BRPI0810246B1 - Inibidor da dpp-iv incluindo o grupo beta-amino.método de preparação do mesmo e composição famacêutica contendo o mesmo para prevenção e tratamento da dibetes ou obesidade - Google Patents

Inibidor da dpp-iv incluindo o grupo beta-amino.método de preparação do mesmo e composição famacêutica contendo o mesmo para prevenção e tratamento da dibetes ou obesidade Download PDF

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Publication number
BRPI0810246B1
BRPI0810246B1 BRPI0810246-5A BRPI0810246A BRPI0810246B1 BR PI0810246 B1 BRPI0810246 B1 BR PI0810246B1 BR PI0810246 A BRPI0810246 A BR PI0810246A BR PI0810246 B1 BRPI0810246 B1 BR PI0810246B1
Authority
BR
Brazil
Prior art keywords
amino
trifluorophenyl
butanoyl
piperazin
compound
Prior art date
Application number
BRPI0810246-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Heung Jae Kim
Chang Yell Shin
Hadong Kim
Jong Pil Min
Jae Young Lee
Song-Hyen Choi
Tae Hyun Yoon
Hae-Sun Kim
Mi-Kyung Kim
Moon-Ho Son
Soon Hoe Kim
Ji Myun Jang
Moohi Yoo
Woo Yuong Kwak
Kyung Jin Park
Original Assignee
Dong-A St Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong-A St Co., Ltd filed Critical Dong-A St Co., Ltd
Publication of BRPI0810246A2 publication Critical patent/BRPI0810246A2/pt
Publication of BRPI0810246B1 publication Critical patent/BRPI0810246B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0810246-5A 2007-04-19 2008-04-18 Inibidor da dpp-iv incluindo o grupo beta-amino.método de preparação do mesmo e composição famacêutica contendo o mesmo para prevenção e tratamento da dibetes ou obesidade BRPI0810246B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2007-0038462 2007-04-19
KR20070038462 2007-04-19
PCT/KR2008/002203 WO2008130151A1 (en) 2007-04-19 2008-04-18 Dpp-iv inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating a diabetes or an obesity

Publications (2)

Publication Number Publication Date
BRPI0810246A2 BRPI0810246A2 (pt) 2015-08-18
BRPI0810246B1 true BRPI0810246B1 (pt) 2021-11-30

Family

ID=39875638

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810246-5A BRPI0810246B1 (pt) 2007-04-19 2008-04-18 Inibidor da dpp-iv incluindo o grupo beta-amino.método de preparação do mesmo e composição famacêutica contendo o mesmo para prevenção e tratamento da dibetes ou obesidade

Country Status (15)

Country Link
US (1) US8030315B2 (https=)
EP (1) EP2142519B1 (https=)
JP (1) JP5148686B2 (https=)
KR (1) KR101007497B1 (https=)
CN (2) CN101663282B (https=)
AU (1) AU2008241692B2 (https=)
BR (1) BRPI0810246B1 (https=)
CA (1) CA2683696C (https=)
ES (1) ES2526338T3 (https=)
IL (1) IL201524A (https=)
MX (1) MX2009011276A (https=)
NZ (1) NZ580701A (https=)
PT (1) PT2142519E (https=)
RU (1) RU2419615C1 (https=)
WO (1) WO2008130151A1 (https=)

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KR101054911B1 (ko) * 2008-10-17 2011-08-05 동아제약주식회사 디펩티딜펩티다아제-ⅳ의 활성을 저해하는 화합물 및 다른 항당뇨 또는 항비만 약물을 유효성분으로 함유하는 당뇨 또는 비만의 예방 및 치료용 약학적 조성물
CN102378751B (zh) * 2009-03-30 2014-08-20 东亚St株式会社 用于制备二肽基肽酶-iv抑制剂和中间体的改进方法
NZ595543A (en) * 2009-03-30 2013-05-31 Dong A Pharm Co Ltd Improved method for manufacturing dipeptidyl peptidase-iv inhibitor and intermediate
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
KR20110107287A (ko) * 2010-03-24 2011-09-30 동아제약주식회사 비알콜성 지방간 질환의 예방 및 치료용 약학적 조성물
KR101180174B1 (ko) 2010-04-23 2012-09-05 동아제약주식회사 신규한 벤즈아미드 유도체
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
KR101290029B1 (ko) 2011-01-20 2013-07-30 에스티팜 주식회사 시타글립틴의 중간체 제조방법
US20140336196A1 (en) * 2011-05-27 2014-11-13 Merck Sharp & Dohme Corp. Phosphoric acid salts of sitagliptin
CN102321014A (zh) * 2011-05-27 2012-01-18 沈阳亿灵医药科技有限公司 新型双苯基吡啶类衍生物
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2014064215A1 (en) 2012-10-24 2014-05-01 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL
MX381222B (es) * 2013-06-26 2025-03-12 Dong A St Co Ltd Composicion para prevenir o tratar enfermedades renales, que contiene inhibidor de dpp-iv.
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
KR101709127B1 (ko) 2015-06-16 2017-02-22 경동제약 주식회사 Dpp-iv 억제제의 제조를 위한 신규 중간체, 이의 제조방법 및 이를 이용한 dpp-iv 억제제의 제조방법
CN107382757A (zh) * 2017-08-11 2017-11-24 苏州信恩医药科技有限公司 不对称烯丙基取代反应在依格列汀中间体合成中的应用
CN107417554A (zh) * 2017-08-15 2017-12-01 苏州信恩医药科技有限公司 一种依格列汀中间体的合成方法
KR20220165346A (ko) 2021-06-08 2022-12-15 동아에스티 주식회사 에보글립틴의 안정성이 개선된 제제

