BRPI0713060A2 - polìmero biodegradável/absorvìvel tendo teor reduzido de catalisador de metal e processo para a produção do mesmo - Google Patents
polìmero biodegradável/absorvìvel tendo teor reduzido de catalisador de metal e processo para a produção do mesmo Download PDFInfo
- Publication number
- BRPI0713060A2 BRPI0713060A2 BRPI0713060-0A BRPI0713060A BRPI0713060A2 BR PI0713060 A2 BRPI0713060 A2 BR PI0713060A2 BR PI0713060 A BRPI0713060 A BR PI0713060A BR PI0713060 A2 BRPI0713060 A2 BR PI0713060A2
- Authority
- BR
- Brazil
- Prior art keywords
- copolymer
- metal catalyst
- polymer
- metal
- less
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title claims abstract description 154
- 229910052751 metal Inorganic materials 0.000 title claims abstract description 148
- 239000002184 metal Substances 0.000 title claims abstract description 148
- 239000003054 catalyst Substances 0.000 title claims abstract description 103
- 238000000034 method Methods 0.000 title claims abstract description 51
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 72
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims abstract description 69
- 229920001577 copolymer Polymers 0.000 claims abstract description 66
- 238000005406 washing Methods 0.000 claims abstract description 49
- 238000004519 manufacturing process Methods 0.000 claims abstract description 35
- 238000001035 drying Methods 0.000 claims abstract description 34
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000012046 mixed solvent Substances 0.000 claims abstract description 29
- 239000007943 implant Substances 0.000 claims abstract description 24
- 238000007334 copolymerization reaction Methods 0.000 claims abstract description 12
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 38
- 239000000463 material Substances 0.000 claims description 38
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 26
- 210000001519 tissue Anatomy 0.000 claims description 20
- 239000002904 solvent Substances 0.000 claims description 16
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 13
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 11
- 239000004310 lactic acid Substances 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 claims description 6
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 claims description 6
- 210000000988 bone and bone Anatomy 0.000 claims description 5
- -1 for tissue coverage Substances 0.000 claims description 5
- NGCDGPPKVSZGRR-UHFFFAOYSA-J 1,4,6,9-tetraoxa-5-stannaspiro[4.4]nonane-2,3,7,8-tetrone Chemical compound [Sn+4].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O NGCDGPPKVSZGRR-UHFFFAOYSA-J 0.000 claims description 4
- UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 230000000181 anti-adherent effect Effects 0.000 claims description 4
- 239000002473 artificial blood Substances 0.000 claims description 4
- 210000004204 blood vessel Anatomy 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- JGFBRKRYDCGYKD-UHFFFAOYSA-N dibutyl(oxo)tin Chemical compound CCCC[Sn](=O)CCCC JGFBRKRYDCGYKD-UHFFFAOYSA-N 0.000 claims description 4
- 239000012975 dibutyltin dilaurate Substances 0.000 claims description 4
- WDQNIWFZKXZFAY-UHFFFAOYSA-M fentin acetate Chemical compound CC([O-])=O.C1=CC=CC=C1[Sn+](C=1C=CC=CC=1)C1=CC=CC=C1 WDQNIWFZKXZFAY-UHFFFAOYSA-M 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 4
- 230000002439 hemostatic effect Effects 0.000 claims description 4
