BRPI0814582A2 - Dispositivo, método, e, usos de um método, e da quantidade de ácidos nucleicos virais totais. - Google Patents

Dispositivo, método, e, usos de um método, e da quantidade de ácidos nucleicos virais totais.

Info

Publication number
BRPI0814582A2
BRPI0814582A2 BRPI0814582-2A2A BRPI0814582A BRPI0814582A2 BR PI0814582 A2 BRPI0814582 A2 BR PI0814582A2 BR PI0814582 A BRPI0814582 A BR PI0814582A BR PI0814582 A2 BRPI0814582 A2 BR PI0814582A2
Authority
BR
Brazil
Prior art keywords
nucleic acids
viral nucleic
total viral
total
acids
Prior art date
Application number
BRPI0814582-2A2A
Other languages
English (en)
Inventor
Eugen Ermantraut
Thomas Kaiser
Torsten Schulz
Katrin Steinmetzer
Thomas Ullrich
Original Assignee
Clondiag Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clondiag Gmbh filed Critical Clondiag Gmbh
Publication of BRPI0814582A2 publication Critical patent/BRPI0814582A2/pt
Publication of BRPI0814582B1 publication Critical patent/BRPI0814582B1/pt

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/708Specific hybridization probes for papilloma
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • AIDS & HIV (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
BRPI0814582-2A 2007-07-23 2008-07-23 método, e, uso da carga viral total em uma amostra de sangue integral não tratada BRPI0814582B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95135807P 2007-07-23 2007-07-23
US60/951,358 2007-07-23
PCT/EP2008/059670 WO2009013321A2 (en) 2007-07-23 2008-07-23 Assays

Publications (2)

Publication Number Publication Date
BRPI0814582A2 true BRPI0814582A2 (pt) 2015-01-20
BRPI0814582B1 BRPI0814582B1 (pt) 2021-05-11

Family

ID=39885074

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814582-2A BRPI0814582B1 (pt) 2007-07-23 2008-07-23 método, e, uso da carga viral total em uma amostra de sangue integral não tratada

Country Status (11)

