BRPI0809088A2 - Pirimidodiazepinas substituídas úteis como inibidoras de plk1 - Google Patents

Pirimidodiazepinas substituídas úteis como inibidoras de plk1 Download PDF

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Publication number
BRPI0809088A2
BRPI0809088A2 BRPI0809088-2A BRPI0809088A BRPI0809088A2 BR PI0809088 A2 BRPI0809088 A2 BR PI0809088A2 BR PI0809088 A BRPI0809088 A BR PI0809088A BR PI0809088 A2 BRPI0809088 A2 BR PI0809088A2
Authority
BR
Brazil
Prior art keywords
methyl
mol
tetrahydro
diazepin
cyclopentyl
Prior art date
Application number
BRPI0809088-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Jianping Cai
Shaoqing Chen
Xin-Jie Chu
Kang Le
Kin-Chun Thomas Luk
Peter Michael Wovkulich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0809088(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0809088A2 publication Critical patent/BRPI0809088A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0809088-2A 2007-03-22 2008-03-11 Pirimidodiazepinas substituídas úteis como inibidoras de plk1 BRPI0809088A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91935807P 2007-03-22 2007-03-22
US60/919,358 2007-03-22
PCT/EP2008/052847 WO2008113711A1 (en) 2007-03-22 2008-03-11 Substituted pyrimidodiazepines useful as plk1 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0809088A2 true BRPI0809088A2 (pt) 2014-09-09

Family

ID=39415299

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809088-2A BRPI0809088A2 (pt) 2007-03-22 2008-03-11 Pirimidodiazepinas substituídas úteis como inibidoras de plk1

Country Status (24)

Country Link
US (1) US7517873B2 (US07981874-20110719-C00313.png)
EP (1) EP2139892B1 (US07981874-20110719-C00313.png)
JP (1) JP5087640B2 (US07981874-20110719-C00313.png)
KR (1) KR101157848B1 (US07981874-20110719-C00313.png)
CN (2) CN102746175B (US07981874-20110719-C00313.png)
AR (1) AR065794A1 (US07981874-20110719-C00313.png)
AT (1) ATE524472T1 (US07981874-20110719-C00313.png)
AU (1) AU2008228303B2 (US07981874-20110719-C00313.png)
BR (1) BRPI0809088A2 (US07981874-20110719-C00313.png)
CA (1) CA2680757A1 (US07981874-20110719-C00313.png)
CL (1) CL2008000785A1 (US07981874-20110719-C00313.png)
CY (1) CY1112102T1 (US07981874-20110719-C00313.png)
DK (1) DK2139892T3 (US07981874-20110719-C00313.png)
ES (1) ES2371832T3 (US07981874-20110719-C00313.png)
HK (1) HK1139936A1 (US07981874-20110719-C00313.png)
HR (1) HRP20110807T1 (US07981874-20110719-C00313.png)
IL (1) IL200617A (US07981874-20110719-C00313.png)
MX (1) MX2009010034A (US07981874-20110719-C00313.png)
PE (1) PE20120495A1 (US07981874-20110719-C00313.png)
PL (1) PL2139892T3 (US07981874-20110719-C00313.png)
PT (1) PT2139892E (US07981874-20110719-C00313.png)
SI (1) SI2139892T1 (US07981874-20110719-C00313.png)
TW (1) TWI363629B (US07981874-20110719-C00313.png)
WO (1) WO2008113711A1 (US07981874-20110719-C00313.png)

