BRPI0714562A2 - composiÇÕes e mÉtodos para o tratamento de mucosites - Google Patents

Info

Publication number

BRPI0714562A2

BRPI0714562A2 BRPI0714562-4A BRPI0714562A BRPI0714562A2 BR PI0714562 A2 BRPI0714562 A2 BR PI0714562A2 BR PI0714562 A BRPI0714562 A BR PI0714562A BR PI0714562 A2 BRPI0714562 A2 BR PI0714562A2

Authority

BR

Brazil

Prior art keywords

compound

formula

alkyl

mucositis

substituted

Prior art date

2006-07-19

Links

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• Global Dossier
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• 238000000034 method Methods 0.000 title claims abstract description 70
• 206010028116 Mucosal inflammation Diseases 0.000 title claims abstract description 41
• 201000010927 Mucositis Diseases 0.000 title claims abstract description 41
• 239000000203 mixture Substances 0.000 title abstract description 49
• 238000011282 treatment Methods 0.000 title description 29
• 150000001875 compounds Chemical class 0.000 claims abstract description 245
• -1 lipoxin compound Chemical class 0.000 claims abstract description 88
• 229930184725 Lipoxin Natural products 0.000 claims abstract description 36
• 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 43
• 229940012843 omega-3 fatty acid Drugs 0.000 claims description 41
• 150000003839 salts Chemical class 0.000 claims description 41
• CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 37
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 34
• 229960001138 acetylsalicylic acid Drugs 0.000 claims description 34
• 239000008194 pharmaceutical composition Substances 0.000 claims description 18
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• 238000001959 radiotherapy Methods 0.000 claims description 14
• 238000002512 chemotherapy Methods 0.000 claims description 12
• 239000003937 drug carrier Substances 0.000 claims description 9
• 230000036269 ulceration Effects 0.000 claims description 9
• 230000004083 survival effect Effects 0.000 claims description 7
• 238000011161 development Methods 0.000 claims description 5
• 238000011285 therapeutic regimen Methods 0.000 claims description 5
• 230000017074 necrotic cell death Effects 0.000 claims description 4
• 210000004400 mucous membrane Anatomy 0.000 claims description 3
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 230000001737 promoting effect Effects 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 description 106
• 125000003118 aryl group Chemical group 0.000 description 74
• YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 61
• 125000001072 heteroaryl group Chemical group 0.000 description 61
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• 239000001257 hydrogen Substances 0.000 description 50
• 125000003342 alkenyl group Chemical group 0.000 description 42
• 125000003545 alkoxy group Chemical group 0.000 description 42
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• 125000001424 substituent group Chemical group 0.000 description 40
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