BRPI0811069A2 - Derivados de amida para inibir o crescimento de células cancerosas - Google Patents

Derivados de amida para inibir o crescimento de células cancerosas

Info

Publication number
BRPI0811069A2
BRPI0811069A2 BRPI0811069-7A2A BRPI0811069A BRPI0811069A2 BR PI0811069 A2 BRPI0811069 A2 BR PI0811069A2 BR PI0811069 A BRPI0811069 A BR PI0811069A BR PI0811069 A2 BRPI0811069 A2 BR PI0811069A2
Authority
BR
Brazil
Prior art keywords
cancer cell
cell growth
inhibit cancer
amida
derivatives
Prior art date
Application number
BRPI0811069-7A2A
Other languages
English (en)
Inventor
Kwang-Ok Lee
Mi Young Cha
Mi Ra Kim
Young Hee Jung
Chang Gon Lee
Se Young Kim
Keukchan Bang
Bum Woo Park
Bo Im Choi
Yun Jung Chae
Mi Young Ko
Han Kyong Kim
Young-Gil Ahn
Maeng Sup Kim
Gwan Sun Lee
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of BRPI0811069A2 publication Critical patent/BRPI0811069A2/pt
Publication of BRPI0811069B1 publication Critical patent/BRPI0811069B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0811069-7A 2007-06-05 2008-06-05 Derivado de amida e composição farmacêutica para inibir o crescimento de células cancerosas compreendendo o mesmo BRPI0811069B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20070054997 2007-06-05
KR10-2007-0054997 2007-06-05
PCT/KR2008/003162 WO2008150118A2 (en) 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells

Publications (2)

Publication Number Publication Date
BRPI0811069A2 true BRPI0811069A2 (pt) 2014-12-09
BRPI0811069B1 BRPI0811069B1 (pt) 2022-08-30

Family

ID=40094307

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0811069-7A BRPI0811069B1 (pt) 2007-06-05 2008-06-05 Derivado de amida e composição farmacêutica para inibir o crescimento de células cancerosas compreendendo o mesmo

Country Status (25)