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EP2190849B1 (en) * 2007-08-15 2013-11-20 Vertex Pharmceuticals Incorporated 4-(9-(3,3-difluorocyclopentyl)-5,7,7-trimethyl-6-oxo-6,7,8,9-tetrahydro-5h-pyrimido[4,5-b[1,4]diazepin-2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases plk1 to plk4 for the treatment of proliferative diseases
CN103122001A (zh) * 2007-09-25 2013-05-29 武田药品工业株式会社 Polo样激酶抑制剂
US8563542B2 (en) * 2007-09-28 2013-10-22 Cyclacel Limited Pyrimidine derivatives as protein kinase inhibitors
WO2009067547A1 (en) * 2007-11-19 2009-05-28 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
WO2009153197A1 (en) * 2008-06-18 2009-12-23 F. Hoffmann-La Roche Ag Halo-substituted pyrimidodiazepines as plkl inhibitors
PT2364314E (pt) * 2008-12-09 2014-06-09 Gilead Sciences Inc Moduladores de recetores toll-like
US9266890B2 (en) 2009-01-06 2016-02-23 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
ES2604667T3 (es) 2009-06-17 2017-03-08 Vertex Pharmaceuticals Incorporated Inhibidores de la replicación de virus de influenza
NO2477987T3 (US07981874-20110719-C00313.png) 2009-09-14 2018-06-09
KR20140014110A (ko) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9676792B2 (en) 2013-03-15 2017-06-13 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone compounds and methods of treating disorders
BR112016001457A2 (pt) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc Inibidores de fatores de transcrição e usos dos mesmos
TWI652014B (zh) * 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
SG10201804021TA (en) 2013-11-13 2018-07-30 Vertex Pharma Methods of preparing inhibitors of influenza viruses replication
PL3068776T3 (pl) 2013-11-13 2019-10-31 Vertex Pharma Inhibitory replikacji wirusów grypy
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
KR20160115953A (ko) 2014-01-31 2016-10-06 다나-파버 캔서 인스티튜트 인크. 디아미노피리미딘 벤젠술폰 유도체 및 그의 용도
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
MX2017001756A (es) 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de diazepano y sus usos.
CA2960436C (en) 2014-09-16 2021-01-05 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
ES2845205T3 (es) 2014-09-16 2021-07-26 Gilead Sciences Inc Métodos para preparar moduladores de receptores tipo Toll
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
AU2016276963C1 (en) 2015-06-12 2021-08-05 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
UA123946C2 (uk) 2015-09-11 2021-06-30 Дана-Фарбер Кенсер Інстітьют, Інк. Ацетамідтієнотриазолодіазепіни й шляхи їх застосування
RU2750164C2 (ru) 2015-09-11 2021-06-22 Дана-Фарбер Кэнсер Инститьют, Инк. Цианотиенотриазолодиазепины и пути их применения
WO2017091673A2 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibtors and uses thereof
AU2017248186B2 (en) * 2016-04-07 2021-10-21 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating PI3K-mediated disorders
WO2021061894A1 (en) * 2019-09-27 2021-04-01 Dana-Farber Cancer Institute, Inc. Erk5 degraders as therapeutics in cancer and inflammatory diseases
EP3911654A4 (en) * 2020-03-27 2022-05-11 Uppthera COMPOUND INDUCING SELECTIVE DEGRADATION OF PLK1
WO2022145989A1 (ko) * 2020-12-31 2022-07-07 (주) 업테라 선택적 plk1 억제제로서의 피리미도디아제핀 유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02002938A (es) * 1999-09-17 2004-12-06 Abbott Gmbh & Co Kg Inhibidores de cinasa como agentes agentes terapeuticos.
HUP0401293A3 (en) 2001-09-04 2008-03-28 Boehringer Ingelheim Pharma Novel dihydropteridinones, method for producing the same and the use thereof as medicaments
WO2007095188A2 (en) * 2006-02-14 2007-08-23 Vertex Pharmaceuticals Incorporated Dihydrodiazepines useful as inhibitors of protein kinases
TW200808325A (en) * 2006-07-06 2008-02-16 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
AR065794A1 (es) 2009-07-01
CN102746175B (zh) 2014-01-15
AU2008228303B2 (en) 2012-04-19
PT2139892E (pt) 2011-11-21
KR101157848B1 (ko) 2012-07-11
TWI363629B (en) 2012-05-11
ES2371832T3 (es) 2012-01-10
KR20090119913A (ko) 2009-11-20
ATE524472T1 (de) 2011-09-15
CY1112102T1 (el) 2015-11-04
DK2139892T3 (da) 2011-12-12
JP5087640B2 (ja) 2012-12-05
IL200617A (en) 2014-02-27
EP2139892B1 (en) 2011-09-14
PL2139892T3 (pl) 2012-03-30
CL2008000785A1 (es) 2009-03-27
AU2008228303A1 (en) 2008-09-25
HRP20110807T1 (hr) 2011-12-31
CN101636399B (zh) 2012-04-18
IL200617A0 (en) 2010-05-17
CA2680757A1 (en) 2008-09-25
EP2139892A1 (en) 2010-01-06
PE20120495A1 (es) 2012-05-12
HK1139936A1 (en) 2010-09-30
CN102746175A (zh) 2012-10-24
US7517873B2 (en) 2009-04-14
SI2139892T1 (sl) 2011-12-30
CN101636399A (zh) 2010-01-27
US20080234255A1 (en) 2008-09-25
TW200843781A (en) 2008-11-16
WO2008113711A1 (en) 2008-09-25
JP2010521514A (ja) 2010-06-24
MX2009010034A (es) 2009-10-12

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2368 DE 24-05-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B25E Requested change of name of applicant rejected

Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)