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PL204753B1 (pl) * 2000-05-25 2010-02-26 Hoffmann La Roche Podstawiony 1-aminoalkilolaktam , zawierający go środek farmaceutyczny, sposób wytwarzania podstawionego 1-aminoalkilolaktamu i jego zastosowanie
WO2001090082A1 (en) * 2000-05-25 2001-11-29 F. Hoffmann-La Roche Ag Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
JP2002088070A (ja) * 2000-09-18 2002-03-27 Mitsubishi Rayon Co Ltd 新規ピペラジノン誘導体およびその製造方法
ATE370141T1 (de) * 2002-10-07 2007-09-15 Merck & Co Inc Antidiabetische heterocyclische beta- aminoverbindungen als inhibitoren von dipeptidylpeptidase
KR20050067418A (ko) 2002-10-18 2005-07-01 머크 앤드 캄파니 인코포레이티드 당뇨병을 치료 또는 예방하기 위한 베타-아미노헤테로사이클릭 디펩티딜 펩티다제 억제제
AU2004261186A1 (en) 2003-07-31 2005-02-10 Merck & Co., Inc. Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
EP1541143A1 (en) * 2003-12-09 2005-06-15 Graffinity Pharmaceuticals Aktiengesellschaft Dpp-iv inhibitors
US7504423B2 (en) * 2003-12-11 2009-03-17 Mitsubishi Tanabe Pharma Corporation α-amino acid derivatives and use thereof as medicines
EP1593671A1 (en) * 2004-03-05 2005-11-09 Graffinity Pharmaceuticals AG DPP-IV inhibitors
EP1604989A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft DPP-IV inhibitors
GB0413389D0 (en) 2004-06-16 2004-07-21 Astrazeneca Ab Chemical compounds
US20090124601A1 (en) 2005-03-29 2009-05-14 Song Zhiguo J Tartaric Acid Salts of a Dipeptidyl Peptidase-IV Inhibitor
JP2008031064A (ja) * 2006-07-27 2008-02-14 Astellas Pharma Inc ジアシルピペラジン誘導体

Also Published As

Publication number Publication date
CA2683696C (en) 2012-05-22
AU2008241692A1 (en) 2008-10-30
HK1172613A1 (en) 2013-04-26
EP2142519A4 (en) 2011-07-13
EP2142519A1 (en) 2010-01-13
WO2008130151A1 (en) 2008-10-30
CN101663282B (zh) 2012-02-15
US20100120790A1 (en) 2010-05-13
KR20080094604A (ko) 2008-10-23
EP2142519B1 (en) 2014-09-24
RU2419615C1 (ru) 2011-05-27
JP5148686B2 (ja) 2013-02-20
BRPI0810246A2 (pt) 2015-08-18
MX2009011276A (es) 2010-01-15
CN102516184B (zh) 2015-03-25
CN101663282A (zh) 2010-03-03
AU2008241692B2 (en) 2011-02-10
HK1138272A1 (en) 2010-08-20
IL201524A (en) 2014-09-30
KR101007497B1 (ko) 2011-01-12
US8030315B2 (en) 2011-10-04
PT2142519E (pt) 2014-12-11
CA2683696A1 (en) 2008-10-30
NZ580701A (en) 2011-07-29
JP2011500508A (ja) 2011-01-06
CN102516184A (zh) 2012-06-27
ES2526338T3 (es) 2015-01-09
IL201524A0 (en) 2010-05-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B25D Requested change of name of applicant approved

Owner name: DONG-A SOCIO HOLDINGS CO., LTD. (KR)

B25A Requested transfer of rights approved

Owner name: DONG-A ST CO., LTD (KR)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/04/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.