- 230000002787 reinforcement Effects 0.000 claims description 4
- 230000009469 supplementation Effects 0.000 claims description 4
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 claims description 4
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims description 4
- 230000017423 tissue regeneration Effects 0.000 claims description 4
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 claims description 3
- 229910001887 tin oxide Inorganic materials 0.000 claims description 3
- 230000001131 transforming effect Effects 0.000 claims 2
- 229910052718 tin Inorganic materials 0.000 description 37
- 230000014759 maintenance of location Effects 0.000 description 29
- 239000000243 solution Substances 0.000 description 26
- 238000006116 polymerization reaction Methods 0.000 description 20
- 239000002245 particle Substances 0.000 description 16
- FYELSNVLZVIGTI-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-5-ethylpyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C=NN(C=1CC)CC(=O)N1CC2=C(CC1)NN=N2 FYELSNVLZVIGTI-UHFFFAOYSA-N 0.000 description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 11
- 238000003756 stirring Methods 0.000 description 10
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 238000012662 bulk polymerization Methods 0.000 description 4
- 238000005227 gel permeation chromatography Methods 0.000 description 4
- 239000011259 mixed solution Substances 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- 229910017604 nitric acid Inorganic materials 0.000 description 4
- 239000012299 nitrogen atmosphere Substances 0.000 description 4
- 238000001637 plasma atomic emission spectroscopy Methods 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 230000002123 temporal effect Effects 0.000 description 4
- 239000011135 tin Substances 0.000 description 4
- 239000010936 titanium Substances 0.000 description 4
- 229910052719 titanium Inorganic materials 0.000 description 4
- 239000013585 weight reducing agent Substances 0.000 description 4
- 229910052725 zinc Inorganic materials 0.000 description 4
- 239000011701 zinc Substances 0.000 description 4
- 206010029350 Neurotoxicity Diseases 0.000 description 3
- 206010044221 Toxic encephalopathy Diseases 0.000 description 3
- 239000000539 dimer Substances 0.000 description 3
- 230000007674 genetic toxicity Effects 0.000 description 3
- 231100000025 genetic toxicology Toxicity 0.000 description 3
- 230000007688 immunotoxicity Effects 0.000 description 3
- 231100000386 immunotoxicity Toxicity 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 231100000228 neurotoxicity Toxicity 0.000 description 3
- 230000007135 neurotoxicity Effects 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- YHWCPXVTRSHPNY-UHFFFAOYSA-N butan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCC[O-].CCCC[O-].CCCC[O-].CCCC[O-] YHWCPXVTRSHPNY-UHFFFAOYSA-N 0.000 description 2
- 150000004697 chelate complex Chemical class 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 239000010865 sewage Substances 0.000 description 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- VOITXYVAKOUIBA-UHFFFAOYSA-N triethylaluminium Chemical compound CC[Al](CC)CC VOITXYVAKOUIBA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 238000012667 polymer degradation Methods 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- YJBKVPRVZAQTPY-UHFFFAOYSA-J tetrachlorostannane;dihydrate Chemical compound O.O.Cl[Sn](Cl)(Cl)Cl YJBKVPRVZAQTPY-UHFFFAOYSA-J 0.000 description 1
