公司 | 一种多西他赛纳米聚合物胶束冻干制剂及其制备方法 |
CN104511021A (zh) * | 2014-05-10 | 2015-04-15 | 上海珀理玫化学科技有限公司 | 一种不含赋形剂的紫杉醇冻干粉制剂及其制备方法 |
RU2617059C2 (ru) * | 2014-11-11 | 2017-04-19 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова" (ФГБНУ НИИВС им. И.И. Мечникова) | Способ получения амфифильных блок-сополимеров N,N-диметиламиноэтилметакрилата для доставки нуклеиновых кислот в живые клетки |
JP6487051B2 (ja) | 2014-12-30 | 2019-03-20 | サムヤン バイオファーマシューティカルズ コーポレイションSamyang Biopharmaceuticals Corporation | ポリマーナノ粒子の凍結乾燥物、及びその製造方法 |
CN104856974A (zh) * | 2015-05-15 | 2015-08-26 | 海南圣欣医药科技有限公司 | 一种难溶性抗肿瘤药物胶束制剂及其制法 |
KR101787447B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
KR101787453B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
KR101748191B1 (ko) * | 2015-07-28 | 2017-06-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
KR101787451B1 (ko) * | 2015-07-28 | 2017-10-19 | 주식회사 삼양바이오팜 | 보관 안정성이 향상된 약학 조성물 및 그의 제조 방법 |
US20170028068A1 (en) | 2015-07-29 | 2017-02-02 | Samyang Biopharmaceuticals Corporation | Pharmaceutical composition with improved storage stability and method for preparing the same |
KR101906321B1 (ko) * | 2016-07-06 | 2018-10-10 | 주식회사 삼양바이오팜 | 수난용성 약물을 포함하는 고분자 미셀 제제의 시험관 내 방출시험 및 평가 방법 |
CA3031691A1 (en) | 2016-09-13 | 2018-03-22 | Rasna Research Inc. | Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
WO2018110870A1 (ko) * | 2016-12-14 | 2018-06-21 | 주식회사 삼양바이오팜 | 미셀 안정성이 향상된 양친성 블록 공중합체 조성물 및 이를 포함하는 약학 조성물 |
CN107625730B (zh) * | 2017-09-21 | 2019-09-17 | 上海凯茂生物医药有限公司 | 制备极窄范围的8至35nm粒径的含紫杉烷的两亲嵌段共聚物胶束组合物的方法 |
CN107998405B (zh) * | 2017-12-14 | 2019-05-07 | 江西本草天工科技有限责任公司 | 包含难溶性药物的no供体型聚合胶束组合物的制备方法及应用 |
US20190231689A1 (en) * | 2018-01-29 | 2019-08-01 | Samyang Biopharmaceuticals Corporation | Amphiphilic Block Copolymer Composition With Enhanced Micelle Stability |
KR102072419B1 (ko) * | 2018-04-19 | 2020-02-03 | 중앙대학교 산학협력단 | 항암제 봉입 마이셀 제제 조성물 |
CN117651571A (zh) * | 2021-07-21 | 2024-03-05 | 三养控股公司 | 用于组织修复的粉末制剂及其制备方法以及包含该粉末制剂的用于组织修复的注射剂组合物 |
KR102640099B1 (ko) * | 2022-11-17 | 2024-02-23 | 주식회사 삼양홀딩스 | 조직 수복용 분말 제형 및 이를 포함하는 조직 수복용 주사제 조성물 |
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-
2008
- 2008-10-08 KR KR1020080098521A patent/KR101024742B1/ko active IP Right Grant
- 2008-10-13 JP JP2010540552A patent/JP2011509322A/ja active Pending
- 2008-10-13 US US12/810,473 patent/US20100286075A1/en not_active Abandoned
- 2008-10-13 AU AU2008344184A patent/AU2008344184B2/en active Active
- 2008-10-13 CN CN201410376919.0A patent/CN104098780A/zh active Pending
- 2008-10-13 BR BRPI0821616A patent/BRPI0821616B8/pt active IP Right Grant
- 2008-10-13 RU RU2010130427/15A patent/RU2449785C2/ru active
- 2008-10-13 CN CN200880123622.6A patent/CN101910274B/zh active Active
- 2008-10-13 CA CA2709993A patent/CA2709993C/en active Active
-
2014
- 2014-11-04 JP JP2014224575A patent/JP5981514B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
CN101910274B (zh) | 2014-07-30 |
JP2015034172A (ja) | 2015-02-19 |
BRPI0821616A2 (pt) | 2015-06-16 |
BRPI0821616B1 (pt) | 2020-10-06 |
CN104098780A (zh) | 2014-10-15 |
AU2008344184B2 (en) | 2012-02-02 |
CA2709993A1 (en) | 2009-07-09 |
JP5981514B2 (ja) | 2016-08-31 |
JP2011509322A (ja) | 2011-03-24 |
US20100286075A1 (en) | 2010-11-11 |
CN101910274A (zh) | 2010-12-08 |
CA2709993C (en) | 2013-07-23 |
RU2010130427A (ru) | 2012-02-10 |
AU2008344184A1 (en) | 2009-07-09 |
KR101024742B1 (ko) | 2011-03-24 |
KR20090073970A (ko) | 2009-07-03 |
RU2449785C2 (ru) | 2012-05-10 |
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