Country Link
US (1) US9925536B2 (pt)
EP (6) EP2626434B1 (pt)
JP (5) JP5859203B2 (pt)
CN (2) CN105543084B (pt)
AU (1) AU2008280121B2 (pt)
BR (1) BRPI0814582B1 (pt)
CA (2) CA3006347A1 (pt)
ES (2) ES2722874T3 (pt)
NZ (1) NZ582786A (pt)
WO (1) WO2009013321A2 (pt)
ZA (1) ZA201000845B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3006347A1 (en) 2007-07-23 2009-01-29 Clondiag Gmbh Methods and devices for determining values indicative of the presence and/or amount of nucleic acids
KR101130698B1 (ko) * 2009-11-03 2012-04-02 삼성전자주식회사 밸브 유닛과 이를 구비한 미세유동장치 및 밸브 유닛의 구동방법
FR2967362B1 (fr) * 2010-11-16 2012-12-21 Genewave Cartouche microfluidique pour diagnostic moleculaire
CN103442809B (zh) 2010-12-03 2016-09-14 美艾利尔技术公司 通过激光照射把材料转换成光学调制状态
US9822890B2 (en) * 2011-08-30 2017-11-21 The Royal Institution For The Advancement Of Learning/Mcgill University Method and system for pre-programmed self-power microfluidic circuits
WO2013096804A2 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Optical assay device with pneumatic sample actuation
CN104053992B (zh) * 2012-01-16 2016-12-14 皇家飞利浦有限公司 确定包括细胞的体液中的靶分子的存在
WO2013116864A1 (en) * 2012-02-03 2013-08-08 Lawrence Livermore National Security Rigid stiffener-reinforced flexible neural probes, and methods of fabrication using wicking channel-distributed adhesives and tissue insertion and extraction
US8804105B2 (en) * 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
CN104508492B (zh) * 2012-05-25 2018-07-27 北卡罗来纳-查佩尔山大学 微流体装置、用于试剂的固体支持体和相关方法
AU2013303237A1 (en) * 2012-08-16 2015-04-09 NVS Technologies, Inc. Assay methods and systems
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
JP6298474B2 (ja) * 2012-12-17 2018-03-20 レウコドゥックス,リミテッド 生物学的状態を検出するシステムおよび方法
KR102529007B1 (ko) * 2013-03-15 2023-05-03 나노바이오심 인크. 핵산들 및 단백질들의 모바일 디바이스 분석을 위한 시스템들 및 방법들
CN105492887A (zh) * 2013-03-15 2016-04-13 理查德·哈理·特纳 用于体液中的颗粒和可溶性化学实体的体外检测的系统和方法
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
CN105609507B (zh) * 2014-11-17 2018-09-07 华邦电子股份有限公司 软性微系统结构
ES2822989T3 (es) * 2015-04-07 2021-05-05 Cell Id Pte Ltd Calentador de corriente continua
CN108025304B (zh) 2015-07-22 2022-01-21 北卡罗来纳-查佩尔山大学 含有具有空间分离的珠保留和信号检测段的珠孔几何结构的流体装置和相关方法
JP6619577B2 (ja) * 2015-08-05 2019-12-11 アルプスアルパイン株式会社 流路構造体、測定ユニット、測定対象液体の測定方法、および測定対象液体の測定装置
PT3436198T (pt) * 2016-03-29 2022-07-13 Univ Rice William M Deteção de ácido nucleico baseada em superfícies num dispositivo fluídico de fluxo de convecção
CN109070076B (zh) * 2016-04-22 2021-10-08 惠普发展公司,有限责任合伙企业 细胞裂解
US20190240661A1 (en) * 2016-10-07 2019-08-08 Boehringer Ingelheim Vetmedica Gmbh Cartridge and analysis system for testing a sample
IT201600104601A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico
JP6978255B2 (ja) * 2017-08-31 2021-12-08 日東電工株式会社 液体吐出装置及び測定用テープ
WO2019070739A1 (en) * 2017-10-03 2019-04-11 Avails Medical, Inc. APPARATUSES, SYSTEMS AND METHODS FOR DETERMINING THE CONCENTRATION OF MICROORGANISMS AND THE SENSITIVITY OF MICROORGANISMS TO ANTI-INFECTIOUS, BASED ON OXIDOREDUCTION REACTIONS
KR102263976B1 (ko) * 2017-12-15 2021-06-14 프리시젼바이오 주식회사 진단 시스템
EP3774046A1 (en) * 2018-04-06 2021-02-17 Boehringer Ingelheim Vetmedica GmbH Analysis device, cartridge, analysis system and method for testing a sample
FR3088340B1 (fr) * 2018-11-12 2021-01-22 Commissariat Energie Atomique Systeme automatise de preparation, de detection et d'analyse d'un echantillon fluidique
CN109884063B (zh) * 2019-04-24 2021-08-20 杭州翔毅科技有限公司 一种用于液体传感器的采集结构
EP3766578A1 (en) * 2019-07-18 2021-01-20 Blink AG A liquid handling and processing tool for analyzing a biological sample
WO2022036323A1 (en) * 2020-08-14 2022-02-17 Ohio State Innovation Foundation Liquid crystal biosensor with ultrahigh sensitivity and selectivity
KR20220120516A (ko) * 2021-02-23 2022-08-30 모던밸류 주식회사 열제어부가 통합된, turn-off 방식의 광신호 측정용 액적 로딩 카트리지
DE102021203409A1 (de) * 2021-04-07 2022-10-13 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zum Nachweis aktiver Viren
CN113101991B (zh) * 2021-04-20 2022-10-04 南方科技大学 一种病毒联合检测的微流控芯片及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666866A (en) 1983-04-19 1987-05-19 Krauth Gary H Immunoassay for antigens employing supported binder
US5279538A (en) 1991-11-18 1994-01-18 E. I. Du Pont De Nemours And Company Centrifuge rotor having a predetermined region of failure
CA2134478C (en) 1992-05-01 2001-12-18 Peter Wilding Microfabricated detection structures
ES2194843T3 (es) * 1992-09-11 2003-12-01 Hoffmann La Roche Deteccion de acidos nucleicos en sangre.
WO1994026414A1 (en) * 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
FR2728687A1 (fr) * 1994-12-21 1996-06-28 Bio Merieux Procede de dosage d'un haptene selon une technique de competition
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JP2000508058A (ja) 1995-12-18 2000-06-27 ニューカーマンズ、アーモンド、ピー マイクロフルイディック弁及び集積マイクロフルイディックシステム
EP1179585B1 (en) * 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6235479B1 (en) * 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
DE60022025T2 (de) * 1999-05-28 2006-06-29 Cepheid, Sunnyvale Anlage zum brechen von zellen
ATE264718T1 (de) 1999-07-02 2004-05-15 Clondiag Chip Tech Gmbh Microchip-matrix-vorrichtung zur vervielfältigung und charakterisierung von nukleinsäuren
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US20060281112A1 (en) * 2000-03-24 2006-12-14 Jose Remacle Design of capture molecules for the detection of amplicons with high sensitivity
US7553453B2 (en) 2000-06-02 2009-06-30 Honeywell International Inc. Assay implementation in a microfluidic format
US6453928B1 (en) 2001-01-08 2002-09-24 Nanolab Ltd. Apparatus, and method for propelling fluids
CN1650027B (zh) * 2002-04-24 2010-04-21 日立化成研究中心公司 用于全血mRNA的高通量定量的装置和方法
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
WO2004072097A2 (en) 2003-02-05 2004-08-26 The General Hospital Corporation A microchip-based system for hiv diagnostics
CA2559778C (en) 2004-03-26 2011-07-05 Infectio Recherche Inc. Removable microfluidic flow cell
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
DE102005052752A1 (de) 2005-11-04 2007-05-10 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE102004022263A1 (de) 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
JP5020818B2 (ja) * 2004-07-01 2012-09-05 ジェン−プローブ・インコーポレーテッド 生物学的試料中の核酸を検出するための方法及び組成物
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
JP4643277B2 (ja) * 2005-01-24 2011-03-02 株式会社島津製作所 反応容器、遺伝子多型検出方法及び装置
CA2610875A1 (en) * 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
US7754474B2 (en) * 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
WO2007024701A2 (en) * 2005-08-19 2007-03-01 The Regents Of The University Of California Microfluidic methods for diagnostics and cellular analysis
EP1928603A1 (en) * 2005-09-02 2008-06-11 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
US20070051415A1 (en) 2005-09-07 2007-03-08 Honeywell International Inc. Microvalve switching array
JP5286786B2 (ja) 2005-11-16 2013-09-11 三菱瓦斯化学株式会社 二重鎖dna量の測定方法および測定用キット
DE102006005287B4 (de) * 2006-02-06 2012-12-27 Siemens Ag Verfahren zum Nachweis von Zielnukleinsäuren
US8137626B2 (en) * 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
EP2674217B1 (en) * 2006-11-06 2019-07-10 Alere Technologies GmbH Device for assays using binding members
CA3006347A1 (en) 2007-07-23 2009-01-29 Clondiag Gmbh Methods and devices for determining values indicative of the presence and/or amount of nucleic acids

