ES2722874T3 - Sistema microfluídico - Google Patents

Sistema microfluídico Download PDF

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Publication number
ES2722874T3
ES2722874T3 ES12192877T ES12192877T ES2722874T3 ES 2722874 T3 ES2722874 T3 ES 2722874T3 ES 12192877 T ES12192877 T ES 12192877T ES 12192877 T ES12192877 T ES 12192877T ES 2722874 T3 ES2722874 T3 ES 2722874T3
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ES
Spain
Prior art keywords
heating
microfluidic cartridge
cooling element
target molecules
cooling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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ES12192877T
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English (en)
Inventor
Eugen Ermantraut
Thomas Kaiser
Katrin Steinmetzer
Thomas Ullrich
Torsten Schulz
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Abbott Rapid Diagnostics Jena GmbH
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Alere Technologies GmbH
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Publication of ES2722874T3 publication Critical patent/ES2722874T3/es
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Abstract

Un sistema (400) para realizar en un cartucho microfluídico (401) al menos las etapas de captura de moléculas diana de una muestra, amplificación de las moléculas diana y detección de uno o más valores indicativos de la presencia de las moléculas diana en la muestra, que comprende: - un sistema de detección (455); - miembros de accionador (441-444) y accionadores (437-440); - un unidad de válvula (435); - un compresor (431); - una unidad de control (471); y - un sistema de calentamiento y/o enfriamiento, comprendiendo al menos una parte del cartucho microfluídico (451) un primer y un segundo elemento de calentamiento/enfriamiento, en el que al menos uno de los elementos de calentamiento/enfriamiento está montado de forma flexible, permitiendo, por tanto, adaptar de forma flexible el elemento de calentamiento/enfriamiento a una estructura del cartucho microfluídico, y en el que el primer elemento de calentamiento/enfriamiento se dispone cerca de una superficie superior de un sustrato del cartucho microfluídico y el segundo elemento de calentamiento/enfriamiento tiene un rebajo central (459) para permitir una detección óptica de moléculas en un pocillo central del cartucho microfluídico (401).
ES12192877T 2007-07-23 2008-07-23 Sistema microfluídico Active ES2722874T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95135807P 2007-07-23 2007-07-23

Publications (1)

Publication Number Publication Date
ES2722874T3 true ES2722874T3 (es) 2019-08-19

Family

ID=39885074

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12192877T Active ES2722874T3 (es) 2007-07-23 2008-07-23 Sistema microfluídico
ES12192879T Active ES2717940T3 (es) 2007-07-23 2008-07-23 Ensayos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES12192879T Active ES2717940T3 (es) 2007-07-23 2008-07-23 Ensayos

Country Status (11)

