PL2167492T3 - Nowa pochodna amidowa do hamowania wzrostu komórek rakowych - Google Patents

Nowa pochodna amidowa do hamowania wzrostu komórek rakowych

Info

Publication number
PL2167492T3
PL2167492T3 PL08766124T PL08766124T PL2167492T3 PL 2167492 T3 PL2167492 T3 PL 2167492T3 PL 08766124 T PL08766124 T PL 08766124T PL 08766124 T PL08766124 T PL 08766124T PL 2167492 T3 PL2167492 T3 PL 2167492T3
Authority
PL
Poland
Prior art keywords
inhibiting
growth
cancer cells
amide derivative
novel amide
Prior art date
Application number
PL08766124T
Other languages
English (en)
Inventor
Kwang-Ok Lee
Mi Young Cha
Mi Ra Kim
Young Hee Jung
Chang Gon Lee
Se Young Kim
Keukchan Bang
Bum Woo Park
Bo Im Choi
Yun Jung Chae
Mi Young Ko
Han Kyong Kim
Young-Gil Ahn
Maeng Sup Kim
Gwan Sun Lee
Original Assignee
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Science Co Ltd filed Critical Hanmi Science Co Ltd
Publication of PL2167492T3 publication Critical patent/PL2167492T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL08766124T 2007-06-05 2008-06-05 Nowa pochodna amidowa do hamowania wzrostu komórek rakowych PL2167492T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20070054997 2007-06-05
PCT/KR2008/003162 WO2008150118A2 (en) 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells
EP08766124.5A EP2167492B1 (en) 2007-06-05 2008-06-05 Novel amide derivative for inhibiting the growth of cancer cells

Publications (1)

Publication Number Publication Date
PL2167492T3 true PL2167492T3 (pl) 2016-03-31

Family

ID=40094307

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08766124T PL2167492T3 (pl) 2007-06-05 2008-06-05 Nowa pochodna amidowa do hamowania wzrostu komórek rakowych

Country Status (25)

Country Link
US (1) US8188102B2 (pl)
EP (1) EP2167492B1 (pl)
JP (1) JP5155391B2 (pl)
KR (1) KR101013319B1 (pl)
CN (1) CN101679384B (pl)
AR (2) AR066876A1 (pl)
AU (1) AU2008260772B2 (pl)
BR (1) BRPI0811069B1 (pl)
CA (1) CA2687180C (pl)
DK (1) DK2167492T3 (pl)
ES (1) ES2558623T3 (pl)
HK (1) HK1142591A1 (pl)
HR (1) HRP20160007T1 (pl)
HU (1) HUE028243T2 (pl)
IL (1) IL202154A (pl)
MX (1) MX2009012772A (pl)
MY (1) MY144972A (pl)
NZ (1) NZ582412A (pl)
PL (1) PL2167492T3 (pl)
PT (1) PT2167492E (pl)
RU (1) RU2434010C2 (pl)
TW (1) TWI377944B (pl)
UA (1) UA96045C2 (pl)
WO (1) WO2008150118A2 (pl)
ZA (1) ZA201000022B (pl)

