BRPI0709338A2 - anticorpo, molécula de ácido nucleico isolada, célula, composições, método de detecção da proteìna alfa5beta1, uso de anticorpo, métodos de tratamento, kit, uso de uma composição, uso de uma antagonista de alfa5beta e uso de uma antagonista de vegf - Google Patents

anticorpo, molécula de ácido nucleico isolada, célula, composições, método de detecção da proteìna alfa5beta1, uso de anticorpo, métodos de tratamento, kit, uso de uma composição, uso de uma antagonista de alfa5beta e uso de uma antagonista de vegf Download PDF

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Publication number
BRPI0709338A2
BRPI0709338A2 BRPI0709338-1A BRPI0709338A BRPI0709338A2 BR PI0709338 A2 BRPI0709338 A2 BR PI0709338A2 BR PI0709338 A BRPI0709338 A BR PI0709338A BR PI0709338 A2 BRPI0709338 A2 BR PI0709338A2
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Brazil
Prior art keywords
antibody
vegf
antagonist
cancer
disease
Prior art date
Application number
BRPI0709338-1A
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English (en)
Portuguese (pt)
Inventor
Anan Chuntharapai
Greg Plowman
Marc Tessier Lavigne
Yan Wu
Weilan Ye
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BRPI0709338A2 publication Critical patent/BRPI0709338A2/pt

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2842—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
BRPI0709338-1A 2006-03-21 2007-03-21 anticorpo, molécula de ácido nucleico isolada, célula, composições, método de detecção da proteìna alfa5beta1, uso de anticorpo, métodos de tratamento, kit, uso de uma composição, uso de uma antagonista de alfa5beta e uso de uma antagonista de vegf BRPI0709338A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US78470406P 2006-03-21 2006-03-21
US60/784.704 2006-03-21
US78533006P 2006-03-22 2006-03-22
US60/785.330 2006-03-22
US87174306P 2006-12-22 2006-12-22
US60/871.743 2006-12-22
PCT/US2007/064572 WO2008060645A2 (en) 2006-03-21 2007-03-21 Combinatorial therapy involving alpha5beta1 antagonists

Publications (1)

Publication Number Publication Date
BRPI0709338A2 true BRPI0709338A2 (pt) 2011-07-12

Family

ID=39402298

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0709338-1A BRPI0709338A2 (pt) 2006-03-21 2007-03-21 anticorpo, molécula de ácido nucleico isolada, célula, composições, método de detecção da proteìna alfa5beta1, uso de anticorpo, métodos de tratamento, kit, uso de uma composição, uso de uma antagonista de alfa5beta e uso de uma antagonista de vegf

Country Status (27)

Country Link
US (3) US20090220504A1 (https=)
EP (2) EP1989231B1 (https=)
JP (2) JP5298007B2 (https=)
KR (1) KR101454491B1 (https=)
AR (1) AR060040A1 (https=)
AU (1) AU2007319757B2 (https=)
BR (1) BRPI0709338A2 (https=)
CA (1) CA2646611A1 (https=)
CR (1) CR10311A (https=)
DK (1) DK1989231T3 (https=)
EC (1) ECSP088835A (https=)
ES (1) ES2544957T3 (https=)
HR (1) HRP20150884T1 (https=)
HU (1) HUE025989T2 (https=)
IL (1) IL193926A (https=)
MA (1) MA30384B1 (https=)
MX (1) MX2008011905A (https=)
MY (1) MY159375A (https=)
NO (1) NO20084396L (https=)
NZ (3) NZ598594A (https=)
PL (1) PL1989231T3 (https=)
PT (1) PT1989231E (https=)
RS (1) RS54156B1 (https=)
RU (1) RU2012129350A (https=)
TW (1) TWI397535B (https=)
UA (1) UA100969C2 (https=)
WO (1) WO2008060645A2 (https=)

Families Citing this family (28)

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HRP20150884T1 (hr) 2006-03-21 2015-09-25 Genentech, Inc. Kombinacijska terapija koja ukljuäśuje antagoniste alfa5beta1
CA2652886A1 (en) * 2006-05-24 2007-11-29 Bayer Schering Pharma Aktiengesellschaft High affinity human and humanized anti-.alpha.5.beta.1 integrin function blocking antibodies with reduced immunogenicity
AU2008282331A1 (en) * 2007-07-27 2009-02-05 Facet Biotech Corporation Pharmaceutical combinations comprising a tyrosine kinase inhibitor and an antibody against integrin alpha 1 beta 5 (CD49E)
CL2008002856A1 (es) * 2007-09-26 2009-01-16 Genentech Inc Anticuerpo novedoso (anticuerpo anti-integrina a5b1; mol}ecula de ácido nucleico que lo codifica; vector y célula huesped; método de producción; composición farmacéutica que lo comprende; su uso para inhibir la angiogénesis y/o permeabilidad vascular y cáncer entre otras patologías; y método de detección de la integrina a5b1).
NZ587440A (en) 2008-02-05 2013-01-25 Pfizer Antibodies specific for human integrin alpha 5 - beta 1 and their uses for treating tumours
WO2010072740A2 (en) 2008-12-23 2010-07-01 Astrazeneca Ab TARGETED BINDING AGENTS DIRECTED TO α5β1 AND USES THEREOF
MY173526A (en) * 2009-03-25 2020-01-31 Genentech Inc Novel anti-?5?1 antibodies and uses thereof
AU2012230809B2 (en) * 2011-03-23 2017-06-29 The Regents Of The University Of California Methods and compositions for improving antiangiogenic therapy with anti-integrins
WO2013025936A1 (en) * 2011-08-18 2013-02-21 Cornell University Detection and treatment of metastatic disease
DK2847231T3 (da) 2012-05-10 2019-10-14 Bioatla Llc Multispecifikke monoklonale antistoffer
CN104870475B (zh) 2012-10-25 2019-11-08 美国比奥维拉迪维股份有限公司 抗补体C1s抗体和其用途
DK2914291T3 (da) * 2012-11-02 2022-05-16 Bioverativ Usa Inc Anti-komplement-c1s-antistoffer og anvendelser deraf
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