Country Link
US (1) US9925536B2 (es)
EP (6) EP2610007B1 (es)
JP (5) JP5859203B2 (es)
CN (2) CN101848765B (es)
AU (1) AU2008280121B2 (es)
BR (1) BRPI0814582B1 (es)
CA (2) CA3006347A1 (es)
ES (2) ES2722874T3 (es)
NZ (1) NZ582786A (es)
WO (1) WO2009013321A2 (es)
ZA (1) ZA201000845B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2610007B1 (en) 2007-07-23 2018-12-05 CLONDIAG GmbH Assays
KR101130698B1 (ko) * 2009-11-03 2012-04-02 삼성전자주식회사 밸브 유닛과 이를 구비한 미세유동장치 및 밸브 유닛의 구동방법
FR2967362B1 (fr) * 2010-11-16 2012-12-21 Genewave Cartouche microfluidique pour diagnostic moleculaire
EP2646155A2 (en) 2010-12-03 2013-10-09 Alere Technologies GmbH Transformation of material into an optically modulating state via laser radiation
WO2013029159A1 (en) * 2011-08-30 2013-03-07 The Royal Institution For The Advancement Of Learning / Mcgill University Method and system for pre-programmed self-power microfluidic circuits
CN104081210B (zh) * 2011-12-23 2018-11-30 雅培医护站股份有限公司 具有气动式样本致动的光学测定装置
EP2805164B1 (en) * 2012-01-16 2017-11-08 Koninklijke Philips N.V. Determining a presence of target molecules in a body fluid comprising cells
EP2809227A4 (en) * 2012-02-03 2015-08-26 L Livermore Nat Security Llc FLEXIBLE NEUROLOGICAL PROBES REINFORCED WITH RIGID STIFFENER AND METHODS OF MANUFACTURING USING WASTE DISTRIBUTED CHANNEL ADHESIVES AND TISSUE INSERTION AND EXTRACTION
US8804105B2 (en) * 2012-03-27 2014-08-12 E. I. Spectra, Llc Combined optical imaging and electrical detection to characterize particles carried in a fluid
EP2856177B1 (en) * 2012-05-25 2020-11-18 The University of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
AU2013303237A1 (en) * 2012-08-16 2015-04-09 NVS Technologies, Inc. Assay methods and systems
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
WO2014097287A1 (en) 2012-12-17 2014-06-26 Leukodx, Ltd. Systems and methods for detecting a biological condition
US10610861B2 (en) 2012-12-17 2020-04-07 Accellix Ltd. Systems, compositions and methods for detecting a biological condition
SG10201707599WA (en) 2013-03-15 2017-10-30 Richard Harry Turner A System And Methods For The In Vitro Detection Of Particles And Soluble Chemical Entities In Body Fluids
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
IL292824A (en) * 2013-03-15 2022-07-01 Nanobiosym Inc Systems and methods for a portable diagnostic device for nucleic acids and proteins
CN105609507B (zh) * 2014-11-17 2018-09-07 华邦电子股份有限公司 软性微系统结构
US9999100B2 (en) * 2015-04-07 2018-06-12 Cell Id Pte Ltd DC heater
US10870111B2 (en) 2015-07-22 2020-12-22 The University Of North Carolina At Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
JP6619577B2 (ja) * 2015-08-05 2019-12-11 アルプスアルパイン株式会社 流路構造体、測定ユニット、測定対象液体の測定方法、および測定対象液体の測定装置
BR112018070197A2 (pt) * 2016-03-29 2019-01-29 Univ Rice William M detecção baseada na superfície de ácidos nucleicos em dispositivos fluidos de fluxo de convecção
WO2017184178A1 (en) * 2016-04-22 2017-10-26 Hewlett-Packard Development Company, L.P. Cell lysis
CN109789419A (zh) * 2016-10-07 2019-05-21 勃林格殷格翰维特梅迪卡有限公司 用于测试样品的储物筒和分析系统
IT201600104601A1 (it) 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico
JP6978255B2 (ja) * 2017-08-31 2021-12-08 日東電工株式会社 液体吐出装置及び測定用テープ
EP3668650A4 (en) * 2017-10-03 2021-06-02 Avails Medical, Inc. APPARATUS, SYSTEMS AND METHODS FOR DETERMINING THE CONCENTRATION OF MICRO-ORGANISMS AND THE SUSCEPTIBILITY OF MICRO-ORGANISMS TO ANTI-INFECTIOUS, BASED ON OXIDOREDUCTION REACTIONS
KR102227029B1 (ko) * 2017-12-15 2021-03-16 프리시젼바이오 주식회사 진단 장치
EP3774046A1 (en) * 2018-04-06 2021-02-17 Boehringer Ingelheim Vetmedica GmbH Analysis device, cartridge, analysis system and method for testing a sample
FR3088340B1 (fr) * 2018-11-12 2021-01-22 Commissariat Energie Atomique Systeme automatise de preparation, de detection et d'analyse d'un echantillon fluidique
CN109884063B (zh) * 2019-04-24 2021-08-20 杭州翔毅科技有限公司 一种用于液体传感器的采集结构
EP3766578A1 (en) * 2019-07-18 2021-01-20 Blink AG A liquid handling and processing tool for analyzing a biological sample
WO2022036323A1 (en) * 2020-08-14 2022-02-17 Ohio State Innovation Foundation Liquid crystal biosensor with ultrahigh sensitivity and selectivity
WO2022182125A1 (ko) * 2021-02-23 2022-09-01 모던밸류 주식회사 열제어부가 통합된, turn-off 방식의 광신호 측정용 액적 로딩 카트리지
DE102021203409A1 (de) * 2021-04-07 2022-10-13 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren zum Nachweis aktiver Viren
CN113101991B (zh) * 2021-04-20 2022-10-04 南方科技大学 一种病毒联合检测的微流控芯片及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666866A (en) 1983-04-19 1987-05-19 Krauth Gary H Immunoassay for antigens employing supported binder
US5279538A (en) 1991-11-18 1994-01-18 E. I. Du Pont De Nemours And Company Centrifuge rotor having a predetermined region of failure
DE69322774T2 (de) 1992-05-01 1999-06-17 Univ Pennsylvania Polynukleotide amplifikationsanalyse mit einer mikrofabrizierten vorrichtung
EP0590327B1 (en) * 1992-09-11 2003-04-09 F. Hoffmann-La Roche Ag Detection of nucleic acids in blood
WO1994026414A1 (en) 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
FR2728687A1 (fr) * 1994-12-21 1996-06-28 Bio Merieux Procede de dosage d'un haptene selon une technique de competition
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
JP2000508058A (ja) * 1995-12-18 2000-06-27 ニューカーマンズ、アーモンド、ピー マイクロフルイディック弁及び集積マイクロフルイディックシステム
US6440725B1 (en) * 1997-12-24 2002-08-27 Cepheid Integrated fluid manipulation cartridge
US6235479B1 (en) * 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
WO2000073412A2 (en) 1999-05-28 2000-12-07 Cepheid Apparatus and method for analyzing a fluid sample
ATE264718T1 (de) 1999-07-02 2004-05-15 Clondiag Chip Tech Gmbh Microchip-matrix-vorrichtung zur vervielfältigung und charakterisierung von nukleinsäuren
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US20060281112A1 (en) * 2000-03-24 2006-12-14 Jose Remacle Design of capture molecules for the detection of amplicons with high sensitivity
US7553453B2 (en) 2000-06-02 2009-06-30 Honeywell International Inc. Assay implementation in a microfluidic format
US6453928B1 (en) * 2001-01-08 2002-09-24 Nanolab Ltd. Apparatus, and method for propelling fluids
EP1504121A4 (en) * 2002-04-24 2005-06-29 Hitachi Chemical Res Ct Inc DEVICE AND METHOD FOR HIGH QUANTIZATION OF MESSENGER RNA FROM TOTAL BLOOD
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
DE602004024285D1 (de) 2003-02-05 2010-01-07 Gen Hospital Corp System auf mikrochipbasis zur hiv-diagnostik
WO2005093388A1 (en) 2004-03-26 2005-10-06 Infectio Recherche Inc. Removable microfluidic flow cell
US8852862B2 (en) * 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
EP1745153B1 (en) 2004-05-03 2015-09-30 Handylab, Inc. Processing polynucleotide-containing samples
DE102004022263A1 (de) 2004-05-06 2005-12-15 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
DE102005052752A1 (de) 2005-11-04 2007-05-10 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
WO2006007567A2 (en) * 2004-07-01 2006-01-19 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
DE102004056735A1 (de) 2004-11-09 2006-07-20 Clondiag Chip Technologies Gmbh Vorrichtung für die Durchführung und Analyse von Mikroarray-Experimenten
JP4643277B2 (ja) * 2005-01-24 2011-03-02 株式会社島津製作所 反応容器、遺伝子多型検出方法及び装置
WO2006132666A1 (en) * 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
US7754474B2 (en) * 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
AU2006283518A1 (en) * 2005-08-19 2007-03-01 The Regents Of The University Of California Microfluidic methods for diagnostics and cellular analysis
JP2009507193A (ja) * 2005-09-02 2009-02-19 カリフォルニア インスティチュート オブ テクノロジー 流体装置におけるバルブの機械的作動に対する方法及び装置
US20070051415A1 (en) 2005-09-07 2007-03-08 Honeywell International Inc. Microvalve switching array
US7851160B2 (en) * 2005-11-16 2010-12-14 Mitsubishi Gas Chemical Company, Inc. Method for determination of amount of double-stranded DNA and kit for the determination
DE102006005287B4 (de) * 2006-02-06 2012-12-27 Siemens Ag Verfahren zum Nachweis von Zielnukleinsäuren
US8137626B2 (en) * 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
CA2966901C (en) * 2006-11-06 2021-08-17 Clondiag Gmbh Assays using binding members and reporter compounds
EP2610007B1 (en) 2007-07-23 2018-12-05 CLONDIAG GmbH Assays