Country Link
US (1) US8188102B2 (pt)
EP (1) EP2167492B1 (pt)
JP (1) JP5155391B2 (pt)
KR (1) KR101013319B1 (pt)
CN (1) CN101679384B (pt)
AR (2) AR066876A1 (pt)
AU (1) AU2008260772B2 (pt)
BR (1) BRPI0811069B1 (pt)
CA (1) CA2687180C (pt)
DK (1) DK2167492T3 (pt)
ES (1) ES2558623T3 (pt)
HK (1) HK1142591A1 (pt)
HR (1) HRP20160007T1 (pt)
HU (1) HUE028243T2 (pt)
IL (1) IL202154A (pt)
MX (1) MX2009012772A (pt)
MY (1) MY144972A (pt)
NZ (1) NZ582412A (pt)
PL (1) PL2167492T3 (pt)
PT (1) PT2167492E (pt)
RU (1) RU2434010C2 (pt)
TW (1) TWI377944B (pt)
UA (1) UA96045C2 (pt)
WO (1) WO2008150118A2 (pt)
ZA (1) ZA201000022B (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009002585A (es) 2006-09-11 2009-08-24 Curis Inc Inhibidores e egfr a base de quinolina que contienen porcion de enlace de zinc.
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
JP5918693B2 (ja) 2009-05-05 2016-05-18 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド Ｅｇｆｒ阻害剤及び疾患の治療方法
KR101217526B1 (ko) 2010-06-11 2013-01-02 한미사이언스 주식회사 아마이드 유도체 또는 이의 약학적으로 허용 가능한 염을 포함하는 약제학적 조성물
US8828391B2 (en) 2011-05-17 2014-09-09 Boehringer Ingelheim International Gmbh Method for EGFR directed combination treatment of non-small cell lung cancer
KR101317809B1 (ko) 2011-06-07 2013-10-16 한미약품 주식회사 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물
KR101272613B1 (ko) * 2011-10-05 2013-06-10 한미사이언스 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온 염산염의 제조 방법 및 이에 사용되는 중간체
US9034885B2 (en) 2012-01-13 2015-05-19 Acea Biosciences Inc. EGFR modulators and uses thereof
CN110194748A (zh) 2012-01-13 2019-09-03 艾森生物科学公司 杂环化合物及其作为抗癌药的用途
US9586965B2 (en) 2012-01-13 2017-03-07 Acea Biosciences Inc. Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
US9464089B2 (en) 2012-01-13 2016-10-11 Acea Biosciences Inc. Heterocyclic compounds and uses thereof
CA2860765C (en) 2012-01-17 2018-06-26 Astellas Pharma Inc. Pyrazinecarboxamide compound
CN102659764A (zh) * 2012-04-16 2012-09-12 中国科学院广州生物医药与健康研究院 酪氨酸激酶不可逆抑制剂及其制备方法和用途
KR20140096571A (ko) * 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
BR112016000195A8 (pt) 2013-07-11 2019-12-31 Acea Biosciences Inc compostos heterocíclicos, composição farmacêutica, combinação, seu uso, e método para inibir uma atividade da tirosina quinase btk ou jak, egfr, alk, pdgfr, blk, bmx/etk, flt3(d835y), itk, tec, txk, e suas respectivas vias
CN104513229A (zh) * 2013-09-28 2015-04-15 正大天晴药业集团股份有限公司 喹唑啉衍生物及其制备方法
WO2015154725A1 (zh) * 2014-04-11 2015-10-15 四川海思科制药有限公司 喹唑啉衍生物及其制备方法和在医药上的应用
EP3226869A4 (en) * 2014-12-03 2018-07-18 Auckland UniServices, Ltd. Kinase inhibitor prodrug for the treatment of cancer
CN107406430B (zh) * 2015-03-20 2019-04-26 正大天晴药业集团股份有限公司 喹唑啉衍生物的盐及其制备方法
JP6889494B2 (ja) 2015-10-09 2021-06-18 エイシア セラピューティクス， インコーポレイテッド ピロロピリミジンキナーゼ阻害剤の薬学的塩、物理的形態、および組成物、ならびにそれらを作製する方法
US10858340B2 (en) * 2016-08-25 2020-12-08 Chia Tai Tianqing Pharmaceutical Group Co. Ltd. Crystal of salt of quinazoline derivative
CN108069946B (zh) * 2016-11-08 2020-06-05 威尚（上海）生物医药有限公司 具有穿过血脑屏障能力的取代的喹唑啉化合物
CN110167928A (zh) * 2016-12-22 2019-08-23 勃林格殷格翰国际有限公司 作为sos1抑制剂的新型经苄基氨基取代的喹唑啉和衍生物
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
WO2018157813A1 (zh) 2017-02-28 2018-09-07 南京明德新药研发股份有限公司 螺环类化合物及其应用
BR112019020840A2 (pt) 2017-04-07 2020-04-28 Acea Therapeutics Inc sais farmacêuticos, formas físicas e composições de inibidores da pirrolopirimidina quinase e métodos de produção dos mesmos
ES2888298T3 (es) * 2017-04-27 2022-01-03 Astrazeneca Ab Compuestos de C5-anilinoquinazolina y su uso en el tratamiento de cáncer
AR113451A1 (es) * 2017-10-18 2020-05-06 Spectrum Pharmaceuticals Inc Inhibidores de tirosina quinasas de la familia de los egfr mutantes
EP3733663B1 (en) * 2017-12-19 2023-05-17 Chengdu Jinrui Foundation Biotech Co., Ltd. 1-[6-[[4-(phenylamino)-6-quinazolinyl]oxy]-3-azabicyclo[3.1.1]hept-3-yl]-2-propen-1-one derivatives and related compounds as irreversible inhibitors of pan-her tyrosine kinase for the treatment of cancer
CN111372932B (zh) 2017-12-21 2023-11-21 勃林格殷格翰国际有限公司 作为sos1抑制剂的新颖苄氨基取代吡啶并嘧啶酮及衍生物
BR112020019251A2 (pt) 2018-03-27 2021-01-12 Board Of Regents, The University Of Texas System Compostos com atividade anti-tumor contra células de câncer com mutações de her2 exon 19
CN110054613B (zh) * 2018-05-24 2020-11-27 深圳市塔吉瑞生物医药有限公司 取代的氨基喹唑啉类化合物及其药物组合物及其用途
CN110577514B (zh) * 2018-06-08 2022-07-05 江苏威凯尔医药科技有限公司 人表皮生长因子受体抑制剂及其制备方法和应用