- UWPPADMWQVNQFC-UHFFFAOYSA-J tetrachlorostannane;hydrochloride Chemical compound Cl.Cl[Sn](Cl)(Cl)Cl UWPPADMWQVNQFC-UHFFFAOYSA-J 0.000 description 1
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
- C08G63/82—Preparation processes characterised by the catalyst used
- C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
- C08G63/82—Preparation processes characterised by the catalyst used
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
- C08G63/90—Purification; Drying
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
- C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Polyesters Or Polycarbonates (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006178808A JP5354844B2 (ja) | 2006-06-28 | 2006-06-28 | 金属触媒の含有量が少ない生体内分解吸収性高分子の製法 |
| JP2006178805A JP5334360B2 (ja) | 2006-06-28 | 2006-06-28 | 金属触媒の含有量が少ない生体内分解吸収性高分子の製法 |
| JP2006-178808 | 2006-06-28 | ||
| JP2006-178805 | 2006-06-28 | ||
| PCT/JP2007/062212 WO2008001633A1 (fr) | 2006-06-28 | 2007-06-18 | Polymère biodégradable/absorbable à teneur en catalyseur métallique réduite, et procédé de production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0713060A2 true BRPI0713060A2 (pt) | 2012-04-10 |
Family
ID=38845401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0713060-0A BRPI0713060A2 (pt) | 2006-06-28 | 2007-06-18 | polìmero biodegradável/absorvìvel tendo teor reduzido de catalisador de metal e processo para a produção do mesmo |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20090171064A1 (enExample) |
| EP (1) | EP2039714B1 (enExample) |
| KR (1) | KR101102475B1 (enExample) |
| AU (1) | AU2007264560B2 (enExample) |
| BR (1) | BRPI0713060A2 (enExample) |
| CA (1) | CA2653295C (enExample) |
| IN (1) | IN2014DN10439A (enExample) |
| NZ (1) | NZ573125A (enExample) |
| TW (1) | TWI440651B (enExample) |
| WO (1) | WO2008001633A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| CA2619571A1 (en) * | 2005-08-18 | 2007-02-22 | Smith & Nephew, Plc | High strength devices and composites |
| US20090274742A1 (en) * | 2005-08-18 | 2009-11-05 | Brown Malcolm Nmi | Multimodal high strength devices and composites |
| CN101594831B (zh) | 2006-11-30 | 2011-09-14 | 史密夫和内修有限公司 | 纤维增强的复合材料 |
| JP5416090B2 (ja) | 2007-04-18 | 2014-02-12 | スミス アンド ネフュー ピーエルシー | 形状記憶ポリマーの膨張成形 |
| AU2008243035B2 (en) | 2007-04-19 | 2013-09-12 | Smith & Nephew, Inc. | Graft fixation |
| JP5520814B2 (ja) | 2007-04-19 | 2014-06-11 | スミス アンド ネフュー インコーポレーテッド | マルチモーダル形状記憶ポリマー |
| GB0715376D0 (en) * | 2007-08-07 | 2007-09-19 | Smith & Nephew | Coating |
| EP2985302B1 (en) | 2013-04-12 | 2018-01-10 | National University Corporation Kyoto Institute of Technology | Method for producing lactide-lactone copolymer |
| CN104983484B (zh) * | 2015-05-26 | 2018-07-24 | 无锡市第二人民医院 | 一种经导管植入高弹性外支架可降解的生物瓣膜系统及制备和应用 |
| SG11202001688WA (en) * | 2017-08-31 | 2020-03-30 | Evonik Corp | Improved resorbable polymer purification process |
| GB2568526A (en) * | 2017-11-20 | 2019-05-22 | Rebio Tech Oy | Composition |
| EP3887425A1 (en) | 2018-11-27 | 2021-10-06 | Evonik Operations GmbH | Process for preparing a resorbable polyester as a granulate or powder by bulk polymerization |
| CN112940234B (zh) * | 2021-01-28 | 2022-05-03 | 广东粤港澳大湾区黄埔材料研究院 | 一种高纯度聚乙丙交酯的制备方法 |
| WO2022221904A1 (en) | 2021-04-20 | 2022-10-27 | Waterco Limited | Multi-cyclone sediment filter |