Also Published As

Publication number Publication date
US9925536B2 (en) 2018-03-27
ZA201000845B (en) 2021-09-29
BRPI0814582A2 (pt) 2015-01-20
BRPI0814582B1 (pt) 2021-05-11
JP2017029151A (ja) 2017-02-09
US20100255473A1 (en) 2010-10-07
EP3527288A1 (en) 2019-08-21
AU2008280121B2 (en) 2015-02-26
CN101848765B (zh) 2016-03-09
JP2014195453A (ja) 2014-10-16
CN105543084A (zh) 2016-05-04
JP2019054794A (ja) 2019-04-11
ES2717940T3 (es) 2019-06-26
EP2610007A1 (en) 2013-07-03
AU2008280121A2 (en) 2010-03-11
EP3527288B1 (en) 2021-05-12
EP2626434A1 (en) 2013-08-14
EP2647432B1 (en) 2018-12-19
EP2612708A1 (en) 2013-07-10
JP5859203B2 (ja) 2016-02-10
JP2010534328A (ja) 2010-11-04
WO2009013321A3 (en) 2009-10-08
CA3006347A1 (en) 2009-01-29
CA2722242A1 (en) 2009-01-29
EP2188054B1 (en) 2017-03-08
AU2008280121A1 (en) 2009-01-29
EP2188054A2 (en) 2010-05-26
JP2020202852A (ja) 2020-12-24
EP2612708B1 (en) 2018-12-19
EP2647432A1 (en) 2013-10-09
JP5993397B2 (ja) 2016-09-14
JP6755533B2 (ja) 2020-09-16
EP2626434B1 (en) 2018-12-12
CN101848765A (zh) 2010-09-29
WO2009013321A2 (en) 2009-01-29
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