WO2019233459A1 (zh) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 人表皮生长因子受体抑制剂及其制备方法和应用
CN108623490A (zh) * 2018-06-22 2018-10-09 苏州市贝克生物科技有限公司 (2z)-4-(二甲基氨基)-2-丁烯酸盐酸盐的合成方法
US20210145834A1 (en) 2018-06-25 2021-05-20 Spectrum Pharmaceuticals, Inc. Combination of poziotinib with cytotoxic agent and/or other molecularly targeted agent and use thereof
TW202012391A (zh) * 2018-07-04 2020-04-01 日商第一三共股份有限公司 二芳基醚型喹唑啉衍生物
KR20210061371A (ko) * 2018-09-14 2021-05-27 스펙트럼 파마슈티컬즈 인크 암 치료용 키트 및 방법
CN113056272A (zh) * 2018-09-21 2021-06-29 光谱医药公司 新的喹唑啉egfr抑制剂
CN113382986A (zh) 2018-09-25 2021-09-10 黑钻治疗公司 酪氨酸激酶抑制剂组合物、其制备方法和使用方法
KR101950942B1 (ko) 2019-01-28 2019-02-22 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
MA55380A (fr) 2019-03-19 2022-01-26 B2Sbio Inc Dérivé hétéroaryle, son procédé de production et composition pharmaceutique le comprenant en tant que constituant efficace
JP2022529518A (ja) * 2019-04-25 2022-06-22 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム チロシンキナーゼの複素環式阻害剤
JP2022534555A (ja) 2019-05-09 2022-08-02 フジフィルム セルラー ダイナミクス，インコーポレイテッド ヘパトサイトの作製方法
US20220242851A1 (en) * 2019-06-19 2022-08-04 Shenzhen Jinrui Foundation Biotech Co., Ltd Crystal form and salt of quinazoline compound and preparation method thereof
WO2020262998A1 (ko) * 2019-06-26 2020-12-30 한미약품 주식회사 항 종양 활성을 갖는 신규 퀴나졸린 유도체 및 이를 포함하는 약학 조성물
KR20210049004A (ko) 2019-10-24 2021-05-04 한미약품 주식회사 암세포의 성장을 억제하는 아마이드 유도체를 포함하는 약제학적 제제 및 이를 포함하는 약제학적 제품
WO2021127397A1 (en) * 2019-12-19 2021-06-24 Black Diamond Therapeutics, Inc. Nitrogen heterocyclic compounds and methods of use
US20230121116A1 (en) * 2020-01-29 2023-04-20 Board Of Regents, The University Of Texas System Use of quinazoline-based tyrosine kinase inhibitors for the treatment of cancers with nrg1 fusions
WO2021231400A1 (en) * 2020-05-12 2021-11-18 Accutar Biotechnology, Inc. Bis-aryl ethers containing n-acyl azetidine as egfr/her2 inhibitors
CN111763215B (zh) * 2020-07-21 2021-05-18 成都海博为药业有限公司 一种具有含氮杂环结构的化合物及其制备方法和用途
WO2022105908A1 (zh) * 2020-11-23 2022-05-27 上海和誉生物医药科技有限公司 Egfr抑制剂及其制备方法与在药学上的应用
WO2022170043A1 (en) * 2021-02-05 2022-08-11 Accutar Biotechnology, Inc. Quinazoline derived compounds as egfr inhibitors and their uses thereof
WO2022265950A1 (en) 2021-06-15 2022-12-22 Genentech, Inc. Egfr inhibitor and perk activator in combination therapy and their use for treating cancer
WO2022266427A1 (en) * 2021-06-17 2022-12-22 Black Diamond Therapeutics, Inc. 4-(aryl-methyl-amino)-quinazoline derivatives and uses thereof
WO2022266426A1 (en) * 2021-06-17 2022-12-22 Black Diamond Therapeutics, Inc. 6-(heterocycloalkyl-oxy)-quinazoline derivatives and uses thereof
CA3229692A1 (en) * 2021-08-24 2023-03-02 Shunqi Yan Quinazoline compounds for treatment of disease
CN115894486B (zh) * 2021-09-30 2024-02-09 北京赛特明强医药科技有限公司 一种氢化吡啶并喹唑啉类化合物、组合物及其应用
WO2023128350A1 (ko) * 2021-12-30 2023-07-06 주식회사 비투에스바이오 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
WO2024083120A1 (zh) * 2022-10-18 2024-04-25 南京明德新药研发有限公司 苄氨基喹啉类化合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324597B (en) * 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
AU2003226705B2 (en) 2002-03-30 2008-11-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg 4-(N-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors
GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
MXPA06001079A (es) * 2003-07-29 2006-04-11 Astrazeneca Ab Derivados de piperidil quinazolina como inhibidores de cinasa de tirosina.
EP1664028A1 (en) * 2003-09-16 2006-06-07 AstraZeneca AB Quinazoline derivatives as tyrosine kinase inhibitors
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
BRPI0414735A (pt) * 2003-09-25 2006-11-21 Astrazeneca Ab derivado de quinazolina, composto, composição farmacêutica, uso de derivado de quinazolina, método para produzir um efeito anti-proliferativo em um animal de sangue quente, e, processo para a preparação de um derivado de quinazolina
EP1734040A4 (en) 2004-03-23 2007-11-28 Banyu Pharma Co Ltd SUBSTITUTED CHINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE
WO2007023073A2 (de) * 2005-08-22 2007-03-01 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
WO2007055513A1 (en) * 2005-11-08 2007-05-18 Hanmi Pharm. Co., Ltd. Quinazoline derivatives as a signal transduction inhibitor and method for the preparation thereof

