KR101007497B1 - 베타 아미노기를 포함하는 ｄｄｐ－ⅳ 저해제, 이의제조방법 및 이를 유효성분으로 함유하는 당뇨 또는 비만예방 및 치료용 약학적 조성물 - Google Patents

베타 아미노기를 포함하는 ｄｄｐ－ⅳ 저해제, 이의제조방법 및 이를 유효성분으로 함유하는 당뇨 또는 비만예방 및 치료용 약학적 조성물 Download PDF

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KR101007497B1
KR101007497B1 KR1020080036052A KR20080036052A KR101007497B1 KR 101007497 B1 KR101007497 B1 KR 101007497B1 KR 1020080036052 A KR1020080036052 A KR 1020080036052A KR 20080036052 A KR20080036052 A KR 20080036052A KR 101007497 B1 KR101007497 B1 KR 101007497B1
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amino
trifluorophenyl
butanoyl
piperazin
formula
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KR20080094604A (ko
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김흥재
곽우영
신창열
김하동
민종필
박경진
이재영
최성현
윤태현
김해선
장지면
김미경
손문호
김순회
유무희
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동아제약주식회사
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Assigned to 동아에스티 주식회사 reassignment 동아에스티 주식회사 권리의 전부이전등록 Assignors: 동아쏘시오홀딩스 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020080036052A 2007-04-19 2008-04-18 베타 아미노기를 포함하는 ｄｄｐ－ⅳ 저해제, 이의제조방법 및 이를 유효성분으로 함유하는 당뇨 또는 비만예방 및 치료용 약학적 조성물 Active KR101007497B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20070038462 2007-04-19
KR1020070038462 2007-04-19

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KR20080094604A KR20080094604A (ko) 2008-10-23
KR101007497B1 true KR101007497B1 (ko) 2011-01-12

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KR1020080036052A Active KR101007497B1 (ko) 2007-04-19 2008-04-18 베타 아미노기를 포함하는 ｄｄｐ－ⅳ 저해제, 이의제조방법 및 이를 유효성분으로 함유하는 당뇨 또는 비만예방 및 치료용 약학적 조성물

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US (1) US8030315B2 (https=)
EP (1) EP2142519B1 (https=)
JP (1) JP5148686B2 (https=)
KR (1) KR101007497B1 (https=)
CN (2) CN101663282B (https=)
AU (1) AU2008241692B2 (https=)
BR (1) BRPI0810246B1 (https=)
CA (1) CA2683696C (https=)
ES (1) ES2526338T3 (https=)
IL (1) IL201524A (https=)
MX (1) MX2009011276A (https=)
NZ (1) NZ580701A (https=)
PT (1) PT2142519E (https=)
RU (1) RU2419615C1 (https=)
WO (1) WO2008130151A1 (https=)

Cited By (1)

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KR20220165346A (ko) 2021-06-08 2022-12-15 동아에스티 주식회사 에보글립틴의 안정성이 개선된 제제

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CN103922971B (zh) 2009-03-30 2016-05-11 东亚St株式会社 用于制备二肽基肽酶-iv抑制剂的中间体的改进方法
EP2415754A4 (en) * 2009-03-30 2012-08-22 Dong A Pharm Co Ltd IMPROVED METHOD FOR PREPARING A DIPEPTIDYL-PEPTIDASE IV HEMMER AND AN INTERMEDIATE PRODUCT THEREOF
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
SG183817A1 (en) * 2010-03-24 2012-10-30 Dong A Pharm Co Ltd Pharmaceutical composition for the prevention or the treatment of non-alcoholic fatty liver disease and the method for prevention or treatment of non-alcoholic fatty liver disease using the same
KR101180174B1 (ko) 2010-04-23 2012-09-05 동아제약주식회사 신규한 벤즈아미드 유도체
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
KR101290029B1 (ko) 2011-01-20 2013-07-30 에스티팜 주식회사 시타글립틴의 중간체 제조방법
CN102321014A (zh) * 2011-05-27 2012-01-18 沈阳亿灵医药科技有限公司 新型双苯基吡啶类衍生物
WO2012166420A1 (en) * 2011-05-27 2012-12-06 Merck Sharp & Dohme Corp. Phosphoric acid salts of sitagliptin
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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
CN105555275B (zh) * 2013-06-26 2021-04-20 东亚St株式会社 含有dpp-iv抑制剂的用于预防和治疗肾脏疾病的组合物
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
KR101709127B1 (ko) 2015-06-16 2017-02-22 경동제약 주식회사 Dpp-iv 억제제의 제조를 위한 신규 중간체, 이의 제조방법 및 이를 이용한 dpp-iv 억제제의 제조방법
CN107382757A (zh) * 2017-08-11 2017-11-24 苏州信恩医药科技有限公司 不对称烯丙基取代反应在依格列汀中间体合成中的应用
CN107417554A (zh) * 2017-08-15 2017-12-01 苏州信恩医药科技有限公司 一种依格列汀中间体的合成方法

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KR20220165346A (ko) 2021-06-08 2022-12-15 동아에스티 주식회사 에보글립틴의 안정성이 개선된 제제

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BRPI0810246B1 (pt) 2021-11-30
MX2009011276A (es) 2010-01-15
RU2419615C1 (ru) 2011-05-27
CA2683696A1 (en) 2008-10-30
US20100120790A1 (en) 2010-05-13
EP2142519B1 (en) 2014-09-24
JP2011500508A (ja) 2011-01-06
EP2142519A4 (en) 2011-07-13
IL201524A (en) 2014-09-30
CN102516184A (zh) 2012-06-27
WO2008130151A1 (en) 2008-10-30
HK1172613A1 (en) 2013-04-26
PT2142519E (pt) 2014-12-11
IL201524A0 (en) 2010-05-31
ES2526338T3 (es) 2015-01-09
KR20080094604A (ko) 2008-10-23
AU2008241692A1 (en) 2008-10-30
CN101663282A (zh) 2010-03-03
CN102516184B (zh) 2015-03-25
BRPI0810246A2 (pt) 2015-08-18
CA2683696C (en) 2012-05-22
US8030315B2 (en) 2011-10-04
JP5148686B2 (ja) 2013-02-20
NZ580701A (en) 2011-07-29
AU2008241692B2 (en) 2011-02-10
HK1138272A1 (en) 2010-08-20
EP2142519A1 (en) 2010-01-13
CN101663282B (zh) 2012-02-15

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