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US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
KR101705158B1 (ko) 2009-05-05 2017-02-09 다나-파버 캔서 인스티튜트 인크. Ｅｇｆｒ 억제제 및 질환 치료방법
KR101217526B1 (ko) * 2010-06-11 2013-01-02 한미사이언스 주식회사 아마이드 유도체 또는 이의 약학적으로 허용 가능한 염을 포함하는 약제학적 조성물
US8828391B2 (en) 2011-05-17 2014-09-09 Boehringer Ingelheim International Gmbh Method for EGFR directed combination treatment of non-small cell lung cancer
KR101317809B1 (ko) * 2011-06-07 2013-10-16 한미약품 주식회사 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물
KR101272613B1 (ko) * 2011-10-05 2013-06-10 한미사이언스 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온 염산염의 제조 방법 및 이에 사용되는 중간체
US9586965B2 (en) 2012-01-13 2017-03-07 Acea Biosciences Inc. Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases
US9034885B2 (en) 2012-01-13 2015-05-19 Acea Biosciences Inc. EGFR modulators and uses thereof
EP2802568A1 (en) 2012-01-13 2014-11-19 Acea Biosciences, Inc. Heterocyclic compounds and uses as anticancer agents.
US9464089B2 (en) 2012-01-13 2016-10-11 Acea Biosciences Inc. Heterocyclic compounds and uses thereof
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KR20140096571A (ko) * 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
ES2761572T3 (es) 2013-07-11 2020-05-20 Acea Therapeutics Inc Derivados de pirimidina como inhibidores de quinasa
CN104513229A (zh) * 2013-09-28 2015-04-15 正大天晴药业集团股份有限公司 喹唑啉衍生物及其制备方法
WO2015154725A1 (zh) * 2014-04-11 2015-10-15 四川海思科制药有限公司 喹唑啉衍生物及其制备方法和在医药上的应用
US10507210B2 (en) * 2014-12-03 2019-12-17 Auckland Uniservices Limited Kinase inhibitor prodrug for the treatment of cancer
CN107406430B (zh) * 2015-03-20 2019-04-26 正大天晴药业集团股份有限公司 喹唑啉衍生物的盐及其制备方法
BR112018006939A2 (pt) 2015-10-09 2018-10-16 Acea Therapeutics Inc sais farmacêuticos, formas físicas, e composições de inibidores de pirrol-pirimidina quinase, e métodos para a produção dos mesmos
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CN108069946B (zh) * 2016-11-08 2020-06-05 威尚（上海）生物医药有限公司 具有穿过血脑屏障能力的取代的喹唑啉化合物
JP7219218B2 (ja) * 2016-12-22 2023-02-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体
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US20210078958A1 (en) * 2017-12-19 2021-03-18 Medshine Discovery Inc. Quinazoline derivative and use thereof
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WO2019233459A1 (zh) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 人表皮生长因子受体抑制剂及其制备方法和应用
CN110577514B (zh) * 2018-06-08 2022-07-05 江苏威凯尔医药科技有限公司 人表皮生长因子受体抑制剂及其制备方法和应用
CN108623490A (zh) * 2018-06-22 2018-10-09 苏州市贝克生物科技有限公司 (2z)-4-(二甲基氨基)-2-丁烯酸盐酸盐的合成方法
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NZ536114A (en) * 2002-03-30 2007-11-30 Boehringer Ingelheim Pharma 4-(N-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors
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Also Published As

Publication number Publication date
CA2687180C (en) 2012-07-24
AU2008260772B2 (en) 2011-06-02
BRPI0811069A2 (pt) 2014-12-09
ES2558623T3 (es) 2016-02-05
IL202154A (en) 2014-05-28
TWI377944B (en) 2012-12-01
WO2008150118A2 (en) 2008-12-11
AR110003A2 (es) 2019-02-13
EP2167492A4 (en) 2010-12-15
NZ582412A (en) 2011-12-22
RU2434010C2 (ru) 2011-11-20
EP2167492B1 (en) 2015-10-14
DK2167492T3 (en) 2016-01-11
CN101679384A (zh) 2010-03-24
JP5155391B2 (ja) 2013-03-06
WO2008150118A3 (en) 2009-01-29
US20100179120A1 (en) 2010-07-15
HUE028243T2 (en) 2016-12-28
ZA201000022B (en) 2011-04-28
CN101679384B (zh) 2013-10-16
HK1142591A1 (en) 2010-12-10
BRPI0811069B1 (pt) 2022-08-30
KR101013319B1 (ko) 2011-02-09
AR066876A1 (es) 2009-09-16
CA2687180A1 (en) 2008-12-11
JP2010529115A (ja) 2010-08-26
EP2167492A2 (en) 2010-03-31
TW200906414A (en) 2009-02-16
UA96045C2 (ru) 2011-09-26
RU2009149307A (ru) 2011-07-20
HRP20160007T1 (hr) 2016-02-12
MX2009012772A (es) 2009-12-15
PT2167492E (pt) 2016-02-04
IL202154A0 (en) 2010-06-16
US8188102B2 (en) 2012-05-29
MY144972A (en) 2011-11-30
KR20080107294A (ko) 2008-12-10
AU2008260772A1 (en) 2008-12-11

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