Also Published As

Publication number Publication date
AU2008260772B2 (en) 2011-06-02
AR066876A1 (es) 2009-09-16
BRPI0811069B1 (pt) 2022-08-30
EP2167492B1 (en) 2015-10-14
NZ582412A (en) 2011-12-22
HUE028243T2 (en) 2016-12-28
KR101013319B1 (ko) 2011-02-09
AU2008260772A1 (en) 2008-12-11
WO2008150118A2 (en) 2008-12-11
HRP20160007T1 (hr) 2016-02-12
CA2687180C (en) 2012-07-24
UA96045C2 (ru) 2011-09-26
ZA201000022B (en) 2011-04-28
MX2009012772A (es) 2009-12-15
EP2167492A2 (en) 2010-03-31
EP2167492A4 (en) 2010-12-15
PT2167492E (pt) 2016-02-04
CN101679384B (zh) 2013-10-16
MY144972A (en) 2011-11-30
US20100179120A1 (en) 2010-07-15
CN101679384A (zh) 2010-03-24
TWI377944B (en) 2012-12-01
JP5155391B2 (ja) 2013-03-06
HK1142591A1 (en) 2010-12-10
KR20080107294A (ko) 2008-12-10
RU2009149307A (ru) 2011-07-20
US8188102B2 (en) 2012-05-29
IL202154A0 (en) 2010-06-16
TW200906414A (en) 2009-02-16
RU2434010C2 (ru) 2011-11-20
WO2008150118A3 (en) 2009-01-29
CA2687180A1 (en) 2008-12-11
IL202154A (en) 2014-05-28
JP2010529115A (ja) 2010-08-26
PL2167492T3 (pl) 2016-03-31
AR110003A2 (es) 2019-02-13
ES2558623T3 (es) 2016-02-05
DK2167492T3 (en) 2016-01-11

Similar Documents

Publication Publication Date Title
BRPI0811069A2 (pt) Derivados de amida para inibir o crescimento de células cancerosas
BRPI1009871A2 (pt) terapia para promover o crescimento celular
ES2397671T8 (es) Procedimiento para preparar voriconazol
BRPI0810411A2 (pt) Derivados de sulfonil amida para o tratamento de crescimento celular anormal
BRPI1008219A2 (pt) Biorreator para o cultivo de células de mamíferos
BRPI0909174A2 (pt) Composição cosméticas para proporcionar peliculas super hidrofóbicas
DE102008055028A8 (de) Solarzelle
BRPI1006175A2 (pt) composição agroquímica estabilizada
BRPI0907608A2 (pt) Formulas dinâmicas para células de planilha
DK3572100T3 (da) Sammensætning til stimulering af epitelcellevækst
BRPI1013618A2 (pt) pirimidinas substituídas para o tratamento de câncer
BRPI0810660A2 (pt) Derivados do ácido lipóico
BRPI0818691A2 (pt) Métodos para melhorar o crescimento vegetal.
DK2403814T3 (da) Landbrugsmæssig sammensætning
BRPI1008253A2 (pt) Metoso para tratar biomassa
BRPI0819633A2 (pt) Métodos para produzir poliolefinas
BRPI0810586A2 (pt) Aplicação de glicerina para produção de gado
BR112012002084A2 (pt) composições e métodos para inibir crescimento de pelo
BRPI0921679A2 (pt) composto útil para tratar celulite
SMT201500113B (it) Processp per preparare derivati di alfa-carbossammide
DE102008055036A8 (de) Solarzelle
BR112012015447A2 (pt) composição tópica para aplicação cutânea
BRPI1014208A2 (pt) "meio para receber cargas."
BRPI0920224A2 (pt) inibição de plgf para tratar leucemia positiva para cromossoma filadélfia
BRPI0809688A2 (pt) Método para fornecer um alojamento de solenoide

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: HANMI HOLDINGS CO., LTD. (KR)

B25D Requested change of name of applicant approved

Owner name: HANMI SCIENCE CO., LTD. (KR)

B25G Requested change of headquarter approved

Owner name: HANMI SCIENCE CO., LTD. (KR)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 403/12

Ipc: C07D 403/12 (2006.01), C07D 401/12 (2006.01), C07D

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/06/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.