| KR20240114490A (ko) * | 2023-01-17 | 2024-07-24 | 한국화학연구원 | 불소기능화 생분해성 고분자, 이의 제조방법 및 이를 이용한 표면 코팅 |
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| US4045418A (en) * | 1975-01-28 | 1977-08-30 | Gulf Oil Corporation | Copolymers of D,L-lactide and epsilon caprolactone |
| US4643734A (en) | 1983-05-05 | 1987-02-17 | Hexcel Corporation | Lactide/caprolactone polymer, method of making the same, composites thereof, and prostheses produced therefrom |
| DE3641692A1 (de) * | 1986-12-06 | 1988-06-09 | Boehringer Ingelheim Kg | Katalysatorfreie resorbierbare homopolymere und copolymere |
| DE3708916A1 (de) * | 1987-03-19 | 1988-09-29 | Boehringer Ingelheim Kg | Verfahren zur reinigung resorbierbarer polyester |
| NL9001984A (nl) * | 1990-09-10 | 1992-04-01 | Stamicarbon | Werkwijze voor het produceren van een voorwerp van een copolymeer van lactide en epsilon-caprolacton voor medische toepassingen. |
| IT1249045B (it) * | 1991-02-21 | 1995-02-11 | Himont Inc | Processo per la sintesi allo stato solido di polimeri dell'acido lattico e prodotti cosi ottenuti |
| JP3184680B2 (ja) * | 1992-10-09 | 2001-07-09 | 三井化学株式会社 | ポリヒドロキシカルボン酸の精製方法 |
| JPH06116381A (ja) * | 1992-10-09 | 1994-04-26 | Mitsui Toatsu Chem Inc | ポリヒドロキシカルボン酸の精製方法 |
| JP3273821B2 (ja) * | 1993-03-02 | 2002-04-15 | 三井化学株式会社 | ポリヒドロキシカルボン酸の精製法 |
| JP3622327B2 (ja) * | 1996-03-28 | 2005-02-23 | トヨタ自動車株式会社 | 脂肪族ポリエステルのペレットの洗浄方法 |
| JP3453648B2 (ja) | 1998-12-26 | 2003-10-06 | 株式会社ビーエムジー | 金属含有量が少ない生体内分解吸収性高分子およびその製造方法。 |
| EP1334990A1 (en) * | 2002-02-06 | 2003-08-13 | Polyganics B.V. | DL-Lactide-epsilon-caprolactone copolymers |
| JP4659451B2 (ja) * | 2004-12-28 | 2011-03-30 | グンゼ株式会社 | 金属触媒の含有量が少ない生体内分解吸収性高分子及びその製法 |
| JP2007070413A (ja) * | 2005-09-05 | 2007-03-22 | Teijin Ltd | ポリ乳酸組成物およびその製造方法 |
-
2007
- 2007-06-18 BR BRPI0713060-0A patent/BRPI0713060A2/pt not_active IP Right Cessation
- 2007-06-18 US US12/305,104 patent/US20090171064A1/en not_active Abandoned
- 2007-06-18 CA CA2653295A patent/CA2653295C/en not_active Expired - Fee Related
- 2007-06-18 KR KR1020087029690A patent/KR101102475B1/ko not_active Expired - Fee Related
- 2007-06-18 AU AU2007264560A patent/AU2007264560B2/en not_active Ceased
- 2007-06-18 EP EP07745462.7A patent/EP2039714B1/en not_active Not-in-force
- 2007-06-18 WO PCT/JP2007/062212 patent/WO2008001633A1/ja not_active Ceased
- 2007-06-18 NZ NZ573125A patent/NZ573125A/en not_active IP Right Cessation
- 2007-06-18 IN IN10439DEN2014 patent/IN2014DN10439A/en unknown
- 2007-06-27 TW TW096123253A patent/TWI440651B/zh not_active IP Right Cessation
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- 2012-09-21 US US13/624,207 patent/US8481673B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090171064A1 (en) | 2009-07-02 |
| US8481673B2 (en) | 2013-07-09 |
| AU2007264560A1 (en) | 2008-01-03 |
| TW200806704A (en) | 2008-02-01 |
| US20130066042A1 (en) | 2013-03-14 |
| AU2007264560B2 (en) | 2011-12-01 |
| CA2653295C (en) | 2014-03-11 |
| WO2008001633A1 (fr) | 2008-01-03 |
| KR101102475B1 (ko) | 2012-01-05 |
| CA2653295A1 (en) | 2008-01-03 |
| TWI440651B (zh) | 2014-06-11 |
| EP2039714A1 (en) | 2009-03-25 |
| KR20090023599A (ko) | 2009-03-05 |
| HK1129123A1 (en) | 2009-11-20 |
| EP2039714A4 (en) | 2010-12-29 |
| EP2039714B1 (en) | 2015-03-04 |
| IN2014DN10439A (enExample) | 2015-08-21 |
| NZ573125A (en) | 2011-12-22 |
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