Also Published As

Publication number Publication date
CN105543084A (zh) 2016-05-04
JP2019054794A (ja) 2019-04-11
ES2722874T3 (es) 2019-08-19
US9925536B2 (en) 2018-03-27
JP5859203B2 (ja) 2016-02-10
CN105543084B (zh) 2019-09-06
EP2610007A1 (en) 2013-07-03
WO2009013321A2 (en) 2009-01-29
JP2010534328A (ja) 2010-11-04
JP5993397B2 (ja) 2016-09-14
CA2722242A1 (en) 2009-01-29
EP2626434B1 (en) 2018-12-12
EP2647432B1 (en) 2018-12-19
EP2188054B1 (en) 2017-03-08
EP2612708B1 (en) 2018-12-19
CN101848765B (zh) 2016-03-09
AU2008280121B2 (en) 2015-02-26
WO2009013321A3 (en) 2009-10-08
ES2717940T3 (es) 2019-06-26
JP6755533B2 (ja) 2020-09-16
EP3527288B1 (en) 2021-05-12
CN101848765A (zh) 2010-09-29
AU2008280121A2 (en) 2010-03-11
EP2626434A1 (en) 2013-08-14
BRPI0814582B1 (pt) 2021-05-11
ZA201000845B (en) 2021-09-29
CA3006347A1 (en) 2009-01-29
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